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Referring to Localized Cognitive Operations in
Referring to Localized Cognitive Operations in

... (Bechtel & Richardson 1993; Bechtel & Abrahamsen 2005; Machamer, Darden, & Craver 2000). Differentiating parts and operations required the development of appropriate research techniques to decompose the brain structurally and functionally. Using staining techniques to differentiate the distribution ...
Olfactory bulb dysgenesis, mirror neuron system dysfunction, and
Olfactory bulb dysgenesis, mirror neuron system dysfunction, and

... set of neurons. We then used electrophysiological signatures of mirror neuron activity to demonstrate such deficits [2], an observation that has now been confirmed in many large-scale studies by several groups including our own [4–7]. Previous studies into the neural basis of autism have found changes ...
The Ear - Dr Magrann
The Ear - Dr Magrann

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Spindle-Like Thalamocortical Synchronization in a Rat Brain Slice
Spindle-Like Thalamocortical Synchronization in a Rat Brain Slice

... cortical afferents caused by thalamocortical firing occurring after excitation of thalamic neurons by corticothalamic inputs. Accordingly, kynurenic acid application to VB abolished this late response without influencing the antidromic or the initial postsynaptic excitatory field potential. In addit ...
Nonmonotonic inferences in neural networks
Nonmonotonic inferences in neural networks

... neural networks that has the desired properties. The definition we propose is that a schema $ corresponds to a vector <$1,...,$n> in the state space S. That a schema $ is currently represented in a neural network with an activity vector x = means that xi % $i, for all 1 ! i ! n. An equiv ...
Enteric Brain Technique - Evolutionary Healing Institute
Enteric Brain Technique - Evolutionary Healing Institute

... The brain sends signals to the gut by talking to a small number of “Command Neurons” or “Master Neurons” that in turn speak to “Interneurons” which are neurons spread through out the entire Enteric Brain complex. Command Neurons control the pattern of activity in the Enteric Brain. The Vagus Nerve a ...
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189084_189084 - espace@Curtin

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Lachesin: an immunoglobulin superfamily protein whose expression
Lachesin: an immunoglobulin superfamily protein whose expression

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An Olfactory Sensory Map in the Fly Brain
An Olfactory Sensory Map in the Fly Brain

... We have isolated the “complete” repertoire of genes encoding the odorant receptors in Drosophila and employ these genes to provide a molecular description of the organization of the peripheral olfactory system. The repertoire of Drosophila odorant receptors is encoded by 57 genes. Individual sensory ...
Transient information flow in a network of excitatory and inhibitory
Transient information flow in a network of excitatory and inhibitory

... simulate networks with a detailed set of biologicallyinspired parameters. They implemented distance-dependent connectivity and different refractory periods and thresholds for the inhibitory and excitatory pools. They also investigated the role of dynamic synapses and introduced stochasticity in the v ...
The Third Generation of Neural Networks
The Third Generation of Neural Networks

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... do not undergo cell division. Pulse-labelling experiments using [3H]thymidine indicate that new nerve cells arise by differentiation throughout the animal (David and Gierer, 1974; Yaross and Bode, 1978). Hence, new nerve cells are constantly being produced. Calculations suggest the rate of productio ...
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Input to the Cerebellar Cortex

... directed by the cerebral motor cortex and other parts of the brain. 2.The cerebellum receives continuously updated information about the desired sequence of muscle contractions from the brain motor control areas; it also receives continuous sensory information from the peripheral parts of the body, ...
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Theme 4: Rhythmical movements (6 p)
Theme 4: Rhythmical movements (6 p)

... associated to various neuropsychiatric diseases. For example, it has been shown that depression can be treated with drugs that increase the levels of serotonin or noradrenaline in the synaptic cleft. Describe two possible ways in which these drugs can produce these effects. (3p) ...
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The NeuronDoctrine: A Revision of Functional

... mitral dendritic ttufts, as mentioned above. The epsp in the dendrites appears to have a dual role: local activation of inliibitory synapses from the PG dendrites back onto the mitral (lenidrites (tlhrouiglh serial or reciprocal (lendroden(lriitic synapses), and spread to the PG cell axon hillock to ...
Chapter 1 - Laboratory Animal Boards Study Group
Chapter 1 - Laboratory Animal Boards Study Group

... integrating spinal nociceptive input and projecting that information to cortical and subcortical areas of the brain. What is modulation? True or False: Most dorsal horn neurons are inhibitory interneurons. What happens when inhibitory interneurons are activated? What is the primary excitatory neurot ...
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Anat3_08_Autonomic_Nervous_System1

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Neurobiology of Addiction - The University of Sydney
Neurobiology of Addiction - The University of Sydney

... including biological (neurobiology), social (family, friends, work) and personal (psychological processes relating to addiction). ...
Neuronal sources of hedgehog modulate neurogenesis in the adult
Neuronal sources of hedgehog modulate neurogenesis in the adult

... nkx2.1 and arx were originally cloned and isolated during an RNAi screen aimed at identifying planarian transcription factors with potential roles in neuronal specification. A unique behavioral defect was observed in all nkx2.1(RNAi) animals, characterized by tonic muscular contractions that bend th ...
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Lec:2

... passive stretch will lead to muscle contraction, however, stronger passive stretch will lead to relaxation due to resistance followed by relaxation. 2. Clonus: regular, rhythmic contraction of a hypertonic muscle that is subjected to sudden sustained passive stretch. It is due to increased gamma eff ...
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Special Senses

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LO #1
LO #1

... LO #2: Compare ionotropic and metabotropic receptors. Fast synaptic potentials: the transmitter binds to and activates receptors that also function as ion channels – these are referred to as ionotropic receptors (1–20 ms in duration, e.g., nicotinic AChR in skeletal muscle).  Recovery of the poten ...
Nervous System - AP Psychology: 2(A)
Nervous System - AP Psychology: 2(A)

... drugs work by blocking this process.) • Enzyme - a complex protein that is manufactured by cells. • One type specifically breaks up acetylcholine because muscle activity needs to happen rapidly, so reuptake would be too slow. Copyright © 2011 Pearson Education, Inc. All rights reserved. ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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