Predicting drug-target interaction in cancers using homology
... DNA has been a major target for anticancer drugs. The effects of nucleic acid binding drugs are known for various diseases such as cancer. The different modes of drug binding to DNA include intercalation between adjacent base pairs, intrusion into the minor groove and into the major groove. In silic ...
... DNA has been a major target for anticancer drugs. The effects of nucleic acid binding drugs are known for various diseases such as cancer. The different modes of drug binding to DNA include intercalation between adjacent base pairs, intrusion into the minor groove and into the major groove. In silic ...
Endoplasmic Reticulum-Localized Amyloid β
... To demonstrate that the export did not result from rupture of the microsomal membranes, the release of the ER-resident chaperone BiP was determined. BiP was not released into the supernatant (Figure 2A, lower panel). In contrast, more than 90% of BiP was released into the supernatant when the micros ...
... To demonstrate that the export did not result from rupture of the microsomal membranes, the release of the ER-resident chaperone BiP was determined. BiP was not released into the supernatant (Figure 2A, lower panel). In contrast, more than 90% of BiP was released into the supernatant when the micros ...
Anti-Apoptotic Proteins in Nerve Cell Survival and
... Fas/APO-1/CD95 and TNF receptors are the best characterised (Schulze-Osthoff et al., 1998; Krammer, 1999). Ligand binding to these receptors, leads to recruitment of associated proteins and coupling of signals to intracellular mediators, such caspases as described below (Schmitz et al., 2000). Caeno ...
... Fas/APO-1/CD95 and TNF receptors are the best characterised (Schulze-Osthoff et al., 1998; Krammer, 1999). Ligand binding to these receptors, leads to recruitment of associated proteins and coupling of signals to intracellular mediators, such caspases as described below (Schmitz et al., 2000). Caeno ...
Structures of nucleotide-bound and free aIF2γ from Sulfolobus
... Here, we report the structures of the aIF2 γ-subunit from S. solfataricus (Sso-aIF2γ) in the nucleotide-free and nucleotide-bound states at 2.9 Å and 2.65 Å resolution, respectively. In the latter case co-crystallization was performed using a preparation of Gpp(NH)p, which contained an impurity of ...
... Here, we report the structures of the aIF2 γ-subunit from S. solfataricus (Sso-aIF2γ) in the nucleotide-free and nucleotide-bound states at 2.9 Å and 2.65 Å resolution, respectively. In the latter case co-crystallization was performed using a preparation of Gpp(NH)p, which contained an impurity of ...
Cell cycle arrest and apoptosis induced by the coronavirus
... Kannourakis, 2002). Viral infection could activate a variety of signal transduction pathways that lead to apoptosis of the infected cells. A number of viruses and their gene products were found to be able to induce apoptosis (Roulston et al., 1999; Teodoro and Branton, 1997). Apoptosis can also faci ...
... Kannourakis, 2002). Viral infection could activate a variety of signal transduction pathways that lead to apoptosis of the infected cells. A number of viruses and their gene products were found to be able to induce apoptosis (Roulston et al., 1999; Teodoro and Branton, 1997). Apoptosis can also faci ...
Leptin Receptor Signaling and Action in the Central Nervous System
... db/db mice) in rodents and humans results in increased food intake in combination with a phenotype of reduced energy expenditure reminiscent of the neuroendocrine starvation response (1,2,4). Leptin also regulates insulin sensitivity and glucose homeostasis by two mechanisms: one by controlling ener ...
... db/db mice) in rodents and humans results in increased food intake in combination with a phenotype of reduced energy expenditure reminiscent of the neuroendocrine starvation response (1,2,4). Leptin also regulates insulin sensitivity and glucose homeostasis by two mechanisms: one by controlling ener ...
Presentation
... Tatyana Avsievich , Tambov State Technical University Elena Nemtseva , Marina Gerasimova, Siberian Federal University, Krasnoyarsk ...
... Tatyana Avsievich , Tambov State Technical University Elena Nemtseva , Marina Gerasimova, Siberian Federal University, Krasnoyarsk ...
Growth factors and tooth development
... ABSTRACT The effects of various growth factors on tooth development were studied in organ cultures of mouse embryonic tooth germs. Transferrin was shown to be a necessary growth factor for early tooth morphogenesis. Transferrin was required for the development of bud- and early cap-staged teeth, and ...
... ABSTRACT The effects of various growth factors on tooth development were studied in organ cultures of mouse embryonic tooth germs. Transferrin was shown to be a necessary growth factor for early tooth morphogenesis. Transferrin was required for the development of bud- and early cap-staged teeth, and ...
Melanization and Hemocyte Homeostasis in the Freshwater
... form of antibodies, which are proteins that are produced by cells of lymphoid lineage within the adaptive immune system (Jiravanichpaisal et al. 2006). The innate system is an important first line of defense that discriminates self from non-self molecules and recognizes conserved molecules produced ...
... form of antibodies, which are proteins that are produced by cells of lymphoid lineage within the adaptive immune system (Jiravanichpaisal et al. 2006). The innate system is an important first line of defense that discriminates self from non-self molecules and recognizes conserved molecules produced ...
Protein Quality Control along the Route to the Plant Vacuole
... however, interactions of newly synthesized polypeptides with ER resident proteins, whose roles are to assist correct structural maturation, seem to be important in the process of ER retention. Proteins that fail to reach the correct maturation because of permanent structural defects are eventually d ...
... however, interactions of newly synthesized polypeptides with ER resident proteins, whose roles are to assist correct structural maturation, seem to be important in the process of ER retention. Proteins that fail to reach the correct maturation because of permanent structural defects are eventually d ...
v(d)j recombination: rag proteins, repair factors, and
... were not present in the starting DNA (8). These variations are highly significant for the antigen receptors. The junctional sequence is within the antigen binding site, so local alterations in coding joints multiply the diversity of Ig and TCR molecules even beyond that generated by combinatorial jo ...
... were not present in the starting DNA (8). These variations are highly significant for the antigen receptors. The junctional sequence is within the antigen binding site, so local alterations in coding joints multiply the diversity of Ig and TCR molecules even beyond that generated by combinatorial jo ...
Archaea
... Halophiles need to maintain osmotic balance This is usually achieved by accumulation or synthesis of organic compatible solutes ...
... Halophiles need to maintain osmotic balance This is usually achieved by accumulation or synthesis of organic compatible solutes ...
Plasmodesmata-Mediated Cell-to-Cell Communication in the Shoot
... there. It is widely accepted that macromolecular signals such as TFs and small non-coding RNA (sRNAs) act as mobile signals that are actively and selectively transported to target cells through PD to specify their fates [18]. Around twenty years ago, the first mobile signal moving between cells via ...
... there. It is widely accepted that macromolecular signals such as TFs and small non-coding RNA (sRNAs) act as mobile signals that are actively and selectively transported to target cells through PD to specify their fates [18]. Around twenty years ago, the first mobile signal moving between cells via ...
Mast cells and dendritic cells form synapses that facilitate antigen
... As immune modulators, both MCs and DCs are capable of secreting a wide variety of cytokines to stimulate or repress immune responses. To determine whether direct cell–cell interactions might influence cellular responses, cytokine secretion was measured using ELISA. MCs and imDCs were co-incubated to ...
... As immune modulators, both MCs and DCs are capable of secreting a wide variety of cytokines to stimulate or repress immune responses. To determine whether direct cell–cell interactions might influence cellular responses, cytokine secretion was measured using ELISA. MCs and imDCs were co-incubated to ...
the RbDe web service - Oxford Academic
... sequence, secondary structure information and residue-level annotations. For transmembrane proteins, where the representation is used extensively as a simplified model because of the lack of better structural information, the term snake-like diagram has been coined, inspired by the layout of the seq ...
... sequence, secondary structure information and residue-level annotations. For transmembrane proteins, where the representation is used extensively as a simplified model because of the lack of better structural information, the term snake-like diagram has been coined, inspired by the layout of the seq ...
University of Groningen The Role of Biomacromolecular
... ions) in the cytoplasm, on macromolecular cytoplasmic crowding, and on the concentration of anionic phospholipids in the membrane (7, 64, 87, 90, 97, 119). For at least two different types of membrane transport systems, it has been shown that the anionic membrane surface interacts electrostatically ...
... ions) in the cytoplasm, on macromolecular cytoplasmic crowding, and on the concentration of anionic phospholipids in the membrane (7, 64, 87, 90, 97, 119). For at least two different types of membrane transport systems, it has been shown that the anionic membrane surface interacts electrostatically ...
Taxonomy, biology and physiology of fungi
... The fungi include species that are obligately aerobic (eg. most Zygomycota), obligately anaerobic (eg. rumen fungi) Organisms can obtain energy by oxidative (respiratory) metabolism or by fermentation O2 is used for oxidative metabolism to generate energy. However it is essential for biosynthesis of ...
... The fungi include species that are obligately aerobic (eg. most Zygomycota), obligately anaerobic (eg. rumen fungi) Organisms can obtain energy by oxidative (respiratory) metabolism or by fermentation O2 is used for oxidative metabolism to generate energy. However it is essential for biosynthesis of ...
Cell cycle: Checkpoint proteins and kinetochores
... checkpoint can be reconstituted in vitro using extracts of Xenopus laevis eggs [20]. Using X. laevis egg extracts, Chen et al. [6] showed that the addition of anti-XMAD2 antibodies to a checkpoint-arrested extract inactivated the checkpoint and allowed progression through mitosis. Additionally, cell ...
... checkpoint can be reconstituted in vitro using extracts of Xenopus laevis eggs [20]. Using X. laevis egg extracts, Chen et al. [6] showed that the addition of anti-XMAD2 antibodies to a checkpoint-arrested extract inactivated the checkpoint and allowed progression through mitosis. Additionally, cell ...
LPS- or Pseudomonas aeruginosa- mediated activation of
... one hand unsaturated fatty acids are discussed to diminish the gene expression of the TLR4 receptor (Lu et al., 2007; Liu et al., 2012). On the other hand PUFA are reported to disrupt membrane microdomain composition (Parker et al., 2008; Wong et al., 2009; Shaikh, Jolly & Chapkin, 2012), which migh ...
... one hand unsaturated fatty acids are discussed to diminish the gene expression of the TLR4 receptor (Lu et al., 2007; Liu et al., 2012). On the other hand PUFA are reported to disrupt membrane microdomain composition (Parker et al., 2008; Wong et al., 2009; Shaikh, Jolly & Chapkin, 2012), which migh ...
Cellular and molecular mechanisms involved in branching
... these tip cells passively; during branch formation, all tracheal cells maintain their epithelial character and remain attached to each other via their subapical adherens junctions (AJ). It is not clear yet whether Bnl/FGF acts as a true chemoattractant or as a motogen. A function as a chemoattractan ...
... these tip cells passively; during branch formation, all tracheal cells maintain their epithelial character and remain attached to each other via their subapical adherens junctions (AJ). It is not clear yet whether Bnl/FGF acts as a true chemoattractant or as a motogen. A function as a chemoattractan ...
Simian Virus 40 Large T Antigen and p53 Are
... 60,000 proteins from suspension cultures of the simian virus 40-transformed mouse cell line mKSA. Partial protease mapping showed each of the associated proteins to be unique. Automated ...
... 60,000 proteins from suspension cultures of the simian virus 40-transformed mouse cell line mKSA. Partial protease mapping showed each of the associated proteins to be unique. Automated ...
Fulltext PDF - Indian Academy of Sciences
... Characterization of the ppGpp0 strain showed it to filament upon nutritional down shift, suggesting a role for (p)ppGpp in the process of cell division (Xiao et al. 1991). Insights of its role in cell division came from the studies carried out in the D’Ari lab to understand the function of PBP2 (pen ...
... Characterization of the ppGpp0 strain showed it to filament upon nutritional down shift, suggesting a role for (p)ppGpp in the process of cell division (Xiao et al. 1991). Insights of its role in cell division came from the studies carried out in the D’Ari lab to understand the function of PBP2 (pen ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.