The Cdk inhibitors p25rum1 and p40SIC1 are functional
... component of the cell cycle machine in that its protein levels or activity is not dependent on external factors. p40SIC1 was first described as a tightly bound substrate of Cdc28 (Mendenhall et al., 1987; Nugroho and Mendenhall, 1994; Reed et al., 1985). p40SIC1 accumulates as cells exit from mitosi ...
... component of the cell cycle machine in that its protein levels or activity is not dependent on external factors. p40SIC1 was first described as a tightly bound substrate of Cdc28 (Mendenhall et al., 1987; Nugroho and Mendenhall, 1994; Reed et al., 1985). p40SIC1 accumulates as cells exit from mitosi ...
Microphysiological Models to Understand Transporter Function
... The creation and maintenance of an in vitro microphysiological system that correctly mimics hepatic function to study drug and xenobiotic metabolism must include functional biotransformation enzymes and transporters. In this section, we review the primary hepatic phase I/II/III enzymes and transport ...
... The creation and maintenance of an in vitro microphysiological system that correctly mimics hepatic function to study drug and xenobiotic metabolism must include functional biotransformation enzymes and transporters. In this section, we review the primary hepatic phase I/II/III enzymes and transport ...
Optimal Control for a Class of Compartmental Models in Cancer Chemotherapy
... between the phases G1 and S by interfering with the formator of the polymerase complex or by hindering the separation of the two polynucleotide strands in the double helix [2]. Another blocking agent is Hydroxyurea - HU [28], [11] which is found to synchronize cells by causing brief and invisible i ...
... between the phases G1 and S by interfering with the formator of the polymerase complex or by hindering the separation of the two polynucleotide strands in the double helix [2]. Another blocking agent is Hydroxyurea - HU [28], [11] which is found to synchronize cells by causing brief and invisible i ...
The Cytoplasm of a Cell and the Courtyard of a Siheyuan
... principle of the need of a public shared space is upheld within an eukaryotic cell. The presence of the cytoplasm gives the cell some advantages that keep this type of organisms in the evolutionary history. First, by being the medium that hold all its suspension together, the cytoplasm supports the ...
... principle of the need of a public shared space is upheld within an eukaryotic cell. The presence of the cytoplasm gives the cell some advantages that keep this type of organisms in the evolutionary history. First, by being the medium that hold all its suspension together, the cytoplasm supports the ...
Effect of Butyric Acid on Lung-colonizing Ability
... Hanks' balanced salt solution; PMSF, phenylmethylsulfonyl fluoride. ...
... Hanks' balanced salt solution; PMSF, phenylmethylsulfonyl fluoride. ...
Processing of human cytomegalovirus envelope glycoproteins in
... extracted with NP40, insoluble material was removed by centrifugation and the supernatant was used for immunoprecipitations using a gB-specific MAb. The MrS of the gB glycoproteins synthesized in SF and U373MG cells and the disulphide-linked complexes formed by gB were compared by S D S - P A G E . ...
... extracted with NP40, insoluble material was removed by centrifugation and the supernatant was used for immunoprecipitations using a gB-specific MAb. The MrS of the gB glycoproteins synthesized in SF and U373MG cells and the disulphide-linked complexes formed by gB were compared by S D S - P A G E . ...
Chaotic expression dynamics implies pluripotency: when theory and
... progressively decreases the number of cell types they can potentially become. Pluripotent stem cells can differentiate into several types of cells, but terminally differentiated cells cannot differentiate any further. A fundamental problem in stem cell biology is the characterization of the differen ...
... progressively decreases the number of cell types they can potentially become. Pluripotent stem cells can differentiate into several types of cells, but terminally differentiated cells cannot differentiate any further. A fundamental problem in stem cell biology is the characterization of the differen ...
CASE 3
... Voltage-gated channel: Pore-forming protein complexes that allow ions to flow across a membrane, and which can be opened (or, in some cases, closed) by a change in membrane potential. ...
... Voltage-gated channel: Pore-forming protein complexes that allow ions to flow across a membrane, and which can be opened (or, in some cases, closed) by a change in membrane potential. ...
The Wall Becomes Surmountable
... France) reported on the results of a screen for suppressor mutations of the prc1-1 mutation. Three Arabidopsis mutant lines were identified in which hypocotyl and root elongation was less impaired than in prc1-1 mutants. The extent of restoration appeared to be Suc dependent. Cellulose synthesis act ...
... France) reported on the results of a screen for suppressor mutations of the prc1-1 mutation. Three Arabidopsis mutant lines were identified in which hypocotyl and root elongation was less impaired than in prc1-1 mutants. The extent of restoration appeared to be Suc dependent. Cellulose synthesis act ...
Heat stress induces different forms of cell death in sea
... immediately following exposure (o2 min) in the host endoderm cells (Figure 4a). A significant response was not detected in ectoderm cells until 20 min exposure at the two higher temperatures (Figure 4b). Zooxanthellae cell death distribution in the temperature treatments was not significantly differ ...
... immediately following exposure (o2 min) in the host endoderm cells (Figure 4a). A significant response was not detected in ectoderm cells until 20 min exposure at the two higher temperatures (Figure 4b). Zooxanthellae cell death distribution in the temperature treatments was not significantly differ ...
Small airway-on-a-chip enables analysis of human lung
... the fluid effluent at day 2 and 8 respectively (Fig. 2c), and a reduction in cilia beating frequency (Fig. 2d) similar to that observed in the airway mucosa of asthma patients27-29. As mucosal inflammation and its exacerbation by viral infections are major components of both asthma and COPD, and it ...
... the fluid effluent at day 2 and 8 respectively (Fig. 2c), and a reduction in cilia beating frequency (Fig. 2d) similar to that observed in the airway mucosa of asthma patients27-29. As mucosal inflammation and its exacerbation by viral infections are major components of both asthma and COPD, and it ...
Unit Operations of Tissue Development: Epithelial
... part of the eggshell. Two recurring motifs can be derived from both systems: Spatially generated signals subdivide an epithelial cell layer into defined regions, and each region is defined by a set of expressed genes that specify the cellular activities and mechanical modifications necessary to generat ...
... part of the eggshell. Two recurring motifs can be derived from both systems: Spatially generated signals subdivide an epithelial cell layer into defined regions, and each region is defined by a set of expressed genes that specify the cellular activities and mechanical modifications necessary to generat ...
Membrane trafficking in Drosophila wing and eye development
... contains eight photoreceptor cells and four cone cells and a number of support cells. The photoreceptors are arranged in a trapezoidal array with their apical surfaces facing the interior of the structure. The rhabdomeres are apical surface membrane expansions of the photoreceptor cells containing t ...
... contains eight photoreceptor cells and four cone cells and a number of support cells. The photoreceptors are arranged in a trapezoidal array with their apical surfaces facing the interior of the structure. The rhabdomeres are apical surface membrane expansions of the photoreceptor cells containing t ...
Clinical Medicine Insights: Oncology emerging pharmacotherapy for
... In an attempt to increase the clinical activity of the anti-CD30 antibodies they were conjugated to toxins (Antibody Drug Conjugates; ADC’s), using the ‘naked’ (unconjugated) antibody as a vehicle for toxin delivery to tumour cells. This has the advantage of potentially sparing the normal tissue fro ...
... In an attempt to increase the clinical activity of the anti-CD30 antibodies they were conjugated to toxins (Antibody Drug Conjugates; ADC’s), using the ‘naked’ (unconjugated) antibody as a vehicle for toxin delivery to tumour cells. This has the advantage of potentially sparing the normal tissue fro ...
Characterization of the pH of Folate Receptor
... Tumor-specific delivery of anti-cancer drugs can often be achieved by attaching the cytotoxic drug to a tumor-recognizing ligand (e.g., an antibody or a low molecular weight ligand). Such attachments, however, can potentially introduce steric hindrances and prevent association of the drug with its m ...
... Tumor-specific delivery of anti-cancer drugs can often be achieved by attaching the cytotoxic drug to a tumor-recognizing ligand (e.g., an antibody or a low molecular weight ligand). Such attachments, however, can potentially introduce steric hindrances and prevent association of the drug with its m ...
Full PDF - Cancer Research
... (Fig. 2A and B). This cell-based vaccine boosted the antitumor activity of the combination of oxaliplatin plus poly(A: U) (Fig. 2C) and enhanced survival (Fig. 2D) when used in a therapeutic setting after the implantation of tumors. Very similar results were obtained when B16-OVA melanoma cells were ...
... (Fig. 2A and B). This cell-based vaccine boosted the antitumor activity of the combination of oxaliplatin plus poly(A: U) (Fig. 2C) and enhanced survival (Fig. 2D) when used in a therapeutic setting after the implantation of tumors. Very similar results were obtained when B16-OVA melanoma cells were ...
Cells - MCQ topic quiz
... If you do not currently offer this OCR qualification but would like to do so, please complete the Expression of Interest Form which can be found here: www.ocr.org.uk/expression-of-interest ...
... If you do not currently offer this OCR qualification but would like to do so, please complete the Expression of Interest Form which can be found here: www.ocr.org.uk/expression-of-interest ...
Low Intracellular Proline: A Cause of Toxicity in Human RPE Cells?
... Gyrate atrophy of the choroid and retina (GA) is an autosomal recessive disease caused by mutations in the nuclear gene coding for the mitochondrial enzyme ornithine aminotransferase (OAT; Valle & Simell, 2001). The primary symptoms for this congenital metabolic disease include night blindness, myop ...
... Gyrate atrophy of the choroid and retina (GA) is an autosomal recessive disease caused by mutations in the nuclear gene coding for the mitochondrial enzyme ornithine aminotransferase (OAT; Valle & Simell, 2001). The primary symptoms for this congenital metabolic disease include night blindness, myop ...
Tea4p Links Microtubule Plus Ends with the Formin For3p in the
... Interactions between the actin and microtubule (MT) cytoskeletons are critical for cell morphogenesis and contribute to diverse cellular processes such as cell migration, axon guidance, spindle orientation, and cytokinesis (Rodriguez et al., 2003). MTs have been proposed to contribute to the spatial ...
... Interactions between the actin and microtubule (MT) cytoskeletons are critical for cell morphogenesis and contribute to diverse cellular processes such as cell migration, axon guidance, spindle orientation, and cytokinesis (Rodriguez et al., 2003). MTs have been proposed to contribute to the spatial ...
Oncogenic potential of a C.elegans cdc25 gene is demonstrated by
... two different genes and display distinct genetic behaviours, the gene identi®ed by allele ij48 acting maternally (see below) while that identi®ed by ij52 is zygotic. The gene identi®ed by ij52 is not discussed further here. ij48 mutants have additional nuclei expressing the cpr-5::gfp transgene when ...
... two different genes and display distinct genetic behaviours, the gene identi®ed by allele ij48 acting maternally (see below) while that identi®ed by ij52 is zygotic. The gene identi®ed by ij52 is not discussed further here. ij48 mutants have additional nuclei expressing the cpr-5::gfp transgene when ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.