Temporary inhibition of AMPA receptors induces a prolonged improvement
... Cln3Dex1e6 mice in dissociated cultures and in organotypic cerebellar slice cultures are significantly more sensitive to AMPA-type, but not NMDA-type, glutamate receptor-mediated toxicity than their wild type counterparts (Kovacs et al., 2006), indicating an abnormally enhanced AMPA receptor activity ...
... Cln3Dex1e6 mice in dissociated cultures and in organotypic cerebellar slice cultures are significantly more sensitive to AMPA-type, but not NMDA-type, glutamate receptor-mediated toxicity than their wild type counterparts (Kovacs et al., 2006), indicating an abnormally enhanced AMPA receptor activity ...
GIORGIO GRIBAUDO - Campusnet Unito
... Since 1991, he has continued the study on the functional characterization of new IFNinducible proteins and, in the meantime, he started the analysis of the molecular mechanisms of the antiviral activity of IFN in different virus models. In particular: 3) Characterization of the molecular mechanisms ...
... Since 1991, he has continued the study on the functional characterization of new IFNinducible proteins and, in the meantime, he started the analysis of the molecular mechanisms of the antiviral activity of IFN in different virus models. In particular: 3) Characterization of the molecular mechanisms ...
Glial Cells: The Other Cells of the Nervous System
... Astrocytes in the CNS are permeable to ions. Following electrical activity, the neuronal microenvironment undergoes a dramatic change. A sudden increase in K+ concentration takes place. Repeated neuronal stimulations may result in K + accumulation that could eventually lead to depolarization of adja ...
... Astrocytes in the CNS are permeable to ions. Following electrical activity, the neuronal microenvironment undergoes a dramatic change. A sudden increase in K+ concentration takes place. Repeated neuronal stimulations may result in K + accumulation that could eventually lead to depolarization of adja ...
Ubiquitin-Proteasome Dependent Regulation of
... gene expression by plastid signals (Jarvis and LópezJuez, 2013). The GLK genes positively regulate the expression of photosynthesis-related genes in numerous plants (Yasumura et al., 2005; Waters et al., 2009). In Arabidopsis (Arabidopsis thaliana), there are two copies of GLK genes, designated as G ...
... gene expression by plastid signals (Jarvis and LópezJuez, 2013). The GLK genes positively regulate the expression of photosynthesis-related genes in numerous plants (Yasumura et al., 2005; Waters et al., 2009). In Arabidopsis (Arabidopsis thaliana), there are two copies of GLK genes, designated as G ...
mpges
... The effects of PGE2 on dendritic cell phenotype and function have also been the subject of investigation. Our recent study with mPGES-1–/– mice showed that mPGES-1 is required for PGE2 production after lipopolysaccharide (LPS) stimulation in dendritic cells derived from bone marrow in vitro 33). Alt ...
... The effects of PGE2 on dendritic cell phenotype and function have also been the subject of investigation. Our recent study with mPGES-1–/– mice showed that mPGES-1 is required for PGE2 production after lipopolysaccharide (LPS) stimulation in dendritic cells derived from bone marrow in vitro 33). Alt ...
Genetic Models of Mechanotransduction: The
... MscS and MscM are two additional mechanically gated channels in E. coli that show different pressure sensitivity, with MscM appearing less frequent in bacterial cells, compared with MscL and MscS, which are typically found in excess. MscS is relatively nonselective, displaying a slight preference fo ...
... MscS and MscM are two additional mechanically gated channels in E. coli that show different pressure sensitivity, with MscM appearing less frequent in bacterial cells, compared with MscL and MscS, which are typically found in excess. MscS is relatively nonselective, displaying a slight preference fo ...
the pdf - University of British Columbia
... chick spinal cord it is possible to examine developmental changes leading to the loss of regenerative ability. These findings (Nelson & Steeves, 1987; Ethell et al., 1988; Shimizu et al., 1990; Hasan et al., 1990) suggest that developmental events occur in the spinal cord around E13 leading to a los ...
... chick spinal cord it is possible to examine developmental changes leading to the loss of regenerative ability. These findings (Nelson & Steeves, 1987; Ethell et al., 1988; Shimizu et al., 1990; Hasan et al., 1990) suggest that developmental events occur in the spinal cord around E13 leading to a los ...
The cell biology of hearing - The Journal of Cell Biology
... into a bundle (Fig. 2 B) and contribute to bundle passive mechanics (Bashtanov et al., 2004). Tip links project in the axis of mechanical sensitivity of the hair bundle and are thought to gate transduction channels at stereociliary tips (Pickles et al., 1984). In support of this model, the hair bund ...
... into a bundle (Fig. 2 B) and contribute to bundle passive mechanics (Bashtanov et al., 2004). Tip links project in the axis of mechanical sensitivity of the hair bundle and are thought to gate transduction channels at stereociliary tips (Pickles et al., 1984). In support of this model, the hair bund ...
Key Residues Controlling Binding of Diverse Ligands to Human
... The net steric effects of these differences alter active site morphology to determine CYP2A compatibility with phenacetin binding and Odeethylation. Other studies of human CYP2A enzymes have revealed that residues 117 and 372 are critical for both coumarin (He et al., 2004b) and NNK metabolism and t ...
... The net steric effects of these differences alter active site morphology to determine CYP2A compatibility with phenacetin binding and Odeethylation. Other studies of human CYP2A enzymes have revealed that residues 117 and 372 are critical for both coumarin (He et al., 2004b) and NNK metabolism and t ...
Xyloglucan Endotransglycosylases Have a Function
... added acceptor into the donor substrate, because other studies have reported that the XG is localized uniquely in the primary wall layers in mature xylem cells (Baba et al., 1994; Stacey et al., 1995). The unexpected pattern of XET activity in the cambial region of poplar led us to investigate the p ...
... added acceptor into the donor substrate, because other studies have reported that the XG is localized uniquely in the primary wall layers in mature xylem cells (Baba et al., 1994; Stacey et al., 1995). The unexpected pattern of XET activity in the cambial region of poplar led us to investigate the p ...
Folie 1 - uni
... • methods are available for efficient analysis of transcription patterns of multiple genes • because proteins ‘turn over’ at different rates, it is also necessary to measure proteins directly • the distribution of expressed protein levels is a kinetic balance between rates of protein synthesis and d ...
... • methods are available for efficient analysis of transcription patterns of multiple genes • because proteins ‘turn over’ at different rates, it is also necessary to measure proteins directly • the distribution of expressed protein levels is a kinetic balance between rates of protein synthesis and d ...
Photoreceptor crosstalk in shade avoidance
... Cryptochromes and shade avoidance Alongside decreases in R:FR ratio, plants shaded within a canopy also perceive a reduction of ultraviolet-A (UV-A) and blue light (B) and an enrichment of green light [2]. The attenuation of blue light is perceived by cry1 and cry2 in seedlings, with cry1 adopting a ...
... Cryptochromes and shade avoidance Alongside decreases in R:FR ratio, plants shaded within a canopy also perceive a reduction of ultraviolet-A (UV-A) and blue light (B) and an enrichment of green light [2]. The attenuation of blue light is perceived by cry1 and cry2 in seedlings, with cry1 adopting a ...
Self Assessment Chapter 11 part 2 - CM
... • Depolarization – sodium channels open, allowing positively charged sodium ions to flow into cell; membrane potential becomes more positive (Figure 11.14a) • Repolarization – potassium ion channels open; allows positively charged potassium ions to flow out of cell; cell becomes more negative, retur ...
... • Depolarization – sodium channels open, allowing positively charged sodium ions to flow into cell; membrane potential becomes more positive (Figure 11.14a) • Repolarization – potassium ion channels open; allows positively charged potassium ions to flow out of cell; cell becomes more negative, retur ...
Supplementary information
... are presented in figure Sup. 1. It is clear that not only the nuclear mobility of any p53 variant is lower than this of ECFP-EYFP but also that the kinetics of fluorescence recovery is different. While p53 recovery curves are best described by the two phase exponential association model (with the ex ...
... are presented in figure Sup. 1. It is clear that not only the nuclear mobility of any p53 variant is lower than this of ECFP-EYFP but also that the kinetics of fluorescence recovery is different. While p53 recovery curves are best described by the two phase exponential association model (with the ex ...
Calcium binding to chromaffin vesicle matrix proteins
... pH 8, 30 pM. ATP (B) binds 800 nmol of Ca"+lpmol, and the dissociation constant calculated from the experimental values obtained at pH 6 (70 pM) decreases by a factor of 5 to 15 p M at pH 7. Thus, the change in the pH from 7 to 6 results in a decrease in the affinity for CaZ+for both components, but ...
... pH 8, 30 pM. ATP (B) binds 800 nmol of Ca"+lpmol, and the dissociation constant calculated from the experimental values obtained at pH 6 (70 pM) decreases by a factor of 5 to 15 p M at pH 7. Thus, the change in the pH from 7 to 6 results in a decrease in the affinity for CaZ+for both components, but ...
Chp 19
... Section 19.2: Protein Synthesis §80S complex - initiation complex binds the 60S subunit §Hydrolysis of GTP bound to eIF2 §eIF5-acts as a guanine nucleotide activating protein §Initiation factors are released from the ribosome ...
... Section 19.2: Protein Synthesis §80S complex - initiation complex binds the 60S subunit §Hydrolysis of GTP bound to eIF2 §eIF5-acts as a guanine nucleotide activating protein §Initiation factors are released from the ribosome ...
The Plant Cell - Utrecht University Repository
... c Institut des Sciences du Végétal du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France d Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200433, People’s Republic of China e Station de Génétique et d’Amélioration des Plantes, Institut Nationa ...
... c Institut des Sciences du Végétal du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France d Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200433, People’s Republic of China e Station de Génétique et d’Amélioration des Plantes, Institut Nationa ...
Role of Adenosine in Response to Vascular Inflammation
... during hypoxia, produce changes in cardiac function that persist into adulthood. Interestingly, they also identify caffeine, a widely consumed adenosine receptor antagonist, as possibly dangerous to the fetus. This emphasizes the point that adenosine produced during tissue stress plays a critically ...
... during hypoxia, produce changes in cardiac function that persist into adulthood. Interestingly, they also identify caffeine, a widely consumed adenosine receptor antagonist, as possibly dangerous to the fetus. This emphasizes the point that adenosine produced during tissue stress plays a critically ...
Chapter 8 & 5 powerpoint file
... stimulated area returns to its resting potential Local current flow causes new section of the membrane to depolarize – this new section is creating a new set of action potentials that will trigger the next area to be depolarized ...
... stimulated area returns to its resting potential Local current flow causes new section of the membrane to depolarize – this new section is creating a new set of action potentials that will trigger the next area to be depolarized ...
Molecular Structure and Physiological Function of Chloride Channels
... nels because Cl is the most abundant anion in organisms and hence is the predominant permeating species under most circumstances. Cl⫺ channel gating may depend on the transmembrane voltage (in voltage-gated channels), on cell swelling, on the binding of signaling molecules (as in ligand-gated anion ...
... nels because Cl is the most abundant anion in organisms and hence is the predominant permeating species under most circumstances. Cl⫺ channel gating may depend on the transmembrane voltage (in voltage-gated channels), on cell swelling, on the binding of signaling molecules (as in ligand-gated anion ...
Tissue-Specific Protein Expression in Plant Mitochondria
... 1989). Although these studies reveal that isolated mitochondria from different tissues or genotypes vary in the complement of proteins they synthesize, no conclusions can be drawn concerning the possible physiological or biochemical roles these unidentified proteins may play. The alternative oxidase ...
... 1989). Although these studies reveal that isolated mitochondria from different tissues or genotypes vary in the complement of proteins they synthesize, no conclusions can be drawn concerning the possible physiological or biochemical roles these unidentified proteins may play. The alternative oxidase ...
This Article Abstract Full Text (PDF) Alert me when this article is cited
... residue outside of the C-terminal tyrosine-rich domain (Y569) was modified by autophosphorylation only, while the C-terminal domain was accessible to transphosphorylation by other WzcCA molecules (16). Furthermore, it was shown in the same study that phosphorylation of the C-terminal region was grea ...
... residue outside of the C-terminal tyrosine-rich domain (Y569) was modified by autophosphorylation only, while the C-terminal domain was accessible to transphosphorylation by other WzcCA molecules (16). Furthermore, it was shown in the same study that phosphorylation of the C-terminal region was grea ...
The Role of NMDA and Non-NMDA Excitatory Amino Acid
... and Willis, 199 I a,b, Dougherty et al., 1992). Recordings from STT cells were made within 750 pm from the nearest edge of the microdialysis fiber and were generally much closer than this. Variation in the distance of the recording sites from the fiber did not result in any apparent differences in t ...
... and Willis, 199 I a,b, Dougherty et al., 1992). Recordings from STT cells were made within 750 pm from the nearest edge of the microdialysis fiber and were generally much closer than this. Variation in the distance of the recording sites from the fiber did not result in any apparent differences in t ...
Dictyostelium discoideum mutant synag 7 with altered G
... Moreover, desensitization to persistent cyclic AMP stimuli is blocked after treatment with pertussis toxin in vivo (Snaar-Jagalska & Van Haastert, unpublished results). These observations suggest that adenylate cyclase regulation by G-protein, while present in D. discoideum, might operate somewhat d ...
... Moreover, desensitization to persistent cyclic AMP stimuli is blocked after treatment with pertussis toxin in vivo (Snaar-Jagalska & Van Haastert, unpublished results). These observations suggest that adenylate cyclase regulation by G-protein, while present in D. discoideum, might operate somewhat d ...
Chem 465 Biochemistry II
... Again only one of the labeled positions are labeled in any single isocitrate molecule. Only ½ of the á-ketoglutarate molecules will be carrying a label after one turn of the TCA cycle. (Page left blank so you can sketch out the TCA pathway to get your answers) ...
... Again only one of the labeled positions are labeled in any single isocitrate molecule. Only ½ of the á-ketoglutarate molecules will be carrying a label after one turn of the TCA cycle. (Page left blank so you can sketch out the TCA pathway to get your answers) ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.