Stem Cell - Active Motif
... form of acetylation, phosphorylation, methylation, citrullination and ubiquitination. By controlling the accessibility of DNA regulatory elements, these modifications modulate the interaction of transcription factor networks with other regulatory factors including transcriptional cofactors, chromati ...
... form of acetylation, phosphorylation, methylation, citrullination and ubiquitination. By controlling the accessibility of DNA regulatory elements, these modifications modulate the interaction of transcription factor networks with other regulatory factors including transcriptional cofactors, chromati ...
microcircuitry of bipolar cells in cat retina1
... Nelson and Kolb, 1983). In view of thesegrowing complexities, it seemedcritical to develop a comprehensiveclassification of bipolar neurons in which each of the diverse morphological categoriescould be associatedwith a distinctive cytology, synaptic circuitry, physiology, and chemistry. If such a cl ...
... Nelson and Kolb, 1983). In view of thesegrowing complexities, it seemedcritical to develop a comprehensiveclassification of bipolar neurons in which each of the diverse morphological categoriescould be associatedwith a distinctive cytology, synaptic circuitry, physiology, and chemistry. If such a cl ...
Ion-channel blocker sensitivity of voltage-gated
... CaCl2 was varied within single experiments, and Ca2+ accumulation in the cells was measured. As shown in Fig. 2, CCH1ox MID1ox, CCH1–MID1 (wild-type) and cch1D mid1D cells (lacking both Cch1 and Mid1) displayed Michaelis–Menten kinetics. Table 2 shows the apparent Km and Vmax values deduced from the ...
... CaCl2 was varied within single experiments, and Ca2+ accumulation in the cells was measured. As shown in Fig. 2, CCH1ox MID1ox, CCH1–MID1 (wild-type) and cch1D mid1D cells (lacking both Cch1 and Mid1) displayed Michaelis–Menten kinetics. Table 2 shows the apparent Km and Vmax values deduced from the ...
LvNotch specifies secondary mesenchyme - Development
... LvNotch in sea urchin embryos. We first show that activation of LvNotch signaling increases SMCs, while loss or reduction of LvNotch signaling eliminates or dramatically reduces SMC specification. An examination of endogenous LvNotch expression and results from a mosaic analysis of LvNotch function ...
... LvNotch in sea urchin embryos. We first show that activation of LvNotch signaling increases SMCs, while loss or reduction of LvNotch signaling eliminates or dramatically reduces SMC specification. An examination of endogenous LvNotch expression and results from a mosaic analysis of LvNotch function ...
Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in
... cell growth, homeostasis, apoptosis, adhesion, transformation, signaling induction, angiogenesis, fibrosis, cancer progression, and metastasis (5). During the bone metastatic process, Gal-3 mediates adhesion at the interface between tumor cells and bone marrow endothelial cells (6, 7). Focusing on th ...
... cell growth, homeostasis, apoptosis, adhesion, transformation, signaling induction, angiogenesis, fibrosis, cancer progression, and metastasis (5). During the bone metastatic process, Gal-3 mediates adhesion at the interface between tumor cells and bone marrow endothelial cells (6, 7). Focusing on th ...
Involvement of antimicrobial peptides in mussel defence
... in anti-infectious processes, however, can be different. Some antimicrobial peptides are produced by epithelial cells which line the respiratory, gastrointestinal and genito-urinary tracts, where they constitute one of the first barriers preventing pathogen invasion. Many antimicrobial peptides have ...
... in anti-infectious processes, however, can be different. Some antimicrobial peptides are produced by epithelial cells which line the respiratory, gastrointestinal and genito-urinary tracts, where they constitute one of the first barriers preventing pathogen invasion. Many antimicrobial peptides have ...
Breakdown of Tolerance to a Neo
... Transgenic (Tg) mice expressing a foreign Ag, hen egg lysozyme (HEL), under control of the ␣A-crystallin promoter (“HEL-Tg” mice) develop immunotolerance to HEL attributed to the expression of HEL in their thymus. In this paper we analyzed the immune response in double (Dbl)-Tg mice generated by mat ...
... Transgenic (Tg) mice expressing a foreign Ag, hen egg lysozyme (HEL), under control of the ␣A-crystallin promoter (“HEL-Tg” mice) develop immunotolerance to HEL attributed to the expression of HEL in their thymus. In this paper we analyzed the immune response in double (Dbl)-Tg mice generated by mat ...
Myeloid Dendritic Cells DHX15 Senses Double
... port showing that STING plays a critical role in DNA sensing but no role in poly I:C sensing (35). We next determined whether DHX15 senses DNA in D2SC cells. The cytokine production was measured after culturing control and knockdown shRNA in D2SC cells. The cells were then stimulated with poly dG:dC ...
... port showing that STING plays a critical role in DNA sensing but no role in poly I:C sensing (35). We next determined whether DHX15 senses DNA in D2SC cells. The cytokine production was measured after culturing control and knockdown shRNA in D2SC cells. The cells were then stimulated with poly dG:dC ...
siRNA Screen Identifies Trafficking Host Factors that Modulate
... cells, alphaviruses rely on a repertoire of cellular host proteins, including trafficking factors that ...
... cells, alphaviruses rely on a repertoire of cellular host proteins, including trafficking factors that ...
Expression of the papillomavirus E2 protein in HeLa cells leads to
... (Schwarz et al., 1985). In the present study, we investigated whether the ectopically expressed E2 protein was able to repress endogenous E6/E7 transcription in HeLa cells. Our main concern was that the HPV18 regulatory region integrated into the genomic DNA could present a chromatin structure diffe ...
... (Schwarz et al., 1985). In the present study, we investigated whether the ectopically expressed E2 protein was able to repress endogenous E6/E7 transcription in HeLa cells. Our main concern was that the HPV18 regulatory region integrated into the genomic DNA could present a chromatin structure diffe ...
Super-resolution microscopy of mitochondria
... is packaged into nucleoprotein complexes (nucleoids) located in the innermost mitochondrial compartment, the aqueous matrix [55,56]. The nucleoids are distributed throughout the mitochondrial network. In humans, the mtDNA encodes 13 proteins, which are essential for the function of OXPHOS. An import ...
... is packaged into nucleoprotein complexes (nucleoids) located in the innermost mitochondrial compartment, the aqueous matrix [55,56]. The nucleoids are distributed throughout the mitochondrial network. In humans, the mtDNA encodes 13 proteins, which are essential for the function of OXPHOS. An import ...
appearance and function of endogenous peroxidase in fetal rat thyroid
... opment, most of the cells are clustered together in groups, although follicles have not yet formed . By electron microscopy, peroxidase activity is still not evident within the cells of thyroids removed from embryos during the 17th day of gestation (Fig . 5) . The cells lie clustered together and ar ...
... opment, most of the cells are clustered together in groups, although follicles have not yet formed . By electron microscopy, peroxidase activity is still not evident within the cells of thyroids removed from embryos during the 17th day of gestation (Fig . 5) . The cells lie clustered together and ar ...
05 Keim
... the cell showing two magnetosome chains (b), two P-rich granules (c, d) and three electron-lucent inclusions (e). The lettering shows the places where EDX analysis were done. Bar = 200 nm. (B) EDX spectrum of a magnetosome showing mainly iron and oxygen peaks. Small P, S, and Cl peaks are derived fr ...
... the cell showing two magnetosome chains (b), two P-rich granules (c, d) and three electron-lucent inclusions (e). The lettering shows the places where EDX analysis were done. Bar = 200 nm. (B) EDX spectrum of a magnetosome showing mainly iron and oxygen peaks. Small P, S, and Cl peaks are derived fr ...
spatial control of cell expansion by the plant cytoskeleton
... have long been recognized because of the growth-arresting effects of actin depolymerizing drugs (cytochalasins and latrunculins). The dependence of cell growth on F-actin was first recognized in tip-growing cells in which growth and extension of the cell wall is focused at a single site on the cell s ...
... have long been recognized because of the growth-arresting effects of actin depolymerizing drugs (cytochalasins and latrunculins). The dependence of cell growth on F-actin was first recognized in tip-growing cells in which growth and extension of the cell wall is focused at a single site on the cell s ...
Expression of collagenolytic/gelatinolytic metalloproteinases
... using sheep anti-rabbit antisera (gifts of C. BrinckerholT, Dartmouth).26 To ensure that the proteins arrived in the culture medium by secretion rather than cell lysis, the protein profile in the culture medium was compared with that which could be extracted from the remaining cell layers with 0.1% ...
... using sheep anti-rabbit antisera (gifts of C. BrinckerholT, Dartmouth).26 To ensure that the proteins arrived in the culture medium by secretion rather than cell lysis, the protein profile in the culture medium was compared with that which could be extracted from the remaining cell layers with 0.1% ...
The cardiac pacemaker current Journal of Molecular and Cellular
... four loss-of-function mutations in patients with mild or severe forms of cardiac rate disturbances. Due to its selective contribution to pacemaking, the If current is also the pharmacological target of a selective heart rate-reducing agent (ivabradine) currently used in the clinical practice. Albeit ...
... four loss-of-function mutations in patients with mild or severe forms of cardiac rate disturbances. Due to its selective contribution to pacemaking, the If current is also the pharmacological target of a selective heart rate-reducing agent (ivabradine) currently used in the clinical practice. Albeit ...
D:Int Agrophysics -2Cybulskacybulska.vp - Research
... in the natural state. An alternative is creating of a model artificial cell wall consisting of polysaccharides which imitate properties of the natural cell wall. Polysaccharides network based on bacterial cellulose supplemented with xyloglucan and pectin was proposed as the model cell wall. In this ...
... in the natural state. An alternative is creating of a model artificial cell wall consisting of polysaccharides which imitate properties of the natural cell wall. Polysaccharides network based on bacterial cellulose supplemented with xyloglucan and pectin was proposed as the model cell wall. In this ...
Nitrogen deficiency inhibits leaf blade growth in Lolium
... choice for unravelling cellular processes underlying growth responses. This is because of the presence of a developmental gradient along the leaf axis that spatially separates cell proliferation from cell expansion and maturation, allowing thus their simultaneous evaluation. Moreover, cell expansion ...
... choice for unravelling cellular processes underlying growth responses. This is because of the presence of a developmental gradient along the leaf axis that spatially separates cell proliferation from cell expansion and maturation, allowing thus their simultaneous evaluation. Moreover, cell expansion ...
Adenosine affects expression of membrane molecules, cytokine and
... Currently, the local concentration of adenosine at inflammatory sites is not known, but measurements in rat heart and brain indicated that under hypoxia the extracellular adenosine concentration is at least in the 10-20 µM range (21,22). Besides action on the cardiovascular and nervous system, an an ...
... Currently, the local concentration of adenosine at inflammatory sites is not known, but measurements in rat heart and brain indicated that under hypoxia the extracellular adenosine concentration is at least in the 10-20 µM range (21,22). Besides action on the cardiovascular and nervous system, an an ...
Running title: Mode of Bactericidal Action of the Jatropha curcas
... and blank without inoculum were used as controls. The bottles were incubated in a water bath shaker at 37°C and 120rpm. One millilitre of each sample was removed at 0, 2.5, 5, 7.5 and 24h and processed for the XTT reduction assay. A solution of 0.5mg/ml XTT was prepared using PBS. The solution was f ...
... and blank without inoculum were used as controls. The bottles were incubated in a water bath shaker at 37°C and 120rpm. One millilitre of each sample was removed at 0, 2.5, 5, 7.5 and 24h and processed for the XTT reduction assay. A solution of 0.5mg/ml XTT was prepared using PBS. The solution was f ...
Prodrugs: Effective Solutions for Solubility, Permeability and
... prodrug design functional group considerations. This was followed by 17 presentations on the application of prodrug approaches for addressing issues in drug delivery and targeting. Topics covered included: (i) the basics of prodrug design; (ii) increasing bioavailability with ester prodrugs; (iii) i ...
... prodrug design functional group considerations. This was followed by 17 presentations on the application of prodrug approaches for addressing issues in drug delivery and targeting. Topics covered included: (i) the basics of prodrug design; (ii) increasing bioavailability with ester prodrugs; (iii) i ...
Exine dehiscing induces rape microspore polarity
... 2001; Fischer et al., 2004). The role of cell polarity in multicellular system development and differentiation, especially during embryo development, has attracted increasing attention (Jurgens et al., 1997; Kropf, 1999; Scheres and Benfey, 1999; Grebe et al., 2002; Ekici and Dane, 2004). Analyses i ...
... 2001; Fischer et al., 2004). The role of cell polarity in multicellular system development and differentiation, especially during embryo development, has attracted increasing attention (Jurgens et al., 1997; Kropf, 1999; Scheres and Benfey, 1999; Grebe et al., 2002; Ekici and Dane, 2004). Analyses i ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.