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JAP Mar. 86/3 - Journal of Applied Physiology
JAP Mar. 86/3 - Journal of Applied Physiology

... ANTITUSSIVE DRUGS, such as codeine and dextromethorphan, are among the most commonly used prescription and over-the-counter drugs in the world (12). These drugs are broadly classified into two groups based on their site of action: peripheral or central. Peripheral antitussive drugs act outside the c ...
an-update-of-taste-m.. - Scholars Research Library
an-update-of-taste-m.. - Scholars Research Library

... It can be seen that tongue is 10,000 times more sensitive to the bitterness of quinine than to sweetness of sugar. Saccharine, on this scale would rate about 0.001%[5]. Pharmaceutical companies can save themselves much grief by addressing the taste factor early in the product development. In so doin ...
CYCLODEXTRINS
CYCLODEXTRINS

... effects, especially their augmentation of solubility, is via the formation of noncovalent, dynamic inclusion complexes. This is a model, which regards drugcyclodextrin interactions as discrete phenomenon and ignores the possible interaction of these complexes with one another. It is becoming increas ...
International Narcotics Control Board
International Narcotics Control Board

... The regular analysis of consumption data, particularly regarding narcotic drugs, convinced the Board that the level of consumption of narcotic drugs was very low in a number of countries. Therefore, in 1989, the Board, in cooperation with WHO, assessed the medical need for opiates in the world. They ...
Bromday_CDER_letter_Nov_30
Bromday_CDER_letter_Nov_30

... Bromday should not be used to treat more than one eye in a postoperative setting. ISTA had at least four options for responding to the complete response letter: (1) resubmit the supplement, addressing the deficiencies identified by the agency; (2) withdraw the supplement; (3) seek formal dispute res ...
Osmotic-Controlled Release Oral Delivery System
Osmotic-Controlled Release Oral Delivery System

... patient compliance and convenience. The main clinical benefits of OROS are their ability to improve treatment tolerability and patient compliance. These advantages are mainly driven by the capacity to deliver drugs in a sustained manner, independent of the drug chemical properties, of the patient’s ...
Liposomes in drug delivery
Liposomes in drug delivery

... Department qf Experimental Therapeutics, Roswell Park Cancer Institute, and Department of Pharmaceutics, SUN Y at Buffalo, Buffalo, NY, USA ...
Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs
Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs

... Taste is one of the most important parameters governing patient compliance. Undesirable taste is one of several important formulation problems that are encountered with certain drugs. Oral administration of bitter drugs with an acceptable degree of palatability is a key issue for health care provide ...
Pricing and Inventories at Unlicensed Online Pharmacies
Pricing and Inventories at Unlicensed Online Pharmacies

... et al. 2011]. We compare these inventories and prices with those of a different group of 265 pharmacies simply characterized as “not recommended” by the National Association of Boards of Pharmacy (NABP). We also compare unlicensed pharmacy inventories with the inventory of a licensed pharmacy (famil ...
Pulmonary Drug Absorption
Pulmonary Drug Absorption

... imipramine, losartan, metoprolol, propranolol, talinolol, terbutaline, and the tetrapeptide TArPP) were used as model compounds. In connection to these investigations, a nebulization catheter device was successfully adapted and evaluated as a new technique for delivery of defined aerosol doses to th ...
10.4103_0975-1483.63169
10.4103_0975-1483.63169

... choosing a specific statin suitable for combination therapy.[11] Drug–drug interaction has become one of the major concerns not only for physician during the treatment of patients but also for pharmaceutical industries during the development of new drugs.[12] Glimepride and atorvastatin are metaboli ...
Influence of posture on pharmacokinetics
Influence of posture on pharmacokinetics

... effects has not yet been reached. Furthermore, the number of potential mechanisms of these effects is quite large, thus complicating a general assessment. In particular, the importance and magnitude of possible postural effects on orally administered drugs has not yet been completely elucidated. In ...
Drug Abuse Warning Network, 2005: National
Drug Abuse Warning Network, 2005: National

... What drugs are included in DAWN?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 What is covered in this publication?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Estimates in this publication . . . . . . . . . . . . ...
Drug Use 17+ - Ruby Translator
Drug Use 17+ - Ruby Translator

... bush-or-airplane-or-angola-or-ashes-or-assassin of youth-or-astro turf-or-atshitshi-or-aunt mary-or-baby bhang-or-babysitter-or-balck bart-or-balck gunion-or-bale-or-balyando spruce-or-bamba-orbambalacha-or-bammy-or-bar-or-bash-or-bhang-or-block-or-blondeor-blowing smoke-or-blue sage -o- bo-or-bo-bo ...
EXTEMPORANEOUS PREPARATION OF PAEDIATRIC ORAL
EXTEMPORANEOUS PREPARATION OF PAEDIATRIC ORAL

... raise concerns about quality, stability, bioavailability, efficacy and safety. Currently, there are no appropriate and comprehensive published standards, and thus decisions in different steps of preparation process have to be done by applying professional pharmaceutical skills. The uniformity of con ...
uniformity (a required drug dose). This led to the develop-
uniformity (a required drug dose). This led to the develop-

... tissue plasminogen activator (1). It is now possible to produce oligonucleotide, peptide, and protein drugs in large quantities, while gene therapies also appear to be clinically feasible. Each of these therapeutic agents, by virtue of size, stability, or the need for targeting, requires a specializ ...
In vitro - In vivo Correlation: From Theory to
In vitro - In vivo Correlation: From Theory to

... of manufacturing and marketing of any therapeutic agent which is indeed a time consuming and costly process. Optimization process may require alteration in formulation composition, manufacturing process, equipment and batch sizes. If these types of changes are applied to a formulation, studies in hu ...
Floating tablet
Floating tablet

... Old and acceptable means of treatment.  The volume and nature of rectal fluid, its buffer capacity, pH and surface tension play a large part in this but are subject to wide variation, even within single subject, resulting in variability of absorption by this route.  Advantages:  Tablets have dist ...
drug information - NurseCe4Less.com
drug information - NurseCe4Less.com

... body is based on the drug concentration at the site of action, which, in turn, depends upon its pharmacokinetic attributes. Pharmacokinetics helps explain how a particular drug affects the target tissue after application through the processes of absorption, distribution, metabolism and excretion, al ...
annual review 2011
annual review 2011

... Activities for other drugs advancing steadily through the development pipeline included Phase III clinical trials for MD-0901, an agent to treat ulcerative colitis;Phase II/III clinical trials for MD-0701, a treatment for pulmonary arterial hypertension; Phase II/III clinical trials on the biosimila ...
B.Pharmacy Syllabus 2015
B.Pharmacy Syllabus 2015

... The prescribed reading textbook for students will be S. P. Dhanavel English and Communication Skills for Students of Science and Engineering (with audio CD), Orient Blackswan. They will go through the reading texts themselves with the help of a dictionary or word power as given at the end. As they p ...
Advice to The Expert Advisory Committee on drugs on: LSD
Advice to The Expert Advisory Committee on drugs on: LSD

... suggestive of a revival in interest in the drug in the last few years. After a longterm downward trend dating back to the 1990s, both the number and the quantity of seizures increased from 2003 but might be declining again7. LSD retail prices (adjusted for inflation) have been slightly declining sin ...
Cucurbit[n]urils as excipients in pharmaceutical dosage forms
Cucurbit[n]urils as excipients in pharmaceutical dosage forms

... A physical characteristic of cucurbit[n]urils that was once thought to limit their medical application is their poor water solubility. Cucurbit[n]urils composed of an odd number of subunits are more soluble than the cucurbit[n]urils with an even number of subunits. Cucurbit[5]uril and CB[7] have a ...
pdf .
pdf .

... interactions can become very dangerous and increase health care costs. Although there are different databases supporting health care professionals in the detection of DDI, these databases are rarely complete, since their update periods can reach three years. Drug interactions are frequently reported ...
LSD Fact Sheet - Drug Policy Alliance
LSD Fact Sheet - Drug Policy Alliance

... century that involved tens of thousands of patients found that carefully monitored and controlled use of LSD may be beneficial for many psychiatric disorders, personal and spiritual development, and creative enhancement for healthy people.xiv However, after LSD was banned in 1970, clinical research ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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