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Chapter 3.05
Chapter 3.05

... N-acetylhexosamine and uronic acid, and exist as proteoglycans (PGs) by attaching to specific serine residues in the core protein.1–3 PGs are ubiquitously distributed on the cell surface and in the extracellular matrix and play critical roles in a variety of physiological phenomena such as cell–cell ...
Susana Lopes, PhD Institution: CEDOC
Susana Lopes, PhD Institution: CEDOC

... This project sets out to investigate the role of time in the left-right organizer (LRO). This transient embryonic organ is crucial for determining the left-right identity of the vertebrate body-plan. Inside this organ there are exciting biophysical mechanisms of development to be investigated. Namel ...
A COMPARISON OF THE CYTOPLASMIC CHANGES INDUCED IN
A COMPARISON OF THE CYTOPLASMIC CHANGES INDUCED IN

... The changes in the cytoplasm of both normal and tumor cells induced by radiation have been described by many workers, including Stenstrom, Alter, Kimura, Dustin, Lucas, Spear, Whitman, Ludford, and others (1-8). The present study is an attempt to compare the changes that occur in the Golgi apparatus ...
Multiple Mechanisms of Resistance to Polyglutamatable and
Multiple Mechanisms of Resistance to Polyglutamatable and

... (Allegra et al., 1987; Borst and Ouelette, 1995). Because lipophilic antifolates can enter cells and tissues by passive or facilitated diffusion, they have been exploited as anticancer agents to circumvent transport-related resistance to classic antifolate drugs such as methotrexate (MTX) (Bertino, ...
Changes in the expression of the carbohydrate
Changes in the expression of the carbohydrate

... HNK-1 and mesoderm induction with other HNK-1-positive cells of the posterior marginal zone. It is rare to see an isolated HNK-1positive cell in this region. After examining many sections of early stage blastoderms, we have localized these exclusively to a narrow crescent in the posterior margin of ...
Characterization of the pH of Folate Receptor
Characterization of the pH of Folate Receptor

... equimolar quantities of folate-FITC (a pH-sensitive dye conjugate) and folate-rhodamine (a pH-insensitive dye conjugate) and then measured endosomal pH by quantitating the ratio of green (fluorescein) to red (rhodamine) fluorescence in each endocytic vesicle. By comparing this ratio to the same rati ...
TOPIC 1. CELL CHARACTERISTICS AND DIGESTIBILITIES What
TOPIC 1. CELL CHARACTERISTICS AND DIGESTIBILITIES What

... alkaloids, essential oils, and organic acids. Those substances, apparently not involved in the basic metabolism of a plant, do reduce herbivory. It must also be pointed out that wild ruminants make up a very small portion of the worldl's herbivores; insects, though much smaller, have the potential f ...
Do Bacteria have Mitotic Spindles, Fusion Tubes and
Do Bacteria have Mitotic Spindles, Fusion Tubes and

... The growing points of Bacterium coli P1. 2, fig. 16, shows a preparation of Bact. coli, unhydrolysed and stained with dilute Giemsa. The stainable areas a t the growing tips and at the points of division (Bergersen, 1952; Bisset, 1948a, 1951 b, 19523) are clearly seen. These stain reasonably well wi ...
glossary - McGraw Hill Higher Education
glossary - McGraw Hill Higher Education

... rates with respect to each other. allopatric speciation A geographic separation of populations leading to divergent evolution and formation of new species. allopolyploid An organism that contains two or more complete sets of chromosomes from two or more different species. allostasis The re-establish ...
A comparison between nuclear dismantling during plant and animal
A comparison between nuclear dismantling during plant and animal

... Therefore, both morphological and biochemical characteristics suggest that plants and animals have developed different strategies that perform cell death. The study of PCD has been a major field of research in different animal model systems not only because it is an essential process to understand d ...
The many ways to age for a single yeast cell
The many ways to age for a single yeast cell

... The identification and characterization of the molecular determinants governing ageing represents the key to counteracting age-related diseases and eventually prolonging our health span. A large number of fundamental insights into the ageing process have been provided by research into the budding yea ...
Formation of Lys63-linked polyubiquitin chains on Gap1p permease
Formation of Lys63-linked polyubiquitin chains on Gap1p permease

... restore NH4+-induced down-regulation of the Gap1p permease. As expected, addition of NH4+ ions to this strain triggered down-regulation of Gap1p similar to that observed in the wildtype strain (Fig. 1A). To confirm that NPI2 is allelic with DOA4, we cloned a DNA fragment containing the YDR069c ORF o ...
Introduction to the Schwann cell - Assets
Introduction to the Schwann cell - Assets

... important functions remained rudimentary. However, the interdependence between the Schwann cell and the neuron underpins the functioning of the entire PNS, and the fates of these two cell types are inextricably entwined (like star-crossed lovers) so that it is no longer valid to consider Schwann cel ...
Cytotoxic T Cells Sufficient to Induce Primary and Memory Soluble
Cytotoxic T Cells Sufficient to Induce Primary and Memory Soluble

... cells, presumably due to competition in the response by the much larger number of Ag-specific transferred cells (data not shown). These results along with those from the adoptive transfer studies indicated that CD40 signaling delivered a powerful proliferative signal to CD8 T cells. CD40 expression ...
Digging for the roots of amoeboid motility
Digging for the roots of amoeboid motility

... Even deeper insight can be obtained from phylogenetic studies of cell biological processes: It has become clear that suites of proteins involved in a particular structure or function are often maintained or lost in tandem. These observations can define the proteins involved in particular cellular fu ...
Meristem-Specific Suppression of Mitosis and a
Meristem-Specific Suppression of Mitosis and a

... cap development, including the structural genes that give specific cell types their unique properties, the regulatory genes and receptors that control the process, or the signals that trigger it (Jacobs, 1994). Studies in our laboratory have confirmed an observation first documented in 1919: the slo ...
Scanned by CamScanner
Scanned by CamScanner

... are undergoing critical early developmental processes such as zygotic genome activation (ZGA) are very susceptible. This event occurs at approximately 3 hours post fertilization (hpf) during the mid blastula transition in zebrafish and at the 4cell stage in humans. Previous to this event, all mRNA f ...
Full PDF - Cancer Research
Full PDF - Cancer Research

... studies. When combined with a candidate protein or viral antigen in mice, poly(A:U) can promote antigen-specific Th1immune responses and boost antibody production (10, 11). Poly(A:U) has been safely used with moderate success for treating breast or gastric cancers as a monotherapy (12– 14). Retrospe ...
Chromosomal DNA demethylation specified by
Chromosomal DNA demethylation specified by

... the experimental interval. These findings suggest that the amount of LacI in the cells plays a role in the percentage of lacO demethylation and the occupancy of lacO by LacI protein is important for lacO demethylation. This study showed that a DNA-binding protein can specify demethylation at its bin ...
In plants which portion occurs transpiration?
In plants which portion occurs transpiration?

...  Which part of plant is the main organ of transpiration?  How many guard cell adjacent the stomata?  Which layer of guard cell is thick?  How many nucleus contains each guard cell? ...
Gene Section CSNK1A1 (casein kinase 1, alpha 1) in Oncology and Haematology
Gene Section CSNK1A1 (casein kinase 1, alpha 1) in Oncology and Haematology

... The Wnt pathway is a complex signaling cascade regulating cell proliferation and differentiation. During recent years, the significance of Wnt signaling in human cancer has been elucidated. Identification of numerous pathway components and mutations in the encoding genes finally result in stabilizat ...
genes and enzyme complexes for polysaccharide synthases
genes and enzyme complexes for polysaccharide synthases

... related to CESAs from other species that are expressed in secondary-wall-forming tissues such as cotton fiber and pine xylem. Expression patterns of CesA genes, as studied by in situ hybridization, support the groupings made on the basis of sequence comparisons [29••]. These findings suggest that th ...
Exploring Bioinorganic Pattern Formation in Diatoms. A Story of
Exploring Bioinorganic Pattern Formation in Diatoms. A Story of

... the two daughter cells (Kröger and Wetherbee, 2000). Association with the terminal girdle band of the hypotheca therefore occurs in the extracellular space. Secretion is thought to occur by general mechanisms of exocytosis, but it is nonetheless an intriguing example of polarized transport specific ...
Organelle Division and Cytoplasmic Inheritance
Organelle Division and Cytoplasmic Inheritance

... bacterial endosymbionts, there may ha ve been a dividing ring such as the FtsZ ring inside chloroplasts and mitochondria at an early stage of evolution (Figure I-H, Ig). However, the nucleus eventually came to control the organelle division from the outside, using PD- and MD-rings made from actinlik ...
LEAVES PRIMITIVE VASCULAR PLANTS CONSISTED OF
LEAVES PRIMITIVE VASCULAR PLANTS CONSISTED OF

... ...
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Cellular differentiation



In developmental biology, cellular differentiation isa cell changes from one cell type to another. Most commonly this is a less specialized type becoming a more specialized type, such as during cell growth. Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, membrane potential, metabolic activity, and responsiveness to signals. These changes are largely due to highly controlled modifications in gene expression and are the study of epigenetics. With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Thus, different cells can have very different physical characteristics despite having the same genome.A cell that can differentiate into all cell types of the adult organism is known as pluripotent. Such cells are called embryonic stem cells in animals and meristematic cells in higher plants. A cell that can differentiate into all cell types, including the placental tissue, is known as totipotent. In mammals, only the zygote and subsequent blastomeres are totipotent, while in plants many differentiated cells can become totipotent with simple laboratory techniques. In cytopathology, the level of cellular differentiation is used as a measure of cancer progression. ""Grade"" is a marker of how differentiated a cell in a tumor is.
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