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Lipid Nanoparticulate Drug Delivery Systems: A
Lipid Nanoparticulate Drug Delivery Systems: A

... matrix of the lipid particles shows a melting point depression compared with the original solid lipid but the matrix is still solid at body temperature. Depending on the method of production and the composition of the lipid blend, different types of NLC are obtained. The ...
The neural basis of drug craving: an incentive
The neural basis of drug craving: an incentive

... we halve provided a glossary with definitions of n~;rny of the most problematic terms. Thus, a refcrc‘ncc’ to the glossary, which will bc indicated by the symbol, t, refers the rcadcr to the definition of ;I term. The reader may not always agree with a given definition, but we hope at least this mak ...
enhancement of dissolution rate of fenofibrate by
enhancement of dissolution rate of fenofibrate by

... was above 90% after 100 minutes in water, 0.1 N HCl and 0.1 M SLS [5]. Despite the long history of using solid dispersions in pharmaceutical products, the multiplicity of polymeric carriers that have been used is still limited. In the present study it was trying to modify the amorphous state propert ...
WHO Drug Dictionary User Guide - User Group Portal
WHO Drug Dictionary User Guide - User Group Portal

... Patients and clinical trial subjects often take other drugs apart from the trial substance. This may confound the outcome of the study – and many organizations choose to exclude subject that take certain drugs in their studies or exclude them from certain types of analysis. The information about the ...
Sustained release microspheres of ropinirole hydrochloride: Effect of
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... A. M. Avachat et al.: Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters, Acta Pharm. 61 (2011) ...
Guideline on the investigation of drug interactions - EMA
Guideline on the investigation of drug interactions - EMA

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Chewable Tablets: A Comprehensive Review

... unpleasant taste. Successful tablet formulation development involves the careful selection of ingredients in order to manufacture a robust solid dosage form. Choosing the appropriate excipient to perform a specific function in a tablet formulation such as disintegration or lubrication can be critica ...
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... menstrual cramps, sprains, and tendinitis. NSAIDs are the most frequently prescribed treatment for osteoarthritis. The drugs don’t cure the disease, but they can help relieve its symptoms. Your doctor will probably consider an NSAID if you have osteoarthritis symptoms that aren’t helped by exercise, ...
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Safe Handling of Hazardous Drugs
Safe Handling of Hazardous Drugs

... Additional protective equipment (biosafety cabinet, face and eye shield, respiratory protection) may be required if altering the dosage form of these drugs constitutes a splash or aerosol risk. See Table 2 for more information. Drugs undergoing review for addition to the Duke University Health (DUHS ...
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2. The contemporary drug problem: characteristics, patterns and

... increased over time, including through a regulatory approach that entails the implementation of an elaborate system of authorizations and quality controls. The control of psychoactive substances developed in that framework. While the use of psychoactive substances has existed for several thousand ye ...
WHO Drug Dictionaries Best Practices v2
WHO Drug Dictionaries Best Practices v2

... If possible to retrieve more exact information about which salt form was used in the specific case to be coded, this is of course the best alternative. However, if the company SOPs do not require specific salt information for the ingredients of the products, the entry with Seq1=01 (base form of the ...
complaint  - AboutLawsuits.com
complaint - AboutLawsuits.com

... never approved by FDA. The campaign was aggressive. In many situations, the off label marketing campaign focused on the use of the drug for first line treatment of non-lifethreatening atrial fibrillation. The off label marketing campaign over-played the alleged benefits of off label uses and downpla ...
National Conference on “Recent Advances in Herbal Drug Technology”
National Conference on “Recent Advances in Herbal Drug Technology”

... Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune411038, ...
PDF - Journal of Applied Pharmaceutical Science
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... and higher level of drug absorption because it is permeable to more com-pounds than the gastrointestinal tract due to lack of pancreatic and gastric enzymatic activity, neutral pH of the nasal mucus and less dilution by gastrointestinal contents(Krishnamoorthy and Mitra, 1998). In recent years many ...
Including information on the therapeutic window in bioequivalence
Including information on the therapeutic window in bioequivalence

... each choice of δ and θ, the upper or the lower acceptance limit is reduced when the tested dose approaches the boundary of the therapeutic window, i.e., when M T D/D or D/LED approach unity. For doses far from the boundary of the therapeutic window, the ratios M T D/D and D/LED are larger and the ac ...
Urine Drug Testing Practices - Canadian Nuclear Safety Commission
Urine Drug Testing Practices - Canadian Nuclear Safety Commission

... want all their workers and or job applicants subject to testing in one laboratory have comparable quality assurance testing standards as found in a second or third laboratory, etc. The actual drugs or drug metabolites included in a forensic workplace drug testing programme are fixed and are not modi ...
Evaluating Steroid Inhalers Used to Treat: Asthma and
Evaluating Steroid Inhalers Used to Treat: Asthma and

... require that much help, it means your asthma or COPD requires more serious medical attention. One other inhaled medicine is sometimes used to treat asthma. It’s called cromolyn (Intal). A recent analysis of the scientific evidence found that inhaled steroids provided significantly better control of ...
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in

... The benets of TDM regarding the optimization of pharmacotherapy, however, can only be obtained if the method is adequately integrated into the clinical treatment process. Current TDM use in psychiatric care is obviously suboptimal [134, 700, 742]. Similar to other medical disciplines, systematic st ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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