Critical role of cytosolic phospholipase A2a in bronchial mucus hypersecretion in
... Cftr-/- mice exhibit increased pulmonary mucus production and MUC5AC expression Histological analyses of lung sections showed a normal structure, no inflammatory cells and no mucus-positive cells in Cftr+/+ mice. However, in Cftr-/- mice, increased numbers of mucus-positive cells (fig. 1a-l) were de ...
... Cftr-/- mice exhibit increased pulmonary mucus production and MUC5AC expression Histological analyses of lung sections showed a normal structure, no inflammatory cells and no mucus-positive cells in Cftr+/+ mice. However, in Cftr-/- mice, increased numbers of mucus-positive cells (fig. 1a-l) were de ...
Curcumin reduces expression of Bcl
... Background: Acute myeloid leukemia (AML) is an immunophenotypically heterogenous malignant disease, in which CD34 positivity is associated with poor prognosis. CD34+ AML cells are 10-15-fold more resistant to daunorubicin (DNR) than CD34- AML cells. Curcumin is a major component of turmeric that has ...
... Background: Acute myeloid leukemia (AML) is an immunophenotypically heterogenous malignant disease, in which CD34 positivity is associated with poor prognosis. CD34+ AML cells are 10-15-fold more resistant to daunorubicin (DNR) than CD34- AML cells. Curcumin is a major component of turmeric that has ...
Pdf - Text of NPTEL IIT Video Lectures
... Now, if we see and magnify, and if we draw the cell wall composition of two different groups of bacteria, then, we can find that, there are certain changes in one group and some differences are there, and it can be distinctly differentiated between one group to the other group. Now, in case of gram ...
... Now, if we see and magnify, and if we draw the cell wall composition of two different groups of bacteria, then, we can find that, there are certain changes in one group and some differences are there, and it can be distinctly differentiated between one group to the other group. Now, in case of gram ...
Formins: Linking Cytoskeleton and Endomembranes in Plant Cells
... 1. Introduction: Cytoskeleton in the Organization of Plant Endomembranes In typical differentiated plant cells, most endomembrane organelles are literally sandwiched in a thin layer of cortical cytoplasm between the plasmalemma and tonoplast, close to each other and in an intimate contact with the c ...
... 1. Introduction: Cytoskeleton in the Organization of Plant Endomembranes In typical differentiated plant cells, most endomembrane organelles are literally sandwiched in a thin layer of cortical cytoplasm between the plasmalemma and tonoplast, close to each other and in an intimate contact with the c ...
Cnidarians: An evolutionarily conserved model system for
... a morphogenetic field occurs only at small scale and growth is needed only to add in cells to produce a structure of larger size. The reason for this may lie in the fact that morphogens can act only over a distance of several cell diameters and a maximum of 300 m. In cnidaria, neither local dediffer ...
... a morphogenetic field occurs only at small scale and growth is needed only to add in cells to produce a structure of larger size. The reason for this may lie in the fact that morphogens can act only over a distance of several cell diameters and a maximum of 300 m. In cnidaria, neither local dediffer ...
Metabolism of Methanol in Plant Cells. Carbon-13
... nutrient medium containing 5 mm [13C]methanol. In the 13C-NMR reference spectra (in which methanol was omitted from the nutrient solution), the strongest signals were from glucosyl and fructosyl moieties of Suc and corresponded to an intracellular concentration of approximately 75 to 80 mol g⫺1 wet ...
... nutrient medium containing 5 mm [13C]methanol. In the 13C-NMR reference spectra (in which methanol was omitted from the nutrient solution), the strongest signals were from glucosyl and fructosyl moieties of Suc and corresponded to an intracellular concentration of approximately 75 to 80 mol g⫺1 wet ...
ANISOTROPIC EXPANSION OF THE PLANT CELL WALL
... time and position. Movements due to growth are three dimensional but methods for observing growth, such as photography, are inherently two dimensional. Furthermore, growth within a volume can be spatially heterogeneous, but usually only the surface is accessible. Thus the velocities at which element ...
... time and position. Movements due to growth are three dimensional but methods for observing growth, such as photography, are inherently two dimensional. Furthermore, growth within a volume can be spatially heterogeneous, but usually only the surface is accessible. Thus the velocities at which element ...
Neutrophil trails guide influenza-specific CD8+ T cells in the airways
... that migrating neutrophils leave behind longlasting trails from their elongated uropods (a protrusion at the rear of a cell) that are prominently enriched in the chemokine CXCL12. We observed that CXCL12 derived from the epithelial cells remained close to the epithelium, whereas CXCL12 derived from ...
... that migrating neutrophils leave behind longlasting trails from their elongated uropods (a protrusion at the rear of a cell) that are prominently enriched in the chemokine CXCL12. We observed that CXCL12 derived from the epithelial cells remained close to the epithelium, whereas CXCL12 derived from ...
role of biodegradable polymers in drug delivery
... protein which is normally produced by denaturing collagen. It has been used in pharmaceutical and medical applications due to its outstanding properties such as biodegradability, biocompatibility, and low antigenicity. In addition, gelatin can be easy to manipulate due to its isoelectric point that ...
... protein which is normally produced by denaturing collagen. It has been used in pharmaceutical and medical applications due to its outstanding properties such as biodegradability, biocompatibility, and low antigenicity. In addition, gelatin can be easy to manipulate due to its isoelectric point that ...
- Wiley Online Library
... with around 10-8 s lifetime. The excited molecules transfer energy to molecular oxygen (3O2) present in the proximity, leading to the generation of singlet oxygen (1O2) and initiate a cascade of energy transfer reactions and intermediates, which are collectively named as ROI (Banks et al., 1985). RO ...
... with around 10-8 s lifetime. The excited molecules transfer energy to molecular oxygen (3O2) present in the proximity, leading to the generation of singlet oxygen (1O2) and initiate a cascade of energy transfer reactions and intermediates, which are collectively named as ROI (Banks et al., 1985). RO ...
technicolour transgenics: imaging tools for functional
... transgene integration41 have been used to mark one of the cellular components in a chimaera, but these could only be detected in fixed tissue. Fluorescentprotein-reporter technology now makes it possible to identify both wild type and mutant components of a chimaera in live embryos or tissues, using ...
... transgene integration41 have been used to mark one of the cellular components in a chimaera, but these could only be detected in fixed tissue. Fluorescentprotein-reporter technology now makes it possible to identify both wild type and mutant components of a chimaera in live embryos or tissues, using ...
The Drosophila centriole – conversion of
... associated with fully elongated daughters that had a smaller diameter (Fig. 2E) likely due to the incomplete C-tubule. Serial sections failed to reveal additional centrioles in this region. Therefore, stem cells were at the beginning of interphase and the centriole pairs examined were inherited from ...
... associated with fully elongated daughters that had a smaller diameter (Fig. 2E) likely due to the incomplete C-tubule. Serial sections failed to reveal additional centrioles in this region. Therefore, stem cells were at the beginning of interphase and the centriole pairs examined were inherited from ...
Step 2. Transfection of plasmid into human neuronal cells
... releases and inhibits reuptake of serotonin from axons producing euphoria. Prolonged use of MDMA results in serotonergic nerve damage and reduced axon function. While use of this drug has escalated, few treatment options exist. We hypothesize that amplification of tryptophan hydroxylase (TPH) enzyme ...
... releases and inhibits reuptake of serotonin from axons producing euphoria. Prolonged use of MDMA results in serotonergic nerve damage and reduced axon function. While use of this drug has escalated, few treatment options exist. We hypothesize that amplification of tryptophan hydroxylase (TPH) enzyme ...
Chapter 1 - Utrecht University Repository
... endosomes because it lacks a functional vacuolar ATPase. Furthermore this compartment is enriched in the raft molecules, sphingomyelin and cholesterol, and raftassociated proteins, caveolin-1 and flotillin-1 (Gagescu et al., 2000). The exact relationship between the biochemical isolated compartments ...
... endosomes because it lacks a functional vacuolar ATPase. Furthermore this compartment is enriched in the raft molecules, sphingomyelin and cholesterol, and raftassociated proteins, caveolin-1 and flotillin-1 (Gagescu et al., 2000). The exact relationship between the biochemical isolated compartments ...
1 Revised manuscript Published in Colloids and Surfaces A
... degradation of the polyester. The PEG-containing triblock copolymer (Pluronic) proved to be an efficient surface modifier which can be applied in a blend form since it is miscible with PLGA in a certain concentration range depending on their composition [11-13]. The adsorption of Pluronic is however ...
... degradation of the polyester. The PEG-containing triblock copolymer (Pluronic) proved to be an efficient surface modifier which can be applied in a blend form since it is miscible with PLGA in a certain concentration range depending on their composition [11-13]. The adsorption of Pluronic is however ...
Sos recruitment system for the analysis of the
... increased serum immunoglobulin E and asthma. In this study, we designed 2 plasmids, pSoswhIL-13 and pSos-mhIL-13 (Arg130Gln), and examined whether they interacted with SUMF2. The National Center for Biotechnology Information identifies 5 SUMF2 subtypes: SUMF2 variant 2, SUMF2 variant 3, SUMF2 varian ...
... increased serum immunoglobulin E and asthma. In this study, we designed 2 plasmids, pSoswhIL-13 and pSos-mhIL-13 (Arg130Gln), and examined whether they interacted with SUMF2. The National Center for Biotechnology Information identifies 5 SUMF2 subtypes: SUMF2 variant 2, SUMF2 variant 3, SUMF2 varian ...
Public Assessment Report
... Appropriate stability studies have been carried out. Results showed no significant change and remained within the specification. Therefore the proposed re-test period is justified based on the stability results when substance is kept in the proposed packaging. Medicinal Product Lindaxa 10 and 15 mg ...
... Appropriate stability studies have been carried out. Results showed no significant change and remained within the specification. Therefore the proposed re-test period is justified based on the stability results when substance is kept in the proposed packaging. Medicinal Product Lindaxa 10 and 15 mg ...
2. Cells and tissue types in tissue engineering
... cells. To proliferate, differentiate and function effectively in engineered tissues, cells must be easily procured and readily available; they must multiply well without losing their potential to generate new functional tissue; they should not be rejected by the recipient and not turn into cancer; a ...
... cells. To proliferate, differentiate and function effectively in engineered tissues, cells must be easily procured and readily available; they must multiply well without losing their potential to generate new functional tissue; they should not be rejected by the recipient and not turn into cancer; a ...
Formation of lipid bodies and fatty acid composition changes upon
... bodies and long mitochondria indicated that the cells were metabolically active (Fig. 1 b). Cells of strain C also showed a large degree of vacuolization (Fig. 1 c) and the pyrenoids were surrounded by massive starch grains (Fig. 1 d). The cytoplasm contained a centrally arranged nucleus, surrounded ...
... bodies and long mitochondria indicated that the cells were metabolically active (Fig. 1 b). Cells of strain C also showed a large degree of vacuolization (Fig. 1 c) and the pyrenoids were surrounded by massive starch grains (Fig. 1 d). The cytoplasm contained a centrally arranged nucleus, surrounded ...
Vesicles: Equal in Neurotransmitter Concentration but Not in Volume
... (see figure, panel B). By increasing the amount of transmitter accumulated in the presence of a relatively fixed leak, increased transporter expression alters the equilibrium ultimately reached, not simply the rate at which it is achieved. Third, vesicles may sense filling with transmitter and shut ...
... (see figure, panel B). By increasing the amount of transmitter accumulated in the presence of a relatively fixed leak, increased transporter expression alters the equilibrium ultimately reached, not simply the rate at which it is achieved. Third, vesicles may sense filling with transmitter and shut ...
literature review
... intracellular targets. The knowledge of the intracellular distribution can also help to understand the side effects and pharmacokinetics of a drug, as well as the lack of response in e.g. some multidrug resistant cancer cells. Intracellular concentrations are also important to know when predicting t ...
... intracellular targets. The knowledge of the intracellular distribution can also help to understand the side effects and pharmacokinetics of a drug, as well as the lack of response in e.g. some multidrug resistant cancer cells. Intracellular concentrations are also important to know when predicting t ...
12-N. Ohno.indd - PJM ONLINE | Polish Journal of Microbiology
... mechanical strength and protection from the hostile environment. Candida cell wall has a dynamic structure and is a complex mixture of different polysaccharides (~85%) and proteins (~15%). Cell wall polysaccharides are composed of β-glucan, chitin, and mannoprotein (Klis et al., 2001). The cell wall ...
... mechanical strength and protection from the hostile environment. Candida cell wall has a dynamic structure and is a complex mixture of different polysaccharides (~85%) and proteins (~15%). Cell wall polysaccharides are composed of β-glucan, chitin, and mannoprotein (Klis et al., 2001). The cell wall ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.