product monograph
... treatment with atypical antipsychotics should undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. Patient ...
... treatment with atypical antipsychotics should undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. Patient ...
Evaluation of 22 SIN List 2.0 substances according to the Danish
... in humans or animal species living in the environment or when there is evidence from animal studies, possibly supplemented with other information, to provide a strong presumption that the substance has the capacity to cause ED effects in humans or animals living in the environment. The animal studie ...
... in humans or animal species living in the environment or when there is evidence from animal studies, possibly supplemented with other information, to provide a strong presumption that the substance has the capacity to cause ED effects in humans or animals living in the environment. The animal studie ...
as terbinafine base
... occur in patients treated with terbinafine tablets should be evaluated and consideration should be given for a possible change in medication regimen, including discontinuation of treatment with terbinafine tablets. Carcinogenesis and Mutagenesis An increase in liver tumours was observed in male rats ...
... occur in patients treated with terbinafine tablets should be evaluated and consideration should be given for a possible change in medication regimen, including discontinuation of treatment with terbinafine tablets. Carcinogenesis and Mutagenesis An increase in liver tumours was observed in male rats ...
METRONIDAZOLE INTRAVENOUS INFUSION
... Disulfiram: Administration of disulfiram with metronidazole has been associated with acute psychoses and confusion in some patients; therefore the two drugs should not be administered. Metronidazole should not be given to patients who have taken disulfiram within the last two weeks. Cyclosporin: The ...
... Disulfiram: Administration of disulfiram with metronidazole has been associated with acute psychoses and confusion in some patients; therefore the two drugs should not be administered. Metronidazole should not be given to patients who have taken disulfiram within the last two weeks. Cyclosporin: The ...
EES Granules - Arbor Pharmaceuticals
... soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels ...
... soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels ...
Patient Information Sheet YOUR PRESCRIPTION FOR BALACET
... Blood gases, pH, and electrolytes should be monitored in order that acidosis and any electrolyte disturbance present may be corrected promptly. Acidosis, hypoxia, and generalized CNS depression predispose to the development of cardiac arrhythmias. Ventricular fibrillation or cardiac arrest may occur ...
... Blood gases, pH, and electrolytes should be monitored in order that acidosis and any electrolyte disturbance present may be corrected promptly. Acidosis, hypoxia, and generalized CNS depression predispose to the development of cardiac arrhythmias. Ventricular fibrillation or cardiac arrest may occur ...
Effective Over-the-Counter Acne Treatments
... 10% benzoyl peroxide wash during the following 2 weeks.28 In both instances, we believe the superiority can be attributed to better compliance with SA because of less irritation. Furthermore, BPO and SA may best be used in combination as part of a complete skin care regimen, as they have two differe ...
... 10% benzoyl peroxide wash during the following 2 weeks.28 In both instances, we believe the superiority can be attributed to better compliance with SA because of less irritation. Furthermore, BPO and SA may best be used in combination as part of a complete skin care regimen, as they have two differe ...
Plavix - Sanofi Canada
... In patients with recent transient ischaemic attack (TIA) or stroke and who are at high risk of recurrent ischemic events, the combination of ASA and PLAVIX has not been shown to be more effective than PLAVIX alone, but the combination has been shown to increase major bleeding (see DRUG INTERACTIONS ...
... In patients with recent transient ischaemic attack (TIA) or stroke and who are at high risk of recurrent ischemic events, the combination of ASA and PLAVIX has not been shown to be more effective than PLAVIX alone, but the combination has been shown to increase major bleeding (see DRUG INTERACTIONS ...
methotrexate - Cancer Care Ontario
... Patients with relevant third space fluid collections have prolonged excretion of methotrexate levels and a resulting increase in toxicity. Evacuation of fluid collections and close monitoring of serum levels are recommended in such patients. There may be an increased risk of tissue necrosis or oste ...
... Patients with relevant third space fluid collections have prolonged excretion of methotrexate levels and a resulting increase in toxicity. Evacuation of fluid collections and close monitoring of serum levels are recommended in such patients. There may be an increased risk of tissue necrosis or oste ...
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
... system depressants (such as tranquilisers, sedatives or hypnotics) (see section 4.5). Studies in animals, as well as clinical experience, have demonstrated that buprenorphine may produce dependence but at a lower level than morphine. Respiratory depression: A number of cases of death due to respirat ...
... system depressants (such as tranquilisers, sedatives or hypnotics) (see section 4.5). Studies in animals, as well as clinical experience, have demonstrated that buprenorphine may produce dependence but at a lower level than morphine. Respiratory depression: A number of cases of death due to respirat ...
Chronic l-Alpha Acetylmethadol in Rhesus Monkeys
... (male monkeys only)] that are commonly observed during mu opioid withdrawal (e.g., Katz, 1986) were scored for the 25-min session. Each period was divided into twenty-five 1-min bins and behavioral signs were recorded as either present or absent during each bin [i.e., a maximum frequency of 25 occur ...
... (male monkeys only)] that are commonly observed during mu opioid withdrawal (e.g., Katz, 1986) were scored for the 25-min session. Each period was divided into twenty-five 1-min bins and behavioral signs were recorded as either present or absent during each bin [i.e., a maximum frequency of 25 occur ...
1 6111 METRONIDAZOLE VAGINAL GEL, 0.75%
... patients with bacterial vaginosis, a mean maximum serum metronidazole concentration of 214 ng/mL on day one and 294 ng/mL (range: 228 to 349 ng/mL) on day five were reported. Steady state metronidazole serum concentrations following oral dosages of 400 to 500 mg BID have been reported to range from ...
... patients with bacterial vaginosis, a mean maximum serum metronidazole concentration of 214 ng/mL on day one and 294 ng/mL (range: 228 to 349 ng/mL) on day five were reported. Steady state metronidazole serum concentrations following oral dosages of 400 to 500 mg BID have been reported to range from ...
PRODUCT MONOGRAPH Pr CILOXAN® 0.3% Ciprofloxacin
... Ciprofloxacin Hydrochloride Ophthalmic Solution administered four times per day to immature Beagle dogs did not demonstrate any articular lesions. Based on ocular toxicology studies performed in rabbits, the ocular effects produced by an exaggerated topical ocular exposure to 0.3%, 0.75% or 1.5% Cip ...
... Ciprofloxacin Hydrochloride Ophthalmic Solution administered four times per day to immature Beagle dogs did not demonstrate any articular lesions. Based on ocular toxicology studies performed in rabbits, the ocular effects produced by an exaggerated topical ocular exposure to 0.3%, 0.75% or 1.5% Cip ...
product monograph
... Sensitivity to topically applied aminoglycosides may occur in some patients. The severity of hypersensitivity reactions may vary from local effects to generalized reactions, such as erythema, itching, urticaria, skin rash, anaphylaxis, anaphylactoid reactions, or bullous reactions. If a hypersensiti ...
... Sensitivity to topically applied aminoglycosides may occur in some patients. The severity of hypersensitivity reactions may vary from local effects to generalized reactions, such as erythema, itching, urticaria, skin rash, anaphylaxis, anaphylactoid reactions, or bullous reactions. If a hypersensiti ...
MAXIDOL® Liquid Gels
... which were performed in the course of the naproxen sodium clinical development program. The meta-analysis included a total of 46 studies, which satisfied the criteria of being randomized, placebo controlled, double-blind and used naproxen sodium in single (SD, 220 mg or 440 mg pooled data), multiple ...
... which were performed in the course of the naproxen sodium clinical development program. The meta-analysis included a total of 46 studies, which satisfied the criteria of being randomized, placebo controlled, double-blind and used naproxen sodium in single (SD, 220 mg or 440 mg pooled data), multiple ...
In vitro and in vivo studies of artemisinin endoperoxides
... In conclusion, artemisinin endoperoxides exert inhibitory effects on the activity of CYP enzymes in vitro, which could result in clinically significant DDIs. This could be a concern in both malaria and cancer therapies, which often include concomitant administration of multiple drugs. Also, for the ...
... In conclusion, artemisinin endoperoxides exert inhibitory effects on the activity of CYP enzymes in vitro, which could result in clinically significant DDIs. This could be a concern in both malaria and cancer therapies, which often include concomitant administration of multiple drugs. Also, for the ...
TRIDURAL Product Monograph
... Abuse and addiction are separate and distinct from physical dependence and tolerance. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances. Tolerance as well as both p ...
... Abuse and addiction are separate and distinct from physical dependence and tolerance. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances. Tolerance as well as both p ...
Dabigatran etexilate for the prevention of stroke in patients with
... only becomes significantly prolonged at supra therapeutic concentrations; as such, it is not useful for monitoring dabigatran. The aPTT response to dabigatran is nonlinear and varies as a function of the plasma concentration. Both therapeutic and supratherapeutic levels of dabigatran may only mildl ...
... only becomes significantly prolonged at supra therapeutic concentrations; as such, it is not useful for monitoring dabigatran. The aPTT response to dabigatran is nonlinear and varies as a function of the plasma concentration. Both therapeutic and supratherapeutic levels of dabigatran may only mildl ...
Nancy Caroline`s Emergency Care in the Streets, Seventh Edition
... (b) Animal reproductive studies have shown an adverse effect (other than decreased fertility) that was not confirmed in controlled studies on women in the first trimester. ...
... (b) Animal reproductive studies have shown an adverse effect (other than decreased fertility) that was not confirmed in controlled studies on women in the first trimester. ...
Theracurmin | Information Sheet
... The clinical usefulness of curcumin has been limited by its chemical instability at intestinal pH values, by its low water solubility, and by its poor oral bioavailability and quick conjugation and excretion. As a result, several human studies of standard curcumin have failed, even at high doses, an ...
... The clinical usefulness of curcumin has been limited by its chemical instability at intestinal pH values, by its low water solubility, and by its poor oral bioavailability and quick conjugation and excretion. As a result, several human studies of standard curcumin have failed, even at high doses, an ...
1 Spironolactone Tablets, USP WARNING
... performed in rats, with its proliferative effects manifested on endocrine organs and the liver. In an 18-month study using doses of about 50, 150 and 500 mg/kg/day, there were statistically significant increases in benign adenomas of the thyroid and testes and, in male rats, a dose-related increase ...
... performed in rats, with its proliferative effects manifested on endocrine organs and the liver. In an 18-month study using doses of about 50, 150 and 500 mg/kg/day, there were statistically significant increases in benign adenomas of the thyroid and testes and, in male rats, a dose-related increase ...
avodart - Urological Sciences Research Foundation
... Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5α-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human a ...
... Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5α-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human a ...
Full Product Information
... distributed in body fluids and tissues (including bones). The average biological half-life is 2.4 hours. Approximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces; the remainder is excreted as bioinactive metabolites. Doses of up to 2 grams of clindamycin per day for 14 day ...
... distributed in body fluids and tissues (including bones). The average biological half-life is 2.4 hours. Approximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces; the remainder is excreted as bioinactive metabolites. Doses of up to 2 grams of clindamycin per day for 14 day ...
Update on the Pharmacodynamics and
... reduction for emergency medications19 n3#{176}including steroids,2 and blocking of exercise-induced chospasm3#{176} documented pg/ml. As to the argument attained ftr some patients ...
... reduction for emergency medications19 n3#{176}including steroids,2 and blocking of exercise-induced chospasm3#{176} documented pg/ml. As to the argument attained ftr some patients ...
Ketorolac Tromethamine Injection, USP
... of action of ketorolac, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. The biological activity of ketorolac tromethamine is associated with the S-form. Ketorolac tromethamine possesses no sedative or anxiolytic properties. The peak ...
... of action of ketorolac, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. The biological activity of ketorolac tromethamine is associated with the S-form. Ketorolac tromethamine possesses no sedative or anxiolytic properties. The peak ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.