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Conditioning: Simple Neural Circuits in the Honeybee
Conditioning: Simple Neural Circuits in the Honeybee

... both enhancement and reduction of odor responses. Second, the postsynaptic sites of lateral PN neurons within the glomeruli show spontaneous Ca2þ fluctuations. After stimulation with an odor, these spontaneous activity fluctuations are more strongly correlated between the glomeruli that had been act ...
What We Can and What We Can`t Do with fMRI
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... of small neural populations in a 100–300 μm radius sphere; and • Perisynaptic activity of a neural population within 0.5–3.0 mm of the electrode tip, which is reflected in the variation of the low-frequency components of the EFP. MUA and local field potential (LFP) can be reliably segregated by freq ...
04/16 PPT - Molecular and Cell Biology
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... • During learning of a new motor task, subject makes mistakes, but the error reduces with practice • The standard notion is that the “error signal” causes changes in brain circuits involved in motor control (e.g., cerebellum), thus improving motor performance ...
Lecture Test 2 2010
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Lecture 6 Locomotion • Early 20th century experiments showed that
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control systems of the body - chapter 11
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... brain's glia to neuron ratio, Hilgetag and Helen Barbas of Boston University highlight the research of neurophysiologist Suzana Herculano-Houzel of the Instituto de Ciências Biomé́dicas/Federal University of Rio de Janeiro, Brazil. She has developed a unique, speedy method for counting all the cells ...
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Synapses - JNCASR Desktop
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lecture9
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Lecture 2 Imaging, Brain Development
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CPB748_JK Nervous
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... salt solution. One end of the tube tapers to an extremely fine tip (diameter < 1 µm). While looking through a microscope, the experimenter uses a micropositioner to insert the tip of the microelectrode into a cell. A voltage recorder (usually an oscilloscope or a computer-based system) measures the ...
Ramayya, A. G., Zaghloul, K. A., Weidemann, C. T., Baltuch, G. H.
Ramayya, A. G., Zaghloul, K. A., Weidemann, C. T., Baltuch, G. H.

... neurons in the SN demonstrate phasic bursts of activity following unexpected rewards, consistent with a reward prediction error (Zaghloul et al., 2009). Second, microstimulation applied in the SN following rewards alters learning by enhancing the reinforcement of preceding actions (Ramayya et al., 2 ...
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2.2.1 Neuron

... In your brain alone, you have as many as 100 billion neurons. But, don’t brag. An octopus has on average 300 billion neurons in its brain. Your neurons vary greatly in size, from as small as 4 microns to as large as nearly one meter. But, if you were to line up all the neurons in your body in a stra ...
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... • The nerve cell membrane pumps sodium (Na+) out of the cell and potassium (K+) into the cell ...
A soft-wired hypothalamus
A soft-wired hypothalamus

... wiring pattern of the hypothalamic peptidergic circuits. Two distinct populations of neurons of the melanocortin system were analyzed: the NPY/AgRP and POMC neurons. Although these studies focused on the arcuate nucleus melanocortin system, it is important to emphasize that regulation of energy meta ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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