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LSD Fact Sheet - Drug Policy Alliance
LSD Fact Sheet - Drug Policy Alliance

... century that involved tens of thousands of patients found that carefully monitored and controlled use of LSD may be beneficial for many psychiatric disorders, personal and spiritual development, and creative enhancement for healthy people.xiv However, after LSD was banned in 1970, clinical research ...
Japanese Guideline on the Investigation of Drug Interactions, 2014
Japanese Guideline on the Investigation of Drug Interactions, 2014

... drug interactions that may become major clinical problems is judged early development phase based on ...
Drug-Induced Lupus Erythematosus
Drug-Induced Lupus Erythematosus

... inhibitor to be released, was first approved in the US for the treatment of Crohn’s disease in 1998. The risk classification system applied to traditional drug-induced lupus has not yet been extended to include the newer biological modulators. This is primarily due to difficulty in establishing crit ...
Pharmacology - Jhalawar Medical College
Pharmacology - Jhalawar Medical College

... renal excretion,clearance,half life, doses ...
SEIKO ABUBAKARI - Kwame Nkrumah University of Science
SEIKO ABUBAKARI - Kwame Nkrumah University of Science

... Malaria is a public health problem worldwide, especially in tropical Africa where it kills around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an impo ...
B.Pharmacy
B.Pharmacy

... widely understood across the globe. They will be able to produce on their own texts which are clear and coherent. 1. Reading: Reading texts of varied complexity; speed reading for global and detailed meaning; processing factual and implied meanings 2. Vocabulary: Building up and expansion of vocabul ...
Prevention Guide - Safe Handling of Hazardous Drugs
Prevention Guide - Safe Handling of Hazardous Drugs

... board of directors that includes an equal number of representatives from labour and management associations in the sector. It is primarily funded through premiums collected from all employers in the health and social service sector. ...
Potential Effects of Introducing Behind the Counter Drugs
Potential Effects of Introducing Behind the Counter Drugs

... the introduction of OTC drugs aimed at treating the condition. We used trend-break analysis to control for other, time-related factors as well as preexisting trends in the number of physicianoffice visits that might confound the results. Overall, we found evidence that, even when prior trends are t ...
50 years of oral lipid-based formulations
50 years of oral lipid-based formulations

... it is also becoming increasingly clear that they may provide advantages in permeability and, under some circumstances, in avoiding first pass metabolism. LBF have been investigated as a means to enhance oral drug absorption for many years. Indeed, it is fitting that as the Journees Galeniques meeting ...
VA Medicaid PDL Criteria (effective 01/01/2010)
VA Medicaid PDL Criteria (effective 01/01/2010)

... drugs, COX-2 inhibitors do not reduce the endogenous production of thromboxane A2, a potent platelet activator and aggregator, thereby causing a potentially prothrombotic cascade of events that could lead to a significant increase in the risk for thrombotic cardiovascular events (myocardial infarcti ...
FEASIBILITY BIOWAIVER EXTENSION OF IMMEDIATE RELEASE ORAL ACYCLOVIR 800 MG
FEASIBILITY BIOWAIVER EXTENSION OF IMMEDIATE RELEASE ORAL ACYCLOVIR 800 MG

... dosage form in which the release profile controls the rate of absorption, and the solubility and permeability of the drug was site independent and an IVIVC is expected. The BCS Class III compounds, dissolution conditions may be set as those performed with Class I drugs as they are also poorly solubl ...
Triptans - Consumer Health Choices
Triptans - Consumer Health Choices

... A migraine is a complex neurological condition that involves several changes in the body, including the dilation (widening) of blood vessels, inflammation, and activation of pain receptors. Different medicines are used to target each of these mechanisms. Triptans—which are used to treat, not prevent ...
Prodrugs for Amines
Prodrugs for Amines

... through biological membranes often hinder the clinical development of biologically active peptides [3]. The major problem in designing amine prodrugs is the general robustness of amine derivatives particularly those, such as amides, in which the capacity to ionize has been obviated. On the other han ...
Curcuminoid drug interactions
Curcuminoid drug interactions

... valuable in the prevention and treatment of many different degenerative diseases. As curcuminoids are often taken as supplements by some population groups, it may be asked whether this can lead to changes in the pharmacokinetics or pharmacodynamics of other drugs taken at the same time. It is partic ...
Ferrario A, Kanavos P, Managed entry agreements for pharmaceuticals: the European experience. EMiNet, Brussels, Belgium
Ferrario A, Kanavos P, Managed entry agreements for pharmaceuticals: the European experience. EMiNet, Brussels, Belgium

... drugs and increasing patient expectations, mean that manufacturers seeking inclusion in reimbursement lists need to demonstrate that their drugs can provide additional benefit in relation to current therapies and value-for-money in order to obtain coverage. Data and the overall evidence base availab ...
LYOPHILIZED GLICLAZIDE­POLOXAMER SOLID DISPERSIONS FOR ENHANCEMENT OF  IN­ VITRO DISSOLUTION AND IN­VIVO BIOAVAILABILITY 
LYOPHILIZED GLICLAZIDE­POLOXAMER SOLID DISPERSIONS FOR ENHANCEMENT OF  IN­ VITRO DISSOLUTION AND IN­VIVO BIOAVAILABILITY 

... Gliclazide (GLC), an oral hypoglycemic agent, is characterized by low solubility in gastric fluid, low dissolution rate and inter‐individual variability in  bioavailability. The objective of this study was therefore to design optimized solid dispersions (SD) of GLC with a hydrophilic carrier viz., p ...
Analysis Reveals that CPX-351 Shifts the Exposure of Cytarabine
Analysis Reveals that CPX-351 Shifts the Exposure of Cytarabine

... • With a few notable exceptions, tissues are exposed to lower drug levels for more prolonged periods of time after CPX-351 vs. NL • CPX-351 accumulates and persists in the bone marrow for over 4 days at concentrations known to have antileukemic activity against AML blasts. • These results provide ad ...
Final Version , 454kb - Erasmus University Thesis Repository
Final Version , 454kb - Erasmus University Thesis Repository

... revenues when they face patent expiry. Pharmaceutical companies of brand name drugs have to find a way to maintain their sales values and overcome the competition of generic drugs when patent expiration is approaching. Pharmaceutical companies have different strategies that they could use: promotion ...
Benzodiazepine usage in the North Eastern Health Board
Benzodiazepine usage in the North Eastern Health Board

... the benzodiazepine-related drugs zolpidem and zopiclone. The total average number of Defined Daily Doses (DDDs) per prescription items for all included drugs was for the period for 22 days supply. All the hypnotics had average number of DDDs per prescription higher than the recommend, for 14 days su ...
here.
here.

... 8 We estimate that about 98 per cent of family health services spending is in general practice. 9 Summary of Scottish Health Service Costs (known as the Costs Book), ISD Scotland, November 2012. 10 A defined daily dose is the amount of a drug a patient would normally take in a day to treat the condi ...
amyotrophic lateral sclerosis (als) – opportunity analysis and
amyotrophic lateral sclerosis (als) – opportunity analysis and

... options that are permanently able to prevent motor neuron damage. The efficacy of Rilutek can be limited by its side effects and interference from symptoms in the advanced stages of the disease, which, over time, can lead to poor patient ...
The diffusion of Performance and Image
The diffusion of Performance and Image

... widely accessible on the Web through online pharmacies (Schifano et al., 2011). These are often illicit; they do not guarantee drug quality and, in 81.4% of cases, they sell medications without any medical prescription (Orizio et al., 2009; Littlejohn, Baldacchino, Schifano, & Deluca, 2005). Marketi ...
Pharmaceutical Administration and Regulations in Japan (2015)
Pharmaceutical Administration and Regulations in Japan (2015)

... http://www.jpma.or.jp/about/issue/gratis/index2.html (Japanese) http://www.jpma.or.jp/english/parj/whole.html (English) ...
enzyme induction and inhibition
enzyme induction and inhibition

... the rate of phase one reactions is recognized. However administration of these agents may also increase the activity of phase two enzymes, such as glucuronyl transferase as demonstrated by the ability of oral contraceptive steroids to increase glycine and glucuronide conjugation pathways (Miners et ...
National Conference on Nanoscience and Nanotechnology (NCNN
National Conference on Nanoscience and Nanotechnology (NCNN

... Administration and therapeutic effectiveness of drugs is limited by several tribulations such as solubility, instability, targeting and side-effects which hoist health concerns for a long time. Nanomaterials have revolutionized this era and have all solutions of emerging troubles. Engineered Carbon ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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