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... involved in both pseudohyphal and haploid invasive growth (Gavrias et al., 1996; Madhani and Fink, 1997; Mosch and Fink, 1997). Other proteins including transcription factors such as Phd1p (Gimeno and Fink, 1994) and Flo8p (Liu et al., 1996), as well as the protein kinase ELM1 (Blacketer et al., 199 ...
... involved in both pseudohyphal and haploid invasive growth (Gavrias et al., 1996; Madhani and Fink, 1997; Mosch and Fink, 1997). Other proteins including transcription factors such as Phd1p (Gimeno and Fink, 1994) and Flo8p (Liu et al., 1996), as well as the protein kinase ELM1 (Blacketer et al., 199 ...
Erythropoietin Regulates Endothelial Progenitor Cells
... Background: Circulating bone marrow-derived endothelial progenitor cells (EPCs) promote vascular reparative processes and neo-angiogenesis, and their number in peripheral blood correlates with endothelial function and cardiovascular risk. We tested the hypothesis that the cytokine erythropoietin (EP ...
... Background: Circulating bone marrow-derived endothelial progenitor cells (EPCs) promote vascular reparative processes and neo-angiogenesis, and their number in peripheral blood correlates with endothelial function and cardiovascular risk. We tested the hypothesis that the cytokine erythropoietin (EP ...
Chapter 5: Membrane Structure and Function 5.1 Membrane Models
... c. Proteins involved in active transport are often called "pumps"; the sodiumpotassium pump is an important carrier system in nerve and muscle cells. d. Salt (NaCl) crosses a plasma membrane because sodium ions are pumped across and the chloride ion is attracted to the sodium ion and simply diffuses ...
... c. Proteins involved in active transport are often called "pumps"; the sodiumpotassium pump is an important carrier system in nerve and muscle cells. d. Salt (NaCl) crosses a plasma membrane because sodium ions are pumped across and the chloride ion is attracted to the sodium ion and simply diffuses ...
Potential effect of spliceosome inhibition in small cell lung
... Small cell lung cancer (SCLC) is a highly aggressive malignancy with few therapeutic advances in the treatment in recent decades. Based on a recent study that identified the spliceosome as a therapeutic vulnerability in MYC-driven breast cancers, we evaluated the efficacy of a spliceosome inhibitor ...
... Small cell lung cancer (SCLC) is a highly aggressive malignancy with few therapeutic advances in the treatment in recent decades. Based on a recent study that identified the spliceosome as a therapeutic vulnerability in MYC-driven breast cancers, we evaluated the efficacy of a spliceosome inhibitor ...
The programme of cell death in plants and animals – A comparison
... function primarily with the mitochondria in controlling cell death in vertebrates. It is now an established fact that mitochondria, which are called the ‘power houses’ of the cell, not only generate energy for cellular activities but also play an important role in cell death42,43 in animals. They re ...
... function primarily with the mitochondria in controlling cell death in vertebrates. It is now an established fact that mitochondria, which are called the ‘power houses’ of the cell, not only generate energy for cellular activities but also play an important role in cell death42,43 in animals. They re ...
annexure-ii
... and delayed ischemia onset without significantly modifying heart rate, blood pressure or both4.Because of its high solubility, short half life(6±1.4 hrs)5 and therapeutic use in chronic disease it is considered as an ideal drug candidate for the design of oral controlled release dosage form. The use ...
... and delayed ischemia onset without significantly modifying heart rate, blood pressure or both4.Because of its high solubility, short half life(6±1.4 hrs)5 and therapeutic use in chronic disease it is considered as an ideal drug candidate for the design of oral controlled release dosage form. The use ...
Syllabus
... Lysosomal signaling in control of degradation pathways (Huber, L.A. and Teis, D. Curr. Opin. Cell Biol. 39 (2016) 8-14 (5 pages)). Coat proteins, tethering and sorting Analysis of the retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease (Seaman, M.N.J. an ...
... Lysosomal signaling in control of degradation pathways (Huber, L.A. and Teis, D. Curr. Opin. Cell Biol. 39 (2016) 8-14 (5 pages)). Coat proteins, tethering and sorting Analysis of the retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease (Seaman, M.N.J. an ...
Polycystin-2 functions as an intracellular calcium release channel.
... made thereof, and also apply to d and e. Wt refers to non-overexpressing cells throughout. d, Approximately 10-fold overexpression of PKD2-D511V in cell lysates and microsomes from the PKD2-D511V-expressing cell line. Calnexin is used as internal loading control. e, The inducible LtTA-2.22 cell line ...
... made thereof, and also apply to d and e. Wt refers to non-overexpressing cells throughout. d, Approximately 10-fold overexpression of PKD2-D511V in cell lysates and microsomes from the PKD2-D511V-expressing cell line. Calnexin is used as internal loading control. e, The inducible LtTA-2.22 cell line ...
lectSides10
... B. Neurons in the mature CNS have a limited capacity to regenerate axons. WHY? CNS axons can regrow, but… Growth is impeded by negative elements in the environment -myelin proteins (NOGO, MAG, Omgp) increase - inhibitory proteoglycans increase ...
... B. Neurons in the mature CNS have a limited capacity to regenerate axons. WHY? CNS axons can regrow, but… Growth is impeded by negative elements in the environment -myelin proteins (NOGO, MAG, Omgp) increase - inhibitory proteoglycans increase ...
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Electrophysiological properties of mouse bone marrow c
... (V h) of 90 mV (data not shown, n=11), indicating that undifferentiated c-kit+ stem cells are not endowed with functional Ca2+ and Na+ channels, while their K+ channels are impermeable to Cs+. To investigate possible in vitro transdifferentiation, we seeded GFP-labeled c-kit+ cells onto neonatal car ...
... (V h) of 90 mV (data not shown, n=11), indicating that undifferentiated c-kit+ stem cells are not endowed with functional Ca2+ and Na+ channels, while their K+ channels are impermeable to Cs+. To investigate possible in vitro transdifferentiation, we seeded GFP-labeled c-kit+ cells onto neonatal car ...
Microtechnology-Based Multi-Organ Models
... cell line that originates from colon cancer has been widely used, and it has shown several key features such as the barrier function and expression of transporter-related genes. For mimicking the liver, the HepG2 cell line has been used in many studies. The HepG2 cell line is derived from the human ...
... cell line that originates from colon cancer has been widely used, and it has shown several key features such as the barrier function and expression of transporter-related genes. For mimicking the liver, the HepG2 cell line has been used in many studies. The HepG2 cell line is derived from the human ...
Microtubules do not promote mitotic slippage when the spindle
... the lower the drug concentration the faster a cell escapes mitosis (Rieder and Maiato, 2004). The reasons for this remain vague. However, work on hamster (Andreassen and Margolis, 1994) and human nontransformed (Brito and Rieder, 2006) and cancer (Jordan et al., 1992) cells reveals that accelerated ...
... the lower the drug concentration the faster a cell escapes mitosis (Rieder and Maiato, 2004). The reasons for this remain vague. However, work on hamster (Andreassen and Margolis, 1994) and human nontransformed (Brito and Rieder, 2006) and cancer (Jordan et al., 1992) cells reveals that accelerated ...
Text Structure and Functions of the Cell Membrane The cell
... animals and cholesterol. Cholesterol is an important steroid which is an integral constituent of animal cell membranes. Cholesterol functions to enhance the fluidity of membranes by preventing close packing of fatty acid chains and also enhances the membrane rigidity. Cholesterol also influences th ...
... animals and cholesterol. Cholesterol is an important steroid which is an integral constituent of animal cell membranes. Cholesterol functions to enhance the fluidity of membranes by preventing close packing of fatty acid chains and also enhances the membrane rigidity. Cholesterol also influences th ...
Cell Receptor To Promote B Cell Survival R Interacts and
... by anti-IgM but not LPS stimulation (19). To further analyze the specificity of FcmR-mediated enhancement of B cell survival, we cultured WT and FcmR2/2 splenic B cells in the presence of antiIgM F(ab9)2 fragment, CD40L, or LPS. Consistent with our previous findings (19), FcmR2/2 splenic B cells sho ...
... by anti-IgM but not LPS stimulation (19). To further analyze the specificity of FcmR-mediated enhancement of B cell survival, we cultured WT and FcmR2/2 splenic B cells in the presence of antiIgM F(ab9)2 fragment, CD40L, or LPS. Consistent with our previous findings (19), FcmR2/2 splenic B cells sho ...
PDF
... differentiation. Lif belongs to the interleukin-6 cytokine family and binds to a heterodimeric receptor consisting of the Lif-receptor  and gp130 (Il6st – Mouse Genome Informatics). This binding results in the activation of the canonical Jak/Stat (Janus kinase signal transducer and activator of tra ...
... differentiation. Lif belongs to the interleukin-6 cytokine family and binds to a heterodimeric receptor consisting of the Lif-receptor  and gp130 (Il6st – Mouse Genome Informatics). This binding results in the activation of the canonical Jak/Stat (Janus kinase signal transducer and activator of tra ...
How is pluripotency determined and maintained?
... differentiation. Lif belongs to the interleukin-6 cytokine family and binds to a heterodimeric receptor consisting of the Lif-receptor  and gp130 (Il6st – Mouse Genome Informatics). This binding results in the activation of the canonical Jak/Stat (Janus kinase signal transducer and activator of tra ...
... differentiation. Lif belongs to the interleukin-6 cytokine family and binds to a heterodimeric receptor consisting of the Lif-receptor  and gp130 (Il6st – Mouse Genome Informatics). This binding results in the activation of the canonical Jak/Stat (Janus kinase signal transducer and activator of tra ...
Geographic Information Systems - CEProfs
... The statistic can be: majority, maximum, mean, median, minimum, minority, range, standard deviation, sum and variety. The neighborhood can have different shapes. To calculate neighborhood statistics, make the grid active, and click on Analysis/Neighborhood Statistics… ...
... The statistic can be: majority, maximum, mean, median, minimum, minority, range, standard deviation, sum and variety. The neighborhood can have different shapes. To calculate neighborhood statistics, make the grid active, and click on Analysis/Neighborhood Statistics… ...
PDF
... relatively early stage, and only later sort into their respective layers (Chazaud et al., 2006). We reasoned that live imaging of PrE formation would provide validation of the model, and that a fluorescent reporter of PrE precursors would provide the necessary tool. A microarray analysis of gene exp ...
... relatively early stage, and only later sort into their respective layers (Chazaud et al., 2006). We reasoned that live imaging of PrE formation would provide validation of the model, and that a fluorescent reporter of PrE precursors would provide the necessary tool. A microarray analysis of gene exp ...
Tricellulin regulates junctional tension of epithelial cells at tricellular
... Tricellulin recruits F-actin and myosin IIB We further found that overexpression of tricellulin in mouse mammary gland epithelial EpH4 cells sometimes produced clusters of tricellulin aggregates on bicellular cell–cell contacts, where F-actin and myosin IIB were concentrated, suggesting that tricell ...
... Tricellulin recruits F-actin and myosin IIB We further found that overexpression of tricellulin in mouse mammary gland epithelial EpH4 cells sometimes produced clusters of tricellulin aggregates on bicellular cell–cell contacts, where F-actin and myosin IIB were concentrated, suggesting that tricell ...
Arabidopsis WPP-Domain Proteins Are
... WPP1-GFP and WPP2-GFP NE Targeting Is Developmentally Regulated in Arabidopsis Plants To investigate the localization pattern of WPP1-GFP, WPP2GFP, and WPP3-GFP in different cell types, Arabidopsis transgenic lines expressing the fusion proteins under the control of the 35S promoter were created. Se ...
... WPP1-GFP and WPP2-GFP NE Targeting Is Developmentally Regulated in Arabidopsis Plants To investigate the localization pattern of WPP1-GFP, WPP2GFP, and WPP3-GFP in different cell types, Arabidopsis transgenic lines expressing the fusion proteins under the control of the 35S promoter were created. Se ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.