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Eryped 200 (erythromycin ethylsuccinate)  Suspension
Eryped 200 (erythromycin ethylsuccinate) Suspension

... soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels, ...
Full Text PDF
Full Text PDF

... patient is unethical and sometimes dangerous. Patch testing may be used as an alternative way to identify the possible drug induced reactions. The role of patch testing in confirming the causative agent of AGEP has been well recognized in recent years.32 Wolkenstein et al. have shown a 50 % sensitiv ...
Aerosol delivery from spacers in wheezy infants: a daily life...
Aerosol delivery from spacers in wheezy infants: a daily life...

... therapeutic aerosols from pressurized metered dose inhalers (pMDI), being especially useful for the treatment of asthma in young children. Spacers are widely used, but little is known about their dose delivery, and dose variability in daily life use. This information is important, since it allows th ...
Handbook of Anti-Tuberculosis Agents
Handbook of Anti-Tuberculosis Agents

... world’s poorest populations, remains one of the biggest public health problems in the 21st century. The spread of multidrug-resistant TB (MDR-TB) and the appearance of extensively drug-resistant TB (XDR-TB) pose new challenges for the prevention, treatment and control of this deadly disease. The con ...
PRODUCT MONOGRAPH PrZOLOFT® (sertraline hydrochloride) 25
PRODUCT MONOGRAPH PrZOLOFT® (sertraline hydrochloride) 25

... 0.14 µg/mL, the half-life 65 hours and the area under the curve 2.3 mg hr/l. Following single or multiple oral once-daily doses of 50 to 400 mg/day the average terminal elimination half-life is approximately 26 hours. Linear dose proportionality has been demonstrated over the clinical dose range of ...
xanax xanax ts
xanax xanax ts

... Interdose Symptoms: Early morning anxiety and emergence of anxiety symptoms between doses of XANAX have been reported in patients with Panic Disorder taking prescribed maintenance doses of XANAX. These symptoms may reflect the development of tolerance or a time interval between doses which is longer ...
auspar-rilpivirine-1.. - Therapeutic Goods Administration (TGA)
auspar-rilpivirine-1.. - Therapeutic Goods Administration (TGA)

... The tablets are film coated tablets in which the drug substance and a number of excipients are wet-granulated, dried and milled then mixed with other excipients prior to compression. The tablets are packaged in HDPE bottles with child resistant polypropylene closures. ...
Octreotide Acetate Injection in a prefilled syringe
Octreotide Acetate Injection in a prefilled syringe

... INDICATIONS AND USAGE: Acromegaly: Octreotide acetate injection is indicated to reduce blood levels of growth hormone and IGF-I (somatomedin C) in acromegaly patients who have had inadequate response to or cannot be treated with surgical resection, pituitary irradiation, and bromocriptine mesylate a ...
Furosemide - Circulation
Furosemide - Circulation

... procedures for blood and urine have been reported previously.15 In the balance studies patients had been on a constant diet for at least 4 days prior to administration of diuretics. In evaluation of the efficacy of different diuretic regimens, at least 1 day intervened between treatment days. In stu ...
Ulipristal acetate - Therapeutic Goods Administration
Ulipristal acetate - Therapeutic Goods Administration

... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
terbutaline sulfate injection usp
terbutaline sulfate injection usp

... been reported after administration of terbutaline sulfate to pregnant women. In the mother, these adverse reactions include increased heart rate, transient hyperglycemia, hypokalemia, cardiac arrhythmias, pulmonary edema and myocardial ischemia. Increased fetal heart rate and neonatal hypoglycemia m ...
presentation source
presentation source

... needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes re ...
Amstan Tablets.FH11
Amstan Tablets.FH11

... Amlodipine elimination from plas ma is biphasic, with a terminal elimination half-life of approximately 30 to 50 hours. Steady-state plasma levels are reached after continuous administration for 7 to 8 days . 10% of the parent compound and 60% of amlodipine metabolites are excreted in urine. Valsart ...
SOTALOL HYDROCHLORIDE TABLETS, USP 80 mg, 120 mg, 160
SOTALOL HYDROCHLORIDE TABLETS, USP 80 mg, 120 mg, 160

... significantly superior to placebo in reducing VPCs, paired VPCs and non-sustained ventricular tachycardia (NSVT); the response was dose-related through 640 mg/day with 80 to 85% of patients having at least a 75% reduction of VPCs. Sotalol hydrochloride was also superior, at the doses evaluated, to p ...
Product Monograph ZANTAC  Histamine H
Product Monograph ZANTAC Histamine H

... Ranitidine injection is well tolerated following intravenous administration at dose levels of up to 100 mg 4 times daily. It is evident that these levels are in excess of those recommended for normal clinical use. At 50 mg intravenously, ranitidine injection had no effect on prolactin levels. Only ...
DRUG NAME: Octreotide  SYNONYM(S): COMMON TRADE NAME(S):
DRUG NAME: Octreotide SYNONYM(S): COMMON TRADE NAME(S):

... Pregnancy: FDA Pregnancy Category B. Animal-reproduction studies have not shown a fetal risk but there are no controlled studies in pregnant women, or animal-reproduction studies have shown a fetal risk (other than decreased fertility) not confirmed in controlled studies in pregnant women in the fir ...
ayout 1
ayout 1

... by microsomal hydroxylation, yielding both active and inactive metabolites. Dronabinol and its principal active metabolite, 11-OH-delta-9-THC, are present in approximately equal concentrations in plasma. Concentrations of both parent drug and metabolite peak at approximately 0.5 to 4 hours after ora ...
ERY-PED - Arbor Pharmaceuticals
ERY-PED - Arbor Pharmaceuticals

... watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Drug Interactions Theophylline: Erythromycin use in patients who are ...
Zeldox oral suspension ENG SmPC
Zeldox oral suspension ENG SmPC

... controlled clinical trials, the combination of ziprasidone plus lithium has not demonstrated an increased clinical risk, compared to lithium alone. There are limited data on co-medication with the mood stabiliser carbamazepine. A pharmacokinetic interaction of ziprasidone with valproate is unlikely ...
PRODUCT INFORMATION ViruPOS OPHTHALMIC OINTMENT
PRODUCT INFORMATION ViruPOS OPHTHALMIC OINTMENT

... mg/kg/day po), rabbit (50 mg/kg/day, sc and iv) or rat (50 mg/kg/day, sc) when dosed throughout the period of major organogenesis. In additional studies in which rats were given 3 sc doses of 100 mg/kg aciclovir on gestation day 10, fetal abnormalities, such as head and tail anomalies, were reported ...
ULTRACET C IV
ULTRACET C IV

... independent of concentration up to 10 g/mL. Saturation of plasma protein binding occurs only at concentrations outside the clinically relevant range. Acetaminophen appears to be widely distributed throughout most body tissues except fat. Its apparent volume of distribution is about 0.9 L/kg. A rela ...
Effect of Khat chewing on the bioavailability of ampicillin and
Effect of Khat chewing on the bioavailability of ampicillin and

... Eight healthy adult male Yemeni volunteers participated in the trials (average age and body weight (mean S.D.) were 26 2.18 years and 60 5.92 kg, respectively). The trials were conducted using a crossover design with a wash-out period of 7 days, throughout all the trials. The volunteers were instruc ...
Product Monograph ZANTAC
Product Monograph ZANTAC

... Ranitidine injection is well tolerated following intravenous administration at dose levels of up to 100 mg 4 times daily. It is evident that these levels are in excess of those recommended for normal clinical use. At 50 mg intravenously, ranitidine injection had no effect on prolactin levels. Only ...
Product Monograph  January 4, 2017
Product Monograph January 4, 2017

... Carcinogenesis, Mutagenesis, Impairment of Fertility There are no animal or laboratory studies on the combination product (tramadol and acetaminophen) to evaluate carcinogenesis, mutagenesis, or impairment of fertility. A slight but statistically significant increase in two common murine tumours, p ...
US Product Labeling @std Template for PLR
US Product Labeling @std Template for PLR

... documented HLA-B*5701 allele assessment. Discontinue ZIAGEN immediately if a hypersensitivity reaction is suspected, regardless of HLA-B*5701 status and even when other diagnoses are possible [see Contraindications (4), Warnings and Precautions (5.1)]. Following a hypersensitivity reaction to ZIAGEN ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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