growth polarity and cytokinesis in fission yeast: the role of the
... large number and variety of mutants that affect the yeast cell division cycle (Pringle & Hartwell, 1981; Nurse, 1981). Thus, the relationship of the cytoskeleton to other cell cycle events is also open to direct study. Two yeasts in particular have been the focus of most attention, the budding yeast ...
... large number and variety of mutants that affect the yeast cell division cycle (Pringle & Hartwell, 1981; Nurse, 1981). Thus, the relationship of the cytoskeleton to other cell cycle events is also open to direct study. Two yeasts in particular have been the focus of most attention, the budding yeast ...
Geldanamycins exquisitely inhibit HGF/SF-mediated tumor
... fM-GAi compounds, are those in which the 17-methoxy group of GA has been replaced by an amino or an alkylamino group (Wenkert et al., manuscript in preparation). To determine whether, like MDCK cells, human tumor cell lines display fM-GAi sensitivity, we first screened several cell lines for HGF/SF-i ...
... fM-GAi compounds, are those in which the 17-methoxy group of GA has been replaced by an amino or an alkylamino group (Wenkert et al., manuscript in preparation). To determine whether, like MDCK cells, human tumor cell lines display fM-GAi sensitivity, we first screened several cell lines for HGF/SF-i ...
Selective Loss of Mitochondrial DNA after Treatment of Cells with
... have been synthesized (1-3). In the series of 7H-pyridocarbazole, dimerization yielded molecules which bis-intercalate into DNA, depending on the nature, the flexibility, and the inni/.ation state of the linking chain. Among these molecules, diter calinium, which bis-intercalates into DNA through th ...
... have been synthesized (1-3). In the series of 7H-pyridocarbazole, dimerization yielded molecules which bis-intercalate into DNA, depending on the nature, the flexibility, and the inni/.ation state of the linking chain. Among these molecules, diter calinium, which bis-intercalates into DNA through th ...
2016 department of medicine research day
... metastasize, leading to poor patient survival. It is urgent to develop new therapeutics to target this deadly disease. Diabetic patients treated with metformin have a reduced incidence of and better survival from breast cancer. Moreover, TNBC cells are reported to be highly sensitive to metformin du ...
... metastasize, leading to poor patient survival. It is urgent to develop new therapeutics to target this deadly disease. Diabetic patients treated with metformin have a reduced incidence of and better survival from breast cancer. Moreover, TNBC cells are reported to be highly sensitive to metformin du ...
The Proteome of Native Adult Müller Glial Cells From Murine
... of the absence of suitable enrichment methods. We established a novel protocol to isolate native, intact Müller cells from adult murine retinae at excellent purity which retain in situ morphology and are well suited for proteomic analyses. Two different strategies of sample preparation - an in Stag ...
... of the absence of suitable enrichment methods. We established a novel protocol to isolate native, intact Müller cells from adult murine retinae at excellent purity which retain in situ morphology and are well suited for proteomic analyses. Two different strategies of sample preparation - an in Stag ...
Multiple Mechanisms of Resistance to Polyglutamatable and
... (DHFR), including piritrexim, trimetrexate (TMQ), pyrimethamine (Pyr), and trimethoprim, find widespread use in the treatment of fungal, protozoal, and bacterial infections (Allegra et al., 1987; Borst and Ouelette, 1995). Because lipophilic antifolates can enter cells and tissues by passive or faci ...
... (DHFR), including piritrexim, trimetrexate (TMQ), pyrimethamine (Pyr), and trimethoprim, find widespread use in the treatment of fungal, protozoal, and bacterial infections (Allegra et al., 1987; Borst and Ouelette, 1995). Because lipophilic antifolates can enter cells and tissues by passive or faci ...
Novel adenosine and cAMP signalling pathways in migrating glial
... of 76 cells). These results indicate that adenosine induces a [Ca2+ ]i response in glial cells in a concentration-dependent manner with maximal effects at 10 M. Adenosine was still able to elicit calcium responses also if experiments were performed in N2 medium (data not shown), instead of Tyrode’s ...
... of 76 cells). These results indicate that adenosine induces a [Ca2+ ]i response in glial cells in a concentration-dependent manner with maximal effects at 10 M. Adenosine was still able to elicit calcium responses also if experiments were performed in N2 medium (data not shown), instead of Tyrode’s ...
Loss of mitochondrial membrane potential triggers the
... significantly higher in the rho+ cox4Δ strain compared to the rho+ control (Figure 2), which we would expect since MMP is lower as shown in Figure 1. CIT2 expression was also measured in the rho0 ATP1-111 mutant containing deletions of either RTG2 or RTG3, both of which are transducers of the retrogr ...
... significantly higher in the rho+ cox4Δ strain compared to the rho+ control (Figure 2), which we would expect since MMP is lower as shown in Figure 1. CIT2 expression was also measured in the rho0 ATP1-111 mutant containing deletions of either RTG2 or RTG3, both of which are transducers of the retrogr ...
Reverse Engineering Models of Cell Cycle Regulation
... The physiological characteristics of living cells-their abilities to grow and divide, to respond to external stimuli, to move around, to find food or sexual partners-are regulated ultimately by networks of interacting genes and proteins. Molecular geneticists have been very successful in identifying ...
... The physiological characteristics of living cells-their abilities to grow and divide, to respond to external stimuli, to move around, to find food or sexual partners-are regulated ultimately by networks of interacting genes and proteins. Molecular geneticists have been very successful in identifying ...
Universal Quantifier Derived from AFM Analysis Links Cellular
... measurements were repeated on mica surfaces before and after probing the bacteria samples to ensure minimal contamination of the silicon nitride AFM tip. A typical cell was identified by large scan size and low-resolution MAC (magnetic acoustic control) mode. The AFM tip was then repositioned over th ...
... measurements were repeated on mica surfaces before and after probing the bacteria samples to ensure minimal contamination of the silicon nitride AFM tip. A typical cell was identified by large scan size and low-resolution MAC (magnetic acoustic control) mode. The AFM tip was then repositioned over th ...
Transcription Domain-Associated Repair in Human Cells
... of lesions, from UV-induced pyrimidine dimers to bulky chemicals or protein DNA adducts to intrastrand cross-links. The mechanistic details of NER are well understood. Lesions are likely detected through the conformational change they introduce in the double-helical DNA structure by the heterotrimer ...
... of lesions, from UV-induced pyrimidine dimers to bulky chemicals or protein DNA adducts to intrastrand cross-links. The mechanistic details of NER are well understood. Lesions are likely detected through the conformational change they introduce in the double-helical DNA structure by the heterotrimer ...
Dependency on Medium and Temperature of Cel Size and
... 1-3, an approximate correction for doublets can be made by multiplying the ordinate values by 0.8. The figures for nuclei /cell (Fig. 4) are based on direct counts of stained preparations. It was not always possible after staining to distinguish between single elements and doublets, particularly whe ...
... 1-3, an approximate correction for doublets can be made by multiplying the ordinate values by 0.8. The figures for nuclei /cell (Fig. 4) are based on direct counts of stained preparations. It was not always possible after staining to distinguish between single elements and doublets, particularly whe ...
PDF
... be dangerous to activate all of these stem cells at the same time because this could jeopardize the ability of the tissue to repair future injuries. In such a scenario, two types of cells capable of regeneration would be required. One type has to respond promptly to physiological and injury cues to ...
... be dangerous to activate all of these stem cells at the same time because this could jeopardize the ability of the tissue to repair future injuries. In such a scenario, two types of cells capable of regeneration would be required. One type has to respond promptly to physiological and injury cues to ...
Actin Microfilaments Regulate Vacuolar Structures and Dynamics
... large and small arrows in Fig. 2C). An intensity profile across the vacuolar surface and cell cortex showed that the MFs localized on the vacuolar surface more intensively (Fig. 2G, large arrow) than close to the cell cortex (Fig. 2G, small arrow). In the cytoplasmic strands, MFs seemed to localize ...
... large and small arrows in Fig. 2C). An intensity profile across the vacuolar surface and cell cortex showed that the MFs localized on the vacuolar surface more intensively (Fig. 2G, large arrow) than close to the cell cortex (Fig. 2G, small arrow). In the cytoplasmic strands, MFs seemed to localize ...
Asymmetric Behavior in Stem Cells
... occurring within the cytoplasm that result in asymmetric partitioning of cytoplasmic contents and, hence, distinct daughter cell phenotypes (Fig. 1B). Alternatively, the event of cell division may yield daughter cells that are equivalent at birth, and the cells then respond to extrinsic cues that pr ...
... occurring within the cytoplasm that result in asymmetric partitioning of cytoplasmic contents and, hence, distinct daughter cell phenotypes (Fig. 1B). Alternatively, the event of cell division may yield daughter cells that are equivalent at birth, and the cells then respond to extrinsic cues that pr ...
Why do muscles shorten? 112ch11
... 4) In smooth muscle cells the actin and myosin are not organized into sarcomeres, but more loosely attached to the plasma membrane and sarcoplasm (no striations) 5) Smooth Muscle can generate force that is sustained for a longer time and uses less ATP (its cells typically have fewer mitochondria and ...
... 4) In smooth muscle cells the actin and myosin are not organized into sarcomeres, but more loosely attached to the plasma membrane and sarcoplasm (no striations) 5) Smooth Muscle can generate force that is sustained for a longer time and uses less ATP (its cells typically have fewer mitochondria and ...
Cell Cycle & Mitosis
... Does a new organism form through mitosis of a eukaryotic multicellular organism? ...
... Does a new organism form through mitosis of a eukaryotic multicellular organism? ...
Chapter 6 A Tour of the Cell Multiple-Choice Questions
... 9) A newspaper ad for a local toy store indicates that a very inexpensive microscope available for a small child is able to magnify specimens nearly as much as the much more costly microscope available in your college lab. What is the primary reason for the price difference? A) The ad agency is misr ...
... 9) A newspaper ad for a local toy store indicates that a very inexpensive microscope available for a small child is able to magnify specimens nearly as much as the much more costly microscope available in your college lab. What is the primary reason for the price difference? A) The ad agency is misr ...
Plant Cell - WordPress.com
... The shape of the cells also varies considerably. It may be Spherical, Polygonal, Oval, Rectangular, Cylinderical etc. The smallest cell found in bacteria is 0.2 to 50 micron LEARNING EXPERIENCE Teacher explain the different shapes of the cell EVALUATION The smallest cell found in bacteria is ------- ...
... The shape of the cells also varies considerably. It may be Spherical, Polygonal, Oval, Rectangular, Cylinderical etc. The smallest cell found in bacteria is 0.2 to 50 micron LEARNING EXPERIENCE Teacher explain the different shapes of the cell EVALUATION The smallest cell found in bacteria is ------- ...
Excitable Properties of Olfactory Receptor Neurons
... Propertiesof repetitive discharges The properties of repetitive dischargesin this cell population are indicated in 2 further examplesin Figure 1B. These 3 examplessummarize several important features of the responses in the normal epithelium. First, up to approximately 20 impulsessee-I, action poten ...
... Propertiesof repetitive discharges The properties of repetitive dischargesin this cell population are indicated in 2 further examplesin Figure 1B. These 3 examplessummarize several important features of the responses in the normal epithelium. First, up to approximately 20 impulsessee-I, action poten ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.