M recombinant human tissue factor
... K-dependent zymogens, activation requires the presence of calcium ions and phospholipids. Formation of this TF/FVIIa complex renders the factor VII bond at Arg152 - Ile153 susceptible to cleavage by trace amounts of factor Xa and factor IXa. Activation by factor Xa is profoundly enhanced by lipidate ...
... K-dependent zymogens, activation requires the presence of calcium ions and phospholipids. Formation of this TF/FVIIa complex renders the factor VII bond at Arg152 - Ile153 susceptible to cleavage by trace amounts of factor Xa and factor IXa. Activation by factor Xa is profoundly enhanced by lipidate ...
Beyond the meristems: similarities in the
... it is tempting to propose that signalling mechanisms regulating plant architecture may have evolved from an ancestral set of components, which adapted to give different developmental and cellular responses. CLV3 and related CLE peptides play a central role in stem cell differentiation or maintenance ...
... it is tempting to propose that signalling mechanisms regulating plant architecture may have evolved from an ancestral set of components, which adapted to give different developmental and cellular responses. CLV3 and related CLE peptides play a central role in stem cell differentiation or maintenance ...
Supplementation of Animal Cell Culture Media
... basic factors include the source animal species; age of animals at the time of collection; geographic origins; the means of blood collection and processing; and a number of postproduction quality control (QC) and lot-designation considerations. For specific cell line and culture purposes, factors to ...
... basic factors include the source animal species; age of animals at the time of collection; geographic origins; the means of blood collection and processing; and a number of postproduction quality control (QC) and lot-designation considerations. For specific cell line and culture purposes, factors to ...
Signalling in Plant Lateral Organ Development
... A plant lateral organ, defined here as either a leaf or a leaflike organ of the shoot or flower, arises from a group of initial cells within the flanks of the shoot apical meristem (SAM) or floral meristem. For example, the tobacco leaf is formed from a group of 100 initial cells in all three histo ...
... A plant lateral organ, defined here as either a leaf or a leaflike organ of the shoot or flower, arises from a group of initial cells within the flanks of the shoot apical meristem (SAM) or floral meristem. For example, the tobacco leaf is formed from a group of 100 initial cells in all three histo ...
Smoking molecular damage in bronchial epithelium
... Several cytogenetic, allelotyping and comparative genomic hybridization (CGH) studies have revealed that multiple genetic changes are found in clinically evident lung cancers, and involve known and putative recessive oncogenes (tumor suppressor genes, TSG) as well as several dominant oncogenes (Seki ...
... Several cytogenetic, allelotyping and comparative genomic hybridization (CGH) studies have revealed that multiple genetic changes are found in clinically evident lung cancers, and involve known and putative recessive oncogenes (tumor suppressor genes, TSG) as well as several dominant oncogenes (Seki ...
Cell cycle`s deregulation and cardiovascular diseases
... Cell cycle role in atherosclerosis • AIF-1 is not present in normal arteries, and it is produced by VSMC when they are stimulated. Constitutive expression of AIF-1 results in a shorter cell cycle, and aberrant expression of cell cycle proteins. • AIF-1 actively participates in the upregulation of VS ...
... Cell cycle role in atherosclerosis • AIF-1 is not present in normal arteries, and it is produced by VSMC when they are stimulated. Constitutive expression of AIF-1 results in a shorter cell cycle, and aberrant expression of cell cycle proteins. • AIF-1 actively participates in the upregulation of VS ...
ECM and Drusen
... With age and before the presence of clinical evidence of macular disease, histopathological studies show BrM becomes thickened and extracellular basal deposits develop between the RPE and BrM (Kliffen et al. 1995; Kliffen et al. 1997; Reale et al. 2009). Basal deposits, accumulations of extracellula ...
... With age and before the presence of clinical evidence of macular disease, histopathological studies show BrM becomes thickened and extracellular basal deposits develop between the RPE and BrM (Kliffen et al. 1995; Kliffen et al. 1997; Reale et al. 2009). Basal deposits, accumulations of extracellula ...
Presence of Human Papillomavirus Type 18 DNA in Vulvar
... To ascertain whether a region of HPV-18 genome was consistently retained during integration, as has been found for HPV-16 (Choo et al., 1987), hybridization experiments with subgenomic probes of HPV-18 DNA were done as shown in Fig. 3. Owing to the low amount of DNA extracted from small biopsies we ...
... To ascertain whether a region of HPV-18 genome was consistently retained during integration, as has been found for HPV-16 (Choo et al., 1987), hybridization experiments with subgenomic probes of HPV-18 DNA were done as shown in Fig. 3. Owing to the low amount of DNA extracted from small biopsies we ...
Heterarchy of transcription factors driving basal and luminal
... gamma (PPARg) is widely known as an essential and sufficient driver of adipogenesis,1,2 but it also plays roles in M1 to M2 polarisation of macrophages3 and differentiation of human urothelial cells of the bladder and associated urinary tract.4–6 When grown in vitro in the absence of serum or other ...
... gamma (PPARg) is widely known as an essential and sufficient driver of adipogenesis,1,2 but it also plays roles in M1 to M2 polarisation of macrophages3 and differentiation of human urothelial cells of the bladder and associated urinary tract.4–6 When grown in vitro in the absence of serum or other ...
ARTICLES Variability in gene expression underlies incomplete penetrance Arjun Raj
... by hindering the transcriptional activation of end-1 by the SKN-1 protein and indirectly by downregulating med-1/med-2 and end-3 (refs 19, 41, 42). To measure how much end-1 expression variability was caused by the lack of end-3 expression, we measured transcript numbers in a strain with an end-3 de ...
... by hindering the transcriptional activation of end-1 by the SKN-1 protein and indirectly by downregulating med-1/med-2 and end-3 (refs 19, 41, 42). To measure how much end-1 expression variability was caused by the lack of end-3 expression, we measured transcript numbers in a strain with an end-3 de ...
Reverse Engineering Models of Cell Cycle Regulation
... Cell Cycle Transitions and Bifurcation Points To an applied mathematician, Figure 2 looks suspiciously like a bifurcation diagram. In dynamical systems theory,18,19 a bifurcation point is a specific parameter value where the steady state solutions of a nonlinear differential equation change in numbe ...
... Cell Cycle Transitions and Bifurcation Points To an applied mathematician, Figure 2 looks suspiciously like a bifurcation diagram. In dynamical systems theory,18,19 a bifurcation point is a specific parameter value where the steady state solutions of a nonlinear differential equation change in numbe ...
Development of zebrafish epidermis
... cells. EVL is essential to blastoderm morphogenesis, as EVL cells drag the deep cells along with YSL cells (Kimmel et al., 1990; Slanchev et al., 2009). On the other hand, the EBL starts to form at the gastrula period after formation of the three embryonic layers. During gastrulation stage, the thre ...
... cells. EVL is essential to blastoderm morphogenesis, as EVL cells drag the deep cells along with YSL cells (Kimmel et al., 1990; Slanchev et al., 2009). On the other hand, the EBL starts to form at the gastrula period after formation of the three embryonic layers. During gastrulation stage, the thre ...
Quantitative Analysis of Microvascular Structure
... inevitably requires movement of tumor cells into the vascular compartment leading to a tumor embolus that is carried on and finally métastasesin distant organs (16, 17). The intravasation of tumor cells into the microvascular lumina was demonstrated by Warren ef al. (17) using electron microscopy. ...
... inevitably requires movement of tumor cells into the vascular compartment leading to a tumor embolus that is carried on and finally métastasesin distant organs (16, 17). The intravasation of tumor cells into the microvascular lumina was demonstrated by Warren ef al. (17) using electron microscopy. ...
Immortalized Murine Striatal Neuronal Cell Lines Expressing
... afferent projections, or neurochemical phenotype (Graybiel, 1990; Gerfen, 1992; Stoof et al., 1992). The regulation of the synthesis and release of neurotransmitters within each of these compartments is under complex control from several pathways including the nigrostriatal dopaminergic projection t ...
... afferent projections, or neurochemical phenotype (Graybiel, 1990; Gerfen, 1992; Stoof et al., 1992). The regulation of the synthesis and release of neurotransmitters within each of these compartments is under complex control from several pathways including the nigrostriatal dopaminergic projection t ...
Genome-Wide Identification of Target Genes for the Key B
... (associated with enhancers) was also observed flanking Ets1binding sites, while there was no enrichment of H3K27me3 (associated with repressed genes) near Ets1-binding peaks. None of the histone marks showed specific enrichment when random chromatin regions were used (not shown). These data indicate ...
... (associated with enhancers) was also observed flanking Ets1binding sites, while there was no enrichment of H3K27me3 (associated with repressed genes) near Ets1-binding peaks. None of the histone marks showed specific enrichment when random chromatin regions were used (not shown). These data indicate ...
Rewiring the retinal ganglion cell gene regulatory
... only modestly rescue Math5 mutant defects by activating some RGC genes. In addition, Neurod1 and Math3 co-expression at the Math5 locus does not lead to the overproduction of amacrine cells. Our results demonstrate that although Neurod1 and Math3 have evolved specialized functions, they are neverthe ...
... only modestly rescue Math5 mutant defects by activating some RGC genes. In addition, Neurod1 and Math3 co-expression at the Math5 locus does not lead to the overproduction of amacrine cells. Our results demonstrate that although Neurod1 and Math3 have evolved specialized functions, they are neverthe ...
Research Area - The University of North Carolina at Chapel Hill
... to day 35, but there were examples of equivalent increases at day 14 and 35. Three miRNAs definitively decreased from day 5 to day 35. Manual observation of the data revealed additional borderline and/or inconsistent changes in several miRNAs. Furthermore, many miRNAs not reliably detected by array ...
... to day 35, but there were examples of equivalent increases at day 14 and 35. Three miRNAs definitively decreased from day 5 to day 35. Manual observation of the data revealed additional borderline and/or inconsistent changes in several miRNAs. Furthermore, many miRNAs not reliably detected by array ...
File
... composed of two sets of heavy chain and four sets of light chains. Myosin II polymers form bipolar filaments that interact with actin stress fibers. Myosin II molecular motors generate cellular tension, thus detaching the cell from a substrate. Protrusive forces cause cell spreading maximizing conta ...
... composed of two sets of heavy chain and four sets of light chains. Myosin II polymers form bipolar filaments that interact with actin stress fibers. Myosin II molecular motors generate cellular tension, thus detaching the cell from a substrate. Protrusive forces cause cell spreading maximizing conta ...
Visualizing the actin cytoskeleton in living plant cells using a photo
... and local alterations and adjustments in F-actin arrays [12] it is important to have locally-inducible F-actin probes. Although an ethanol-inducible GFP::mTn probe [19] has been created it is difficult to control the degree of its over-expression since neither the uptake of the inducing chemical, no ...
... and local alterations and adjustments in F-actin arrays [12] it is important to have locally-inducible F-actin probes. Although an ethanol-inducible GFP::mTn probe [19] has been created it is difficult to control the degree of its over-expression since neither the uptake of the inducing chemical, no ...
pH and Cancer: Acidic pH Levels Can Lead To Cancer
... is too acidic, toxins will not be released from your cells into the blood. So your cells can't be detoxified. This buildup of toxins in your cells results in acidic, poorly oxygenated cells, which can turn cancerous. He explains, "In general, degenerative diseases are the result of acid waste buildu ...
... is too acidic, toxins will not be released from your cells into the blood. So your cells can't be detoxified. This buildup of toxins in your cells results in acidic, poorly oxygenated cells, which can turn cancerous. He explains, "In general, degenerative diseases are the result of acid waste buildu ...
Identification of Motile Sperm Domain–Containing Protein 2 as
... sites of inflammation and cancerous tissues. Although targeting of selected chemokine receptors on monocytes exhibited preclinical efficacy, attempts to translate these studies to the clinic have failed thus far, possibly due to redundancy of the target receptor. We reveal that motile sperm domain–c ...
... sites of inflammation and cancerous tissues. Although targeting of selected chemokine receptors on monocytes exhibited preclinical efficacy, attempts to translate these studies to the clinic have failed thus far, possibly due to redundancy of the target receptor. We reveal that motile sperm domain–c ...
