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Review Questions
Review Questions

... backwards through the central dogma determine the gene in the DNA. However, in eukaryotic cells (animals, plants, fungi, protists), the raw polypeptides are often much shorter than the genes that coded for them. In fact, whole sections of a gene may not be translated at all. Eukaryotic cells have mR ...
[i,j].
[i,j].

... independent on their sequences. There are three kinds of double helices that have been observed in DNA: type A, type B, and type Z, which differ in their geometries. The double helical structure is essential to the coding functional of DNA. Watson (biologist) and Crick (physicist) first discovered d ...
Archaeal Transcription Initiation - IMBB
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... this designation, these are not histone-like and do not form DNA–protein complexes structurally related to the nucleosome. Bacterial RNA polymerases do not, therefore, appear to face the same promoter-access problem, and bacterial RNA polymerases are structurally simpler than their eucaryal counterp ...
Chapter 8
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ELSI Learning Objective
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Chance and Necessity in the Selection of Nucleic Acid Catalysts
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concept mapping challenge - McGraw Hill Higher Education
concept mapping challenge - McGraw Hill Higher Education

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Polyadenylation



Polyadenylation is the addition of a poly(A) tail to a messenger RNA The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for translation. It, therefore, forms part of the larger process of gene expression.The process of polyadenylation begins as the transcription of a gene finishes, or terminates. The 3'-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3' end. In some genes, these proteins may add a poly(A) tail at any one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing.The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.mRNA molecules in both prokaryotes and eukaryotes have polyadenylated 3'-ends, with the prokaryotic poly(A) tails generally shorter and less mRNA molecules polyadenylated.
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