Pathogenesis of cognitive dysfunction in phenylketonuria
... blood–brain barrier (BBB) is considered to be important in the pathogenesis of PKU. First, PKU symptomatology almost exclusively concerns the brain [1]. Second, individuals with untreated PKU have been described as having the biochemical characteristics of untreated PKU, but with normal intelligence ...
... blood–brain barrier (BBB) is considered to be important in the pathogenesis of PKU. First, PKU symptomatology almost exclusively concerns the brain [1]. Second, individuals with untreated PKU have been described as having the biochemical characteristics of untreated PKU, but with normal intelligence ...
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami
... drive CAG/CTG expansions. In vivo mouse models suggest that MutSb is required to drive CAG expansions [13,27,35] and to protect against repeat contractions [16,26,27,34–36,49]. The role of MutSb in expansions extends beyond its ability to bind slippedDNAs [50] as an ATPase-functional MutSb complex i ...
... drive CAG/CTG expansions. In vivo mouse models suggest that MutSb is required to drive CAG expansions [13,27,35] and to protect against repeat contractions [16,26,27,34–36,49]. The role of MutSb in expansions extends beyond its ability to bind slippedDNAs [50] as an ATPase-functional MutSb complex i ...
TRANSLATION OF mRNA - E-Learning/An
... amino acid glycine. The codon AUG, which specifies methionine, is used as a start codon; it is usually the first codon that begins a polypeptide sequence. The AUG codon can also be used to specify additional methionines within the coding sequence. Finally, three codons are used to end the process of ...
... amino acid glycine. The codon AUG, which specifies methionine, is used as a start codon; it is usually the first codon that begins a polypeptide sequence. The AUG codon can also be used to specify additional methionines within the coding sequence. Finally, three codons are used to end the process of ...
Isoleucine Synthesis by Clostridium sporogenes from
... maintaining the culture and for preparation of inocula were as previously described (Costilow, 1977). Except where noted, the minimal medium was that described in Results. The bacteria were grown in an anaerobic chamber (Coy Manufacturing, Ann Arbor, Mich, USA) at 37 "C in an atmosphere of 5 % (v/v) ...
... maintaining the culture and for preparation of inocula were as previously described (Costilow, 1977). Except where noted, the minimal medium was that described in Results. The bacteria were grown in an anaerobic chamber (Coy Manufacturing, Ann Arbor, Mich, USA) at 37 "C in an atmosphere of 5 % (v/v) ...
The Role of Amino Acids
... chemical properties of the amino acids of proteins determine the biological activity of the protein. Proteins not only catalyze all (or most) of the reactions in living cells, they control virtually all cellular process. In addition, proteins contain within their amino acid sequences the necessary i ...
... chemical properties of the amino acids of proteins determine the biological activity of the protein. Proteins not only catalyze all (or most) of the reactions in living cells, they control virtually all cellular process. In addition, proteins contain within their amino acid sequences the necessary i ...
Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells
... 2. Exploring the Epigenetics of FXS Despite the tight correlation between transcriptional inactivation and chromatin compaction, the precise mechanism governing the silencing of FMR1 is not fully understood. In addition, it remains unclear when FMR1 gene inactivation takes place during embryo develo ...
... 2. Exploring the Epigenetics of FXS Despite the tight correlation between transcriptional inactivation and chromatin compaction, the precise mechanism governing the silencing of FMR1 is not fully understood. In addition, it remains unclear when FMR1 gene inactivation takes place during embryo develo ...
Inhibition of the Epstein–Barr virus lytic cycle by
... antiviral effect of interferon, we measured the phosphorylation of STAT1, a common signalling event triggered by interferon (Sledz et al., 2003; Stark et al., 1998). While treatment with interferon a induced significant phosphorylation of STAT1 in NA cells, expression of siZ1 caused little enhanceme ...
... antiviral effect of interferon, we measured the phosphorylation of STAT1, a common signalling event triggered by interferon (Sledz et al., 2003; Stark et al., 1998). While treatment with interferon a induced significant phosphorylation of STAT1 in NA cells, expression of siZ1 caused little enhanceme ...
Acetylglutamate kinase is required for both gametophyte function
... Plant coexpressing NAGK-GFP and the chloroplast marker chloroplast-RFP were examined with confocal laser scanning microscopy. (A–D) Colocalization in root cells. (A) Bright field of root cells. (B) Red fluorescent signal from the plastid marker plastid-RFP. (C) Green fluorescent signal from NAGK-GFP. ( ...
... Plant coexpressing NAGK-GFP and the chloroplast marker chloroplast-RFP were examined with confocal laser scanning microscopy. (A–D) Colocalization in root cells. (A) Bright field of root cells. (B) Red fluorescent signal from the plastid marker plastid-RFP. (C) Green fluorescent signal from NAGK-GFP. ( ...
Evolution, structure and function of mitochondrial carriers: a
... Only six MCs were sequenced after their purification from mitochondria by direct amino acid analysis or by DNA sequencing (Indiveri et al., 1997 and references therein). These early studies led to the conclusion that they all belonged to the same protein family which was named MCF. In the genomic er ...
... Only six MCs were sequenced after their purification from mitochondria by direct amino acid analysis or by DNA sequencing (Indiveri et al., 1997 and references therein). These early studies led to the conclusion that they all belonged to the same protein family which was named MCF. In the genomic er ...
Brooker Chapter 5 - Volunteer State Community College
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
Mutations
... Whether a mutation is negative or beneficial depends on how its DNA changes relative to the organism’s situation. Mutations are often thought of as negative because they disrupt the normal function of genes. However, without mutations, organisms cannot evolve, because mutations are the source of gen ...
... Whether a mutation is negative or beneficial depends on how its DNA changes relative to the organism’s situation. Mutations are often thought of as negative because they disrupt the normal function of genes. However, without mutations, organisms cannot evolve, because mutations are the source of gen ...
Significance of Single-Pollen Genotyping in Ecological
... isolation in a population. Human impact (habitat loss or degradation, overexploitation, usage of agrochemicals, global warming, etc.) will result in reduction or changes in the number of pollinators. The consequent changes in pollen movement can be used as an indicator to evaluate the effects of hum ...
... isolation in a population. Human impact (habitat loss or degradation, overexploitation, usage of agrochemicals, global warming, etc.) will result in reduction or changes in the number of pollinators. The consequent changes in pollen movement can be used as an indicator to evaluate the effects of hum ...
CH # 13-3
... Whether a mutation is negative or beneficial depends on how its DNA changes relative to the organism’s situation. Mutations are often thought of as negative because they disrupt the normal function of genes. However, without mutations, organisms cannot evolve, because mutations are the source of gen ...
... Whether a mutation is negative or beneficial depends on how its DNA changes relative to the organism’s situation. Mutations are often thought of as negative because they disrupt the normal function of genes. However, without mutations, organisms cannot evolve, because mutations are the source of gen ...
Fungi use the SakA (HogA) pathway for phytochrome
... ccgA 11,12, was quantified by real time polymerase chain reaction (RT-qPCR). The values were normalized to the constitutive H2B (histone) gene. In seven strains both genes were not light-inducible, whereas in mutant M17-3 light induction was not affected. Thus seven blind mutant strains were isolated ...
... ccgA 11,12, was quantified by real time polymerase chain reaction (RT-qPCR). The values were normalized to the constitutive H2B (histone) gene. In seven strains both genes were not light-inducible, whereas in mutant M17-3 light induction was not affected. Thus seven blind mutant strains were isolated ...
Different Effects of PCR Inhibitors on Multiplex STR Assays
... as blood and semen which are often found on soil, sand, wood or leaf litter can contain substances which co-extract with the perpetrator’s DNA and prevent PCR amplification. Textile dyes, leather and wood from interior crime scenes can also contain inhibitors that interfere with the DNA polymerase’s ...
... as blood and semen which are often found on soil, sand, wood or leaf litter can contain substances which co-extract with the perpetrator’s DNA and prevent PCR amplification. Textile dyes, leather and wood from interior crime scenes can also contain inhibitors that interfere with the DNA polymerase’s ...
From CO2 to cell: energetic expense of creating biomass using the
... (Konneke et al. 2014), or kept the tallies of ATP and cellular electron donors separate (Boyle 2011), which complicates comparisons between different autotrophic pathways, since the different pathways utilize different cellular reductants in differing amounts, and these cellular reductants differ in ...
... (Konneke et al. 2014), or kept the tallies of ATP and cellular electron donors separate (Boyle 2011), which complicates comparisons between different autotrophic pathways, since the different pathways utilize different cellular reductants in differing amounts, and these cellular reductants differ in ...
Nucleic acid vaccines against rickettsial diseases and methods of use
... must be carefully selected and presented to the immune system such that shared epitopes are recogniZed. These factors have contributed to the search for effective vaccines. A protective vaccine against rickettsiae that elicits a complete immune response can be advantageous. A feW antigens Which pote ...
... must be carefully selected and presented to the immune system such that shared epitopes are recogniZed. These factors have contributed to the search for effective vaccines. A protective vaccine against rickettsiae that elicits a complete immune response can be advantageous. A feW antigens Which pote ...
gsea user guide
... dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not filter the expression dataset and does not benefit from your filtering of the expression dataset. During the analysis, g ...
... dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not filter the expression dataset and does not benefit from your filtering of the expression dataset. During the analysis, g ...
ppt - Chair of Computational Biology
... play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shapi ...
... play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shapi ...
PpASCL, a moss ortholog of antherspecific chalcone synthaselike
... that the major component of the exine layer of the moss spores is sporopollenin, as in flowering plants (Wellman, 2004). Recently, molecular genetic and biochemical studies have begun to reveal the biochemical pathways leading to sporopollenin synthesis. In Arabidopsis, several genes have been impli ...
... that the major component of the exine layer of the moss spores is sporopollenin, as in flowering plants (Wellman, 2004). Recently, molecular genetic and biochemical studies have begun to reveal the biochemical pathways leading to sporopollenin synthesis. In Arabidopsis, several genes have been impli ...
Intersubunit contacts are often facilitated by specificity
... recognition of the interaction partner ...
... recognition of the interaction partner ...