Molecular assembly of the period-cryptochrome circadian
... the crystal, PER2-CBD meanders along one side of CRY2-PHR and sinuously wraps around the region. With nearly half of the PER2 residues involved in binding, the two proteins bury a total 2800 Å2 of solvent accessible surface area at the interface, which stretches over a distance of more than 215 Å. T ...
... the crystal, PER2-CBD meanders along one side of CRY2-PHR and sinuously wraps around the region. With nearly half of the PER2 residues involved in binding, the two proteins bury a total 2800 Å2 of solvent accessible surface area at the interface, which stretches over a distance of more than 215 Å. T ...
Bartonella Clarridgeiae: Invasion of Human
... were included with B. bacilliformis in the genus. A similar event took place in 1995 when the genus Grahamella was combined with Bartonella, and B. talpae, B. peromysci, B. grahamii, B. taylorii and B. doshiae joined the genus. This brought the number of Bartonella species to 10, although the origin ...
... were included with B. bacilliformis in the genus. A similar event took place in 1995 when the genus Grahamella was combined with Bartonella, and B. talpae, B. peromysci, B. grahamii, B. taylorii and B. doshiae joined the genus. This brought the number of Bartonella species to 10, although the origin ...
1 Function of the Arabidopsis kinesin-4, FRA1, requires
... Our data show that abundant and processive motility are important for FRA1’s function in vivo, consistent with a proposed vesicular trafficking function of FRA1. While several studies have analyzed kinesin processivity mutants in vitro, to the best of our knowledge, this is the first study to measur ...
... Our data show that abundant and processive motility are important for FRA1’s function in vivo, consistent with a proposed vesicular trafficking function of FRA1. While several studies have analyzed kinesin processivity mutants in vitro, to the best of our knowledge, this is the first study to measur ...
Neuroscience - Thermo Fisher Scientific
... Synapse formation during nervous system development and degeneration in the pathogenesis of human neurological diseases are highly regulated processes. Subtle changes in the environment of the complex neuronal network may cause either breakdown or creation of synaptic connections. Drug discovery scr ...
... Synapse formation during nervous system development and degeneration in the pathogenesis of human neurological diseases are highly regulated processes. Subtle changes in the environment of the complex neuronal network may cause either breakdown or creation of synaptic connections. Drug discovery scr ...
Understanding the acetylome: translating targeted
... physical activity to regulate metabolic health, numerous research groups have focused on the molecular mechanisms that sense, interpret, and translate this contractile signal into postexercise adaptation. While our current understanding is that contraction-sensitive allosteric factors (e.g., Ca2⫹, A ...
... physical activity to regulate metabolic health, numerous research groups have focused on the molecular mechanisms that sense, interpret, and translate this contractile signal into postexercise adaptation. While our current understanding is that contraction-sensitive allosteric factors (e.g., Ca2⫹, A ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... ingredients [1]. One of the wide spread complaint against modern medicines is its side effect that can be attributed to a single biochemical pathway that is triggered by the molecule of interest. On the contrary herbal medicines mediate multifaceted biochemical attack on inflammation due to the dive ...
... ingredients [1]. One of the wide spread complaint against modern medicines is its side effect that can be attributed to a single biochemical pathway that is triggered by the molecule of interest. On the contrary herbal medicines mediate multifaceted biochemical attack on inflammation due to the dive ...
Tumor necrosis factor-alpha in normal and diseased brain
... difficult, yet exceedingly important, to understand the molecular mechanisms by which it may achieve these numerous effects through receptor activation of only a limited set of cell signaling pathways. Here, we provide evidence for our assertion that modulating the signaling pathways of growth facto ...
... difficult, yet exceedingly important, to understand the molecular mechanisms by which it may achieve these numerous effects through receptor activation of only a limited set of cell signaling pathways. Here, we provide evidence for our assertion that modulating the signaling pathways of growth facto ...
NROSCI/BIOSC 1070 and MSNBIO 2070 September 12, 2016
... 1) Control the rate of enzymatic reactions 2) Control transport of molecules across cell membranes 3) Control gene expression and synthesis ...
... 1) Control the rate of enzymatic reactions 2) Control transport of molecules across cell membranes 3) Control gene expression and synthesis ...
Assigned Reading
... in a position to modulate or mediate a wide variety of events in cell–cell, cell–matrix, and cell–molecule interactions critical to the development and function of a complex multicellular organism. They can also act as mediators in the interactions between different organisms (e.g., between host and ...
... in a position to modulate or mediate a wide variety of events in cell–cell, cell–matrix, and cell–molecule interactions critical to the development and function of a complex multicellular organism. They can also act as mediators in the interactions between different organisms (e.g., between host and ...
The topology of the proton translocating F0 component of the ATP
... hydrophilic amino acid residues. A long stretch of hydrophilic residues is found only at the N terminus from residue 1 to 35 in the coding sequence a' (Nielsen et al., 1981). The polypeptide chain probably traverses the membrane several times, with the major protein mass being in the Iipid bilayer. ...
... hydrophilic amino acid residues. A long stretch of hydrophilic residues is found only at the N terminus from residue 1 to 35 in the coding sequence a' (Nielsen et al., 1981). The polypeptide chain probably traverses the membrane several times, with the major protein mass being in the Iipid bilayer. ...
Mitochondria in lung biology and pathology: more than - AJP-Lung
... single molecule of mtDNA is associated with ⬃30 core proteins in a structure known as the nucleoid. Most if not all of the enzymes needed for mtDNA replication and mtRNA expression appear to be components of the nucleoid (9). Another difference between mitochondrial and nuclear DNA particularly rele ...
... single molecule of mtDNA is associated with ⬃30 core proteins in a structure known as the nucleoid. Most if not all of the enzymes needed for mtDNA replication and mtRNA expression appear to be components of the nucleoid (9). Another difference between mitochondrial and nuclear DNA particularly rele ...
chapter 1: exploring life
... 11. Explain how acids and bases may directly or indirectly alter the hydrogen ion concentration of a solution. 12. Using the bicarbonate buffer system as an example, explain how buffers work. 13. Briefly explain the causes and effects of acid precipitation. ...
... 11. Explain how acids and bases may directly or indirectly alter the hydrogen ion concentration of a solution. 12. Using the bicarbonate buffer system as an example, explain how buffers work. 13. Briefly explain the causes and effects of acid precipitation. ...
Cells Double-Stranded RNA in Myeloid Dendritic DHX9 Pairs with
... transcriptional activity of NF-kB (14). DHX9 is a microbial DNA sensor that is dependent on MyD88 and triggers NF-kB responses in plasmacytoid DCs (pDCs) (15). DHX9 was found as an autoantigen in the autoimmune disease systemic lupus erythematosus (16). DHX9 has two dsRNA-binding motifs. These motif ...
... transcriptional activity of NF-kB (14). DHX9 is a microbial DNA sensor that is dependent on MyD88 and triggers NF-kB responses in plasmacytoid DCs (pDCs) (15). DHX9 was found as an autoantigen in the autoimmune disease systemic lupus erythematosus (16). DHX9 has two dsRNA-binding motifs. These motif ...
Transport and Utilization of Lipids in Insect Flight
... Antwerpen et al. (33) confirmed these finding and showed that bound HDLp can be replaced in vitro by LDLp; the efficient exchange of DAG-depleted and DAG-enriched lipophorin species is an essential element of the lipophorin shuttle mechanism. Through ligand blotting techniques, a number of flight mu ...
... Antwerpen et al. (33) confirmed these finding and showed that bound HDLp can be replaced in vitro by LDLp; the efficient exchange of DAG-depleted and DAG-enriched lipophorin species is an essential element of the lipophorin shuttle mechanism. Through ligand blotting techniques, a number of flight mu ...
Drug resistance patterns and susceptibility to
... Micro-organisms have been used for bioassay (Clements, 1968; Jayaraman et al., 1968; Boutibonnes and Jacquet, 1976) and detoxification (Ciegler et al., 1966) of aflatoxins. The lethal effects of aflatoxins on micro-organisms include: growth inhibition (Arai et al., 1967; Burmeister and Hesseltine, 1 ...
... Micro-organisms have been used for bioassay (Clements, 1968; Jayaraman et al., 1968; Boutibonnes and Jacquet, 1976) and detoxification (Ciegler et al., 1966) of aflatoxins. The lethal effects of aflatoxins on micro-organisms include: growth inhibition (Arai et al., 1967; Burmeister and Hesseltine, 1 ...
Receptors Distinct Parasite Molecules and Host Chemoattractant
... transcription factors and members of the mitogen-activated protein kinase family (10 –12). The finding that MyD88⫺/⫺ mice are acutely susceptible to T. gondii infection implicates TLR in innate immune recognition of this parasite (13). Furthermore, TLR2⫺/⫺ mice have recently been shown to display hi ...
... transcription factors and members of the mitogen-activated protein kinase family (10 –12). The finding that MyD88⫺/⫺ mice are acutely susceptible to T. gondii infection implicates TLR in innate immune recognition of this parasite (13). Furthermore, TLR2⫺/⫺ mice have recently been shown to display hi ...
Chapter 1
... reviewed by Cominelli et al., 2010) [4]. MYB proteins are a class of transcription factors that are present in all eukaryotes, and share a common DNA-binding domain. In plants, the most highly represented MYB protein group is the R2R3 subfamily, members of which contain two MYB repeats in their DNA- ...
... reviewed by Cominelli et al., 2010) [4]. MYB proteins are a class of transcription factors that are present in all eukaryotes, and share a common DNA-binding domain. In plants, the most highly represented MYB protein group is the R2R3 subfamily, members of which contain two MYB repeats in their DNA- ...
PDF
... For all constructs, cloning junction and point mutations were verified by sequencing. The pCS2-spry4 vector was obtained by subcloning the zebrafish spry4 open reading frame into pCS2+ (RZPD). To generate the dominant-negative form of Spry4 (Spry4Y52A), a mutation of TAC (tyrosine) to GCC (alanine) ...
... For all constructs, cloning junction and point mutations were verified by sequencing. The pCS2-spry4 vector was obtained by subcloning the zebrafish spry4 open reading frame into pCS2+ (RZPD). To generate the dominant-negative form of Spry4 (Spry4Y52A), a mutation of TAC (tyrosine) to GCC (alanine) ...
UvA-DARE (Digital Academic Repository)
... recombinant DNA technology to restructure metabolic networks for improvement of production of bioproducts (Bailey, 1991), provides many possibilities to optimize cellular functions for a particular application. In contrast to the precision that recombinant DNA techniques offer to change the cell gen ...
... recombinant DNA technology to restructure metabolic networks for improvement of production of bioproducts (Bailey, 1991), provides many possibilities to optimize cellular functions for a particular application. In contrast to the precision that recombinant DNA techniques offer to change the cell gen ...
Glial heterogeneity: the increasing complexity of the brain
... total cell number. Modern imaging techniques such as functional magnetic resonance imaging (fMRI) or diffusion-tensor imaging (DTI) show us many functional details of our brain’s plastic activities and have provided exciting new insights of how and where the brain processes specific information (. F ...
... total cell number. Modern imaging techniques such as functional magnetic resonance imaging (fMRI) or diffusion-tensor imaging (DTI) show us many functional details of our brain’s plastic activities and have provided exciting new insights of how and where the brain processes specific information (. F ...
Enriched Expression of GluD1 in Higher Brain Regions and Its
... Of the two members of the ␦ subfamily of ionotropic glutamate receptors, GluD2 is exclusively expressed at parallel fiber–Purkinje cell (PF–PC) synapses in the cerebellum and regulates their structural and functional connectivity. However, little is known to date regarding cellular and synaptic expr ...
... Of the two members of the ␦ subfamily of ionotropic glutamate receptors, GluD2 is exclusively expressed at parallel fiber–Purkinje cell (PF–PC) synapses in the cerebellum and regulates their structural and functional connectivity. However, little is known to date regarding cellular and synaptic expr ...
Production and Characterization of Islet Amyloid Polypeptide Using
... the contrast between physiological (normal) and pathological (high) amounts of amylin in the body [6]. At physiological amount, amylin behaves like a growth factor which contributes to bone calcification [6], thereby preventing the resorptive activities of osteoclasts [7]. Amylin regulates nutrient ...
... the contrast between physiological (normal) and pathological (high) amounts of amylin in the body [6]. At physiological amount, amylin behaves like a growth factor which contributes to bone calcification [6], thereby preventing the resorptive activities of osteoclasts [7]. Amylin regulates nutrient ...
Regulation of the Eukaryotic Redox-State through - diss.fu
... Cells which use aerobic metabolism gain more ATP per mole glucose, but also have to face the toxic side effects of oxygen. The mitochondrial electron transport chain is always somewhat “leaky”, leading to direct one-electron transfer to molecular oxygen and to the formation of the superoxide anion r ...
... Cells which use aerobic metabolism gain more ATP per mole glucose, but also have to face the toxic side effects of oxygen. The mitochondrial electron transport chain is always somewhat “leaky”, leading to direct one-electron transfer to molecular oxygen and to the formation of the superoxide anion r ...
- Wiley Online Library
... ATP per mol of glucose consumed in whole cells [34,35]. All KDPG proteins have been purified [36], making Z. mobilis one of the few bacteria where this has been achieved, and most of the respective genes have been identified and their DNA sequences established [8]. The paramount activities of the KD ...
... ATP per mol of glucose consumed in whole cells [34,35]. All KDPG proteins have been purified [36], making Z. mobilis one of the few bacteria where this has been achieved, and most of the respective genes have been identified and their DNA sequences established [8]. The paramount activities of the KD ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.