... alternate sets of presynaptic inputs. This mechanism, however, shows regional specificity along the length of the ventral nerve cord. Ectopic expression of ceh-12 in unc-4 mutants is limited to posterior VA motor neurons and VA input specificity in this location depends on ceh-12. These findings sug ...
05 October 2000
... Correspondence and requests for materials should be addressed to M.C. (e-mail: mario.cappadocia@umontreal.ca). ...
... Correspondence and requests for materials should be addressed to M.C. (e-mail: mario.cappadocia@umontreal.ca). ...
PDF - Iqbal Hamza
... yeast, but a chimeric molecule consisting of the aminoterminal domain of yeast sco1 and the carboxyl-terminal domain of human sco1 containing the CXXXC motif will correct the respiratory incompetence in this mutant strain (Paret et al., 1999). Using this approach, the P147L patient mutation was foun ...
... yeast, but a chimeric molecule consisting of the aminoterminal domain of yeast sco1 and the carboxyl-terminal domain of human sco1 containing the CXXXC motif will correct the respiratory incompetence in this mutant strain (Paret et al., 1999). Using this approach, the P147L patient mutation was foun ...
Pentose phosphates in nucleoside interconversion and catabolism
... UPase. It has long been assumed that UPase, in analogy to PNP, acts catabolically, even though in 1985 Schwartz et al. [21] gave convincing evidence for its anabolic role in 5-fluouracil (5-FU) activation to cytotoxic compounds. More recent in vitro experiments have established that indeed UPase may ...
... UPase. It has long been assumed that UPase, in analogy to PNP, acts catabolically, even though in 1985 Schwartz et al. [21] gave convincing evidence for its anabolic role in 5-fluouracil (5-FU) activation to cytotoxic compounds. More recent in vitro experiments have established that indeed UPase may ...
nitrogen assimilation and global regulation in escherichia coli
... variety of compounds. The biosynthetic requirement of each nitrogen-containing metabolite (how much must be synthesized) can be calculated from the chemical composition of E. coli (the amount of each component that would be obtained from complete hydrolysis of whole cells) (Table 1). The difference ...
... variety of compounds. The biosynthetic requirement of each nitrogen-containing metabolite (how much must be synthesized) can be calculated from the chemical composition of E. coli (the amount of each component that would be obtained from complete hydrolysis of whole cells) (Table 1). The difference ...
Recent Advances Towards New Anti-Infective Agents that Inhibit
... During the anchoring reaction SrtA recognizes two substrates, the LPXTG sorting signal within the CWS of its protein substrate, and the (Gly)5 cross-bridge peptide located within lipid II (Fig. (2)). SrtA is highly specific for the LPXTG-motif, since only the central ‘X’ residue can be altered witho ...
... During the anchoring reaction SrtA recognizes two substrates, the LPXTG sorting signal within the CWS of its protein substrate, and the (Gly)5 cross-bridge peptide located within lipid II (Fig. (2)). SrtA is highly specific for the LPXTG-motif, since only the central ‘X’ residue can be altered witho ...
The autophagy conundrum in cancer: influence of
... kinase M2 (Dang et al., 2009). Finally, activation of the PI3K pathway, which frequently occurs in malignant cells through deregulated growth factor receptor signaling, mutations in the p110a catalytic subunit, loss of phosphatase and tensin homolog (PTEN) or amplification of Akt, also results in inc ...
... kinase M2 (Dang et al., 2009). Finally, activation of the PI3K pathway, which frequently occurs in malignant cells through deregulated growth factor receptor signaling, mutations in the p110a catalytic subunit, loss of phosphatase and tensin homolog (PTEN) or amplification of Akt, also results in inc ...
Bioelectric Phenomena
... models. Much of the physiological interest in models of a neuron involves the neuron’s use in transferring and storing information, while much engineering interest involves the neuron’s use as a template in computer architecture and neural networks. New developments in brain-machine interfacing make ...
... models. Much of the physiological interest in models of a neuron involves the neuron’s use in transferring and storing information, while much engineering interest involves the neuron’s use as a template in computer architecture and neural networks. New developments in brain-machine interfacing make ...
Hopanoids Play a Role in Membrane Integrity and pH
... transformed into the E. coli mating strain BW29427 and mated into the ⌬shc mutant strain on YP agar plates supplemented with diaminopimelic acid (23). Transformants were selected on YP agar containing 400 g/ml kanamycin. Kanamycin-resistant colonies were screened for the presence of pPVW8 by PCR. A ...
... transformed into the E. coli mating strain BW29427 and mated into the ⌬shc mutant strain on YP agar plates supplemented with diaminopimelic acid (23). Transformants were selected on YP agar containing 400 g/ml kanamycin. Kanamycin-resistant colonies were screened for the presence of pPVW8 by PCR. A ...
The Role of Cyclin B in Meiosis I
... at the end of oogenesis and fertilization activates the onset of the mitotic cell cycles (Masui and Clarke, 1979). However, in contrast to somatic ceils, most embryonic cells have abbreviated cell cycles consisting of rapid, alternating periods of DNA synthesis (interphase) and mitosis (M phase). Th ...
... at the end of oogenesis and fertilization activates the onset of the mitotic cell cycles (Masui and Clarke, 1979). However, in contrast to somatic ceils, most embryonic cells have abbreviated cell cycles consisting of rapid, alternating periods of DNA synthesis (interphase) and mitosis (M phase). Th ...
Salinity Effects on the Activity of Plasma Membrane H+ and Ca2+
... What is even more important, vanadate treatment also prevented NaCl-induced H extrusion (compare Fig. 1A and C). These results suggest that the ATP-dependent H -pump (inhibited by vanadate) forms a signi®cant part of the H extrusion mechanism involved in response to salt stress. Its level of a ...
... What is even more important, vanadate treatment also prevented NaCl-induced H extrusion (compare Fig. 1A and C). These results suggest that the ATP-dependent H -pump (inhibited by vanadate) forms a signi®cant part of the H extrusion mechanism involved in response to salt stress. Its level of a ...
Differential recruitment of Dishevelled provides signaling specificity
... among the recognized DEP domains. To verify that this substitution confers the dsh1 phenotype, this mutation was created in a wild-type genomic DNA fragment, Pelement transformants were created, and these were used to rescue dsh null mutant flies. The rescued flies were viable and had the dsh1 pheno ...
... among the recognized DEP domains. To verify that this substitution confers the dsh1 phenotype, this mutation was created in a wild-type genomic DNA fragment, Pelement transformants were created, and these were used to rescue dsh null mutant flies. The rescued flies were viable and had the dsh1 pheno ...
(Nurr1, Nur77, and Nor-1) by Typical and Atypical Antipsychotics i
... (Beaudry et al., 2000). Neuroleptic-induced acute parkinsonism (catalepsy) and vacuous chewing movements (similar to tardive dyskinesias) responses, which occur after prolonged exposure to antipsychotic drugs in rodents, are profoundly altered by genetic ablation of the Nur77 gene (knockout) (Ethier ...
... (Beaudry et al., 2000). Neuroleptic-induced acute parkinsonism (catalepsy) and vacuous chewing movements (similar to tardive dyskinesias) responses, which occur after prolonged exposure to antipsychotic drugs in rodents, are profoundly altered by genetic ablation of the Nur77 gene (knockout) (Ethier ...
p23 and organization of the Golgi apparatus
... Belden and Barlowe, 1996). Until now, no specific association between a p24 protein and a cargo molecule has been reported. However, it is possible that p24-cargo interactions are weak and/or transient, and cannot be revealed by classical biochemical approaches. Alternatively, it is possible that p2 ...
... Belden and Barlowe, 1996). Until now, no specific association between a p24 protein and a cargo molecule has been reported. However, it is possible that p24-cargo interactions are weak and/or transient, and cannot be revealed by classical biochemical approaches. Alternatively, it is possible that p2 ...
FOCAL ADHESION KINASE: IN COMMAND AND CONTROL OF
... The best-characterized FAK phosphorylation event is AUTOPHOSPHORYLATION at Tyr397, which can occur in either cis or trans 35. Phosphorylation of FAK at Tyr397 creates a motif that is recognized by various SH2-DOMAINcontaining proteins, such as SRC-FAMILY KINASES (SFKs), phospholipase Cγ (PLCγ), supp ...
... The best-characterized FAK phosphorylation event is AUTOPHOSPHORYLATION at Tyr397, which can occur in either cis or trans 35. Phosphorylation of FAK at Tyr397 creates a motif that is recognized by various SH2-DOMAINcontaining proteins, such as SRC-FAMILY KINASES (SFKs), phospholipase Cγ (PLCγ), supp ...
PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and
... in a number of cell types, especially melanocytes, and cells of hematopoietic origin (11, 12). Lysosome secretion plays an essential role in cellular entry of bacteria and parasites, immune responses, pigmentation, membrane repair, and platelet aggregation. Cellular and molecular studies of Griscell ...
... in a number of cell types, especially melanocytes, and cells of hematopoietic origin (11, 12). Lysosome secretion plays an essential role in cellular entry of bacteria and parasites, immune responses, pigmentation, membrane repair, and platelet aggregation. Cellular and molecular studies of Griscell ...
Hypothalamic Nesfatin-1 Stimulates Sympathetic Nerve
... central nesfatin-1 may regulate the function of peripheral organs through neural activity to maintain homeostasis and regulate a number of physiological processes. Regarding the neural mechanism of physiological regulation by nesfatin-1, our previous study demonstrated that sympathetic nervous suppl ...
... central nesfatin-1 may regulate the function of peripheral organs through neural activity to maintain homeostasis and regulate a number of physiological processes. Regarding the neural mechanism of physiological regulation by nesfatin-1, our previous study demonstrated that sympathetic nervous suppl ...
1 Introduction of autophagy
... • Bcl-2: It is well known that Bcl-2 is a protein that inhibits apoptosis. A recent study found that Bcl-2 can inhibit the expression of Beclin-1 after coupling with Beclin-1, resulting in weaken level of autophagy. Separating Bcl-2 from Beclin-1 promotes autophagy and inhibits apoptosis. ...
... • Bcl-2: It is well known that Bcl-2 is a protein that inhibits apoptosis. A recent study found that Bcl-2 can inhibit the expression of Beclin-1 after coupling with Beclin-1, resulting in weaken level of autophagy. Separating Bcl-2 from Beclin-1 promotes autophagy and inhibits apoptosis. ...
Inflammation and ER Stress Regulate Branched
... the case of liver, was increased (Figure 1D). These results demonstrate the pathway-specific down regulation of the BCAA metabolism enzymes in visceral adipose tissue. Immune cell-derived inflammatory factors have been shown to down-regulate many metabolic genes, and to determine the effect of cytok ...
... the case of liver, was increased (Figure 1D). These results demonstrate the pathway-specific down regulation of the BCAA metabolism enzymes in visceral adipose tissue. Immune cell-derived inflammatory factors have been shown to down-regulate many metabolic genes, and to determine the effect of cytok ...
Mechanisms of transport through the Golgi complex
... Fig. 3. (A) Vesicle budding and fusion. Activation of a small G protein (such as Arf1 or Sar1) (red) by the exchange of GDP for GTP results in the recruitment of a coat complex (blue) to the membrane by the GTP-bound form of the G protein. Membrane curvature and sorting of cargo (yellow) into the fo ...
... Fig. 3. (A) Vesicle budding and fusion. Activation of a small G protein (such as Arf1 or Sar1) (red) by the exchange of GDP for GTP results in the recruitment of a coat complex (blue) to the membrane by the GTP-bound form of the G protein. Membrane curvature and sorting of cargo (yellow) into the fo ...
Regulation of neuronal survival and death by extracellular signals
... and C, are shown. Group B neurons obtain neurotrophic factors from four sources: (i) from target cells or neurons [group A neurons secrete this neurotrophic factor (red dots) which binds to receptors on the axon terminals of neurons B, and is internalized and retrogradely transported (direction of r ...
... and C, are shown. Group B neurons obtain neurotrophic factors from four sources: (i) from target cells or neurons [group A neurons secrete this neurotrophic factor (red dots) which binds to receptors on the axon terminals of neurons B, and is internalized and retrogradely transported (direction of r ...
The Drosophila Planar Polarity Proteins Inturned and
... required for either or both of the subcellular locations where Mwh accumulated, we immunolocalized Mwh in cells mutant for the PCP genes fz, Vang and stan and the PPE genes fy, frtz and in. We first considered the proximal accumulation seen just prior to and at hair initiation (32 hrs). The accumula ...
... required for either or both of the subcellular locations where Mwh accumulated, we immunolocalized Mwh in cells mutant for the PCP genes fz, Vang and stan and the PPE genes fy, frtz and in. We first considered the proximal accumulation seen just prior to and at hair initiation (32 hrs). The accumula ...
NAD - SBI
... • NAD-binding proteins show small sequence identity. • The overall topologies of the NAD-binding domain show variations. Not all the 6 strands are essential to NAD- binding. • There is a minimum structure conserved in most proteins: first motif (βαβαβ) and β4. β1 and β4 are located in the center of ...
... • NAD-binding proteins show small sequence identity. • The overall topologies of the NAD-binding domain show variations. Not all the 6 strands are essential to NAD- binding. • There is a minimum structure conserved in most proteins: first motif (βαβαβ) and β4. β1 and β4 are located in the center of ...
Word document
... 2001). It remains unclear why the GR-bound array responded differently to transcriptional inhibitors than the VP16-bound array. In this work, we have addressed the potential mechanism that transcription itself disrupts large-scale chromatin structure (Chapter 2). A second strong possibility is that ...
... 2001). It remains unclear why the GR-bound array responded differently to transcriptional inhibitors than the VP16-bound array. In this work, we have addressed the potential mechanism that transcription itself disrupts large-scale chromatin structure (Chapter 2). A second strong possibility is that ...
Volume 94, issue 2 July 2011 ...
... potential mechanisms of how forces could translate into changes of cellular physiology and signaling as well as the question whether a universal mechanism of axonal elongation exists across different species. 2. Forces and axonal elongation 2.1. Forces cause axons to grow It is utterly remarkable th ...
... potential mechanisms of how forces could translate into changes of cellular physiology and signaling as well as the question whether a universal mechanism of axonal elongation exists across different species. 2. Forces and axonal elongation 2.1. Forces cause axons to grow It is utterly remarkable th ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.