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Neurobiology
Neurobiology

... The most striking differences between humans and other animals are in the size and the complexity of our brains. With our big brains we have acquired a rich culture, which far exceeds that of any other species in scope and complexity. We have developed science to understand how and why an immensity ...
Transcript
Transcript

... lectures are exciting but they can't cover everything, so let me draw you attention to a website, one of our websites that helps supplement some of this. It's called www.biointeractive.org, biointeractive.org. if you go there you'll find streaming videos of all the Holiday Lectures and animations an ...
Chater 2 - Study Guide
Chater 2 - Study Guide

... 15. Dr. Frankenstein made a mistake during neurosurgery on his monster. After the operation, the monster “saw” with his ears and “heard” with his eyes. It is likely that Dr. Frankenstein “rewired” neural connections in the monster's: A) hypothalamus. B) cerebellum. C) amygdala. D) thalamus. E) hipp ...
PDF-document - homepage.ruhr-uni
PDF-document - homepage.ruhr-uni

... during specific phases of visually guided reaches (Figure 1). A surprisingly high proportion of the SC units that modulated during the reach tasks were significantly distinct from previously described reach neurons (Werner, 1993; Werner et al., 1997a, 1997b; Stuphorn et al., 1999; Lünenburger et al ...
Natwest Bank - Brain Mind Forum
Natwest Bank - Brain Mind Forum

... punctuation and symbols. And these binary codes are also used to digitise images and music. One of the most powerful aspects of computing is that a stream of programming instructions appears identical to a string of words, part of a picture or piece of music. In the jargon: data and algorithms are i ...
Loss of Notch Activity in the Developing Central Nervous System
Loss of Notch Activity in the Developing Central Nervous System

... thought to regulate glial versus neuronal identity [Wang et al., 1998; Furukawa et al., 2000; Gaiano et al., 2000; Morrison et al., 2000]. Radial glia are stem cells in the nervous system [Malatesta et al., 2000; Noctor et al., 2001, 2004; Anthony et al., 2004] and brain lipid binding protein, a ma ...
Eye presentation
Eye presentation

... ● they are embedded in membranous discs that are stacked within the receptor cells. Iodopsins ● light sensitive pigment in cones ...
Ear to Auditory Cortex
Ear to Auditory Cortex

... that smells trigger have 200 million more brain activity in receptors. women than in men. Research indicates that women’s smell sensitivity is better than that of men. ...
PDF - Molecules and Cells
PDF - Molecules and Cells

... (Zeiss). All confocal images are maximal intensity Z-projections. We performed all image processing with ImageJ. Statistics We used GraphPad Prism 5 to compare experimental groups with multiple control groups using the ANOVA followed by Tukey’s test for multiple comparisons. ...
GI Physiology I: Introduction & Motility Mechanisms
GI Physiology I: Introduction & Motility Mechanisms

... Cells mediate between efferent neurons and smooth muscle cells: Responsible for slow waves and pacemaker activity of smooth muscle. Also amplify neuronal input. Central to GI motility regulation. Loss of ICC implicated in many human motility disorders (Hirshsprung’s disease, severe constipation, IBD ...
Steroids: The Brain`s Response
Steroids: The Brain`s Response

... Many of the effects of steroids are brought about through their actions in the brain. Once steroids enter the brain, they are distributed to many regions, including the hypothalamus and limbic system. When a person takes steroids, the functioning of neurons in both of these areas is altered, resulti ...
Here - Statistical Analysis of Neuronal Data
Here - Statistical Analysis of Neuronal Data

... bias traditional measures using large batteries of simulated data. Traditional methods are biased by a number of features, including firing rate and dwell time in a cell s receptive field. To combat this, we have used a maximum likelihood estimation approach as a less biased and more sensitive way t ...
Ominous odors: olfactory control of instinctive fear and aggression in
Ominous odors: olfactory control of instinctive fear and aggression in

... those of putative predators such as rats, snakes, and birds), and a minority activated by both conspecific and heterospecific stimuli. This last class of sensory neurons could form the basis of responses that are shared in both fear and aggression (e.g., increased sympathetic outflow [26]), while th ...
CASE 47
CASE 47

... C. The basal ganglia and thalamus form a motor loop with the cerebral cortex. Input to the basal ganglia comes from prefrontal and sensory association areas of the cerebral cortex and leaves the basal ganglia via the internal segment of the globus pallidus. The immediate target of these neurons is t ...
Lateral olfactory processing
Lateral olfactory processing

... while in odorant-rich environments the tonic activity is elevated, driving a global lateral inhibition. The results of the Olsen and Wilson model suggest a number of further lines of experimentation. Foremost, it should be possible to directly test the global gain control hypothesis they propose by ...
Chapter Two
Chapter Two

... the potential for exciting or inhibiting many other neurons. VII. The Human Nervous Systems: The Big Picture A. The central nervous system (CNS) includes all neurons and supporting cells in the spinal cord and brain. B. The peripheral nervous system (PNS) consists of all neurons not found in the bra ...
The Auditory Brain and Perceiving Auditory Scenes
The Auditory Brain and Perceiving Auditory Scenes

... Recap - Auditory Cortex ◦ Primary auditory cortex (A1): The first area within the temporal lobes of the brain responsible for processing acoustic organization ◦ Belt area: A region of cortex, directly adjacent to A1, with inputs from A1, where neurons respond to more complex characteristics of sou ...
The vestibular stimulus is provided by Earth`s
The vestibular stimulus is provided by Earth`s

... (endolymph movement is initially slower than head mvmt); - cupula bending slightly moves the cilia of hair cells; - this bending changes rate of action potentials in bipolar vestibular sensory neurons; - when head movement stops: endolymph movement _______________________, again bending the cupula b ...
1. A biological psychologist would be more likely to study
1. A biological psychologist would be more likely to study

... D) MRI. 12. The technique that uses magnetic fields and radio waves to produce computer images of structures within the brain is called: A) the EEG. B) a CT scan. C) a PET scan. D) MRI. 13. Following a head injury, a person has ongoing difficulties staying awake. Most likely, the damage occurred to ...
Structure and Function of Neurons - Assets
Structure and Function of Neurons - Assets

... locations within the neuron’s specialized structure; therefore some functions occur in one part of the neuron but not another. For example, all the nuclear DNA is transcribed in the soma but all protein synthesis does not occur there, because the synthetic machinery of polysomes and endoplasmic reti ...
Shaping dendrites with machinery borrowed from
Shaping dendrites with machinery borrowed from

... between the two compartments. These complexes are coupled to intracellular regulators of cell polarity, notably the MAGUK family of proteins. The vertebrate nervous system begins as a specialized epithelium, termed a neuroepithelium, that invaginates to form the neural tube, creating an apical lumen ...
Slide 1
Slide 1

... Responses in excitatory and inhibitory networks of firing-rate neurons. A. Response of a purely excitatory recurrent network to a square step of input (hE). The blue curve is the response without excitatory feedback. Adding recurrent excitation increases the response but makes it rise and fall more ...
Excitation of Ventral Tegmental Area Dopaminergic and
Excitation of Ventral Tegmental Area Dopaminergic and

... GABAergic neurons generally fired at higher frequencies (7.31 ⫾ 1.35Hz), had briefer action potentials (⬍1.5 msec), and were unaffected by quinpirole and their firing rate was reduced by DAMGO (1 ␮M) to 44.4 ⫾ 6.4% of baseline (n ⫽ 10). The third group of cells fired much more slowly (0.89 ⫾ 0.33 Hz ...
Hebbian Learning with Winner Take All for
Hebbian Learning with Winner Take All for

... Where, Δt=(tpre – tpost) is the time delay between the presynaptic spike and the postsynaptic spike. If the presynaptic spike occurs before the postsynaptic spike, it probably helped cause the postsynaptic spike, and consequently we should encourage this by increasing the synaptic weight. And if the ...
1. Identify the functions of the nervous system and relate nervous
1. Identify the functions of the nervous system and relate nervous

... Label the following brain parts on this page. Indicate the role of each brain structure in your notebook. ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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