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January 7, 2014 Notes Transcription: process of copying DNA into
January 7, 2014 Notes Transcription: process of copying DNA into

... January 7, 2014 Notes Transcription: process of copying DNA into an RNA template. (Occurs in nucleus) ...
Bio 313 worksheet 14 - Iowa State University
Bio 313 worksheet 14 - Iowa State University

... For the following state whether it is a characteristic of Prokaryotes, Eukaryotes, or both 1. Transcription occurs in the nucleus and translation in the cytoplasm 2. Able to utilize post-transcriptional control 3. Transcription unit contains promoter, RNA coding region, and terminator 4. Transcripti ...
Eukaryotic Transcription
Eukaryotic Transcription

... – RNA Polymerase I: synthesis of pre-rRNA, which is processed into 28S, 5.8S, and 18S rRNAs – RNA polymerase III: synthesis of tRNA, 18 S rRNA, and small, stable RNAs – RNA polymerase II: synthesis of mRNAs and four small nuclear RNAs that take part in RNA splicing ...
Molecular Genetics
Molecular Genetics

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second of Chapter 10: RNA processing
second of Chapter 10: RNA processing

... molecules were larger than predicted, based on protein structure. • In 1977, internal, non-coding sequences were discovered. • These internal, non-coding sequences are called introns. ...
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Model of Star‐PAP‐mediated cleavage of target RNA. Direct contact

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messenger RNA (mRNA)
messenger RNA (mRNA)

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Ji et al J Theor Biol 2010
Ji et al J Theor Biol 2010

< 1 ... 187 188 189 190 191

Polyadenylation



Polyadenylation is the addition of a poly(A) tail to a messenger RNA The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for translation. It, therefore, forms part of the larger process of gene expression.The process of polyadenylation begins as the transcription of a gene finishes, or terminates. The 3'-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3' end. In some genes, these proteins may add a poly(A) tail at any one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing.The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.mRNA molecules in both prokaryotes and eukaryotes have polyadenylated 3'-ends, with the prokaryotic poly(A) tails generally shorter and less mRNA molecules polyadenylated.
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