Liver cytokine production and ICAM
... disorders, alcoholic hepatitis, and liver allograft rejection (1, 2, 7, 21, 37, 41, 48). It has also been reported that during high-dose endotoxin shock, death is primarily due to liver damage caused by the accumulation of neutrophils in liver tissue (22, 24). Since the levels of ICAM-1 are elevated ...
... disorders, alcoholic hepatitis, and liver allograft rejection (1, 2, 7, 21, 37, 41, 48). It has also been reported that during high-dose endotoxin shock, death is primarily due to liver damage caused by the accumulation of neutrophils in liver tissue (22, 24). Since the levels of ICAM-1 are elevated ...
Part 3 (Archaea - Updates Book)
... c) Korarcheota are only known from their DNA sequences—nothing more is known about them (they have only recently been discovered). b. Archaea differ in their chemical make-up from other lifeforms. 1) While archaea have many features that look similar to those found on other cells, these features are ...
... c) Korarcheota are only known from their DNA sequences—nothing more is known about them (they have only recently been discovered). b. Archaea differ in their chemical make-up from other lifeforms. 1) While archaea have many features that look similar to those found on other cells, these features are ...
A Novel Modular Polymer Platform for the Treatment of Head and
... radiator (Cs-137 source; Atomic Energy of Canada Ltd) at a dose rate of approximately 0.6 Gy/min. Tumors were irradiated with a total dose of 16 Gy given in 4-Gy fractions on 4 consecutive days. Dosimetry was performed using a LiF: Mg,Cu,P dosimeter (TLD-100H; Thermo Electron) and film (GAFCHROMIC E ...
... radiator (Cs-137 source; Atomic Energy of Canada Ltd) at a dose rate of approximately 0.6 Gy/min. Tumors were irradiated with a total dose of 16 Gy given in 4-Gy fractions on 4 consecutive days. Dosimetry was performed using a LiF: Mg,Cu,P dosimeter (TLD-100H; Thermo Electron) and film (GAFCHROMIC E ...
Interim Report and Unaudited Accounts 2008
... parallel to these studies Silence has selected in Germany the clinical study site and a contract research organization (CRO) for its planned phase Ib clinical study. Currently the data from these pre-clinical studies are being finalized for regulatory submission in order to progress Atu027 into the ...
... parallel to these studies Silence has selected in Germany the clinical study site and a contract research organization (CRO) for its planned phase Ib clinical study. Currently the data from these pre-clinical studies are being finalized for regulatory submission in order to progress Atu027 into the ...
MSc Dissertation The toxicity and therapeutic index of a methotrexate polymeric
... MTX-polyglutamates inhibits the enzymatic conversion of 5-aminoimidazole-4carboxamide-ribonucleotide (AICAR) to formyl-AICAR by the enzyme AICARtransformylase. This leads to the intracellular accumulation of AICAR (Figure 1.3). This then in turn leads to the inhibition of adenosine production that i ...
... MTX-polyglutamates inhibits the enzymatic conversion of 5-aminoimidazole-4carboxamide-ribonucleotide (AICAR) to formyl-AICAR by the enzyme AICARtransformylase. This leads to the intracellular accumulation of AICAR (Figure 1.3). This then in turn leads to the inhibition of adenosine production that i ...
chronic lymphocytic leukemia (cll)
... • Naïve B cells have unmutated V regions – Make initial IgM and IgG that bind Ag poorly ...
... • Naïve B cells have unmutated V regions – Make initial IgM and IgG that bind Ag poorly ...
A Simple and Efficient Method for Isolating Trichomes for
... lected trichomes are a representative sample of the trichomes present on the leaves. One of our motivations for developing this procedure was to use the trichomes for immunolocalization studies. Microscopic observations of trichomes in our lab indicated that the base of the trichome has a thinner ce ...
... lected trichomes are a representative sample of the trichomes present on the leaves. One of our motivations for developing this procedure was to use the trichomes for immunolocalization studies. Microscopic observations of trichomes in our lab indicated that the base of the trichome has a thinner ce ...
OSMOSIS (A self-instructional package)
... Did you say something like: the osmotic pressure of a solution is that pressure which must be applied to the solution to just prevent pure water from entering the solution across an ideal semipermeable membrane? Good! If we compare two solutions, the one with the greater tendency to draw water (the ...
... Did you say something like: the osmotic pressure of a solution is that pressure which must be applied to the solution to just prevent pure water from entering the solution across an ideal semipermeable membrane? Good! If we compare two solutions, the one with the greater tendency to draw water (the ...
CURRICULUM VITAE
... 26. Consales CA, Mendonça RZ, Gallina NM, Pereira CA. - Cytopathic effect induced by rabies virus in McCoy cells. J.Virol.Meth. 1990,27:277. 27. Consales CA, Mendonça RZ, Lucchiari MA, Vassão RC, Pereira CA. - The macrophage action on rabies virus infection in genetically selected high and low antib ...
... 26. Consales CA, Mendonça RZ, Gallina NM, Pereira CA. - Cytopathic effect induced by rabies virus in McCoy cells. J.Virol.Meth. 1990,27:277. 27. Consales CA, Mendonça RZ, Lucchiari MA, Vassão RC, Pereira CA. - The macrophage action on rabies virus infection in genetically selected high and low antib ...
Journal of Bacteriology
... phase (Fig. 3). Similar results were found for R. leguminosarum RBL1. Optimal attachment coincided with agglutination of the cells to glass as judged from the clearly visible ring of clumped cells on the glass wall of the Erlenmeyer flask at the liquid-air interphase. Growth limitation. After the in ...
... phase (Fig. 3). Similar results were found for R. leguminosarum RBL1. Optimal attachment coincided with agglutination of the cells to glass as judged from the clearly visible ring of clumped cells on the glass wall of the Erlenmeyer flask at the liquid-air interphase. Growth limitation. After the in ...
Masking the Pathogen: Evolutionary Strategies of Fungi and Their
... In addition to its use in clinical detection, the extracellular capsules of C. neoformans are also crucial for success of the pathogen [1]. Thus, understanding capsular synthesis may help identify fungal targets for new therapies which do not require uptake of inhibitory materials into the interior ...
... In addition to its use in clinical detection, the extracellular capsules of C. neoformans are also crucial for success of the pathogen [1]. Thus, understanding capsular synthesis may help identify fungal targets for new therapies which do not require uptake of inhibitory materials into the interior ...
Metapopulation persistence of insects living in hollow oaks:
... or variable population sizes and low dispersal abilities (Thomas et al. 1992, Fahrig & Merriam 1994, Kruess & Tscharntke 1994, Bender et al. 1998). One of the most fragmented habitats is temperate broad-leaved forest in Europe. In Central Europe, only 0.2% of the original amount is considered undist ...
... or variable population sizes and low dispersal abilities (Thomas et al. 1992, Fahrig & Merriam 1994, Kruess & Tscharntke 1994, Bender et al. 1998). One of the most fragmented habitats is temperate broad-leaved forest in Europe. In Central Europe, only 0.2% of the original amount is considered undist ...
Activation Mechanism of Protein Kinase B by DNA
... cells with insulin (Fig. 1). These finding was further supported by the observation that PKB activation is blocked in human glioblastoma cells expressing an inactive mutant form of DNA-PK, M059J cells while PKB activation is normal in control M059K cells (Fig. 2). In addition, the treatment of cells ...
... cells with insulin (Fig. 1). These finding was further supported by the observation that PKB activation is blocked in human glioblastoma cells expressing an inactive mutant form of DNA-PK, M059J cells while PKB activation is normal in control M059K cells (Fig. 2). In addition, the treatment of cells ...
Expression of the Nucleus-Encoded Chloroplast Division Genes and
... division-related genes and proteins that are encoded in some of these algal chloroplast genomes were analyzed. The results show that most but not all the nucleus-encoded chloroplast division genes and proteins, regardless of origin, are expressed during the S phase and that the expression of the chl ...
... division-related genes and proteins that are encoded in some of these algal chloroplast genomes were analyzed. The results show that most but not all the nucleus-encoded chloroplast division genes and proteins, regardless of origin, are expressed during the S phase and that the expression of the chl ...
www.pnlab.org - Paul Nghiem Laboratory
... tea but not decaffeinated tea was found to protect mice from UV carcinogenesis, which led to subsequent direct tests of caffeine’s effects on this process (Huang et al., 1997; Lou et al., 1999). Hairless mice treated with UV twice weekly for 20 weeks had normal-appearing skin, but were at a higher r ...
... tea but not decaffeinated tea was found to protect mice from UV carcinogenesis, which led to subsequent direct tests of caffeine’s effects on this process (Huang et al., 1997; Lou et al., 1999). Hairless mice treated with UV twice weekly for 20 weeks had normal-appearing skin, but were at a higher r ...
Carbon Nanotubes: Biorisks and Biodefence
... organs. Similarly to any other nanoparticles, CNT toxicity is dependent on their shape, size, purity, charge, dose, entry route into the body, concentration in the field of body-target, duration of influence and other factors. The research on toxicity and biocompatibility of CNT of different origin, ...
... organs. Similarly to any other nanoparticles, CNT toxicity is dependent on their shape, size, purity, charge, dose, entry route into the body, concentration in the field of body-target, duration of influence and other factors. The research on toxicity and biocompatibility of CNT of different origin, ...
151 Compact cell image projector
... Cardiac inotropy depends, among other factors, on the interval between contractions. In this study, we developed instrumentation for cell shortening recording, which was used to investigate the influence of stimulatory rhythm on contraction amplitude of isolated rat ventricular myocytes. Peak cell s ...
... Cardiac inotropy depends, among other factors, on the interval between contractions. In this study, we developed instrumentation for cell shortening recording, which was used to investigate the influence of stimulatory rhythm on contraction amplitude of isolated rat ventricular myocytes. Peak cell s ...
Cell delamination in the mesencephalic neural fold
... of ectodermal and mesodermal markers, such as platelet-derived growth factor receptor alpha (PDGFRα) (Weston et al., 2004). This idea is supported by the finding that these cells were found in established mouse strains that label the ectomesenchyme (Breau et al., 2008). Studies have yet to directly ...
... of ectodermal and mesodermal markers, such as platelet-derived growth factor receptor alpha (PDGFRα) (Weston et al., 2004). This idea is supported by the finding that these cells were found in established mouse strains that label the ectomesenchyme (Breau et al., 2008). Studies have yet to directly ...
The Lymphatic System
... The flow of lymph 1-way flow from tissue towards heart Lymph arises from extracellular fluid Lymph capillaries flow into (→) Lymphatic vessels →Through lymph nodes → Lymph trunks → Lymph ducts → Subclavian veins → → heart ...
... The flow of lymph 1-way flow from tissue towards heart Lymph arises from extracellular fluid Lymph capillaries flow into (→) Lymphatic vessels →Through lymph nodes → Lymph trunks → Lymph ducts → Subclavian veins → → heart ...
Production and Characterization of Islet Amyloid Polypeptide Using
... The role of amylin is not completely comprehended. Part of the problem is understanding the contrast between physiological (normal) and pathological (high) amounts of amylin in the body [6]. At physiological amount, amylin behaves like a growth factor which contributes to bone calcification [6], the ...
... The role of amylin is not completely comprehended. Part of the problem is understanding the contrast between physiological (normal) and pathological (high) amounts of amylin in the body [6]. At physiological amount, amylin behaves like a growth factor which contributes to bone calcification [6], the ...
Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis
... which has been used therapeutically for decades[1]. Besides being an anticancer drug against acute promyelocytic leukemia (APL), arsenic trioxide has also been proved as an effective compound that can inhibit the growth of many solid tumors both in vitro and in vivo[1, 2]. It has been reported that ...
... which has been used therapeutically for decades[1]. Besides being an anticancer drug against acute promyelocytic leukemia (APL), arsenic trioxide has also been proved as an effective compound that can inhibit the growth of many solid tumors both in vitro and in vivo[1, 2]. It has been reported that ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.