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FLURBIPROFEN FAST DISINTEGRATING TABLETS Research Article  AMAL S. M. ABU EL-ENIN
FLURBIPROFEN FAST DISINTEGRATING TABLETS Research Article AMAL S. M. ABU EL-ENIN

... convenience in terms of self-administration, compactness and easy in manufacturing [1]. Fast disintegrating tablets are gaining prominence as new drug delivery systems. These dosage forms dissolve or disintegrate in oral cavity within a minute without the need of water or chewing. These are not only ...
Grapefruit-medication interactions: Forbidden fruit or avoidable
Grapefruit-medication interactions: Forbidden fruit or avoidable

... increased from 17 to 43, representing an average rate of increase exceeding 6 drugs per year. This increase is a result of the introduction of new chemical entities and formulations. This review identifies the key scientific concepts and clinical implications of grapefruit– drug interactions relevan ...
Suboxone Contract
Suboxone Contract

... been using; and whether I have become pregnant or have developed hepatitis.  I agree to cooperate with urine drug testing whenever requested by Dr Mian, to confirm if I have been using any alcohol, prescription drugs, or street drugs.  I have been informed that buprenorphine, as found in Suboxone, ...
Blue with White Corner
Blue with White Corner

... • Time of Peak concentration (tmax). ...
the 2014 drug trend report
the 2014 drug trend report

... of thousands of dollars per prescription. These medications treat extremely rare conditions and diseases with very small, very specific populations – typically only several thousand patients or fewer. The high price tag is necessary – and justified – to fund manufacturer research and development cos ...
Medication used in the Treatment of Parkinson`s
Medication used in the Treatment of Parkinson`s

... • The main aim of drug treatments for Parkinson’s is to: increase the level of dopamine that reaches the brain, stimulate the parts of the brain where dopamine works, or block the action of other chemicals that affect dopamine such as acetylcholine. In most newly diagnosed people considerable impro ...
Pharmaceutical Chemistry-IX - Keshav Group Of Institutions
Pharmaceutical Chemistry-IX - Keshav Group Of Institutions

... Note: 1.Examiner has to set FOUR questions from each part and the candidate is required to attempt five questions with at least two from each part. PART-A 1. Introduction Definition, History and scope of pharmacy, Introduction to pharmacopoeia, Sources of information required for pharmacists, Genera ...
Overview of drug-interactions between coumarin
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... acenocoumarol and phenprocoumon interactions with noscapine. In the literature there are several reports of warfarin and interactions with noscapine. Sixteen cases have been reported of a drug interaction between noscapine and warfarin which lead to an INR increase in 15 cases and bleeding in one ca ...
Review on Prodrugs
Review on Prodrugs

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MICRONEEDLES: AN INNOVATIVE APPROACH TO TRANSDERMAL DELIVERY- A REVIEW  Review Article
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... Skin is the multilayered organ of the human body, comprising of number of histological layers. It is one of the most extensive and readily accessible organs of the human body, exhibiting an extremely good barrier to the penetration of drugs. The skin of an average adult covers an area of about two s ...
Fig. 1 - BioImpacts
Fig. 1 - BioImpacts

... Drug pharmacokinetic (PK) analyses in human subjects are prerequisite for any new pharmaceutical. For the ocular drug products, however, the PK studies in human subjects are waved because the serial sampling from the aqueous humor or the vitreous humor is not applicable for PK assessments. As a subs ...
PRAG
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... possible by identification A,B and C • constituents as technical markers (proper ...
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... A normal adult male subject has a GFR of approximately 125 mL/min. About 180 L of fluid per day are filtered through the kidneys. In spite of this large filtration volume, the average urine volume is 1–1.5 L. Up to 99% of the fluid volume filtered at the glomerulus is reabsorbed. Besides fluid regul ...
Primer for Investigational New Drug
Primer for Investigational New Drug

... Studies that Require INDs In Appendix A is a tool that you can use to decide whether you need to file an IND application or not. You should also consult with the Human Subjects Research Office (HSRO). In general, you will need an IND if your study: 1. uses a drug that has not been approved by the FD ...
Discovering drug interactions: a text
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... reside in the liver. A drug is expected to be eliminated by the body within a certain amount of time after being taken. In case when the drug elimination process takes longer than expected, toxicity can be accumulated or the pharmacological effect of the drug can be exaggerated. The induction or inh ...
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... 9.5.1 When CDs are delivered to a ward or department they should be identified as such by the person making the delivery. Stock orders placed before 12noon will be delivered in a locked trolley via a porter who will sign a porter’s book. On reciept, the nurse who accepts delivery of stock CDs must a ...
A theory of drug tolerance and dependence I
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... the ‘‘equilibrium’’ or ‘‘steady state’’ of Cannon. Adaptive processes, on the other hand, change their functioning in response to changes in their environment to continue functioning optimally, which in a changed environment can imply functioning at a different level or even in a different way (Bell ...
Moore - AL.com
Moore - AL.com

... approval of application ANDA 75-188 to market, manufacture, and sell an anti-arrhythmic heart medication bioequivalent and therapeutically equivalent to the Cordarone® tablets from Defendant Wyeth.12 Defendant Par took advantage of the pervasive brand innovator promotional activities of Defendant Wy ...
Federal Regulation of Prescription Drug Advertising and Labeling
Federal Regulation of Prescription Drug Advertising and Labeling

... the detail men of the drug companies, whose primary interest is to push their products, or gleaned from drug company advertising in one form or another. This is where the problems of both the doctor and the patient begin. R. Harris, The Real Voice 188 (1964). 24 May, supra note 10, at 5, 7. See gene ...
Knowledge Objectives
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... directions for the drug provider (pharmacist) and for the patient. Physicians must guard against prescribing too many drugs, or preparations of little value. Drugs of unproven clinical value should be avoided, as well as potentially toxic agents if drugs equally effective but less dangerous are avai ...
Drug Review - Shodhganga
Drug Review - Shodhganga

... Any substance that when taken into the living organism may modify one or more of its function is defined as Drug. W.H.O. has given a more comprehensive definition as “Drug is any substance or product that is used or intended to be used to modify or explore physiological systems or pathological statu ...
Dabigatran
Dabigatran

... safety and efficacy profile. 5. Additional clinical trials are needed to determine the merit of these drugs beyond the ‘clinical trial’ populations, and to address unanswered questions. 6. Warfarin’s low cost, efficacy, and track record will prolong its life. Its use may decrease but it will remain ...
DOTS strategy
DOTS strategy

... 2nd-line anti-TB drugs in patients with extensive disease. Increasing the number of 2nd line drugs in a regimen is permissible if the effectiveness of some of the drugs is uncertain. ...
Prodrugs—from Serendipity to Rational Design
Prodrugs—from Serendipity to Rational Design

... to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or pr ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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