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21. Basal ganglion
21. Basal ganglion

... Originates from the pars compacta of the ipsilateral substantia nigra of the midbrain tegmentum to caudate nucleus and putamen. The neurons of pars compacta contain the dark pigment neuromelanin. Their transmitter is the monoamine dopamine which has both excitatory and inhibitory effects upon striat ...
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... model was driven by temporally and spatially unstructured noise I(t); different instances of Figure 1. Time prediction from sequential neural activity in a memory task. A, Average raster over 18 s for a population of noise was thus the only difference between trisimultaneously recorded neurons durin ...
Lecture 4 : Nervous System
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Untitled
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Regents Biology
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Transcript
Transcript

... lectures are exciting but they can't cover everything, so let me draw you attention to a website, one of our websites that helps supplement some of this. It's called www.biointeractive.org, biointeractive.org. if you go there you'll find streaming videos of all the Holiday Lectures and animations an ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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