Stimulation of naive T cell adhesion and immunological synapse
... defined as a ring of lymphocyte function associated (LFA)-1–ICAM-1 interactions surrounding a central cluster of MHC–peptide complexes, on supported planar bilayers containing ICAM-1 and relevant MHC–peptide complexes. Chemokines stimulated an increase in the percentage of naı̈ve cells that adhered ...
... defined as a ring of lymphocyte function associated (LFA)-1–ICAM-1 interactions surrounding a central cluster of MHC–peptide complexes, on supported planar bilayers containing ICAM-1 and relevant MHC–peptide complexes. Chemokines stimulated an increase in the percentage of naı̈ve cells that adhered ...
Differentiation of primordial germ cells in the
... to it. These vesicles are termed the 'dense bodies'. They arise from nuclear processes filled with material of a much higher electron density than that of the nucleus interior (Fig. 8). Microtubules are involved in the separation of nuclear fragments (Fig. 5). The initially irregular shape of the de ...
... to it. These vesicles are termed the 'dense bodies'. They arise from nuclear processes filled with material of a much higher electron density than that of the nucleus interior (Fig. 8). Microtubules are involved in the separation of nuclear fragments (Fig. 5). The initially irregular shape of the de ...
Multimeric Protein Structures of African Horsesickness Virus
... AHSV virion is composed of seven structural proteins organised into a double layered capsid, which encloses ten double-stranded RNA segments. The double stranded (ds) RNA genome of AHSV encodes, in addition to the seven structural proteins, at least three non-structural assembly of viral proteins in ...
... AHSV virion is composed of seven structural proteins organised into a double layered capsid, which encloses ten double-stranded RNA segments. The double stranded (ds) RNA genome of AHSV encodes, in addition to the seven structural proteins, at least three non-structural assembly of viral proteins in ...
Ideal Drug for Blood Pressure
... and Telmisartan showed a poor binding with the active sites of the receptor ACE. Out of ten sites available all the four drug molecules showed the binding with the site no.1 and the precision rate was less than 16.5%. Lisinopril, Fosinopril, Moexipril and Telmisartan showed e-values of the binding a ...
... and Telmisartan showed a poor binding with the active sites of the receptor ACE. Out of ten sites available all the four drug molecules showed the binding with the site no.1 and the precision rate was less than 16.5%. Lisinopril, Fosinopril, Moexipril and Telmisartan showed e-values of the binding a ...
Expression of the papillomavirus E2 protein in HeLa cells leads to
... The papillomavirus E2 protein plays a central role in the viral life cycle as it regulates both transcription and replication of the viral genome. In this study, we showed that transient expression of bovine papillomavirus type 1 or human papillomavirus type 18 (HPV18) E2 proteins in HeLa cells acti ...
... The papillomavirus E2 protein plays a central role in the viral life cycle as it regulates both transcription and replication of the viral genome. In this study, we showed that transient expression of bovine papillomavirus type 1 or human papillomavirus type 18 (HPV18) E2 proteins in HeLa cells acti ...
Studying the pathogenesis of renal disease in cystinosis
... Pathogenesis of cystinosis • How cystinosin defects lead to cell dysfunction in cystinosis is still unknown • Existing hypotheses from in vitro studies: – Cystinosin dysfunction leads to defective gluthation synthesis in cystinosis enhanced oxidative stress leading to cell damage (Levtchenko et a ...
... Pathogenesis of cystinosis • How cystinosin defects lead to cell dysfunction in cystinosis is still unknown • Existing hypotheses from in vitro studies: – Cystinosin dysfunction leads to defective gluthation synthesis in cystinosis enhanced oxidative stress leading to cell damage (Levtchenko et a ...
Link - Semantic Scholar
... resides in phagolysosomes, where it resists the highly adverse conditions and captures amino acids released from proteins as part of the normal host cell protein turnover [22]. Anaplasma phagocytophilum uses the type IV-translocated effector 1 (Ats-1) to promote the host autophagy degradation pathwa ...
... resides in phagolysosomes, where it resists the highly adverse conditions and captures amino acids released from proteins as part of the normal host cell protein turnover [22]. Anaplasma phagocytophilum uses the type IV-translocated effector 1 (Ats-1) to promote the host autophagy degradation pathwa ...
Cholinergic Responses and Intrinsic Membrane Properties of
... et al. 1996a,b). TC neurons are present throughout the “specific” and some “nonspecific” thalamic nuclei and are bushy, multidendritic cells with stereotypical intrinsic properties, i.e., bistable states of tonic versus bursting patterns of activity caused by the ubiquitous incidence of low-threshol ...
... et al. 1996a,b). TC neurons are present throughout the “specific” and some “nonspecific” thalamic nuclei and are bushy, multidendritic cells with stereotypical intrinsic properties, i.e., bistable states of tonic versus bursting patterns of activity caused by the ubiquitous incidence of low-threshol ...
Fast Facts: EGFR Act MUT+ Lung Cancer
... binds8. When EGF binding happens the tyrosine kinase of the EGFR is activated and triggers a complex signalling cascade in and between cells that is part of normal cell activity, however in lung cancers it can lead to accelerated cell growth and division, development of metastases and angiogenesis9, ...
... binds8. When EGF binding happens the tyrosine kinase of the EGFR is activated and triggers a complex signalling cascade in and between cells that is part of normal cell activity, however in lung cancers it can lead to accelerated cell growth and division, development of metastases and angiogenesis9, ...
Parallels between tissue repair and embryo morphogenesis
... used to repair an embryonic epithelial wound as is involved during the morphogenetic episodes of dorsal closure in Drosophila and eyelid fusion in the mouse foetus. For both naturally occurring and wound-activated tissue ...
... used to repair an embryonic epithelial wound as is involved during the morphogenetic episodes of dorsal closure in Drosophila and eyelid fusion in the mouse foetus. For both naturally occurring and wound-activated tissue ...
Two-Component Systems of Mycobacterium tuberculosis as
... Every living organism senses changes in environmental and intracellular signals and responds accordingly to adapt to and survive in these new conditions. For this purpose, bacteria have evolved surface-exposed signal transduction systems, typically comprised of transmembrane proteins that channel th ...
... Every living organism senses changes in environmental and intracellular signals and responds accordingly to adapt to and survive in these new conditions. For this purpose, bacteria have evolved surface-exposed signal transduction systems, typically comprised of transmembrane proteins that channel th ...
Correlating mRNA and protein Abundance
... 441) have significantly uncorrelated mRNA and protein levels (2STDEV from trendline) Transcription Assoc. genes are 25% of the essential genes in yeast. Essential Genes as a group have higher correlations than the general yeast population 7% of Cell Cycle associated genes (n = 432) have ...
... 441) have significantly uncorrelated mRNA and protein levels (2STDEV from trendline) Transcription Assoc. genes are 25% of the essential genes in yeast. Essential Genes as a group have higher correlations than the general yeast population 7% of Cell Cycle associated genes (n = 432) have ...
Macrophages but Not MyD88, in Bacteria
... TLR2 upon treatment with conserved bacterial components (10, 13–15, 17). To elucidate these apparently discrepant findings, we investigated the roles of TLR adapter proteins as proapoptotic signal transmitters downstream from TLR activation. Several Toll/IL-1R (TIR) domain-containing adapter molecul ...
... TLR2 upon treatment with conserved bacterial components (10, 13–15, 17). To elucidate these apparently discrepant findings, we investigated the roles of TLR adapter proteins as proapoptotic signal transmitters downstream from TLR activation. Several Toll/IL-1R (TIR) domain-containing adapter molecul ...
interaction of salinity and temperature on net protein synthesis and
... protein synthesis occurs for 30 min at 22C. The decrease in the rate of protein synthesis at 15C after 30 min of incubation in SSPU medium at 15 and 20%0 may either result in, or result from, the inability of cells to grow at these low salinities. Thus, at growth medium salinities of E-30%0, althoug ...
... protein synthesis occurs for 30 min at 22C. The decrease in the rate of protein synthesis at 15C after 30 min of incubation in SSPU medium at 15 and 20%0 may either result in, or result from, the inability of cells to grow at these low salinities. Thus, at growth medium salinities of E-30%0, althoug ...
Smooth Muscle
... • Responses to local factors provide a means for altering smooth muscle contraction in response to changes in the muscle’s immediate internal environment, independent of long-distance signals from nerves and hormones. • Many of these local factors induce smooth muscle relaxation. Nitric oxide (NO) w ...
... • Responses to local factors provide a means for altering smooth muscle contraction in response to changes in the muscle’s immediate internal environment, independent of long-distance signals from nerves and hormones. • Many of these local factors induce smooth muscle relaxation. Nitric oxide (NO) w ...
Dr. Parker`s CV - Cornell University College of Veterinary Medicine
... ectopic expression of µ1 allows a detailed analysis of the processes mediated only by that protein. In this project we will define the mechanisms by which μ1 induces apoptosis, how the process is regulated during infection, and the consequences of µ1-induced membrane destabilization for viral replic ...
... ectopic expression of µ1 allows a detailed analysis of the processes mediated only by that protein. In this project we will define the mechanisms by which μ1 induces apoptosis, how the process is regulated during infection, and the consequences of µ1-induced membrane destabilization for viral replic ...
Fission yeast meu14+ is required for proper nuclear division and
... the meu14+ DNA fragment generated by PCR to contain NdeI and NotI sites at the ends was inserted into pRGT81, a modified pRGT1 vector designed to carry a weak nmt promoter. This construct is termed pRGT81-meu14+. To obtain the 5′ upstream promoter region of meu14+, we performed PCR using the primers ...
... the meu14+ DNA fragment generated by PCR to contain NdeI and NotI sites at the ends was inserted into pRGT81, a modified pRGT1 vector designed to carry a weak nmt promoter. This construct is termed pRGT81-meu14+. To obtain the 5′ upstream promoter region of meu14+, we performed PCR using the primers ...
Cooperative organization of bacterial colonies: from genotype to
... bacterial cells. This feature reflects the local cooperation in the behavior of the bacteria (the analog of a surface tension in nonliving systems). Note that, to a first approximation, [N.sub.c] represents the agar concentration, since more "collisions" are needed to push the envelope on a harder s ...
... bacterial cells. This feature reflects the local cooperation in the behavior of the bacteria (the analog of a surface tension in nonliving systems). Note that, to a first approximation, [N.sub.c] represents the agar concentration, since more "collisions" are needed to push the envelope on a harder s ...
Light-dependent Dl Protein Synthesis and Translocation Is
... Blue-stained RCII (compare with CBB panels, Fig. 3), off diagonal. When the thylakoids were heat-denatured prior to the first dimension electrophoretic separation, all proteins appeared on a diagonal line (data not shown). These results could be explained only if pD1 is integrated into RCII located ...
... Blue-stained RCII (compare with CBB panels, Fig. 3), off diagonal. When the thylakoids were heat-denatured prior to the first dimension electrophoretic separation, all proteins appeared on a diagonal line (data not shown). These results could be explained only if pD1 is integrated into RCII located ...
Chemical Effectors of Plant Endocytosis and Endomembrane
... vesicles, and partially of MVB fragments (Satiat-Jeunemaitre et al. 1996; Merigout et al. 2002). To better elucidate the highly specific trafficking routes supported by different endomembrane compartments, including responses to either environmental stimuli or developmental signals, it is important ...
... vesicles, and partially of MVB fragments (Satiat-Jeunemaitre et al. 1996; Merigout et al. 2002). To better elucidate the highly specific trafficking routes supported by different endomembrane compartments, including responses to either environmental stimuli or developmental signals, it is important ...
M recombinant human tissue factor
... spanning domain (aa 220-242) and a cytoplasmic tail (aa 243263).2 It functions as a receptor and cofactor for the latent serine proteases factor VII and VIIa.3,4 Contact between TF and blood is sufficient to initiate the extrinsic pathway of coagulation. TF is located on the cells in the adventitia ...
... spanning domain (aa 220-242) and a cytoplasmic tail (aa 243263).2 It functions as a receptor and cofactor for the latent serine proteases factor VII and VIIa.3,4 Contact between TF and blood is sufficient to initiate the extrinsic pathway of coagulation. TF is located on the cells in the adventitia ...
Calmodulin-binding protein disrupts mitosis
... perturbed mitotic spindle functions, although spindle pole duplication was apparently normal. Both aspects of the phenotype induced by this cDNA product, which we term Sha1 (for spindle and hydroxyurea checkpoint abnormal), were suppressed by simultaneous overexpression of calmodulin. Sha1 is struct ...
... perturbed mitotic spindle functions, although spindle pole duplication was apparently normal. Both aspects of the phenotype induced by this cDNA product, which we term Sha1 (for spindle and hydroxyurea checkpoint abnormal), were suppressed by simultaneous overexpression of calmodulin. Sha1 is struct ...
Nedd8 processing enzymes inSchizosaccharomyces pombe
... differences in Nedd8 substrates between these organisms. Just as ubiquitylation is reversed by ubiquitin isopeptidases, Nedd8 conjugation is reversed by Nedd8 isopeptidases in a process known as deneddylation. The best characterized deneddylating enzymes include the COP9 signalosome subunit Csn5 [11 ...
... differences in Nedd8 substrates between these organisms. Just as ubiquitylation is reversed by ubiquitin isopeptidases, Nedd8 conjugation is reversed by Nedd8 isopeptidases in a process known as deneddylation. The best characterized deneddylating enzymes include the COP9 signalosome subunit Csn5 [11 ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.