the publication - Oncovet Clinical Research
... because of their growth over long periods of time in an intact immune system, interindividual and intratumoral heterogeneity, development of recurrent or resistant diseases, and metastasis (13). Clinical presentation, biologic behavior, tumor genetics, and treatment response are very similar between ...
... because of their growth over long periods of time in an intact immune system, interindividual and intratumoral heterogeneity, development of recurrent or resistant diseases, and metastasis (13). Clinical presentation, biologic behavior, tumor genetics, and treatment response are very similar between ...
The MAP Kinase MPK4 Is Required for Cytokinesis in
... mutant plants exhibited severe aboveground dwarfism (Figures 1A and 1C), retarded root growth (Figure 1C), and the protrusion of many epidermal cells from roots (Figures 1G and 1I). The mpk4-2 homozygous mutant set only a few flowers, and these flowers produced very few viable seeds or none at all. ...
... mutant plants exhibited severe aboveground dwarfism (Figures 1A and 1C), retarded root growth (Figure 1C), and the protrusion of many epidermal cells from roots (Figures 1G and 1I). The mpk4-2 homozygous mutant set only a few flowers, and these flowers produced very few viable seeds or none at all. ...
Heading forwards: anterior visceral endoderm migration in
... Basal projections driven by Rho-GTPases and the WAVE complex activity are sent out in the direction of migration forming new cell–cell contact sites (blue gradients). Progressively, apical junctional complexes are turned over and remodelled at the leading edge and back of the cell as the cortical ac ...
... Basal projections driven by Rho-GTPases and the WAVE complex activity are sent out in the direction of migration forming new cell–cell contact sites (blue gradients). Progressively, apical junctional complexes are turned over and remodelled at the leading edge and back of the cell as the cortical ac ...
The Effect of Ethambutol on Mycobacterial Cell Wall Permeability to
... mycolic acids, peptidoglycan and arabinogalactan (Daffe and Draper, 1998; Nikaido et al., 1993). Mycolic acids play a crucial role in the permeation compounds through the mycobacterial cell wall envelope. Using mutants lacked 50% of cell-wall-bound corynemycolates (Puech et al., 2000) or mutant stra ...
... mycolic acids, peptidoglycan and arabinogalactan (Daffe and Draper, 1998; Nikaido et al., 1993). Mycolic acids play a crucial role in the permeation compounds through the mycobacterial cell wall envelope. Using mutants lacked 50% of cell-wall-bound corynemycolates (Puech et al., 2000) or mutant stra ...
Anti inflammatory and immunmodulatory effects of
... manner and reduced anaphylactic mortality. At both dose levels, UNIM-352 was able to significantly inhibit the serum IgE levels when compared to vehicle treated control group. All these effects were comparable to prednisolone which was used as reference standard for the experiments. In studies for c ...
... manner and reduced anaphylactic mortality. At both dose levels, UNIM-352 was able to significantly inhibit the serum IgE levels when compared to vehicle treated control group. All these effects were comparable to prednisolone which was used as reference standard for the experiments. In studies for c ...
Calmodulin-binding protein disrupts mitosis
... components or regulators of the replication machinery itself, fail both to initiate DNA replication and to inhibit progression into mitosis (Kelly et al., 1993; Araki et al., 1995; D’Urso et al., 1995; Navas et al., 1995; Sugimoto et al., 1996). For both classes the mutant phenotype is characterised ...
... components or regulators of the replication machinery itself, fail both to initiate DNA replication and to inhibit progression into mitosis (Kelly et al., 1993; Araki et al., 1995; D’Urso et al., 1995; Navas et al., 1995; Sugimoto et al., 1996). For both classes the mutant phenotype is characterised ...
Essential fatty acids in membrane: physical properties and function
... which can be ascribed to a cell membrane and which are subject to modification by alterations in the level o f unsaturation. In addition, the membrane can be subdivided into at least three distinct areas: the phospholipid head group region, the central hydrocarbon chain region and the region adjacen ...
... which can be ascribed to a cell membrane and which are subject to modification by alterations in the level o f unsaturation. In addition, the membrane can be subdivided into at least three distinct areas: the phospholipid head group region, the central hydrocarbon chain region and the region adjacen ...
Cellular Maturation Defects in Bruton`s Tyrosine
... specifically recognizes MHC class I molecules of the H2-Kk/b allotype (11), and thus reflects an innocuous BCR in mice that have an H2-Kd background. Mice with such a nonautoreactive background (also called nondeleting mice) contain a virtually monoclonal B cell population. Since the prematurely exp ...
... specifically recognizes MHC class I molecules of the H2-Kk/b allotype (11), and thus reflects an innocuous BCR in mice that have an H2-Kd background. Mice with such a nonautoreactive background (also called nondeleting mice) contain a virtually monoclonal B cell population. Since the prematurely exp ...
Regulation by Polyamines of Ornithine
... Polyamines are ubiquitous cell components essential for normal growth of both eukaryotic and prokaryotic cells (Tabor and Tabor, 1984; Marton and Pegg, 1995). In higher plants, polyamines also influence developmental processes and play an important role in the response to abiotic stress (Galston et ...
... Polyamines are ubiquitous cell components essential for normal growth of both eukaryotic and prokaryotic cells (Tabor and Tabor, 1984; Marton and Pegg, 1995). In higher plants, polyamines also influence developmental processes and play an important role in the response to abiotic stress (Galston et ...
Aging and Mitochondria - SENS Research Foundation
... •Links Lysine to Arginine Sell DR, Biemel KM, Reihl O, Lederer MO, Strauch CM, Monnier VM. Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes. J Biol Chem. 2005 ...
... •Links Lysine to Arginine Sell DR, Biemel KM, Reihl O, Lederer MO, Strauch CM, Monnier VM. Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes. J Biol Chem. 2005 ...
Tumor Necrosis Factor-related Apoptosis
... TRAIL has extensive homology with TNF-␣, which can also trigger apoptosis, in part, by inducing lysosomal permeabilization (20 –23). The release of lysosomal cathepsins, especially cathepsin B, into the cytosol is associated with apoptosis (20, 23, 24). Cytosolic cathepsin B triggers mitochondrial d ...
... TRAIL has extensive homology with TNF-␣, which can also trigger apoptosis, in part, by inducing lysosomal permeabilization (20 –23). The release of lysosomal cathepsins, especially cathepsin B, into the cytosol is associated with apoptosis (20, 23, 24). Cytosolic cathepsin B triggers mitochondrial d ...
Ectodermal progenitors derived from epiblast
... into either epidermis or neural tissue depending on BMP signaling (Li et al., 2013). Several studies show that there may be intermediate ectodermal progenitor cells, such as neuro-ectodermal progenitors or epidermal progenitors, existing during the differentiation of the pluripotent stem cells (Kawa ...
... into either epidermis or neural tissue depending on BMP signaling (Li et al., 2013). Several studies show that there may be intermediate ectodermal progenitor cells, such as neuro-ectodermal progenitors or epidermal progenitors, existing during the differentiation of the pluripotent stem cells (Kawa ...
The Electrochemical Gradient - Advanced
... One particular ion gradient with biological significance is the proton (H+ ) gradient. This type of gradient is established through active transport involving proton pumps. The proton gradient is used during photosynthesis and cellular respiration to generate a chemiosmotic potential, or proton moti ...
... One particular ion gradient with biological significance is the proton (H+ ) gradient. This type of gradient is established through active transport involving proton pumps. The proton gradient is used during photosynthesis and cellular respiration to generate a chemiosmotic potential, or proton moti ...
CpG-ODN 2006 and human parvovirus B19 genome consensus
... 1Department of Hematology, Nephrology, and Rheumatology. Akita University Graduate School of Medicine, Akita, Japan; 2Department of Rheumatology, First Affiliated Hospital of China Medical University, Shenyang, China; 3Department of Medical Microbiology, Mycology and Immunology, Tohoku University Gr ...
... 1Department of Hematology, Nephrology, and Rheumatology. Akita University Graduate School of Medicine, Akita, Japan; 2Department of Rheumatology, First Affiliated Hospital of China Medical University, Shenyang, China; 3Department of Medical Microbiology, Mycology and Immunology, Tohoku University Gr ...
Development of bacterial oxidative stress assays
... upregulating the production of reactive oxygen species. Reactive oxygen species are also produced by host immune cells as protection against infectious bacteria. Superoxide dismutase (SOD) is a defensive enzyme that protects bacteria from the damage caused by reactive oxygen species. It is hypothesi ...
... upregulating the production of reactive oxygen species. Reactive oxygen species are also produced by host immune cells as protection against infectious bacteria. Superoxide dismutase (SOD) is a defensive enzyme that protects bacteria from the damage caused by reactive oxygen species. It is hypothesi ...
Expression of Growth Factor Receptors in
... either anti-IL-3R or GM-CSFR monoclonal antibodies (MoAbs) confirmed that CD34+ cell subsets express IL-3Rs andor GM-CSFRs. Furthermore, studies on fractionated BM CD34' cells showed that small cells possess a higher IL6R, IL-3R, and GM-CSFR density than large ones.'' These studies did not provide i ...
... either anti-IL-3R or GM-CSFR monoclonal antibodies (MoAbs) confirmed that CD34+ cell subsets express IL-3Rs andor GM-CSFRs. Furthermore, studies on fractionated BM CD34' cells showed that small cells possess a higher IL6R, IL-3R, and GM-CSFR density than large ones.'' These studies did not provide i ...
The PXY-CLE41 receptor ligand pair defines a
... vascular initials are long thin cells, yet they divide down the centre of their long axis and parallel to the outside of the plant (periclinally) in order to generate files of cells along the radial axis that are also aligned along the apical basal axis (Fig. 1A; Fig. 2E; Fig. 4E). This process is d ...
... vascular initials are long thin cells, yet they divide down the centre of their long axis and parallel to the outside of the plant (periclinally) in order to generate files of cells along the radial axis that are also aligned along the apical basal axis (Fig. 1A; Fig. 2E; Fig. 4E). This process is d ...
The Science of the Total Environment
... The ratio of EUBrDAPI did not change significantly with different amounts of NP. These results ŽDAPI-staining and oligonucleotide probing. clearly indicate that there has been no toxic effect of NP on microorganisms. In contrast, a stimulating effect on the bacteria could be observed with increased ...
... The ratio of EUBrDAPI did not change significantly with different amounts of NP. These results ŽDAPI-staining and oligonucleotide probing. clearly indicate that there has been no toxic effect of NP on microorganisms. In contrast, a stimulating effect on the bacteria could be observed with increased ...
Lysosomal Sequestration of Polyamine
... MGBG analogues because of its potent and selective enzyme inhib itory properties, its metabolic stability, and, most importantly, its minimized antimitochondrial activity (3-5). The specificity of the inhibitor in cell culture conditions is based on observed alterations in polyamine pool perturbatio ...
... MGBG analogues because of its potent and selective enzyme inhib itory properties, its metabolic stability, and, most importantly, its minimized antimitochondrial activity (3-5). The specificity of the inhibitor in cell culture conditions is based on observed alterations in polyamine pool perturbatio ...
Document
... 1. All three are secreted soluble factors that elicit their biological effects at pM concentrations. 2. Growth factors tend to be produced constitutively, whereas cytokine production is carefully regulated. Cytokines are usually secreted after activation of a particular cell, and secretion is short- ...
... 1. All three are secreted soluble factors that elicit their biological effects at pM concentrations. 2. Growth factors tend to be produced constitutively, whereas cytokine production is carefully regulated. Cytokines are usually secreted after activation of a particular cell, and secretion is short- ...
PC7 and the related proteases Furin and Pace4 regulate E
... inner and outer cells, and the regulation of Cdx2 expression critically depend on the cell–cell adhesion molecule E-cadherin (Stephenson et al., 2012). Until the early eight-cell stage, E-cadherin localizes on all cell surfaces, but thereafter becomes restricted to cell contacts during compaction (V ...
... inner and outer cells, and the regulation of Cdx2 expression critically depend on the cell–cell adhesion molecule E-cadherin (Stephenson et al., 2012). Until the early eight-cell stage, E-cadherin localizes on all cell surfaces, but thereafter becomes restricted to cell contacts during compaction (V ...
separation of cell types from embryonic chicken and rat spinal cord
... defined at the cellular level and these include cell proliferation, differentiation, migration, growth, and death. A large body of information from experimental embryology suggests that specific interactions between cells, either by direct contact or via humoral factors, influence all of these featu ...
... defined at the cellular level and these include cell proliferation, differentiation, migration, growth, and death. A large body of information from experimental embryology suggests that specific interactions between cells, either by direct contact or via humoral factors, influence all of these featu ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.