• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Ch04
Ch04

... • Measuring activity in a control state • Measuring activity in a stimulation state • Subtracting the control activity from the stimulation activity ...
Chapter 4
Chapter 4

... • Measuring activity in a control state • Measuring activity in a stimulation state • Subtracting the control activity from the stimulation activity ...
Neuronal circuitries involved in thermoregulation
Neuronal circuitries involved in thermoregulation

... investigating thermoregulation directed their efforts to the analysis of these thermosensitive neurons. Their (implicit) assumption was that thermosensitivity is a distinctive characteristic of neurons playing a role in thermoregulation. Neurons displaying thermosensitivity, however, could be record ...
58 Limbic System Physiology
58 Limbic System Physiology

... The three principles of memory are: – Storage – occurs in stages and is continually ...
BASICS OF NEUROBIOLOGY Zsolt Liposits and Imre Kalló 2016
BASICS OF NEUROBIOLOGY Zsolt Liposits and Imre Kalló 2016

... The first lecture describes the major steps of nervous system development from the formation of neural plate till the cyto-differentiation of the cerebral cortex. The second lecture provides an overview about the structural organization of the spinal cord, and explains the term of spinal cord segmen ...
NERVE SYSTEM The nervous system is divided anatomically into
NERVE SYSTEM The nervous system is divided anatomically into

... Cells of Martinotti are small polygonal cells with a few short dendrites; the axon extends towards the surface and bifurcates to run horizontally, usually in the most superficial layer. Fusiform cells are spindle-shaped cells oriented at right angles to the surface of the cerebral cortex. The axon a ...
Neuro Review for Quiz 1 (lectures organized according
Neuro Review for Quiz 1 (lectures organized according

...  Glial cells convert Glutamate to Lactate, which it uses as energy source. Glial cells will provide Glutamare precursor, Glutamine  Glial cells sense and modulates metabolic activity of neuron (via Glutamate)  Receptors: -need to be specific for neurotransmitter substances -need to be saturable - ...
Nerve impulses and Synapses Electro
Nerve impulses and Synapses Electro

... acetyl-cholinesterase (AChE), preventing binding to another AChR. • The choline produced by ACh breakdown is taken back up into the presynaptic bouton and recycled. ...
Dear Notetaker:
Dear Notetaker:

... o In the retina and LGN there are neurons that are classified as M-like, P-like, or K-like with different anatomical features and functions o In V1 the info from P, K, and M cells is recombined, it does not stay segregated o The recombined info is sent to extra striate areas for even more processing ...
PPTX - Bonham Chemistry
PPTX - Bonham Chemistry

... gland into the bloodstream and transported therein to reach its target cell. The distinction between a neurotransmitter and a hormone is physiological, not chemical. It depends on whether the molecule acts over a short distance (across a synapse) or over a long distance (from the secretory organ, th ...
Untitled - inetTeacher
Untitled - inetTeacher

... • Messages are sent from the axon terminals of one neuron to the dendrites of other neurons • In order for this process to happen, the message must cross a synapse. • A synapse is a junction between the axon terminals of one neuron and the dendrites of another. • Messages travel in only one directio ...
The Nervous System
The Nervous System

... between neurons that the action potential cannot “jump”. They are just too far apart. When the signal reaches the end of the axon and wants to go to the next cell in line, it must change to a chemical messenger instead of an electrical impulse. These chemical messengers are called neurotransmitters ...
the physiological approach
the physiological approach

... K Na Na Na+Na+ + ...
Information processes in neurons
Information processes in neurons

... the neurons should have continuous input-output relations, moreover real neurons and circuits have integration time delays due to the capacitance of the neuronal membrane. Therefore, the time evolution of the state of such systems should be represented by a continuous time representation. In his res ...
Timing of Impulses From the Central Amygdala and Bed Nucleus of
Timing of Impulses From the Central Amygdala and Bed Nucleus of

... by combining micrometer readings and histology. To be included in the analysis, cells had to be histologically confirmed as being located in the regions of interest. Analyses were performed off-line with commercial software (IGOR, WaveMetrics, Lake Oswego, OR; Matlab, Natick, MA) and custom-designed ...
Neuroanatomy 18 [4-20
Neuroanatomy 18 [4-20

... Output from hippocampus via subiculum (and then fornix): Diencephalon and septal nuclei ...
Brain Anatomy “Science erases what was previously true.”
Brain Anatomy “Science erases what was previously true.”

... negative events, like a punishment out of the blue,  or the absence of an expected reward. It is part of  the “disappointment circuit.” It lacks an opposing  set of neuronal inputs. Antidepressants are active  here, and may correct the negative bias present in  ...
Cognitive Disorders
Cognitive Disorders

... •Clear organic causes, where primary symptom is a significant deficit in cognitive ability •changes in the person’s personality and behavior (due to the brain disorder) ...
Chapter 9
Chapter 9

... o  Contains sensory receptors that convert info into a nerve impulse and transmit it back to the CNS to make sense of it. o  Monitors environmental changes such as light and sound o  Detects changes in homeostasis ( ex: temperature, oxygen level) ...
File Now
File Now

... most widely available neurotransmitter, paradoxically both main neurotransmitter for memory and main one responsible for cell death ...
Ch 28 CNS Money [5-11
Ch 28 CNS Money [5-11

... o loss of reflexes o amnesia for the event o post-concussive neuropsychiatric syndromes - direct parenchymal injuries o contusion (bruising)  wedge shaped  edema/hemorrhage  evidence of neuronal injury in about 24 hrs o laceration (penetration and tearing of tissue) o crests of gyri most suscepti ...
Auditory Nerve - Neurobiology of Hearing
Auditory Nerve - Neurobiology of Hearing

... physiological properties suggested that they must have different structural properties. Charlie Liberman and I were collaborating on this work and while he looked in the inner ear, I looked in the brain. The top panel is a surface preparation view of 3 IHCs. What Charlie found was that the low thres ...
MARMORATAl - Journal of Neuroscience
MARMORATAl - Journal of Neuroscience

... during the life of the animal these antigens first appear, and what the degree of cell differentiation is when the antigens are first expressed. A practical reason also stimulates our interest in studying the developmental pattern of labeling with the mAbs raised to adult tissues. Whereas particular ...
Axonal conduction properties of antidromically identified neurons in
Axonal conduction properties of antidromically identified neurons in

... cortical column contain different types of local circuits. Even within the same lamina, nearby cells may participate in different circuits. Thus, anatomical findings have shown that neurons within the same neuropil may receive quite different patterns of thalamocortical inputs, and, at least in the ...
Document
Document

... Overview: Command and Control System ...
< 1 ... 271 272 273 274 275 276 277 278 279 ... 467 >

Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report