Size evolution in microorganisms masks trade-offs
... Our objective was to investigate the relationship between the capacity for rapid growth (mmax), competitive ability for nutrients (CP and CN for phosphorus and nitrogen, respectively), and cell size using experimental evolution of microbial cells. We took advantage of the rapid multiplication rate o ...
... Our objective was to investigate the relationship between the capacity for rapid growth (mmax), competitive ability for nutrients (CP and CN for phosphorus and nitrogen, respectively), and cell size using experimental evolution of microbial cells. We took advantage of the rapid multiplication rate o ...
The Vam6 GEF Controls TORC1 by Activating the
... (A) The nucleotide-binding states of Gtr1 and Gtr2 control both the cell’s ability to recover from rapamycin treatment and TORC1 activity. Rapamycin recovery and TORC1 activity assays (as in Figure 1A) were determined in a gtr1D gtr2D double-mutant strain carrying all combinations of plasmids betwee ...
... (A) The nucleotide-binding states of Gtr1 and Gtr2 control both the cell’s ability to recover from rapamycin treatment and TORC1 activity. Rapamycin recovery and TORC1 activity assays (as in Figure 1A) were determined in a gtr1D gtr2D double-mutant strain carrying all combinations of plasmids betwee ...
DELIVERY OF PROTEIN USING NANOPARTICLE Research Article A.ROBIN
... Trypsin can diminish or denature the monomer of ALPase by proteolysis before forming the active form in the periplasm region, but this is prevented by the protease inhibitors present inside the cell wall. It is here, where the Au nanoparticles play its role as carrier and protective agent for the se ...
... Trypsin can diminish or denature the monomer of ALPase by proteolysis before forming the active form in the periplasm region, but this is prevented by the protease inhibitors present inside the cell wall. It is here, where the Au nanoparticles play its role as carrier and protective agent for the se ...
mesenchymal transition in colon cancer
... Figure S1 and Daumar et al.36 for BAP-1 preparation).37 BAP-1 mimics neo’s effects on EMT by downregulating vimentin, Slug, ZEB1 and c-Myc. Our next goal was to determine if neo’s anticancer effects resulted from inhibiting an alternative target other than TopoIIα. Protein kinases have emerged as th ...
... Figure S1 and Daumar et al.36 for BAP-1 preparation).37 BAP-1 mimics neo’s effects on EMT by downregulating vimentin, Slug, ZEB1 and c-Myc. Our next goal was to determine if neo’s anticancer effects resulted from inhibiting an alternative target other than TopoIIα. Protein kinases have emerged as th ...
Blood and Marrow Stem Cell Transplantation
... Autologous Stem Cell Transplantation. This type of transplantation involves the use of a patient’s own stem cells. The stem cells are collected from marrow or blood, then frozen. The thawed cells are returned to the patient after he or she has received intensive chemotherapy and/or radiation therapy ...
... Autologous Stem Cell Transplantation. This type of transplantation involves the use of a patient’s own stem cells. The stem cells are collected from marrow or blood, then frozen. The thawed cells are returned to the patient after he or she has received intensive chemotherapy and/or radiation therapy ...
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... animals accumulate fewer eggs than do wild-type animals. Representative wild-type (A) and vs29 (B) animals are shown. The average number of eggs accumulated by each strain, the vulva (asterisk), and eggs (arrowheads) are indicated. (C) vs29 animals begin to lay eggs earlier than do wild-type animals ...
... animals accumulate fewer eggs than do wild-type animals. Representative wild-type (A) and vs29 (B) animals are shown. The average number of eggs accumulated by each strain, the vulva (asterisk), and eggs (arrowheads) are indicated. (C) vs29 animals begin to lay eggs earlier than do wild-type animals ...
Blood and Marrow Stem Cell Transplantation 2013
... Autologous Stem Cell Transplantation. This type of transplantation involves the use of a patient’s own stem cells. The stem cells are collected from marrow or blood, then frozen. The thawed cells are returned to the patient after he or she has received intensive chemotherapy and/or radiation therapy ...
... Autologous Stem Cell Transplantation. This type of transplantation involves the use of a patient’s own stem cells. The stem cells are collected from marrow or blood, then frozen. The thawed cells are returned to the patient after he or she has received intensive chemotherapy and/or radiation therapy ...
DAZL is essential for stress granule formation
... regulator, was translocated to SGs upon heat stress. Furthermore, SG assembly activity was significantly diminished in the early male germ cells of Dazl-knockout mice. The DAZL-containing SGs played a protective role against heat stress-induced apoptosis by the sequestration of specific signaling mo ...
... regulator, was translocated to SGs upon heat stress. Furthermore, SG assembly activity was significantly diminished in the early male germ cells of Dazl-knockout mice. The DAZL-containing SGs played a protective role against heat stress-induced apoptosis by the sequestration of specific signaling mo ...
Modeling the Gastric Mill Central Pattern Generator of the Lobster
... ties appear to play an important role in pattern formation (Russell and Hartline 1984; Selverston et al. 1976). No single cell has been shown to be a strong endogenous b urster. In a few preparations, however, the DG cell has been found to have the capability for endogenous bursting when subjected t ...
... ties appear to play an important role in pattern formation (Russell and Hartline 1984; Selverston et al. 1976). No single cell has been shown to be a strong endogenous b urster. In a few preparations, however, the DG cell has been found to have the capability for endogenous bursting when subjected t ...
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... of corneal epithelial cells leads to 10- to 100-fold increases in P. aeruginosa adherence and rendered the cornea susceptible to infection (14, 28). Apical addition of P. aeruginosa to the apical surfaces of MDCK and corneal epithelial cells induced cytotoxicity as expanding foci of dying cells, ind ...
... of corneal epithelial cells leads to 10- to 100-fold increases in P. aeruginosa adherence and rendered the cornea susceptible to infection (14, 28). Apical addition of P. aeruginosa to the apical surfaces of MDCK and corneal epithelial cells induced cytotoxicity as expanding foci of dying cells, ind ...
Figure 1 - Journal of The Royal Society Interface
... Trees increase in diameter as wood cells are added by the cambium, a dividing layer of cells at the periphery of the tree just inside the bark [2]. Outer cells in the cambial zone develop into bark, while inner cells differentiate into wood, with a layer of cambial cells remaining between the two. O ...
... Trees increase in diameter as wood cells are added by the cambium, a dividing layer of cells at the periphery of the tree just inside the bark [2]. Outer cells in the cambial zone develop into bark, while inner cells differentiate into wood, with a layer of cambial cells remaining between the two. O ...
Germ disc differentiation
... –Endoderm: migrated cells displace hypoblast cells –Mesoderm: cells btw the endo and ...
... –Endoderm: migrated cells displace hypoblast cells –Mesoderm: cells btw the endo and ...
Studies of the cat`s medial interlaminar nucleus
... Extracellular recordings from 102 single-units in MIN indicate t h a t these cells have properties essentially identical to lamLGN Y-cells. That is, they had short latencies to orthodromic stimulation of the optic chiasm and antidromic stimulation of the visual cortices, responded in a phasic manner ...
... Extracellular recordings from 102 single-units in MIN indicate t h a t these cells have properties essentially identical to lamLGN Y-cells. That is, they had short latencies to orthodromic stimulation of the optic chiasm and antidromic stimulation of the visual cortices, responded in a phasic manner ...
Potassium regulation
... cell causing hyperkalemia • For each 10 mOsm increase in osmalrity, this will make 0.4-0.8 mEqv increase in potassium extracellular concentration • Remember that the normal osmolarity in the plasma is 284mOsm • -Epinephrine pushes potassium inside the cells, so giving beta blocker as propranolol wil ...
... cell causing hyperkalemia • For each 10 mOsm increase in osmalrity, this will make 0.4-0.8 mEqv increase in potassium extracellular concentration • Remember that the normal osmolarity in the plasma is 284mOsm • -Epinephrine pushes potassium inside the cells, so giving beta blocker as propranolol wil ...
In Vivo Analysis of Riboswitch Activity Using Luciferase Assays
... organisms today, but riboswitches may have provided an advantageous method of gene regulation in the ancient hypothesized RNA-based world (Winkler, 2003). Riboswitches control gene expression by binding small ligands, which results in a conformation change of the RNA structure and leads to gene repr ...
... organisms today, but riboswitches may have provided an advantageous method of gene regulation in the ancient hypothesized RNA-based world (Winkler, 2003). Riboswitches control gene expression by binding small ligands, which results in a conformation change of the RNA structure and leads to gene repr ...
Infection of Mesothelial Cells with Human Herpes Virus 8 in
... in the mantle zone of lymphoid follicles and interfollicular areas (11, 13–15). These cells are infected with the virus in either its latent or lytic phase, thus expressing either latent nuclear antigens or the viral homolog of human interleukin-6 (vIL-6), respectively (10, 11, 13–15). In primary ef ...
... in the mantle zone of lymphoid follicles and interfollicular areas (11, 13–15). These cells are infected with the virus in either its latent or lytic phase, thus expressing either latent nuclear antigens or the viral homolog of human interleukin-6 (vIL-6), respectively (10, 11, 13–15). In primary ef ...
Putative Autocleavage of Outer Capsid Protein 1, Allowing Release
... and the particles are then internalized, most likely by receptormediated endocytosis (10, 62). Within the endocytic vesicles, lysosomal proteases cleave the outer capsid proteins (30, 62) to generate particles very similar to the infectious subvirion particles (ISVPs) that can be generated in vitro ...
... and the particles are then internalized, most likely by receptormediated endocytosis (10, 62). Within the endocytic vesicles, lysosomal proteases cleave the outer capsid proteins (30, 62) to generate particles very similar to the infectious subvirion particles (ISVPs) that can be generated in vitro ...
Nucleolar targeting of BN46/51 - Journal of Cell Science
... 1160 G. M. Trimbur and others basal body complex, monoclonal antibodies (mAbs) were developed against proteins derived from a basal body fraction (Trimbur and Walsh, 1992). The mAb BN5.1 was identified based on its specific reaction to the basal body region. BN5.1 also reacts with the large central ...
... 1160 G. M. Trimbur and others basal body complex, monoclonal antibodies (mAbs) were developed against proteins derived from a basal body fraction (Trimbur and Walsh, 1992). The mAb BN5.1 was identified based on its specific reaction to the basal body region. BN5.1 also reacts with the large central ...
Cell cycle control of septin ring dynamics in the
... immunofluorescence on fixed cells for the Cdc3, Cdc11 and Cdc12 septins in the classic work by J. Pringle and coworkers (Ford & Pringle, 1991 ; Kim et al., 1991) and to that observed in vivo throughout the cytokinetic stage for a Cdc12-GFP fusion (Lippincott & Li, 1998), suggesting that the localiza ...
... immunofluorescence on fixed cells for the Cdc3, Cdc11 and Cdc12 septins in the classic work by J. Pringle and coworkers (Ford & Pringle, 1991 ; Kim et al., 1991) and to that observed in vivo throughout the cytokinetic stage for a Cdc12-GFP fusion (Lippincott & Li, 1998), suggesting that the localiza ...
UVA radiation causes DNA strand breaks, chromosomal
... UV-dependent mutations (Ikehata et al., 2003, 2004). In addition, ROS are involved in generating DNA single strand (ss) breaks (Kielbassa et al., 1997). If ss breaks are not repaired during the G1 phase of the cell cycle they can generate double strand (ds) breaks during S-phase which then can resul ...
... UV-dependent mutations (Ikehata et al., 2003, 2004). In addition, ROS are involved in generating DNA single strand (ss) breaks (Kielbassa et al., 1997). If ss breaks are not repaired during the G1 phase of the cell cycle they can generate double strand (ds) breaks during S-phase which then can resul ...
Hunt, D.E. Motility in the marine environment: an adaptive response
... the marine environment through exudation, representing a potentially significant nutrient point source. Bell and Mitchell (1972) first suggested the importance of the “phycosphere”, the region surrounding a photosynthesizing alga analogous to the rhizosphere of plants containing high levels of photo ...
... the marine environment through exudation, representing a potentially significant nutrient point source. Bell and Mitchell (1972) first suggested the importance of the “phycosphere”, the region surrounding a photosynthesizing alga analogous to the rhizosphere of plants containing high levels of photo ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.