Research Interests
... morphogenesis. Repeated pair-wise changes in these morphogenic characters (from cellular processes to patterning elements) that are phylogenetically correlated will suggest hypotheses of functional relationships between the correlated characters that can then be tested. Likewise, variations in a mo ...
... morphogenesis. Repeated pair-wise changes in these morphogenic characters (from cellular processes to patterning elements) that are phylogenetically correlated will suggest hypotheses of functional relationships between the correlated characters that can then be tested. Likewise, variations in a mo ...
Making a firm decision: multifaceted regulation of cell fate in the
... The first hypothesis that was proposed to explain how inside and outside cells become different stressed the importance of cell position. By changing the position of cells, it was found that inside cells tended to develop into the ICM and outside ones into trophectoderm39. The resulting ‘inside–outs ...
... The first hypothesis that was proposed to explain how inside and outside cells become different stressed the importance of cell position. By changing the position of cells, it was found that inside cells tended to develop into the ICM and outside ones into trophectoderm39. The resulting ‘inside–outs ...
a complexity drain on cells in the evolution of
... A second rationale is that selection on a multicellular entity favors a reduction in the range of behavioral possibilities in its component cells. To play its proper role, a cell must not only behave appropriately, it must be constrained from behaving inappropriately. One way to eliminate inappropri ...
... A second rationale is that selection on a multicellular entity favors a reduction in the range of behavioral possibilities in its component cells. To play its proper role, a cell must not only behave appropriately, it must be constrained from behaving inappropriately. One way to eliminate inappropri ...
Beginnings of a Good Apoptotic Meal: The Find-Me and
... through soluble ‘‘find-me’’ signals advertise their presence to phagocytes at the earliest stages of cell death. Phagocytes sense the find-me signal gradient, and in turn the presence of dying cells, and migrate to their vicinity. The apoptotic cells also expose specific ‘‘eat-me’’ signals on their ...
... through soluble ‘‘find-me’’ signals advertise their presence to phagocytes at the earliest stages of cell death. Phagocytes sense the find-me signal gradient, and in turn the presence of dying cells, and migrate to their vicinity. The apoptotic cells also expose specific ‘‘eat-me’’ signals on their ...
AtLSG1-2 Regulates Leaf Growth by Affecting Cell Proliferation and
... In this study, we focus on the roles of AtLSG1-2 on leaf development and investigated how loss of function of AtLSG1-2 may affect leaf growth. Compared to wild-type plant, atlsg1-2 mutant had reduced leaf size. Leaf kinematic analysis and flow cytometry analysis revealed that cell division, differen ...
... In this study, we focus on the roles of AtLSG1-2 on leaf development and investigated how loss of function of AtLSG1-2 may affect leaf growth. Compared to wild-type plant, atlsg1-2 mutant had reduced leaf size. Leaf kinematic analysis and flow cytometry analysis revealed that cell division, differen ...
Normal and c-Myc-promoted human keratinocyte di
... they constituted more than a fourth of terminally dierentiating cells (26.3% on basis of light scatter; 29.3(+1.6%) on basis of involucrin staining; Figure 2a,b). Therefore polyploidy was not a random consequence of the conditions in culture, but it was tightly associated with terminal dierentiati ...
... they constituted more than a fourth of terminally dierentiating cells (26.3% on basis of light scatter; 29.3(+1.6%) on basis of involucrin staining; Figure 2a,b). Therefore polyploidy was not a random consequence of the conditions in culture, but it was tightly associated with terminal dierentiati ...
αvβ3 integrin-dependent endothelial cell dynamics in
... movies, endothelial cells are labeled with Cy3-QH1 and appear white unless otherwise noted. All still images found in figures that have been taken from movies, are inverted so that the endothelial cells and structures appear as black on a white background. The normal vasculogenesis of a HH stage 8 q ...
... movies, endothelial cells are labeled with Cy3-QH1 and appear white unless otherwise noted. All still images found in figures that have been taken from movies, are inverted so that the endothelial cells and structures appear as black on a white background. The normal vasculogenesis of a HH stage 8 q ...
The endocytic network in plants
... Moreover, plant cells can internalize components of their cell wall [10,11,13,15], which might provide an important paradigm of an effective mechanism for remodelling extracellular matrices in other organisms. Compartments, molecules and markers The endocytic machinery, which encompasses both molecu ...
... Moreover, plant cells can internalize components of their cell wall [10,11,13,15], which might provide an important paradigm of an effective mechanism for remodelling extracellular matrices in other organisms. Compartments, molecules and markers The endocytic machinery, which encompasses both molecu ...
Introduction to Cell fate and plasticity Introduction, fate maps
... Figure 5 Gradient interpretation. (a) Interpretation by DNA-binding sites with varying affinity for transcriptional regulator ( gold ). The promoter of the top gene contains three low-affinity binding sites (blue; high-threshold gene); the promoter of the bottom gene contains three high-affinity bin ...
... Figure 5 Gradient interpretation. (a) Interpretation by DNA-binding sites with varying affinity for transcriptional regulator ( gold ). The promoter of the top gene contains three low-affinity binding sites (blue; high-threshold gene); the promoter of the bottom gene contains three high-affinity bin ...
Role of CD45 Signaling Pathway in Galactoxylomannan- Induced T Cell Damage
... cell apoptosis, using CD45+/+ and CD452/2 cell lines, derived from BW5147 murine T cell lymphoma. Our results show that whereas CD45 expression is not required for GalXM association by the cells, it is essential for apoptosis induction. In CD45+/+ cells, CD45 triggering by GalXM reduces the activati ...
... cell apoptosis, using CD45+/+ and CD452/2 cell lines, derived from BW5147 murine T cell lymphoma. Our results show that whereas CD45 expression is not required for GalXM association by the cells, it is essential for apoptosis induction. In CD45+/+ cells, CD45 triggering by GalXM reduces the activati ...
Article - Research | www.stowers.org
... epithelia reveals a direct relationship between the duration of exposure to this signaling pathway, the accumulation of activated Myosin II, and the degree of tissue invagination. INTRODUCTION Organogenesis requires the precise regulation of cell proliferation, movement, and apoptosis to achieve pro ...
... epithelia reveals a direct relationship between the duration of exposure to this signaling pathway, the accumulation of activated Myosin II, and the degree of tissue invagination. INTRODUCTION Organogenesis requires the precise regulation of cell proliferation, movement, and apoptosis to achieve pro ...
Plant Phosphoglycerolipids: The Gatekeepers of Vascular Cell
... Plant Phosphoglycerolipids: The Gatekeepers of Vascular Cell Differentiation Bojan Gujas and Antia Rodriguez-Villalon * Vascular Development Group, Department of Biology, Institute of Agricultural Science, Swiss Federal Institute of Technology in Zürich, Zürich, Switzerland ...
... Plant Phosphoglycerolipids: The Gatekeepers of Vascular Cell Differentiation Bojan Gujas and Antia Rodriguez-Villalon * Vascular Development Group, Department of Biology, Institute of Agricultural Science, Swiss Federal Institute of Technology in Zürich, Zürich, Switzerland ...
The Arabidopsis Exocyst Complex Is Involved in Cytokinesis and
... exocyst was also revealed to be crucial for seed coat development (Kulich et al., 2010) and pollen–pistil interaction (Samuel et al., 2009). The study of plant exocyst regulators is only beginning; however, Lavy et al. (2007) demonstrated that the SEC3 subunit interacts with plant-specific Rho GTPas ...
... exocyst was also revealed to be crucial for seed coat development (Kulich et al., 2010) and pollen–pistil interaction (Samuel et al., 2009). The study of plant exocyst regulators is only beginning; however, Lavy et al. (2007) demonstrated that the SEC3 subunit interacts with plant-specific Rho GTPas ...
synchronous pollen mitosis and the formation of the generative cell
... During meiosis, each massula is invested in a thick callose sheath, and thinner callose walls exist between the meiocytes themselves (Fig. 14). The callose investment is drastically reduced by the onset of the pollen mitosis (Fig. 15). As already indicated, by this time the principal material of the ...
... During meiosis, each massula is invested in a thick callose sheath, and thinner callose walls exist between the meiocytes themselves (Fig. 14). The callose investment is drastically reduced by the onset of the pollen mitosis (Fig. 15). As already indicated, by this time the principal material of the ...
For unknown reasons, p21 expression induces different effects in
... activating its tumour suppressor properties without also inducing its potentially oncogenic features, the design of antineoplastic therapies involving p21 regulation has so far been controversial ...
... activating its tumour suppressor properties without also inducing its potentially oncogenic features, the design of antineoplastic therapies involving p21 regulation has so far been controversial ...
Structure–function relationships during secondary phloem
... the cell. Transmission electron microscopy showed parallel CMTs at both tangential walls of the cell, also arranged in a manner consistent with a helical arrangement (Figure 8). At this early stage of differentiation it was not possible to identify which cell type the element would become. In cells ...
... the cell. Transmission electron microscopy showed parallel CMTs at both tangential walls of the cell, also arranged in a manner consistent with a helical arrangement (Figure 8). At this early stage of differentiation it was not possible to identify which cell type the element would become. In cells ...
Development of Peltate Glandular Trichomes of
... the various steps defined, more recent attention has turned to the regulation of metabolism of these constitutively produced natural products. Developmental and environmental factors are both known to markedly influence the yield and composition of peppermint oil, with obvious consequences for the c ...
... the various steps defined, more recent attention has turned to the regulation of metabolism of these constitutively produced natural products. Developmental and environmental factors are both known to markedly influence the yield and composition of peppermint oil, with obvious consequences for the c ...
Cell-cycle regulation
... The cdk-4 Cdk4/6 kinase and cyd-1 D-type cyclin genes are required for progression through G1 phase during larval development (Boxem and van den Heuvel, 2001; Park and Krause, 1999). CYD-1 and CDK-4 likely act in complex, as indicated by their direct interaction in vitro and close similarity in null ...
... The cdk-4 Cdk4/6 kinase and cyd-1 D-type cyclin genes are required for progression through G1 phase during larval development (Boxem and van den Heuvel, 2001; Park and Krause, 1999). CYD-1 and CDK-4 likely act in complex, as indicated by their direct interaction in vitro and close similarity in null ...
Control of the Plant Cell Cycle by Developmental
... metaphase to anaphase. In contrast, the activity of APC/ CCDH1 is increased during late anaphase to promote the degradation of other APC/C substrates including mitotic CYCs and CDC20, to trigger an exit from mitosis (Kramer et al. 2000, Pfleger and Kirschner 2000). The Arabidopsis genome contains fi ...
... metaphase to anaphase. In contrast, the activity of APC/ CCDH1 is increased during late anaphase to promote the degradation of other APC/C substrates including mitotic CYCs and CDC20, to trigger an exit from mitosis (Kramer et al. 2000, Pfleger and Kirschner 2000). The Arabidopsis genome contains fi ...
The Arabidopsis Exocyst Complex Is Involved in
... exocyst was also revealed to be crucial for seed coat development (Kulich et al., 2010) and pollen–pistil interaction (Samuel et al., 2009). The study of plant exocyst regulators is only beginning; however, Lavy et al. (2007) demonstrated that the SEC3 subunit interacts with plant-specific Rho GTPas ...
... exocyst was also revealed to be crucial for seed coat development (Kulich et al., 2010) and pollen–pistil interaction (Samuel et al., 2009). The study of plant exocyst regulators is only beginning; however, Lavy et al. (2007) demonstrated that the SEC3 subunit interacts with plant-specific Rho GTPas ...
Pro-Survival Role of Gelsolin in Mouse β
... Detection ELISAPLUS kit, which detects mono- and oligonucleosomes present in the cytoplasm of apoptotic cells (Fig. 1B). Because caspase-3 is known to be a main mediator of apoptosis, levels of its cleaved (active) form were examined. As expected, Western blot analysis showed that after induction of ...
... Detection ELISAPLUS kit, which detects mono- and oligonucleosomes present in the cytoplasm of apoptotic cells (Fig. 1B). Because caspase-3 is known to be a main mediator of apoptosis, levels of its cleaved (active) form were examined. As expected, Western blot analysis showed that after induction of ...
The Arabidopsis Exocyst Complex Is Involved in Cytokinesis and
... exocyst was also revealed to be crucial for seed coat development (Kulich et al., 2010) and pollen–pistil interaction (Samuel et al., 2009). The study of plant exocyst regulators is only beginning; however, Lavy et al. (2007) demonstrated that the SEC3 subunit interacts with plant-specific Rho GTPas ...
... exocyst was also revealed to be crucial for seed coat development (Kulich et al., 2010) and pollen–pistil interaction (Samuel et al., 2009). The study of plant exocyst regulators is only beginning; however, Lavy et al. (2007) demonstrated that the SEC3 subunit interacts with plant-specific Rho GTPas ...
Regulation of Vascular Development - Size
... 1999; Deyholos and others 2000; Koizumi and others 2000). Mutant phenotypes typically display reduced continuity of leaf vasculature: in cotyledons and foliage leaves, the midvein and occasionally the marginal veins are intact, but the connecting secondary and higher order veins are disrupted, often ...
... 1999; Deyholos and others 2000; Koizumi and others 2000). Mutant phenotypes typically display reduced continuity of leaf vasculature: in cotyledons and foliage leaves, the midvein and occasionally the marginal veins are intact, but the connecting secondary and higher order veins are disrupted, often ...
Cell death by autophagy: facts and apparent artefacts
... Is autophagic cell death relevant to human pathologies and can it be targeted therapeutically for treatment of disease? What is the evolutionary significance of autophagic cell death? Programmed cell death (PCD) is a fundamental biological process that is highly evolutionarily conserved. In anim ...
... Is autophagic cell death relevant to human pathologies and can it be targeted therapeutically for treatment of disease? What is the evolutionary significance of autophagic cell death? Programmed cell death (PCD) is a fundamental biological process that is highly evolutionarily conserved. In anim ...
The cell cycle and pluripotency
... restricted and in addition cyclins and CDKs display tissue-specific patterns of expression [13]. These data are consistent with our general metazoan model that differentiation requires a G1 -phase for the integration of differentiation signals and suggests that cell cycle components may play roles b ...
... restricted and in addition cyclins and CDKs display tissue-specific patterns of expression [13]. These data are consistent with our general metazoan model that differentiation requires a G1 -phase for the integration of differentiation signals and suggests that cell cycle components may play roles b ...
Programmed cell death
Programmed cell-death (or PCD) is death of a cell in any form, mediated by an intracellular program. PCD is carried out in a regulated process, which usually confers advantage during an organism's life-cycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits are separate. PCD serves fundamental functions during both plant and metazoa (multicellular animals) tissue development.Apoptosis and autophagy are both forms of programmed cell death, but necrosis is a non-physiological process that occurs as a result of infection or injury.Necrosis is the death of a cell caused by external factors such as trauma or infection and occurs in several different forms. Recently a form of programmed necrosis, called necroptosis, has been recognized as an alternate form of programmed cell death. It is hypothesized that necroptosis can serve as a cell-death backup to apoptosis when the apoptosis signaling is blocked by endogenous or exogenous factors such as viruses or mutations.