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The Cranial Nerves
The Cranial Nerves

... ganglia.Also, the dermatomes of this region of the body wall and upper limb have their neuronal cell bodies in the same dorsal root ganglia . and synapse in the same second order neurons in the spinal cord segments (T1-5) as the general visceral sensory fibers from the heart. The CNS does not clearl ...
PDF - The Journal of Cell Biology
PDF - The Journal of Cell Biology

... Balancing cell death and cell survival enables structural plasticity and homeostasis, regeneration, and repair and fails in cancer and neurodegeneration. In the nervous system, cell number plasticity is linked to neural circuit formation, adjusting neuronal number to functional requirements (Levi-Mo ...
Tansley review - Professor Gero Steinberg
Tansley review - Professor Gero Steinberg

... (Genre et al., 2005). Thus, the molecular mechanisms of polarized fungal growth are of crucial importance for an understanding of the relationship between fungi and plants. It has long been discussed that the expansion of the tip involves local release or surface exposure of exoenzymes and proteins ...
Stage-Specific Histone Modification Profiles Reveal Global
Stage-Specific Histone Modification Profiles Reveal Global

... Our knowledge about the epigenetic changes, which accompany the determination of definitive somatic cell lineages in the mammalian embryo, are derived largely from in vitro differenti- ...
The Skeletal System - Bio-Guru
The Skeletal System - Bio-Guru

... Degenerative scoliosis is caused by deterioration of the bony material (discs) that separate the vertebrae. Arthritis in the spinal cord can also lead to degenerative scoliosis. In four out of five scoliosis cases, however, the cause is unknown. Such cases are known as idiopathic scoliosis. Children ...
Structure and Organelles
Structure and Organelles

... Several organelles are involved in making and processing proteins. • The nucleus stores genetic information. • Many processes occur in the endoplasmic reticulum. • There are two types of endoplasmic reticulum. – rough endoplasmic reticulum – smooth endoplasmic reticulum ...
Novel role for the Lu/BCAM–spectrin interaction in actin cytoskeleton
Novel role for the Lu/BCAM–spectrin interaction in actin cytoskeleton

... common form in nucleated cells. Moreover, αI-spectrin is not expressed in epithelial cells. Each spectrin subunit is organized as an alignment of spectrin repeats, made up of three α-helices each; α-spectrins contain 20 spectrin repeats. In RBCs, the Lu/BCAMbinding site in αI-spectrin has been delim ...
The nucleolus through the years
The nucleolus through the years

The GARP complex is required for cellular sphingolipid homeostasis
The GARP complex is required for cellular sphingolipid homeostasis

... four of five subunits of retromer (vps17Δ, pep8Δ, vps35Δ, vps29Δ; Figure 1B). In addition, our screen identified two of the three SNARE proteins important for GARP-dependent trafficking (tlg2Δ, vti1DAMP) and VPS63, a gene overlapping almost completely with the GTPase YPT6 that is involved in Golgi-e ...
Only a subset of the binary cell fate decisions
Only a subset of the binary cell fate decisions

Keratin Alterations during Embryonic Epidermal Differentiation: A
Keratin Alterations during Embryonic Epidermal Differentiation: A

... keratin proteins in the molecular weight range of 40,000-59,000. The stratification of the epithelium into two cell layers at 20 d of development coincided with the appearance of a 65Walton keratin . When a thick stratum corneum developed at 29 d, several additional keratins became prominent, most n ...
The Use of Conditional Lethal Cell Cycle Mutants for
The Use of Conditional Lethal Cell Cycle Mutants for

Ezrin: a protein requiring conformational activation to link
Ezrin: a protein requiring conformational activation to link

... The plasma membrane is the interface a cell has with its environment and its neighbors. It is the site of vectorial transport of ions and nutrients, reception of signalling molecules, and attachments to adjacent cells and the extracellular matrix. To perform these functions, the membrane is supporte ...
Peer-reviewed Article PDF
Peer-reviewed Article PDF

... and maintenance of the myofibrils in cardiac and skeletal muscle cells. Evidence from our research as well as from other laboratories favors the premyofibril model of myofibrillogenesis. This three-step model (premyofibril to nascent myofibril to mature myofibril) not only provides a reasonable mech ...
The epithelial junction: bridge, gate, and fence.
The epithelial junction: bridge, gate, and fence.

... a method for virtually complete elimination of edge damage. With this new method Lewis and I found junctional resistance of rabbit urinary bladder to exceed 300,000 a -cm2. Here is a tissue in which the tight junctions really are like cement, as classical anatomists assumed. The transcellular resist ...
The zebrafish midblastula transition - Development
The zebrafish midblastula transition - Development

... indicating possible MBT-like cell cycle lengthening. In studies on the loach, Misgurnus fossilis, Rott and Shevelava (1967) found a more defined cell cycle lengthening, which did not occur until cycle 11, and, in the same study, they found the equivalent cell cycle lengthening in haploid embryos occ ...
Isolation of a New High Molecular Weight Protein Associated with
Isolation of a New High Molecular Weight Protein Associated with

... vimentin and desmin, as well as the vimentin- and desmin-associated high molecular weight protein, synemin (230,000 mol wt) . In addition, they contain a previously unidentified high molecular weight protein (280,000 mol wt) which differs from synemin by isoelectric point, molecular weight, and immu ...
United States Navy Hospital Corpsman NAVEDTRA
United States Navy Hospital Corpsman NAVEDTRA

... tissue acts as a reservoir for energy-producing foods; helps to reduce body heat loss (because of its poor heat conductivity); and serves as support for various organs and fragile structures, such as the kidneys, blood vessels, and nerves. Osseous Connective Tissue This type of tissue, known as “bon ...
Plastid degeneration in Tillandsia (Bromeliaceae) provides
Plastid degeneration in Tillandsia (Bromeliaceae) provides

... bodies mainly containing lipids and proteins, appear or increase in number, as shown also by Evans et al. (2010), Biswal et al. (2013) and Sakuraba et al. (2014). The membranes in such plastids may show one major membrane swirl (Dennis et al. 1967) or several such swirls (Evans et al. 2010). In othe ...
56-6935 Human Female Genital Organs
56-6935 Human Female Genital Organs

... Extending from the mons veneris are the labia majora, two rounded folds of adipose tissue covered with skin. The labia majora are wider at the point of con­ nection with the mons veneris. They taper as they pass on either side of the vulva, and then posterior to the vaginal opening they are joined t ...
CLC Chloride Channels in Caenorhabditis elegans*
CLC Chloride Channels in Caenorhabditis elegans*

zero-term rank preservers of integer matrices - DML-PL
zero-term rank preservers of integer matrices - DML-PL

... One of the most active and continuing subjects in matrix theory during the past century is the study of those linear operators on matrices that leave certain properties or relations of subsets invariant. The earliest papers in this subject are those of Frobenius and Kantor in 1897 (see [8]). Since m ...
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma

... cells. Mouse model with expressing KrasG12D and conditional Stat3 knockout (Ptf1a-Cre; KrasG12D; Stat3f/f) was established to study whether the presence of Stat3 would affect PanIN/PDA formation in caerulin-treated KRASG12D mice. Spontaneous and caerulin-induced PanIN formation was inhibited with pa ...
Dynamic Tubular Vacuoles Radiate Through the
Dynamic Tubular Vacuoles Radiate Through the

... Textbook images of the plant vacuole show a large, static organelle, surrounded by the vacuolar membrane (tonoplast), which sits passively in the centre of the cell. This central vacuole performs multiple functions, and is important not only for the generation of turgor pressure but also as a store ...
Medicinal Chemistry of Antifungal Agents
Medicinal Chemistry of Antifungal Agents

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Extracellular matrix



In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).
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