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Review on N acylation reaction
Review on N acylation reaction

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Acid strength

The strength of an acid refers to its ability or tendency to lose a proton (H+). A strong acid is one that completely ionizes (dissociates) in a solution. In water, one mole of a strong acid HA dissolves yielding one mole of H+ (as hydronium ion H3O+) and one mole of the conjugate base, A−. Essentially, none of the non-ionized acid HA remains. Examples of strong acids are hydrochloric acid (HCl), hydroiodic acid (HI), hydrobromic acid (HBr), perchloric acid (HClO4), nitric acid (HNO3) and sulfuric acid (H2SO4). In aqueous solution, each of these essentially ionizes 100%.In contrast, a weak acid only partially dissociates. Examples in water include carbonic acid (H2CO3) and acetic acid (CH3COOH). At equilibrium, both the acid and the conjugate base are present in solution.Stronger acids have a larger acid dissociation constant (Ka) and a smaller logarithmic constant (pKa = - log Ka) than weaker acids. The stronger an acid is, the more easily it loses a proton, H+. Two key factors that contribute to the ease of deprotonation are the polarity of the H—A bond and the size of atom A, which determines the strength of the H—A bond. Acid strengths also depend on the stability of the conjugate base.While Ka measures the strength of an acidic molecule, the strength of an aqueous acid solution is measured by pH, which is a function of the concentration of hydronium ions in solution. The pH of a simple solution of an acid in water is determined by both Ka and the acid concentration. For weak acid solutions, it depends on the degree of dissociation, which may be determined by an equilibrium calculation. For concentrated solutions of strong acids with a pH less than about zero, the Hammett acidity function is a better measure of acidity than the pH.Sulfonic acids, which are organic oxyacids, are a class of strong acids. A common example is p-toluenesulfonic acid (tosylic acid). Unlike sulfuric acid itself, sulfonic acids can be solids. In fact, polystyrene functionalized into polystyrene sulfonate is a solid strongly acidic plastic that is filterable.Superacids are acid solutions that are more acidic than 100% sulfuric acid. Examples of superacids are fluoroantimonic acid, magic acid and perchloric acid. Superacids can permanently protonate water to give ionic, crystalline hydronium ""salts"". They can also quantitatively stabilize carbocations.
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