EP 1790660 B1
... [0020] The method will typically involve the steps of: obtaining nucleic acid encoding a protein of the invention; manipulating said nucleic acid to remove at least one domain from within the protein. The resulting nucleic acid may be inserted into an expression vector, or may already be part of an ...
... [0020] The method will typically involve the steps of: obtaining nucleic acid encoding a protein of the invention; manipulating said nucleic acid to remove at least one domain from within the protein. The resulting nucleic acid may be inserted into an expression vector, or may already be part of an ...
Zaenab Aljassim thesis-6_1
... or, in their absence, by the Head of the Department in which my thesis work was done. It is understood that any copying or publication or use of this thesis or parts thereof for financial gain shall not be allowed without my written permission. It is also understood that this copy is being made avai ...
... or, in their absence, by the Head of the Department in which my thesis work was done. It is understood that any copying or publication or use of this thesis or parts thereof for financial gain shall not be allowed without my written permission. It is also understood that this copy is being made avai ...
It`s In Your Genes
... Is it the same? If not, how many letters have changed? Have deletions occurred (code is now less than 6)? Each change represents a mutation. A mutation is a chemical change to a gene. Mutations may alter a gene’s output. For example, mutations may alter the structure of the enzyme the gene makes ...
... Is it the same? If not, how many letters have changed? Have deletions occurred (code is now less than 6)? Each change represents a mutation. A mutation is a chemical change to a gene. Mutations may alter a gene’s output. For example, mutations may alter the structure of the enzyme the gene makes ...
Hydroxy carboxylic acids
... It is known for its ability to ease aches and pains and reduce fevers. The medicinal properties of salicylate, mainly for fever relief, have been known since ancient times, and it was used as an antiinflammatory drug. Also known as 2-hydroxybenzoic acid, one of several beta hydroxy acids (compare to ...
... It is known for its ability to ease aches and pains and reduce fevers. The medicinal properties of salicylate, mainly for fever relief, have been known since ancient times, and it was used as an antiinflammatory drug. Also known as 2-hydroxybenzoic acid, one of several beta hydroxy acids (compare to ...
Reciprocal deletion and duplication at 2q23.1 indicates a
... Copy number variations associated with abnormal gene dosage have an important role in the genetic etiology of many neurodevelopmental disorders, including intellectual disability (ID) and autism. We hypothesize that the chromosome 2q23.1 region encompassing MBD5 is a dosage-dependent region, wherein ...
... Copy number variations associated with abnormal gene dosage have an important role in the genetic etiology of many neurodevelopmental disorders, including intellectual disability (ID) and autism. We hypothesize that the chromosome 2q23.1 region encompassing MBD5 is a dosage-dependent region, wherein ...
Genetic control of cellularisation
... conventional cytokinesis are under the same genetic and molecular control, we analysed endosperm development in several cytokinesis mutants. Visual screens of Arabidopsis embryos or seedlings with altered morphology have identified numerous genes required for cytokinesis. Mutants with very similar p ...
... conventional cytokinesis are under the same genetic and molecular control, we analysed endosperm development in several cytokinesis mutants. Visual screens of Arabidopsis embryos or seedlings with altered morphology have identified numerous genes required for cytokinesis. Mutants with very similar p ...
biochem ch 23 [2-9
... o Fatty acid levels rise because of decreased β-oxidation; because of this, ω-oxidation increases, and dicarboxylic acids excreted in urine o Diminished capacity to oxidize fatty acids in liver mitochondria results in decreased levels of acetyl-CoA (substrate for ketone body synthesis) Fatty acids ...
... o Fatty acid levels rise because of decreased β-oxidation; because of this, ω-oxidation increases, and dicarboxylic acids excreted in urine o Diminished capacity to oxidize fatty acids in liver mitochondria results in decreased levels of acetyl-CoA (substrate for ketone body synthesis) Fatty acids ...
Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene
... determine associations between the genotype and fibre traits in Chinese Inner Mongolia cashmere goats. The fibre traits data investigated were cashmere fibre diameter, combed cashmere weight, cashmere fibre length and guard hair length. Five hundred and forty-two animals were used to detect polymorp ...
... determine associations between the genotype and fibre traits in Chinese Inner Mongolia cashmere goats. The fibre traits data investigated were cashmere fibre diameter, combed cashmere weight, cashmere fibre length and guard hair length. Five hundred and forty-two animals were used to detect polymorp ...
Ligand Binding and Allosteric Regulation
... adult HbA (Hb F is 22; HbA is 22) – Amino acid differences between and reduces HbF's affinity for 2,3-BPG, thus increasing its affinity for O2 under physiological conditions. ...
... adult HbA (Hb F is 22; HbA is 22) – Amino acid differences between and reduces HbF's affinity for 2,3-BPG, thus increasing its affinity for O2 under physiological conditions. ...
How to recognize and diagnose chromosome rearrangements. David D. Perkins Background
... were detected and verified using these methods (McClintock 1945, Houlahan et al. 1949). However, characteristics of Neurospora provide an easier method that depends on ascospore pigmentation, and this has been used to identify most of the Neurospora rearrangements that have been detected since 1950. ...
... were detected and verified using these methods (McClintock 1945, Houlahan et al. 1949). However, characteristics of Neurospora provide an easier method that depends on ascospore pigmentation, and this has been used to identify most of the Neurospora rearrangements that have been detected since 1950. ...
INFINITI CYP450 2C19+ Assay
... xenobiotics metabolism. CYP450 2C19 (CYP2C19) is a highly polymorphic liver enzyme of the liver and is involved in the metabolism and elimination of many commonly prescribed drugs including antidepressants, antiepileptics, barbiturates and proton pump inhibitors. Genetic polymorphisms in CYP2C19 are ...
... xenobiotics metabolism. CYP450 2C19 (CYP2C19) is a highly polymorphic liver enzyme of the liver and is involved in the metabolism and elimination of many commonly prescribed drugs including antidepressants, antiepileptics, barbiturates and proton pump inhibitors. Genetic polymorphisms in CYP2C19 are ...
word
... Epigenetic regulation of the X chromosome in C. elegans The X chromosome has no partner during XO male meiosis in C. elegans, and as such is targeted for repression by meiotic silencing mechanisms recognizing unsynapsed/unpaired chromatin. The near-complete paucity of germlineexpressed genes on the ...
... Epigenetic regulation of the X chromosome in C. elegans The X chromosome has no partner during XO male meiosis in C. elegans, and as such is targeted for repression by meiotic silencing mechanisms recognizing unsynapsed/unpaired chromatin. The near-complete paucity of germlineexpressed genes on the ...
Chromatin Evolution and Molecular Drive in Speciation
... unusual concerted pattern of fixation permits the establishment of biological novelty and species discontinuities [i.e., reproductive isolation]. . .” Genes encoding heterochromatin proteins may have evolved rapidly to counteract mutations within repetitive DNA sequences in heterochromatin, which ac ...
... unusual concerted pattern of fixation permits the establishment of biological novelty and species discontinuities [i.e., reproductive isolation]. . .” Genes encoding heterochromatin proteins may have evolved rapidly to counteract mutations within repetitive DNA sequences in heterochromatin, which ac ...
Nonribosomal peptide synthesis in Aspergillus
... Thus, much further work is needed to fully understand the process of NRPS in A. fumigatus and to investigate if nonribosomally synthesized peptides contribute to the success of this organism as a pathogen of immunocompromised individuals. Moreover, information gleaned from molecular studies of Asper ...
... Thus, much further work is needed to fully understand the process of NRPS in A. fumigatus and to investigate if nonribosomally synthesized peptides contribute to the success of this organism as a pathogen of immunocompromised individuals. Moreover, information gleaned from molecular studies of Asper ...
Functional characterisation of the TUP5 gene in - diss.fu
... the precursor of polyamines and nitric oxide which play an important role in many developmental processes and the response to various environmental stresses. Plant amino acid pathways have for a long time been mainly deduced from studies in bacteria and fungi. In this work the first conclusive study ...
... the precursor of polyamines and nitric oxide which play an important role in many developmental processes and the response to various environmental stresses. Plant amino acid pathways have for a long time been mainly deduced from studies in bacteria and fungi. In this work the first conclusive study ...
Novel targets for tuberculosis drug discovery
... acid and quinones. The whole pathway is essential in M. tuberculosis [33], and the aroK gene could only be disrupted in the presence of a functional copy elsewhere on the chromosome. AroE [34] and AroA [35] have been characterized in detail; furthermore, the structures of AroQ [36], AroC [37] and Ar ...
... acid and quinones. The whole pathway is essential in M. tuberculosis [33], and the aroK gene could only be disrupted in the presence of a functional copy elsewhere on the chromosome. AroE [34] and AroA [35] have been characterized in detail; furthermore, the structures of AroQ [36], AroC [37] and Ar ...
Quantitative RT-PCR Platform to Measure Transcript Levels of C and
... down-regulated the photosynthetic capacity and led to the loss of N compounds, including Rubisco; ...
... down-regulated the photosynthetic capacity and led to the loss of N compounds, including Rubisco; ...
mic.sgmjournals.org
... be included in the module (Lautru & Challis, 2004; Marahiel et al., 1997; Sieber & Marahiel, 2005). Microcystins typically contain the unusual non-proteinogenic amino acid Nmethyldehydroalanine (Mdha) (Fig. 1). N-Methylation of the microcystins is achieved by the N-methyltransferase (NMT) domain in ...
... be included in the module (Lautru & Challis, 2004; Marahiel et al., 1997; Sieber & Marahiel, 2005). Microcystins typically contain the unusual non-proteinogenic amino acid Nmethyldehydroalanine (Mdha) (Fig. 1). N-Methylation of the microcystins is achieved by the N-methyltransferase (NMT) domain in ...
Human RIF1 and protein phosphatase 1 stimulate DNA replication
... interactions are required for origin stabilization as much of the data provided relies on broadspectrum PP1 inhibitors. These data would significantly strengthen the novel findings in this paper. This is a very good suggestion. We have added a panel (‘Extended View’ Fig. EV3A in the revised version) ...
... interactions are required for origin stabilization as much of the data provided relies on broadspectrum PP1 inhibitors. These data would significantly strengthen the novel findings in this paper. This is a very good suggestion. We have added a panel (‘Extended View’ Fig. EV3A in the revised version) ...
The relevance of carbon dioxide metabolism in
... upstream and downstream of the 1687 bp deletion were independently amplified using CarB1–CarB2 and CarB3–CarB4 primer pairs (CarB1, 59-CTATTATCATTGGTCAGGCT-39; CarB2, 59-GTTACATACCACAAGAGCAT-39; CarB3, 59-GCGTGATGCCGAAGACAATGCTCTTGTGGTATGTAACTCCAAGAGACTATCGCTGA-39; CarB4, 59-TATCAAGGGCTGTGAAGAGT-39) ...
... upstream and downstream of the 1687 bp deletion were independently amplified using CarB1–CarB2 and CarB3–CarB4 primer pairs (CarB1, 59-CTATTATCATTGGTCAGGCT-39; CarB2, 59-GTTACATACCACAAGAGCAT-39; CarB3, 59-GCGTGATGCCGAAGACAATGCTCTTGTGGTATGTAACTCCAAGAGACTATCGCTGA-39; CarB4, 59-TATCAAGGGCTGTGAAGAGT-39) ...
Internal expression of Yarrowia NDH2
... 1×10–5 (Barth and Gaillardin, 1996). In our experiment, 5′FOA resistant colonies appeared with approximately 10 times lower frequency. Southern blot analysis of ten colonies demonstrated that, although the URA3 marker had been lost or damaged by spontaneous mutations in all of these strains, the pla ...
... 1×10–5 (Barth and Gaillardin, 1996). In our experiment, 5′FOA resistant colonies appeared with approximately 10 times lower frequency. Southern blot analysis of ten colonies demonstrated that, although the URA3 marker had been lost or damaged by spontaneous mutations in all of these strains, the pla ...
Meiosis - Aurora City Schools
... 40 Potpourri When genes are placed in the reverse order on a chromosome, this is called… ...
... 40 Potpourri When genes are placed in the reverse order on a chromosome, this is called… ...
SUC1 and SUC2: two sucrose transporters from Arabidopsis
... different from those found in STP1 and MST1 (Table 1). For various monosaccharide transporters it has been postulated that their present structure with 12 transmembrane segments might have evolved, by gene duplication and fusion of an ancestral transporter gene which only had six transmembrane helic ...
... different from those found in STP1 and MST1 (Table 1). For various monosaccharide transporters it has been postulated that their present structure with 12 transmembrane segments might have evolved, by gene duplication and fusion of an ancestral transporter gene which only had six transmembrane helic ...
Point mutation
A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.