The co-chaperone BAG3 regulates Herpes Simplex Virus replication
... roductive infection by herpes simplex virus (HSV) is temporally regulated in a tightly coordinated cascade. Control of this process involves a complex and largely unknown network of interactions between host- and virus-encoded proteins. HSV genes are classified as immediate early (␣), early (), and ...
... roductive infection by herpes simplex virus (HSV) is temporally regulated in a tightly coordinated cascade. Control of this process involves a complex and largely unknown network of interactions between host- and virus-encoded proteins. HSV genes are classified as immediate early (␣), early (), and ...
Mitochondrial GFA2 Is Required for Synergid Cell
... Little is known about the molecular processes that govern female gametophyte (FG) development and function, and few FG-expressed genes have been identified. We report the identification and phenotypic analysis of 31 new FG mutants in Arabidopsis. These mutants have defects throughout development, in ...
... Little is known about the molecular processes that govern female gametophyte (FG) development and function, and few FG-expressed genes have been identified. We report the identification and phenotypic analysis of 31 new FG mutants in Arabidopsis. These mutants have defects throughout development, in ...
Euglena gracilis by Cadmium
... The physiochemical properties and physiological significance of the cadmium-binding protein (CdBP) of the algae Euglena gracilis have been studied. Following in vivo exposure of cells to 0.4 or 1.3 ,ug/mL of Cd2", all the cytosolic Cd is bound to high molecular weight species. At 4.7 ,ug/mL, appreci ...
... The physiochemical properties and physiological significance of the cadmium-binding protein (CdBP) of the algae Euglena gracilis have been studied. Following in vivo exposure of cells to 0.4 or 1.3 ,ug/mL of Cd2", all the cytosolic Cd is bound to high molecular weight species. At 4.7 ,ug/mL, appreci ...
Evolutionary tradeoffs in cellular composition across
... In general, we describe the scaling of a generic cell component (e.g., DNA) as C i ¼ C 0 V bc i , where βi is the exponent for volume (measured in m3 throughout this paper) dependence of the component. It is important to note that if βio1 then component Ci will be a decreasing fraction of total cell ...
... In general, we describe the scaling of a generic cell component (e.g., DNA) as C i ¼ C 0 V bc i , where βi is the exponent for volume (measured in m3 throughout this paper) dependence of the component. It is important to note that if βio1 then component Ci will be a decreasing fraction of total cell ...
Mycobacterial virulence and specialized secretion: same story
... disruption of individual RD1-region genes did not prevent production of ESAT-6 or CFP-10. However, an intact RD1 region was required to ensure that these proteins were secreted by the bacterium8,11,12. This virulence region was therefore identified as a new specialized secretion system with an unkno ...
... disruption of individual RD1-region genes did not prevent production of ESAT-6 or CFP-10. However, an intact RD1 region was required to ensure that these proteins were secreted by the bacterium8,11,12. This virulence region was therefore identified as a new specialized secretion system with an unkno ...
Document
... Stimulus intensity and first spike latency • To find if hard-wired ‘delay lines’ exist in the network, we can vary different stimulus parameters and see if the latency changes. • For the final experiment, they test whether intensity has an effect on the latency of the late ...
... Stimulus intensity and first spike latency • To find if hard-wired ‘delay lines’ exist in the network, we can vary different stimulus parameters and see if the latency changes. • For the final experiment, they test whether intensity has an effect on the latency of the late ...
Bordoli Discussion Questions
... 5) What are some possible reasons for seeing no activity of PCAT1 in 3B? (Hint: read discussion!) Fig. 4A 1) How were amino acids selected that would be mutated? 2) What is the meaning of the nomenclature “ML” or “WY” for the mutants? 3) What is being detected on the blot? (i.e. why are histones vis ...
... 5) What are some possible reasons for seeing no activity of PCAT1 in 3B? (Hint: read discussion!) Fig. 4A 1) How were amino acids selected that would be mutated? 2) What is the meaning of the nomenclature “ML” or “WY” for the mutants? 3) What is being detected on the blot? (i.e. why are histones vis ...
pdf file
... and the plasma membrane. Here, we report the identification of COD1/SPF1 (control of HMGCoA reductase degradation/SPF1) through genetic strategies intended to uncover genes involved in protein maturation and endoplasmic reticulum (ER)-associated degradation (ERAD), a quality control pathway that rid ...
... and the plasma membrane. Here, we report the identification of COD1/SPF1 (control of HMGCoA reductase degradation/SPF1) through genetic strategies intended to uncover genes involved in protein maturation and endoplasmic reticulum (ER)-associated degradation (ERAD), a quality control pathway that rid ...
IDENTIFICATION OF LEAD COMPOUNDS WITH COBRA VENOM NEUTRALISING ACTIVITY IN
... which may be hazardous to the patient and likely to be less effective. In fact, majority of the snake bite victims depend on herbal medicines which have no side effects or fewer side effects, cost effective and need not require sophisticated storage system when compared to the antivenom therapy. The ...
... which may be hazardous to the patient and likely to be less effective. In fact, majority of the snake bite victims depend on herbal medicines which have no side effects or fewer side effects, cost effective and need not require sophisticated storage system when compared to the antivenom therapy. The ...
Co-ordination of signalling elements in guard cell ion
... ulation. Much of the solute lost during stomatal closure originates from the vacuole. Equally, osmotic accumulation on stomatal opening is associated predominantly with this storage organelle. The importance of vacuole in this function implies a high degree of transport co-ordination at the tonoplas ...
... ulation. Much of the solute lost during stomatal closure originates from the vacuole. Equally, osmotic accumulation on stomatal opening is associated predominantly with this storage organelle. The importance of vacuole in this function implies a high degree of transport co-ordination at the tonoplas ...
Division of Cellular Immunology and Immunohematology Head
... Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T-cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner. Naturally occurring CD4+CD25highFoxp3+ regulatory T-cells (Treg) orchestrate tolerance to self-antigens by suppressing effector T-cell func ...
... Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T-cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner. Naturally occurring CD4+CD25highFoxp3+ regulatory T-cells (Treg) orchestrate tolerance to self-antigens by suppressing effector T-cell func ...
chapt12_lecturenew
... • cover entire brain surface and most nonsynaptic regions of the neurons in the gray matter of the CNS • diverse functions – form a supportive framework of nervous tissue – have extensions (perivascular feet) that contact blood capillaries that stimulate them to form a tight seal called the blood-br ...
... • cover entire brain surface and most nonsynaptic regions of the neurons in the gray matter of the CNS • diverse functions – form a supportive framework of nervous tissue – have extensions (perivascular feet) that contact blood capillaries that stimulate them to form a tight seal called the blood-br ...
Chapter 54: The Nervous System
... Alligators are among the most interesting of animals for a biologist to study. Their ecology is closely tied to the environment, and their reptilian biology offers an interesting contrast to that of mammals like ourselves. Studies of alligator development offer powerful general lessons well worthy o ...
... Alligators are among the most interesting of animals for a biologist to study. Their ecology is closely tied to the environment, and their reptilian biology offers an interesting contrast to that of mammals like ourselves. Studies of alligator development offer powerful general lessons well worthy o ...
Proteins - virtual laboratories
... Having introduced the genetic code and RNA, however, briefly, we now return to the process by which a polypeptide is specified by a DNA sequence. Our first task is to understand how it is that we can find the specific region of the DNA molecule that encodes a specific polypeptide, since we are looki ...
... Having introduced the genetic code and RNA, however, briefly, we now return to the process by which a polypeptide is specified by a DNA sequence. Our first task is to understand how it is that we can find the specific region of the DNA molecule that encodes a specific polypeptide, since we are looki ...
Diversity of the Superfamily of Phloem Lectins (Phloem Protein 2) in
... appears to be a consistent feature of gymnosperms (Schulz, 1990) and seedless vascular plants. Cucurbits have been used as a model plant for many phloem studies because of their distinctive phloem anatomy and prolific vascular exudation. In Cucurbita spp., two predominant P-proteins, the phloem fila ...
... appears to be a consistent feature of gymnosperms (Schulz, 1990) and seedless vascular plants. Cucurbits have been used as a model plant for many phloem studies because of their distinctive phloem anatomy and prolific vascular exudation. In Cucurbita spp., two predominant P-proteins, the phloem fila ...
Chlamydomonas IFT 88 and Its Mouse Homologue, Polycystic
... selectable marker. In Chlamydomonas, transforming DNA is integrated randomly throughout the genome and disrupts genes at the site of integration. DNA was isolated from ⵑ400 insertional mutants having behavioral or motility defects and was screened by Southern blotting using a fragment of IFT88 genom ...
... selectable marker. In Chlamydomonas, transforming DNA is integrated randomly throughout the genome and disrupts genes at the site of integration. DNA was isolated from ⵑ400 insertional mutants having behavioral or motility defects and was screened by Southern blotting using a fragment of IFT88 genom ...
Specific Growth Inhibition by Acetate of an Escherichia coli Strain
... The crystal structure of E. coli Era has been solved (Chen et al., 1999). It consists of two domains: a GTPbinding N-terminal domain whose three dimensional structure is similar to those of the GTPase domains of other G-proteins (Bourne et al., 1991) and a C-terminal domain which is conserved within ...
... The crystal structure of E. coli Era has been solved (Chen et al., 1999). It consists of two domains: a GTPbinding N-terminal domain whose three dimensional structure is similar to those of the GTPase domains of other G-proteins (Bourne et al., 1991) and a C-terminal domain which is conserved within ...
Document
... As a messenger RNA is first translated, EJC proteins are removed as the ribosome passes by. Normally, translation termination will occur ...
... As a messenger RNA is first translated, EJC proteins are removed as the ribosome passes by. Normally, translation termination will occur ...
The proPO and clotting system in crustaceans
... ester in the vertebrate complement molecule becomes highly active and it can react with the hydroxyl or amino group on biological surfaces, which leads to immobilization of this molecule to a foreign surface. Whether this mechanism occurs with invertebrate proPOs has to be further clarified. By comp ...
... ester in the vertebrate complement molecule becomes highly active and it can react with the hydroxyl or amino group on biological surfaces, which leads to immobilization of this molecule to a foreign surface. Whether this mechanism occurs with invertebrate proPOs has to be further clarified. By comp ...
Non-human Primate Schlafen11 Inhibits Production of Both
... Schlafen11 is weak compared to that of some other primate versions of this protein, with the Schlafen11 proteins encoded by chimpanzee, orangutan, gibbon, and marmoset being particularly potent inhibitors of HIV-1 protein production. Interestingly, the strong inhibitors such as marmoset Schlafen11 c ...
... Schlafen11 is weak compared to that of some other primate versions of this protein, with the Schlafen11 proteins encoded by chimpanzee, orangutan, gibbon, and marmoset being particularly potent inhibitors of HIV-1 protein production. Interestingly, the strong inhibitors such as marmoset Schlafen11 c ...
Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel
... their sorting to either divergent recycling or degradative membrane pathways. The prevailing model proposes that internalized receptors are prevented from recycling by becoming sequestered and retained in multivesicular bodies (Sorkin and von Zastrow, 2002). According to this model, recycling is con ...
... their sorting to either divergent recycling or degradative membrane pathways. The prevailing model proposes that internalized receptors are prevented from recycling by becoming sequestered and retained in multivesicular bodies (Sorkin and von Zastrow, 2002). According to this model, recycling is con ...
Chapter List
... Know the structure and function of all of the macromolecules. Know the ratio of C, H, and O in the macromolecules. How do the macromolecules interact within cells? Know storage polysaccharides: starch in plants; glycogen in animals (shows us evolutionarily we have been separate a long time); structu ...
... Know the structure and function of all of the macromolecules. Know the ratio of C, H, and O in the macromolecules. How do the macromolecules interact within cells? Know storage polysaccharides: starch in plants; glycogen in animals (shows us evolutionarily we have been separate a long time); structu ...
REVIEWS TBP-associated factors (TAF s): multiple, selective
... three major proposed mechanisms of action are that TAFIIs: (1) serve as activator-binding sites, (2) mediate corepromoter recognition, or (3) provide an essential catalytic activity. The original in vitro studies on TAFIIs led to the so-called ‘coactivator hypothesis’, which posited that TAFIIs are ...
... three major proposed mechanisms of action are that TAFIIs: (1) serve as activator-binding sites, (2) mediate corepromoter recognition, or (3) provide an essential catalytic activity. The original in vitro studies on TAFIIs led to the so-called ‘coactivator hypothesis’, which posited that TAFIIs are ...
Alfred G. Gilman - Nobel Lecture
... supportive data for something more specific were soon forthcoming. Rodbell, Birnbaumer, and their colleagues made the surprising discovery that one regulatory ligand (the receptor agonist) was not sufficient to activate adenylyl cyclase. A hormone could not activate the enzyme unless guanosine triph ...
... supportive data for something more specific were soon forthcoming. Rodbell, Birnbaumer, and their colleagues made the surprising discovery that one regulatory ligand (the receptor agonist) was not sufficient to activate adenylyl cyclase. A hormone could not activate the enzyme unless guanosine triph ...
A tour of the cell - The Open University
... Uranium binds preferentially to nucleic acids and proteins, while lead binds preferentially to lipids. So, after staining, cell components that are rich in lipids and areas where proteins and DNA are concentrated prevent the passage of electrons and so appear relatively dark, or 'electron-dense', on ...
... Uranium binds preferentially to nucleic acids and proteins, while lead binds preferentially to lipids. So, after staining, cell components that are rich in lipids and areas where proteins and DNA are concentrated prevent the passage of electrons and so appear relatively dark, or 'electron-dense', on ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.