Hallmarks of epithelial to mesenchymal transition are detectable in
... the fact that the pathogenesis of CD-related fibrosis is only poorly understood. Here, we demonstrate the presence of EMT-associated events in fibrotic areas of colonic tissue specimens derived from CD patients. A characteristic feature of EMT is the translocation of β-catenin from the cytosol, whe ...
... the fact that the pathogenesis of CD-related fibrosis is only poorly understood. Here, we demonstrate the presence of EMT-associated events in fibrotic areas of colonic tissue specimens derived from CD patients. A characteristic feature of EMT is the translocation of β-catenin from the cytosol, whe ...
Essential roles of the Fas-Fas ligand pathway in the development of
... Model of bleomycin-induced pulmonary fibrosis in mice. Six- pathological grade for each lung section was deterweek-old ICR mice were used in the study of hFas-Fc. mined according to the following criteria: 0 = no lung Following measurement of their body weight, the ani- abnormality; 1 = presence of ...
... Model of bleomycin-induced pulmonary fibrosis in mice. Six- pathological grade for each lung section was deterweek-old ICR mice were used in the study of hFas-Fc. mined according to the following criteria: 0 = no lung Following measurement of their body weight, the ani- abnormality; 1 = presence of ...
Starfish ApDOCK protein essentially functions in larval
... subsequently migrated to the ectodermal and mesendodermal walls (n4100, respectively). By using MC5 monoclonal antibody (mAb) (see Methods), we examined the spatial distribution of mesenchyme cells from thirty 4-day-old ApDOCK-MO and control-MO larvae; these larvae were obtained from eggs that had b ...
... subsequently migrated to the ectodermal and mesendodermal walls (n4100, respectively). By using MC5 monoclonal antibody (mAb) (see Methods), we examined the spatial distribution of mesenchyme cells from thirty 4-day-old ApDOCK-MO and control-MO larvae; these larvae were obtained from eggs that had b ...
PHAGOLYSOSOME FORMATION IN NORMAL AND
... colchicine (1-6) or vinblastine (7) would inhibit fusion of lysosomes with phagosomes or pinosomes . We have previously shown (8) that in the macrophage no inhibition of lysosomal fusion resulting from microtubular disruption could be demonstrated by evaluation of the functional consequences of fusi ...
... colchicine (1-6) or vinblastine (7) would inhibit fusion of lysosomes with phagosomes or pinosomes . We have previously shown (8) that in the macrophage no inhibition of lysosomal fusion resulting from microtubular disruption could be demonstrated by evaluation of the functional consequences of fusi ...
Retinal Ganglion Cells in Goldfish
... The dendrites of a single subtype of ganglion cell (see below) were digitized using a Zeiss Universal microscope (2000x magnification), interfaced with a PDP 1l/34 computer through stepping motors on the mechanical controls of the stage and fine focus. Data points were entered sequentially, every 5- ...
... The dendrites of a single subtype of ganglion cell (see below) were digitized using a Zeiss Universal microscope (2000x magnification), interfaced with a PDP 1l/34 computer through stepping motors on the mechanical controls of the stage and fine focus. Data points were entered sequentially, every 5- ...
Cultivation of Trypanosoma brucei sspp. in
... greatest obstacle to the development of a defined medium. It was assumed that its removal would necessitate the addition of haemin, but it was thought likely that the lysate would be supplying other essential growth factors. The lysate was found to contain free fatty acids including linoleic acid. O ...
... greatest obstacle to the development of a defined medium. It was assumed that its removal would necessitate the addition of haemin, but it was thought likely that the lysate would be supplying other essential growth factors. The lysate was found to contain free fatty acids including linoleic acid. O ...
Diversification of epithelial adherens junctions with independent
... EGF-like (CE) domain, and the laminin globular-like (LG) domain (Oda and Tsukita 1999). All known nonchordate cadherins and chick cHz-cadherin have a domain complex called the primitive classic cadherin domain (PCCD) complex (Oda and Tsukita 1999; Oda et al. 2002) which consists of NC, CE, and LG do ...
... EGF-like (CE) domain, and the laminin globular-like (LG) domain (Oda and Tsukita 1999). All known nonchordate cadherins and chick cHz-cadherin have a domain complex called the primitive classic cadherin domain (PCCD) complex (Oda and Tsukita 1999; Oda et al. 2002) which consists of NC, CE, and LG do ...
RNA Processing Bodies, Peroxisomes, Golgi
... et al. 2010). Interestingly, although actin filaments sustain long-distance transport of plant organelles, it has recently been observed that microtubules influence short-distance behavior, causing pauses for both peroxisomes (Chuong et al. 2005) and the Golgi (Crowell et al. 2009, Gutierrez et al. ...
... et al. 2010). Interestingly, although actin filaments sustain long-distance transport of plant organelles, it has recently been observed that microtubules influence short-distance behavior, causing pauses for both peroxisomes (Chuong et al. 2005) and the Golgi (Crowell et al. 2009, Gutierrez et al. ...
Document
... stance which is not characteristic of M. avium infection, there may be clinical evidence of infection including an elevation in body temperature, anorexia, and weight loss.^' ^ Tuberculous lesions in swine are usually limited to the lymph nodes of the pharyngeal a ...
... stance which is not characteristic of M. avium infection, there may be clinical evidence of infection including an elevation in body temperature, anorexia, and weight loss.^' ^ Tuberculous lesions in swine are usually limited to the lymph nodes of the pharyngeal a ...
How and why does β-actin mRNA target?
... microtubule depolymerizing drug) and kinesin antisense oligonucleotides inhibit transport of microinjected MBP mRNA (Carson et al., 1997). In addition, Staufen, the mRNA-binding protein that is required for Oskar and Bicoid mRNA localization in Drosophila (St Johnston et al., 1991), induces the form ...
... microtubule depolymerizing drug) and kinesin antisense oligonucleotides inhibit transport of microinjected MBP mRNA (Carson et al., 1997). In addition, Staufen, the mRNA-binding protein that is required for Oskar and Bicoid mRNA localization in Drosophila (St Johnston et al., 1991), induces the form ...
Establishment of Polarity during Organization of the Acentrosomal
... stochastic parameters, which by themselves do not explain how cortical MT organization can occur. Recently, it was shown that the stochastic cortical MT dynamics are deterministically modified by the angle at which they encounter one another (Dixit and Cyr, 2004b). These deterministic events provide ...
... stochastic parameters, which by themselves do not explain how cortical MT organization can occur. Recently, it was shown that the stochastic cortical MT dynamics are deterministically modified by the angle at which they encounter one another (Dixit and Cyr, 2004b). These deterministic events provide ...
Chapter 3 Cells and Tissues
... – Formerly thought to be responsible for apoptosis (programmed cell death) Centrosome ...
... – Formerly thought to be responsible for apoptosis (programmed cell death) Centrosome ...
USMLE MAY 14
... are outpouchings of tissue visible on the external neck of the embryo. They are separated by the pharyngeal clefts (each one caudal to its arch). • The pharyngeal pouches are the outpouchings of the pharynx visible inside the embryo that correspond to the arches. • The defect described is due to abn ...
... are outpouchings of tissue visible on the external neck of the embryo. They are separated by the pharyngeal clefts (each one caudal to its arch). • The pharyngeal pouches are the outpouchings of the pharynx visible inside the embryo that correspond to the arches. • The defect described is due to abn ...
In-Cell Solid-State NMR - Institut de Biologie Physico
... versus specific labeling of the alanines) and many parameters were optimized to reduce the intensity of lipid signals versus protein signals. Purified membrane signals were also compared with signals of the same protein reconstituted in detergent micelles. The following year, in-cell 13C and 15N MAS ...
... versus specific labeling of the alanines) and many parameters were optimized to reduce the intensity of lipid signals versus protein signals. Purified membrane signals were also compared with signals of the same protein reconstituted in detergent micelles. The following year, in-cell 13C and 15N MAS ...
The Vam6 GEF Controls TORC1 by Activating the
... loading of RagA/B, but it is not known which factors regulate the GTP loading of these GTPases. We previously reported that the EGO complex in yeast, consisting of Ego1/Meh1, Ego3/Slm4, Gtr2, and Gtr1, which was identified subsequently (Gao and Kaiser, 2006; Gao et al., 2005), may function upstream o ...
... loading of RagA/B, but it is not known which factors regulate the GTP loading of these GTPases. We previously reported that the EGO complex in yeast, consisting of Ego1/Meh1, Ego3/Slm4, Gtr2, and Gtr1, which was identified subsequently (Gao and Kaiser, 2006; Gao et al., 2005), may function upstream o ...
regulates cortical cell migration out of the
... GABAergic neurons migrate into the neocortex1 and lateral olfactory tract guidepost neurons migrate from the neocortex2, radial migration of neurons from the ventricular zone within the neocortex towards the pial surface is essential and supplies most neocortical excitatory neurons3–6. In this radia ...
... GABAergic neurons migrate into the neocortex1 and lateral olfactory tract guidepost neurons migrate from the neocortex2, radial migration of neurons from the ventricular zone within the neocortex towards the pial surface is essential and supplies most neocortical excitatory neurons3–6. In this radia ...
Ultrastructural Observations on Lumbar Spinal Cord
... Eight individuals with transected lumbar spinal cord, previously utilized for the analysis of behavioral recovery and histology at 29, 36 and 45 post-lesion were also utilized for the present electron microscopic study (Alibardi, 2010, 2014). The progressive time-points were selected to detect possi ...
... Eight individuals with transected lumbar spinal cord, previously utilized for the analysis of behavioral recovery and histology at 29, 36 and 45 post-lesion were also utilized for the present electron microscopic study (Alibardi, 2010, 2014). The progressive time-points were selected to detect possi ...
Xenopus ADAM13 and ADAM19 are Important for Proper
... underlying this process can be classified into a variety of different types of cellular movements. I will focus on investigating in this thesis two types of cell movements in the dorsal mesoderm; mediolateral cell intercalation and convergence and extension. During gastrulation, mesoderm cells send ...
... underlying this process can be classified into a variety of different types of cellular movements. I will focus on investigating in this thesis two types of cell movements in the dorsal mesoderm; mediolateral cell intercalation and convergence and extension. During gastrulation, mesoderm cells send ...
One-eyed pinhead regulates cell motility independent of Squint
... and human cripto, Xenopus FRL-1 and zebrafish one-eyed pinhead (oep), encode extracellular molecules essential during early vertebrate development (Schier and Shen, 2000). These genes also may play a role in oncogenesis. The first member of this family, cripto, was identified as a gene expressed in ...
... and human cripto, Xenopus FRL-1 and zebrafish one-eyed pinhead (oep), encode extracellular molecules essential during early vertebrate development (Schier and Shen, 2000). These genes also may play a role in oncogenesis. The first member of this family, cripto, was identified as a gene expressed in ...
ER storage diseases: a role for ERGIC
... microscopy. At day 4, small, bright dots became evident in 2040% of ⌬CH1 producing cells (see inset). These dots, usually one in each cell, probably represent the first morphological sign of ⌬CH1 aggregation. With time, they increased progressively in size, and this correlated with an increase in ...
... microscopy. At day 4, small, bright dots became evident in 2040% of ⌬CH1 producing cells (see inset). These dots, usually one in each cell, probably represent the first morphological sign of ⌬CH1 aggregation. With time, they increased progressively in size, and this correlated with an increase in ...
Intracellular calcium: friend or foe?
... outside, the cell is able to accumulate up to millimolar concentrations of the indicator inside. Though these fluors have now been used widely in many cells types their precise intracellular location has rarely been fully documented. Other complications can be ester hydrolysis, occurring extracellul ...
... outside, the cell is able to accumulate up to millimolar concentrations of the indicator inside. Though these fluors have now been used widely in many cells types their precise intracellular location has rarely been fully documented. Other complications can be ester hydrolysis, occurring extracellul ...
Regulation of tubulin heterodimer partitioning during interphase and
... and evolution of multi-cellular organisms. The cytoskeleton encompasses microtubules, intermediate filaments and actin filaments (also known as microfilaments), which are polymers of evolutionary conserved protein subunits. Given that polymerization of these subunits in general is rapid and reversib ...
... and evolution of multi-cellular organisms. The cytoskeleton encompasses microtubules, intermediate filaments and actin filaments (also known as microfilaments), which are polymers of evolutionary conserved protein subunits. Given that polymerization of these subunits in general is rapid and reversib ...
Epithelium of Mice T Cells in the Small Intestinal δγ with Variable
... fraction of TCR ␥␦⫹ intestinal intraepithelial lymphocytes (IEL) express TCRGV gene 5 (TCRGV5), often in conjunction with TCRDV4 in C57BL/6 mice (nomenclature of Garman et al. (2)). DETC express TCRGV3, and the few ␥␦⫹ T cells in nonmucosal/ epithelial sites in the periphery of mice use TCRGV1.1, TC ...
... fraction of TCR ␥␦⫹ intestinal intraepithelial lymphocytes (IEL) express TCRGV gene 5 (TCRGV5), often in conjunction with TCRDV4 in C57BL/6 mice (nomenclature of Garman et al. (2)). DETC express TCRGV3, and the few ␥␦⫹ T cells in nonmucosal/ epithelial sites in the periphery of mice use TCRGV1.1, TC ...
A Simple and Efficient Method for Isolating Trichomes for
... be suitable for nuclear DNA content measurements by staining isolated mature trichomes with DAPI. We found that staining of mature trichome nuclei was strong and consistent (Fig. 2B). Because the trichomes are stained and viewed after their removal from the leaves, background fluorescence from other ...
... be suitable for nuclear DNA content measurements by staining isolated mature trichomes with DAPI. We found that staining of mature trichome nuclei was strong and consistent (Fig. 2B). Because the trichomes are stained and viewed after their removal from the leaves, background fluorescence from other ...
Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).