summary of product characteristics
... improvement is usually accompanied by a reduction in plasma VIP levels, which may fall into the normal reference range. Glucagonomas: Administration of octreotide results in most cases in substantial improvement of the necrolytic migratory rash which is characteristic of the condition. The effect of ...
... improvement is usually accompanied by a reduction in plasma VIP levels, which may fall into the normal reference range. Glucagonomas: Administration of octreotide results in most cases in substantial improvement of the necrolytic migratory rash which is characteristic of the condition. The effect of ...
Asthma in pregnancy. Wendel. Obstet Gynecol Clin North Am. 2001
... reported on the increased potential adverse effects of asthma on pregnancy. These adverse outcomes were collected from multiple epidemiologic studies and included an increased incidence of preterm labor, low birth weight infants, pre-eclampsia, and perinatal morbidity [8] . An increased incidence of ...
... reported on the increased potential adverse effects of asthma on pregnancy. These adverse outcomes were collected from multiple epidemiologic studies and included an increased incidence of preterm labor, low birth weight infants, pre-eclampsia, and perinatal morbidity [8] . An increased incidence of ...
Sinemet® CR Product Monograph
... carbidopa) and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including the driving of a car, which has sometimes resulted in accidents. Although some of the patients reported somnolence while on SINEMET® CR, others perceived that they ha ...
... carbidopa) and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including the driving of a car, which has sometimes resulted in accidents. Although some of the patients reported somnolence while on SINEMET® CR, others perceived that they ha ...
PrSOLU-MEDROL
... be minimal or absent. Signs of peritoneal irritation following gastrointestinal perforation in patients receiving corticosteroids may be minimal or absent. Glucocorticoid therapy may mask the symptoms of peptic ulcer so that perforation or haemorrhage may occur without significant pain. In combinati ...
... be minimal or absent. Signs of peritoneal irritation following gastrointestinal perforation in patients receiving corticosteroids may be minimal or absent. Glucocorticoid therapy may mask the symptoms of peptic ulcer so that perforation or haemorrhage may occur without significant pain. In combinati ...
Product Monograph Template - Standard
... The safety and efficacy of AERIUS DUAL ACTION 12 HOUR has not been established in patients with impaired hepatic function, and there are insufficient data to give adequate dose recommendations. The combination product is not recommended for use in patients with impaired hepatic function (See ACTION ...
... The safety and efficacy of AERIUS DUAL ACTION 12 HOUR has not been established in patients with impaired hepatic function, and there are insufficient data to give adequate dose recommendations. The combination product is not recommended for use in patients with impaired hepatic function (See ACTION ...
PRODUCT INFORMATION STOCRIN® (efavirenz) Tablets and Oral
... In the clinical studies described below, the primary efficacy measure was the percent of patients with plasma HIV-RNA <400 copies/mL, using the Roche RT-PCR (AmplicorTM) HIV1 Monitor assay. Using this assay, which has a lower quantification limit of 400 copies/mL, values obtained which were below th ...
... In the clinical studies described below, the primary efficacy measure was the percent of patients with plasma HIV-RNA <400 copies/mL, using the Roche RT-PCR (AmplicorTM) HIV1 Monitor assay. Using this assay, which has a lower quantification limit of 400 copies/mL, values obtained which were below th ...
Tetracycline Phosphate Complex
... Increases in liver enzyme values have been reported with tetracyclines. In some cases severe and sometimes fatal hepatotoxicity, associated with fatty changes in the liver and pancreatitis, has occurred in pregnant women and in patients with renal impairment or those given high doses. However, hepat ...
... Increases in liver enzyme values have been reported with tetracyclines. In some cases severe and sometimes fatal hepatotoxicity, associated with fatty changes in the liver and pancreatitis, has occurred in pregnant women and in patients with renal impairment or those given high doses. However, hepat ...
EXELON Patch
... Skin application site reactions may occur with Exelon Patch and are usually mild or moderate in intensity (see section 7 Adverse drug reactions – Application site reactions). These reactions are not in themselves an indication of sensitization. However, use of rivastigmine patch may lead to allergic ...
... Skin application site reactions may occur with Exelon Patch and are usually mild or moderate in intensity (see section 7 Adverse drug reactions – Application site reactions). These reactions are not in themselves an indication of sensitization. However, use of rivastigmine patch may lead to allergic ...
Use of Thromboelastography (TEG) for Detection of New Oral
... permanent,’’ selective, and competitive. Rivaroxaban and apixaban are oral direct inhibitors of factor Xa and are also competitive, selective, and not permanent.11 Dabigatran is the only NOAC administered as a prodrug and metabolized to the active form. All 3 agents are licensed in the European Unio ...
... permanent,’’ selective, and competitive. Rivaroxaban and apixaban are oral direct inhibitors of factor Xa and are also competitive, selective, and not permanent.11 Dabigatran is the only NOAC administered as a prodrug and metabolized to the active form. All 3 agents are licensed in the European Unio ...
ROCEPHIN® (ceftriaxone sodium) FOR INJECTION Rx only To
... fluid ceftriaxone concentrations in the 23 to 25 hour and the 46 to 50 hour sampling time intervals, a half-life of 25 hours was calculated. Ceftriaxone is highly bound to plasma proteins. The extent of binding to proteins in the middle ear fluid is unknown. Interaction with Calcium: Two in vitro st ...
... fluid ceftriaxone concentrations in the 23 to 25 hour and the 46 to 50 hour sampling time intervals, a half-life of 25 hours was calculated. Ceftriaxone is highly bound to plasma proteins. The extent of binding to proteins in the middle ear fluid is unknown. Interaction with Calcium: Two in vitro st ...
Digitalis Intoxication
... digitalis concentrations in individuals, and the so-called ‘PTQ score’ (which combines PR and QT intervals and an assessment of the T-wave) may prove useful in distinguishing toxic from non-toxic individuals 1201. The technique has not yet been proven to be valuable in routine clinical use, although ...
... digitalis concentrations in individuals, and the so-called ‘PTQ score’ (which combines PR and QT intervals and an assessment of the T-wave) may prove useful in distinguishing toxic from non-toxic individuals 1201. The technique has not yet been proven to be valuable in routine clinical use, although ...
Module 2: The Science of Addiction
... • Partial Opioid Agonist – Produces a ceiling effect at higher doses – Has effects of typical opioid agonists—these effects are dose dependent up to a limit – Binds strongly to opiate receptor and is long-acting • Safe and effective therapy for opioid maintenance and detoxification ...
... • Partial Opioid Agonist – Produces a ceiling effect at higher doses – Has effects of typical opioid agonists—these effects are dose dependent up to a limit – Binds strongly to opiate receptor and is long-acting • Safe and effective therapy for opioid maintenance and detoxification ...
Zerit_1212_515US12PBS00101wip3.indd 1 1/3/13 1:24 PM
... lactic acidosis has been reported in pregnant women who received the combination of stavudine and didanosine with other antiretroviral agents. The combination of stavudine and didanosine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs t ...
... lactic acidosis has been reported in pregnant women who received the combination of stavudine and didanosine with other antiretroviral agents. The combination of stavudine and didanosine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs t ...
prescribing information - Purdue Pharma (Canada)
... benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics (see DRUG INTERACTIONS). If th ...
... benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics (see DRUG INTERACTIONS). If th ...
Word 68KB
... The PBAC recommended the Authority Required (STREAMLINED) listing of tenofovir alafenamide 25 mg on a cost-minimisation basis to entecavir 0.5 mg and entecavir 1 mg for treatment of chronic hepatitis B in patients that have not been treated before for hepatitis B (treatment naïve) and patients who h ...
... The PBAC recommended the Authority Required (STREAMLINED) listing of tenofovir alafenamide 25 mg on a cost-minimisation basis to entecavir 0.5 mg and entecavir 1 mg for treatment of chronic hepatitis B in patients that have not been treated before for hepatitis B (treatment naïve) and patients who h ...
Isosorbide Mononitrate Extended-Release Tablets, USP Rx only
... testing to assess the antianginal efficacy of continuously delivered nitrates. In the large majority of these trials, active agents were indistinguishable from placebo after 24 hours (or less) of continuous therapy. Attempts to overcome tolerance by dose escalation, even to doses far in excess of th ...
... testing to assess the antianginal efficacy of continuously delivered nitrates. In the large majority of these trials, active agents were indistinguishable from placebo after 24 hours (or less) of continuous therapy. Attempts to overcome tolerance by dose escalation, even to doses far in excess of th ...
Rosiver - Galderma
... adult subjects with severe papulopustular rosacea, under maximal use conditions. At steady state (after 2 weeks of treatment), the highest mean (± standard deviation) plasma concentrations of ivermectin peaked within 10 ± 8 hours post-dose (Cmax: 2.10 ± 1.04 ng/mL range: 0.69 - 4.02 ng/mL) and the h ...
... adult subjects with severe papulopustular rosacea, under maximal use conditions. At steady state (after 2 weeks of treatment), the highest mean (± standard deviation) plasma concentrations of ivermectin peaked within 10 ± 8 hours post-dose (Cmax: 2.10 ± 1.04 ng/mL range: 0.69 - 4.02 ng/mL) and the h ...
Product Monograph
... pregnant women requires that the likely benefit from the drug be weighed against the possible risk to the mother and fetus. Animal studies following parenteral administration have shown cefuroxime to affect bone calcification in the fetus and to cause maternal toxicity in the rabbit. Reproduction st ...
... pregnant women requires that the likely benefit from the drug be weighed against the possible risk to the mother and fetus. Animal studies following parenteral administration have shown cefuroxime to affect bone calcification in the fetus and to cause maternal toxicity in the rabbit. Reproduction st ...
Lucrin® PDs Depot 3.75 mg
... estrogens are reduced to post-menopausal levels. These hormonal Following a single administration of Leuprorelin Acetate for Depot Suspension in prostatic carcinoma patients, doses of 3.75 mg and 7.5 mg by subcutaneous and intramuscular routes provided mean leuprorelin acetate plasma concentrations ...
... estrogens are reduced to post-menopausal levels. These hormonal Following a single administration of Leuprorelin Acetate for Depot Suspension in prostatic carcinoma patients, doses of 3.75 mg and 7.5 mg by subcutaneous and intramuscular routes provided mean leuprorelin acetate plasma concentrations ...
Buprenorphine and Naloxone: Clinical Pharmacology Abuse Liability
... Indicates high affinity for µ-receptor – Can precipitate opiate withdrawal in highly µ-dependent people ...
... Indicates high affinity for µ-receptor – Can precipitate opiate withdrawal in highly µ-dependent people ...
of aspirin
... platelet cyclooxygenase for the life of the platelet (8 to 11 days); in human beings, a daily dose of aspirin as small as 40 mg is sufficient to produce this effect. ANALGESIA: • The types of pain usually relieved by aspirin are those of low intensity that arise from integumental structures rather t ...
... platelet cyclooxygenase for the life of the platelet (8 to 11 days); in human beings, a daily dose of aspirin as small as 40 mg is sufficient to produce this effect. ANALGESIA: • The types of pain usually relieved by aspirin are those of low intensity that arise from integumental structures rather t ...
Warfarin Management - Adult
... by UW Health Orthopedic surgeon consensus and based on the American Association of Orthopedic Surgeons clinical guideline on Prevention of Symptomatic Pulmonary Embolism in Patients Undergoing Total Hip or Knee Arthroplasty9 (Class IIb, Level C) 1.2. Alternative INR goals may be chosen for specific ...
... by UW Health Orthopedic surgeon consensus and based on the American Association of Orthopedic Surgeons clinical guideline on Prevention of Symptomatic Pulmonary Embolism in Patients Undergoing Total Hip or Knee Arthroplasty9 (Class IIb, Level C) 1.2. Alternative INR goals may be chosen for specific ...
Drug effects on acetic acid-depressed locomotor
... G.W. Stevenson et al. / Life Sciences xxx (2009) xxx–xxx ...
... G.W. Stevenson et al. / Life Sciences xxx (2009) xxx–xxx ...
The effect of oral midazolam ... on respiration in normal subjects
... healthy volunteers. FoRSTER et a/ [7] used equipotent doses of parenteral midazolam and diazepam in eight healthy volunteers, and found that the ventilatory and mouth occlusion pressure responses to carbon dioxide were equally depressed by both drugs. It is more common to use the oral rather than th ...
... healthy volunteers. FoRSTER et a/ [7] used equipotent doses of parenteral midazolam and diazepam in eight healthy volunteers, and found that the ventilatory and mouth occlusion pressure responses to carbon dioxide were equally depressed by both drugs. It is more common to use the oral rather than th ...
Top 300 Drug List
... with a low-fat snack and 325mg aspirin to reduce effects. Doses higher than 2g/day may cause hepatotoxicity. Pregnancy category X. Myopathy is a serious reaction; discontinue immediately and report any signs (muscle pain, brown urine) to MD and/or RPh. May be taken at any time of day. Avoid excessiv ...
... with a low-fat snack and 325mg aspirin to reduce effects. Doses higher than 2g/day may cause hepatotoxicity. Pregnancy category X. Myopathy is a serious reaction; discontinue immediately and report any signs (muscle pain, brown urine) to MD and/or RPh. May be taken at any time of day. Avoid excessiv ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.