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Principles of Sensory Coding
Principles of Sensory Coding

... Coding with time: As you’ve already seen, neurons can become phase-locked to a stimulus. In this case, it is the time of occurrence of a spike that is the signal. This mechanism is well established in the auditory system. It is also possible that the time of occurrence of the first spike response to ...
Human brainstem preganglionic parasympathetic
Human brainstem preganglionic parasympathetic

... the facial nucleus, whereas dorsally located neurons became more concentrated in a region dorsomedial to the oral spinal trigeminal nucleus (Fig. IE). Further caudally, at the level ~10 mm rostral to the obex, the ventral cell group was no longer present, whereas the dorsal group was still quite wel ...
Pathophysiology of Pain
Pathophysiology of Pain

... After a period of time, atypical connections may develop between nerve sprouts or demyelinated axons in the region of the nerve damage, permitting “cross-talk” between somatic or sympathetic efferent nerves and nociceptors. Dorsal root fibers may also sprout following injury to peripheral nerves ...
last lecture neurophysiology - Evans Laboratory: Environmental
last lecture neurophysiology - Evans Laboratory: Environmental

... • sensory neurons are found in animal senses: sight, hearing, touch, taste, smell • at one end of the neuron is a receptor that is associated with that particular sense • for example, olfactory receptors involved in smell are activated by airborne chemicals • at the other end are lots of dendrites t ...
Capogna Curr Opin Neurobiol 2014
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... and data from the basomedial nucleus will not be discussed. Excellent, more detailed reviews on GABAergic neurons of amygdala and inhibitory circuits involved in fear encoding have recently been published [4–7]. The amygdala is one of the most powerful brain areas to address questions regarding the ...
Chapter 10 - Nervous System I
Chapter 10 - Nervous System I

... Neuroglia carry out a variety of functions to aid and protect components of the nervous system. B. Organs of the nervous system can be divided into the central nervous system (CNS), made up of the brain and spinal cord, and the peripheral nervous system (PNS), made up of peripheral nerves that conne ...
Chapter-01
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... light. This is because of the peculiarities in their pigments. Rod cells contain the pigment rhodopsin and cone cells contain the pigment photopsin. Retinal formed from vitamin A and opsin the protein molecule are their basic components. In the presence of light these pigments dissociate to form ret ...
Equal numbers of neuronal and nonneuronal cells make the human
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Summative Assessment 4
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gustatory and olfactory senses
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... chemical signal must cause membrane channels to open. This produces an electrical signal that will be transmitted to the central nervous system. How can sensory systems detect such a broad range of stimuli intensity? The sensitivity range of a sensory organ is much broader than the range of a single ...
Spontaneous firing patterns of identified spiny neurons in the rat
Spontaneous firing patterns of identified spiny neurons in the rat

... outflow is thus of central importance for the functioning of all basal ganglia structures. Results from single unit recordings of neostriatal neurons have emphasized the low tonic firing rates of these cells (see e.g. refs. 3, 5, 11, 13, 21, 28). The relative silence of neostriatal neurons is no dou ...
serotonergic modulation of swimming speed in the pteropod mollusc
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Brains of Primitive Chordates - CIHR Research Group in Sensory
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Sample pages 1 PDF

... slows by approximately 14 % in response to 20 Hz electrical stimulation of the fiber for 20 s, whereas nociceptive C-fibers slow by 27–29 %. Interestingly, while other C-fibers show a stable rate of slowing over time, C-LTMR CV slows more abruptly over the first 6 s followed by a plateau. This initi ...
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No Slide Title

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Pathways - Orange Coast College
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... Motor programs require conscious directions from the frontal lobes. Movement is initiated when commands are received by the primary motor cortex from the motor association areas. The cerebellum is critically important in coordinating movements because it specifies the exact timing of control signals ...
A Type of Basket Cell in Superficial Layers of the Cat Visual Cortex
A Type of Basket Cell in Superficial Layers of the Cat Visual Cortex

... on cell bodies of both pyramidal and non-pyramidal cells in superficial layers of the cat visual cortex. On the basis of this efferent synaptic pattern, this interneuron is considered to be a basket cell. Although it is clear that convergence must play a role in the building up of a pericellular bas ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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