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Optic Glomeruli and Their Inputs inDrosophilaShare an
Optic Glomeruli and Their Inputs inDrosophilaShare an

... Studying the insect visual system provides important data on the basic neural mechanisms underlying visual processing. As in vertebrates, the first step in visual processing in insects is through a series of retinotopic neurons. Recent studies on flies have found that these converge onto assemblies ...
Getting to Know: Nervous
Getting to Know: Nervous

... include sensory, interneuron, and motor neurons. ...
Complexity in Neuronal Networks
Complexity in Neuronal Networks

... both experimentalists and theoreticians, have continued to assume that circuit dynamics depend exclusively on synaptic connectivity and synaptic strength. This view has changed in the last five years, mainly for two reasons: 1) patch recording techniques are no longer restricted to the soma and now ...
Growing Pains for fMRI
Growing Pains for fMRI

... Yet even with the promise of these new tools, fMRI remains limited to revealing correlations between cognitive processes and activity in the brain. “The way to use it well is as one tool in a toolbox, as a way of testing hypotheses where you have converging techniques and evidence,” says Aron. To th ...
Cortical Neurons and Circuits: A Tutorial
Cortical Neurons and Circuits: A Tutorial

... The neocortex is that part of the brain which makes up the outer 2 to 4 mm of the cerebral hemispheres. It is the ‘gray matter’ of the brain lying atop the cerebral ‘white matter’ composed of myelinated axons that interconnect different regions of the brain. All the higher-level psychophysical funct ...
Cortical Neurons and Circuits: A Tutorial
Cortical Neurons and Circuits: A Tutorial

... The neocortex is that part of the brain which makes up the outer 2 to 4 mm of the cerebral hemispheres. It is the ‘gray matter’ of the brain lying atop the cerebral ‘white matter’ composed of myelinated axons that interconnect different regions of the brain. All the higher-level psychophysical funct ...
Artificial Neural Networks
Artificial Neural Networks

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Chapter 15
Chapter 15

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Teacher Guide

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Texture discrimination and unit recordings in the rat
Texture discrimination and unit recordings in the rat

... randomized between the two ports. In Stage 4, discriminanda were introduced using the motorized carousel. White noise cued the presentation of a discriminandum, and when the animal interrupted the light beam, water, accompanied by an explicit click, was delivered to the appropriate lick port. The te ...
Engineering new synaptic connections in the C. elegans connectome
Engineering new synaptic connections in the C. elegans connectome

... direct and specific insertion of new synapses into neural circuits using genetic engineering tools. We have successfully applied this method to C. elegans, and were thus able to edit its connectome.22 How is this done? Our goal was to introduce a new transgenic synapse between 2 neurons A and B. We ...
Neural Network Hidden Layer Number Determination Using Pattern
Neural Network Hidden Layer Number Determination Using Pattern

... number of forms, in a number of group between the two values. The idea is to find that number of group for which a t least 90% from the forms are grouped in groups having the same number of forms. The number of groups obtained will be considered as the optimal number of hidden layers for a neural ne ...
Telencephalic cells take a tangent: non
Telencephalic cells take a tangent: non

... LGE cells migrated to the olfactory bulb, but not to the neocortex50. However, the idea that the LGE also contributes to the cortical interneuron population cannot be discounted. Analysis of mice lacking Nkx2.1, in which the MGE is lost, and in vitro transplantation studies, have suggested that a se ...
pdf 2.5M
pdf 2.5M

... unveiled, overcoming the limitations and criticism that result from working with single-unit or otherwise very small networks [9]. Unstable Periodic Orbits (UPOs) can be stabilized from within chaos, very fast and with minimum perturbation of the original system. The original chaotic attractor conta ...
a real-time spike domain sensory information processing system
a real-time spike domain sensory information processing system

... of processing beyond complex cells. While we have not yet integrated these operations in a single netlist, there are no technical barriers preventing us from doing so. Rather, we are currently limited by the number of I&F neurons available. However, the architecture of the combined system described ...
1 - Center for the Ecological Study of Perception and Action
1 - Center for the Ecological Study of Perception and Action

... 18. An object seen only out of the corner of the eye, in the peripheral vision: A. is best seen in infrared light. B. can only be seen at night. C. activates the opponent-color system. D. primarily stimulates rods. 19. Televisions are designed in a way that is consistent with the YoungHelmholtz theo ...
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3680Lecture27

... – Visual neurons tuned to aspects of that stimulus fire action potentials (single unit recording) – Ensemble depolarizations of pyramidal cells in various parts of visual cortex (and elsewhere) (ERP, MEG) – Increased metabolic demand ensues in various parts of the visual cortex (and elsewhere) (fMRI ...
as a PDF
as a PDF

... the facial nucleus, whereas dorsally located neurons became more concentrated in a region dorsomedial to the oral spinal trigeminal nucleus (Fig. IE). Further caudally, at the level ~10 mm rostral to the obex, the ventral cell group was no longer present, whereas the dorsal group was still quite wel ...
Copper/zinc superoxide dismutase-like
Copper/zinc superoxide dismutase-like

... With only the somata labeled, it was difficult to identify neurons unequivocally by comparison with published data and also to recognize the same neurons in different stages, in that neighboring cell bodies might gain SOD immunoreactivity (-ir). In spite of these ambiguities, some cells and especiall ...
computerized visualization of brainstem respiratory areas
computerized visualization of brainstem respiratory areas

... D2.3  Serious games, simulation and models for medical education Keywords: brainstem, model, reflex, tidal breathing, cough Recent scientific papers showed that respiratory reflexes like cough, aspiration and expiration reflex do not only have a salient role in airway defence but they also have a re ...
Summary - VU Research Portal
Summary - VU Research Portal

... area is the receptive field of the neuron. A neuron with a receptive field that overlaps with a figure fires action potentials at a higher rate than neurons with a receptive field on a background. The difference in firing rate is known as figure-ground modulation (FGM). FGM in early visual cortex is ...
Use of a Recombinant Pseudorabies Virus to
Use of a Recombinant Pseudorabies Virus to

... the intracortical horizontal connections play a decisive role (Sanes and Donoghue, 2000). Our earlier studies revealed that the motor cortices of both hemispheres, interconnected commissurally, are involved in n7x-induced cortical plasticity (Toldi et al., 1999; Farkas et al., 2000). Most of the stu ...
Visual circuits in flies: beginning to see the whole picture
Visual circuits in flies: beginning to see the whole picture

... The eye and the optic lobe The fly eye contains about 800 independent unit eyes called ommatidia, corresponding to 800 pixels in the animal’s visual field. Each ommatidium is composed of eight photoreceptor cells: six outers (R1–6) and two inners (R7 and R8) (for review on this section, see [1]) (Fi ...
1. What different types of attention exist? Name and describe at least
1. What different types of attention exist? Name and describe at least

... through of as a salience map with added top-down / endogenous effects. 4. How would you study the brain areas involved in directing selective attention in humans? A common way to study brain functions in humans is to combine psychophysical studies with brain imaging techniques. This approach is attr ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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