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Action, time and the basal ganglia - Philosophical Transactions of
Action, time and the basal ganglia - Philosophical Transactions of

... velocity. It is this higher order input variable that is fed into the velocity control system and compared with the velocity reference signal. Still higher levels can also use velocity control for their purposes by sending their reference signals that are proportional to their own error signals. For ...
Stereologic analysis of the lateral geniculate nucleus of the
Stereologic analysis of the lateral geniculate nucleus of the

... Several abnormalities in structural and neurochemical composition of the visual cortex have emerged despite its inclusion in many studies only as a “control” comparison region for the dorsolateral prefrontal cortex (for review, see Selemon, 2001). These abnormalities include increased neuronal cell ...
Nicotinic Receptors in Addiction Pathways
Nicotinic Receptors in Addiction Pathways

... subunit composition across brain regions (Livingstone and Wonnacott, 2009). The ventral striatum, or nucleus accumbens, is a major output for reinforced behavior and is the target of VTA mesostriatal dopamine projection neurons. Immunoprecipitation, coupled with cell-specific lesions, has shown that ...
PSNS 2nd Lecture 1433 - Home - KSU Faculty Member websites
PSNS 2nd Lecture 1433 - Home - KSU Faculty Member websites

... Two kinds of effects produced by ACh. Ach causes a fall in BP due to arteriolar vasodilatation and slowing of the heart A larger dose of ACh also produces bradycardia, further reducing BP Atropine blocks the effect of ACh in lowering BP Still under the influence of atropine, a much larger dose of AC ...
storyboards
storyboards

... internal segment and the substantia nigra reticulata, which control the motor cortex through the thalamus. (N.B. erase big arrow and unhighlight the striatum and highlight the SNr and Gpi as output structures with an arrow going to the thalamus and another arrow going to the motor cortex.) ...
Book of Abstracts - Oxygen Club of California
Book of Abstracts - Oxygen Club of California

... Fernandez-Checa, J.C. .....................54 Fischer, S.J.................................. 47,63 Fiskum, G..........................................11 Flohé, L. .................................... 82,128 Fogolari, F...................................... 128 Forster, M.F. ......................... ...
Development of the rat thalamus: VI. The posterior lobule of the
Development of the rat thalamus: VI. The posterior lobule of the

... day E l 4 into two components, the intermediate lobule and that described in detail in the first paper of this series (Altthe posterior lobule (Figs. 4,5in Altman and Bayer, '88a). In man and Bayer, '88a). We made particular use of three colthe subsequent papers we sought to provide evidence that le ...
Knockdown of the Dyslexia-Associated Gene
Knockdown of the Dyslexia-Associated Gene

... being compared between activity evoked by speech sound X versus speech sound Y. For vowel sounds, the classifier counted the number of action potentials over a single 400 ms bin and compared the singletrial response with the 2 PSTH templates (Ranasinghe, Vrana, et al. 2012). We used t-tests for all p ...
download file
download file

... being compared between activity evoked by speech sound X versus speech sound Y. For vowel sounds, the classifier counted the number of action potentials over a single 400 ms bin and compared the singletrial response with the 2 PSTH templates (Ranasinghe, Vrana, et al. 2012). We used t-tests for all p ...
Knockdown of the Dyslexia-Associated Gene
Knockdown of the Dyslexia-Associated Gene

... being compared between activity evoked by speech sound X versus speech sound Y. For vowel sounds, the classifier counted the number of action potentials over a single 400 ms bin and compared the singletrial response with the 2 PSTH templates (Ranasinghe, Vrana, et al. 2012). We used t-tests for all p ...
Anatomical identification of primary auditory cortex in the developing
Anatomical identification of primary auditory cortex in the developing

... those of Büdinger and Scheich (2009; Figure 1B). These brains were additionally used to evaluate the transportation time required for the tracer to exit the cortex and reach the MGB in the later experiments. Once the anatomical references were confirmed in the perfused brain at P9, three neonate ge ...
Cover page
Cover page

... priming of cortical sensory representations may arise from amygdalar and hypothalamic synaptic inputs to cortex, as well as from local hormonal and neuromodulatory actions on specific cortical neurons. To monitor motivation-related changes in neural activity in the same large populations of neurons ...
What We Know About the Brain and Learning
What We Know About the Brain and Learning

... In the early part of her pregnancy, almost every mother wonders what this growing creation inside her belly will become. The baby’s brain metamorphosis begins early. A faint neural plate forms just days after conception from a small ball of beginning cells. If you could see it under a microscope, th ...
NEOCORTEX
NEOCORTEX

... Similar modern case studies of aphasias have become celebrated in the popular culture of books, television, and films. With the advent of functional imaging studies with positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG), there has been ...
BSCI338N, Spring 2013, Dr. Singer
BSCI338N, Spring 2013, Dr. Singer

... other spinal-muscular atrophies: can be UMN or LMN only; can affect brain stem or spinal MNs infections that target MNs: polio, West Nile (variant that targets MN specifically) post-polio syndrome: surviving neurons innervate more fibers → stressors → activate apoptotic processes presentation: 20% b ...
Imaging the Functional Organization of Zebrafish
Imaging the Functional Organization of Zebrafish

... whereas caudal stimuli should activate just the Mauthner cell. These predictions have not been tested previously because no one has been able to record the activity of MiD2cm and MiD3cm during escapes. We have recently developed methods to label neurons with a calcium indicator and observe their act ...
Spatial organization of thalamocortical and corticothalamic
Spatial organization of thalamocortical and corticothalamic

... provided evidence that each barrel is the morphological correlate of a single functional column that extends throughout the thickness of the cortex (Woolsey and Van der Loos, '70). One function of a cortical column is the integration of information arising from the array of whiskers on the face (see ...
Changes in Intracellular pH Associated with Glutamate Excitotoxicity
Changes in Intracellular pH Associated with Glutamate Excitotoxicity

... only slightly retarded by the nominally “calcium-free” condition (Table 1). Other manipulations of external calcium failed to produce any changesin the rates of recovery (Table 1). To manipulate [CaZ], further, cultures were preincubated for an hour in 4 PM BAPTA-AM, a cell-permeant calcium chelator ...
The Biological Perspective
The Biological Perspective

... small at this time for the big sodium ions to enter. But when the cell receives a strong enough stimulation from another cell (meaning that the dendrites are activated), the cell membrane opens up special gates, one after the other, all down its surface that allow the sodium ions (the “fans”) to rus ...
A Hierarchical Artificial Retina Architecture - USC
A Hierarchical Artificial Retina Architecture - USC

... differed in the way the electrical current was applied (cortex or retina), which means that the systems that generate these electrical signals vary in dramatic ways. Implementing a chip that stimulates the cortex directly may help blind people suffering from retinal and non-retinal disorders, which ...
The neural encoding of self-generated and externally applied
The neural encoding of self-generated and externally applied

... The   vestibular   system   is   vital   for   maintaining   an   accurate   representation   of   self-­‐ motion.  As  one  moves  (or  is  moved)  toward  a  new  place  in  the  environment,  signals   from   the   vestibular   sensors   ...
Odor and nutrition - ernährungs umschau
Odor and nutrition - ernährungs umschau

... circular adenosine mono phosphate, intracellular chemical messenger (second messenger) which is formed from ATP after activation of an adenylyl cyclase enzyme ...
ExamView - Unit 3 Practice Test.tst
ExamView - Unit 3 Practice Test.tst

... ____ 16. Your conscious awareness of your own name and self-identity depends primarily on the normal ...
Title: Gene expression analysis of human induced pluripotent stem
Title: Gene expression analysis of human induced pluripotent stem

... q13.1 region is subject to genomic imprinting, which is an epigenetic process that results in monoallelic gene expression. The 15q11-q13.1 duplications that lead to autism are most frequently of maternal origin. In addition to autism, individuals with maternally-inherited or derived duplications of ...
What are Neural Networks? - Teaching-WIKI
What are Neural Networks? - Teaching-WIKI

... output from the given training data input; 4. Ensure that the training data passes successfully, and test the network with other training/testing data; 5. Go back to Step 3 if performance is not good enough; 6. Repeat from Step 2 if Step 5 still lacks performance; or 7. Repeat from Step 1 if the net ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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