Sootheze Six Plus Paracetamol 250mg/5ml Oral Suspension
... paracetamol is the subject of BP and Ph Eur monographs. Analytical methods have been appropriately validated and are satisfactory for ensuring compliance with the relevant specifications. Active paracetamol is stored in appropriate packaging. It is bulk packed in 25kg or 50kg lots and packed into fi ...
... paracetamol is the subject of BP and Ph Eur monographs. Analytical methods have been appropriately validated and are satisfactory for ensuring compliance with the relevant specifications. Active paracetamol is stored in appropriate packaging. It is bulk packed in 25kg or 50kg lots and packed into fi ...
Prescribing Information
... with caution in diabetics as blood glucose levels may be elevated, usually after extended use. • In the overall management of portal-systemic encephalopathy, it should be recognized that there is serious underlying liver disease with complications such as electrolyte disturbance (e.g., hypokalemia) ...
... with caution in diabetics as blood glucose levels may be elevated, usually after extended use. • In the overall management of portal-systemic encephalopathy, it should be recognized that there is serious underlying liver disease with complications such as electrolyte disturbance (e.g., hypokalemia) ...
Pharmacokinetics, toxicity, and cytochrome P450
... nM, respectively. The mean IC50 values of the standard antimalarial drugs artesunate, mefloquine, quinine and chloroquine against K1 and 3D7 P. falciparum clones are 1.5 vs. 2 nM, 12 vs. 10 nM, 133- vs. 52 nM and 130 vs. 8 nM, respectively [5]. The activity against P. falciparum enzyme succinate deh ...
... nM, respectively. The mean IC50 values of the standard antimalarial drugs artesunate, mefloquine, quinine and chloroquine against K1 and 3D7 P. falciparum clones are 1.5 vs. 2 nM, 12 vs. 10 nM, 133- vs. 52 nM and 130 vs. 8 nM, respectively [5]. The activity against P. falciparum enzyme succinate deh ...
antihistamines in allergic disease
... onset of effect occurs within 1-3 hours; their duration of action varies from several hours to 24 hours, (second-generation drugs being generally around 24 hours) (Table II).7 First-generation antihistamines and some of the second-generation agents are oxidatively metabolised by the hepatic cytochro ...
... onset of effect occurs within 1-3 hours; their duration of action varies from several hours to 24 hours, (second-generation drugs being generally around 24 hours) (Table II).7 First-generation antihistamines and some of the second-generation agents are oxidatively metabolised by the hepatic cytochro ...
Vedani Nicola
... reported to be 13 to 43 mol/L (3 to 10 g/mL), with those for the majority of patients in the range of 17 to 34 mol/L (4 to 8 g/mL). Procainamide's apparent volume of distribution (Vd) is usually between 1.75 and 2.5 L/kg body weight. About 75% of the procainamide is concentrated in highly perfus ...
... reported to be 13 to 43 mol/L (3 to 10 g/mL), with those for the majority of patients in the range of 17 to 34 mol/L (4 to 8 g/mL). Procainamide's apparent volume of distribution (Vd) is usually between 1.75 and 2.5 L/kg body weight. About 75% of the procainamide is concentrated in highly perfus ...
Key Test Findings Affiliated Genetics
... Aripiprazole dose should initially be reduced to one-half (50%) of the usual dose and then adjusted to achieve a favorable clinical response. Reduce the maximum dose to 10 mg/day (67% of the maximum recommended daily dose). The dose of aripiprazole for poor metabolizers patients who are administered ...
... Aripiprazole dose should initially be reduced to one-half (50%) of the usual dose and then adjusted to achieve a favorable clinical response. Reduce the maximum dose to 10 mg/day (67% of the maximum recommended daily dose). The dose of aripiprazole for poor metabolizers patients who are administered ...
ATACAND HCT® 16-12.5 candesartan cilexetil−hydrochlorothiazide TABLETS ATACAND HCT® 32-12.5
... stimulation, and renal reabsorption of sodium. Candesartan blocks the vasoconstrictor and aldosteronesecreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, the ...
... stimulation, and renal reabsorption of sodium. Candesartan blocks the vasoconstrictor and aldosteronesecreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, the ...
VIOXX® - Merck.com
... pain, was assessed up to 2 hours after dosing. Associated symptoms such as nausea, photophobia, and phonophobia were also assessed. Maintenance of relief was assessed for up to 24 hours postdose. Other medication, with the exception of NSAIDs (including COX-2 inhibitors) or combination medications t ...
... pain, was assessed up to 2 hours after dosing. Associated symptoms such as nausea, photophobia, and phonophobia were also assessed. Maintenance of relief was assessed for up to 24 hours postdose. Other medication, with the exception of NSAIDs (including COX-2 inhibitors) or combination medications t ...
Part I: Summary of Product Information
... If sofosbuvir is used in combination with peginterferon alfa, and a patient has a serious adverse reaction potentially related to this drug, the peginterferon alfa dose should be reduced or discontinued. Refer to the leaflet of peginterferon alfa for additional information about how to reduce and/or ...
... If sofosbuvir is used in combination with peginterferon alfa, and a patient has a serious adverse reaction potentially related to this drug, the peginterferon alfa dose should be reduced or discontinued. Refer to the leaflet of peginterferon alfa for additional information about how to reduce and/or ...
O A
... The current study compared acceptance and behavioral responses to sublingual administration of midazolam and Ketamine in cat. Ten male cats received different doses of Ketamine or midazolam via sublingual route. Each animal was observed continuously for CNS depression as standard grades on the behav ...
... The current study compared acceptance and behavioral responses to sublingual administration of midazolam and Ketamine in cat. Ten male cats received different doses of Ketamine or midazolam via sublingual route. Each animal was observed continuously for CNS depression as standard grades on the behav ...
PROLOPA Product Monograph
... reduction can diminish those reactions though often at the expense of increasing parkinsonism. Other serious adverse reactions are oscillations in performance, psychiatric disorders and, less frequently, cardiovascular effects. Involuntary Movements: choreiform, dystonic, athetotic and other involun ...
... reduction can diminish those reactions though often at the expense of increasing parkinsonism. Other serious adverse reactions are oscillations in performance, psychiatric disorders and, less frequently, cardiovascular effects. Involuntary Movements: choreiform, dystonic, athetotic and other involun ...
Document
... errors. Oral Methotrexate was prescribed for non-oncological indications on the hospital’s electronic prescribing system. (See Figure 1 and 2) As the drug was not in the medicines index prescribers were required to free-type Methotrexate on the computer system then select a dosage and frequency from ...
... errors. Oral Methotrexate was prescribed for non-oncological indications on the hospital’s electronic prescribing system. (See Figure 1 and 2) As the drug was not in the medicines index prescribers were required to free-type Methotrexate on the computer system then select a dosage and frequency from ...
Rocephin Prescribing Information
... minimally altered in elderly subjects and in patients with renal impairment or hepatic dysfunction (Table 4); therefore, dosage adjustments are not necessary for these patients with ceftriaxone dosages up to 2 gm per day. Ceftriaxone was not removed to any significant extent from the plasma by hemod ...
... minimally altered in elderly subjects and in patients with renal impairment or hepatic dysfunction (Table 4); therefore, dosage adjustments are not necessary for these patients with ceftriaxone dosages up to 2 gm per day. Ceftriaxone was not removed to any significant extent from the plasma by hemod ...
(Dihydroergotamine mesylate) Nasal Spray 4 mg/mL
... unrecognized coronary artery disease (CAD) is predicted by the presence of risk factors (e.g. hypertension, hypercholesterolemia, smoker, obesity, diabetes, strong family history of CAD, females who are surgically or physiologically postmenopausal, or males who are over 40 years of age) unless a car ...
... unrecognized coronary artery disease (CAD) is predicted by the presence of risk factors (e.g. hypertension, hypercholesterolemia, smoker, obesity, diabetes, strong family history of CAD, females who are surgically or physiologically postmenopausal, or males who are over 40 years of age) unless a car ...
Product Monograph Template - Standard - GlaxoSmithKline
... Although systemic effects have been minimal with recommended doses of FLONASE® aqueous nasal spray, potential risk increases with larger doses. Therefore, larger than recommended doses of FLONASE® aqueous nasal spray should be avoided. When intranasal steroids are used at higher than recommended dos ...
... Although systemic effects have been minimal with recommended doses of FLONASE® aqueous nasal spray, potential risk increases with larger doses. Therefore, larger than recommended doses of FLONASE® aqueous nasal spray should be avoided. When intranasal steroids are used at higher than recommended dos ...
Diagnosis, Screening, Prevention, and Treatment of Osteoporosis
... perimenopausal women, more than 50% of cases are associated with secondary causes (most commonly hypoestrogenemia, glucocorticoid use, thyroid hormone excess, and anticonvulsant therapy). The prevalence of secondary conditions is thought to be lower in postmenopausal women, but the actual proportion ...
... perimenopausal women, more than 50% of cases are associated with secondary causes (most commonly hypoestrogenemia, glucocorticoid use, thyroid hormone excess, and anticonvulsant therapy). The prevalence of secondary conditions is thought to be lower in postmenopausal women, but the actual proportion ...
Product Monograph Template - Standard
... Rarely, in children, hyperactivity occurs and occasionally, sleep disturbances, hallucination or atypical psychosis have been reported. Pediatrics (< 4 years of age): The safety and efficacy in children below the age of 4 years has not been established. Geriatrics: As with other beta2-agonists, spec ...
... Rarely, in children, hyperactivity occurs and occasionally, sleep disturbances, hallucination or atypical psychosis have been reported. Pediatrics (< 4 years of age): The safety and efficacy in children below the age of 4 years has not been established. Geriatrics: As with other beta2-agonists, spec ...
Advicor® (niacin extended-release/lovastatin tablets)
... patients with Type IIa and IIb hyperlipidemia, ADVICOR was compared to each of its components (NIASPAN and lovastatin). Using a forced dose-escalation study design, patients received each dose for at least 4 weeks. Patients randomized to treatment with ADVICOR initially received 500 mg/20 mg. The do ...
... patients with Type IIa and IIb hyperlipidemia, ADVICOR was compared to each of its components (NIASPAN and lovastatin). Using a forced dose-escalation study design, patients received each dose for at least 4 weeks. Patients randomized to treatment with ADVICOR initially received 500 mg/20 mg. The do ...
Platelet inhibitory activity and pharmacokinetics of prasugrel
... after dosing; Tmax, the time at which Cmax was apparent; and t1/2, plasma elimination half-life for each dose group in the study are presented. Results Subjects Twenty-four healthy male subjects were enrolled in the study of prasugrel administered as single doses of 2.5, 10, 30, or 75 mg (five subje ...
... after dosing; Tmax, the time at which Cmax was apparent; and t1/2, plasma elimination half-life for each dose group in the study are presented. Results Subjects Twenty-four healthy male subjects were enrolled in the study of prasugrel administered as single doses of 2.5, 10, 30, or 75 mg (five subje ...
PROPOSAL FOR THE INCLUSION OF RISPERIDONE FOR THE
... since its inception in 1977. The three antipsychotics listed above while effective are not well tolerated by many patients owing to potentially serious side effects. Second generation (atypical) antipsychotics have been widely used in developed nations for the past twenty years. Risperidone, an atyp ...
... since its inception in 1977. The three antipsychotics listed above while effective are not well tolerated by many patients owing to potentially serious side effects. Second generation (atypical) antipsychotics have been widely used in developed nations for the past twenty years. Risperidone, an atyp ...
The Use of Midazolam in Paediatric Dentistry: A Review of the
... the psycho-motor coordination was also significantly impaired in the midazolam group. Midazolam was also associated with anterograde amnesia before discharge and at 48 hours (36). This indicates that impairment of children’s cognitive function and amnesia lasting for up to 48 hours post-GA should be ...
... the psycho-motor coordination was also significantly impaired in the midazolam group. Midazolam was also associated with anterograde amnesia before discharge and at 48 hours (36). This indicates that impairment of children’s cognitive function and amnesia lasting for up to 48 hours post-GA should be ...
the absorption, distribution, metabolism and excretion of rofecoxib, a
... from 0.56 to 40.1 Ci/mg, and each animal received approximately 20 to 25 Ci. For those studies requiring only unlabeled rofecoxib, the i.v. solutions were prepared in DMSO, and the oral solutions were prepared as 0.5% methylcellulose suspensions at the required concentrations. Animal Studies. Male ...
... from 0.56 to 40.1 Ci/mg, and each animal received approximately 20 to 25 Ci. For those studies requiring only unlabeled rofecoxib, the i.v. solutions were prepared in DMSO, and the oral solutions were prepared as 0.5% methylcellulose suspensions at the required concentrations. Animal Studies. Male ...
How to Reduce Trenbolone Enanthate Side Effects
... Men who do not already experience male pattern baldness can avoid this side effect of Trenbolone Enanthate use; however, other sex related problems will occur, especially at higher dosages. Men may experience erectile dysfunction, an enlarged prostate and a fluctuating libido. Like Nandrolone, Trenb ...
... Men who do not already experience male pattern baldness can avoid this side effect of Trenbolone Enanthate use; however, other sex related problems will occur, especially at higher dosages. Men may experience erectile dysfunction, an enlarged prostate and a fluctuating libido. Like Nandrolone, Trenb ...
PRODUCT MONOGRAPH CLARUS Isotretinoin 10 mg and 40 mg
... A careful assessment of the patient’s mental state should be made, including whether or not they have a history of previous psychiatric illness (see WARNINGS AND PRECAUTIONS, Serious Warnings and Precautions, Psychiatric). It is strongly recommended that each CLARUS® prescription be limited to a one ...
... A careful assessment of the patient’s mental state should be made, including whether or not they have a history of previous psychiatric illness (see WARNINGS AND PRECAUTIONS, Serious Warnings and Precautions, Psychiatric). It is strongly recommended that each CLARUS® prescription be limited to a one ...
triumeq - GSK Source
... less than 1% of subjects receiving TIVICAY® in Phase 3 clinical trials. Discontinue TRIUMEQ and other suspect agents immediately if signs or symptoms of hypersensitivity reactions develop (including, but not limited to, severe rash or rash accompanied by fever, general malaise, fatigue, muscle or jo ...
... less than 1% of subjects receiving TIVICAY® in Phase 3 clinical trials. Discontinue TRIUMEQ and other suspect agents immediately if signs or symptoms of hypersensitivity reactions develop (including, but not limited to, severe rash or rash accompanied by fever, general malaise, fatigue, muscle or jo ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.