Modulation of the Cell Cycle-dependent
... treatment alone did not affect the GSH level of cells in all phases of the cell cycle. These results show that the enhance ment of 4-OOH-CP cytotoxicity by NOVO was not simply due to a direct effect on the level of GSH per se. However, the sensitizing action of NOVO may nevertheless involve GSH. Thi ...
... treatment alone did not affect the GSH level of cells in all phases of the cell cycle. These results show that the enhance ment of 4-OOH-CP cytotoxicity by NOVO was not simply due to a direct effect on the level of GSH per se. However, the sensitizing action of NOVO may nevertheless involve GSH. Thi ...
Loss of Growth Factor Dependence and Conversion of Transforming
... effects of basic fibroblast growth factor, platelet-derived growth factor, epidermal growth factor, and transforming growth factor-/?i (TGF-0i) on these lines were then examined to determine if the changes in the serum dependence of metastatic cells may be due to altered responsiveness to specific g ...
... effects of basic fibroblast growth factor, platelet-derived growth factor, epidermal growth factor, and transforming growth factor-/?i (TGF-0i) on these lines were then examined to determine if the changes in the serum dependence of metastatic cells may be due to altered responsiveness to specific g ...
Signaling pathways at the leading edge of chemotaxing cells
... kinase and lipid-kinase-accessory domains, PI3Ks contain a Ras binding domain, a C2 domain, and a long Nterminal domain with little homology to other proteins. Surprisingly, the domain that is necessary and sufficient for chemoattractant-mediated localization resides in the N-terminal domain of PI3Ks. ...
... kinase and lipid-kinase-accessory domains, PI3Ks contain a Ras binding domain, a C2 domain, and a long Nterminal domain with little homology to other proteins. Surprisingly, the domain that is necessary and sufficient for chemoattractant-mediated localization resides in the N-terminal domain of PI3Ks. ...
Primary cell wall
... •In cellulose beta-1,4 glycosidic bonds alternate up and down the plane of the molecule. In starch α-1,4 glycosidic bonds are all on the same side. •These chemical differences are at the base of the different functions of these molecules in plant cells. •Cellulose is not digested by animals. ...
... •In cellulose beta-1,4 glycosidic bonds alternate up and down the plane of the molecule. In starch α-1,4 glycosidic bonds are all on the same side. •These chemical differences are at the base of the different functions of these molecules in plant cells. •Cellulose is not digested by animals. ...
PKCδ is Required for Survival of Cells Expressing
... and apoptosis by relaying mitogenic and growth signals from the membrane into the cytoplasm and the nucleus. Specific point mutations localized in codons 12, 13, 59, 61, 63, 116, 117, and 146 can lock the p21Ras protein in the active GTP-bound state and permit stimulation of downstream signaling cas ...
... and apoptosis by relaying mitogenic and growth signals from the membrane into the cytoplasm and the nucleus. Specific point mutations localized in codons 12, 13, 59, 61, 63, 116, 117, and 146 can lock the p21Ras protein in the active GTP-bound state and permit stimulation of downstream signaling cas ...
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... was evident that this approach holds much promise to address experimentally the role of extrinsic tethered and soluble factors that regulate satellite cell fate determination and self-renewal. Transcription factor control of satellite cell proliferation and differentiation A handful of specific tran ...
... was evident that this approach holds much promise to address experimentally the role of extrinsic tethered and soluble factors that regulate satellite cell fate determination and self-renewal. Transcription factor control of satellite cell proliferation and differentiation A handful of specific tran ...
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... Amino acids (AA) are known as anabolic factors, which induce protein gain by stimulating protein synthesis while inhibiting proteolysis. Lysine (Lys) is often the first limiting AA for dairy cows. Several authors have shown that Lys supplementation, at levels above the requirement for maximal growth ...
... Amino acids (AA) are known as anabolic factors, which induce protein gain by stimulating protein synthesis while inhibiting proteolysis. Lysine (Lys) is often the first limiting AA for dairy cows. Several authors have shown that Lys supplementation, at levels above the requirement for maximal growth ...
Regulation of germinal center responses, memory B cells and
... recently shown to activate or silence its expression, respectively, and to consequently inhibit or abnormally enhance plasma cell differentiation [66]. Myb, long known as a mediator of differentiation in haematopoietic cells [67] is required for GC-derived plasmablasts to exit their organ of formati ...
... recently shown to activate or silence its expression, respectively, and to consequently inhibit or abnormally enhance plasma cell differentiation [66]. Myb, long known as a mediator of differentiation in haematopoietic cells [67] is required for GC-derived plasmablasts to exit their organ of formati ...
Developmental roles of Rhomboid proteases
... triggered by a combination of transcription factors that collectively define the correct time and place. For example, activation by the midline transcription factor Single minded triggers rhomboid1 expression in the midline [27]. This type of expression is spatially “static” and temporally transient, ...
... triggered by a combination of transcription factors that collectively define the correct time and place. For example, activation by the midline transcription factor Single minded triggers rhomboid1 expression in the midline [27]. This type of expression is spatially “static” and temporally transient, ...
Octamer-binding transcription factors: genomics and functions
... The Octamer-binding proteins (Oct) are a group of highly conserved transcription factors that specifically bind to the octamer motif (ATGCAAAT) and closely related sequences in promoters and enhancers of a wide variety of genes. Oct factors belong to the larger family of POU domain factors that are ...
... The Octamer-binding proteins (Oct) are a group of highly conserved transcription factors that specifically bind to the octamer motif (ATGCAAAT) and closely related sequences in promoters and enhancers of a wide variety of genes. Oct factors belong to the larger family of POU domain factors that are ...
Catalog No
... Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation in rodents. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat ...
... Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation in rodents. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat ...
Protein traffic in polarized epithelial cells: the polymeric
... We next studied the biosynthesis and processing of plgR in a human colon carcinoma cell line, HT29, which was known to secrete SC (Mostov and Blobel, 1982). Biosyn thetic labelling of these cells revealed that the plg-R was found initially as a single species of 90 kDa. Its carbohy drate side chai ...
... We next studied the biosynthesis and processing of plgR in a human colon carcinoma cell line, HT29, which was known to secrete SC (Mostov and Blobel, 1982). Biosyn thetic labelling of these cells revealed that the plg-R was found initially as a single species of 90 kDa. Its carbohy drate side chai ...
The mechanism of leaf morphogenesis
... the site of leaf organogenesis (Wyrzykowska et al. 2002). As shown in Fig. 1A, these manipulations led to an accumulation of smaller cells on one flank of the apical meristem. Despite these changes, meristem function and leaf formation proceeded normally (Fig. 1B). These experiments demonstrate that ...
... the site of leaf organogenesis (Wyrzykowska et al. 2002). As shown in Fig. 1A, these manipulations led to an accumulation of smaller cells on one flank of the apical meristem. Despite these changes, meristem function and leaf formation proceeded normally (Fig. 1B). These experiments demonstrate that ...
Candida albicans Iff11, a Secreted Protein Required for Cell Wall
... 2; assembly 20 was released after the present study was completed). The majority of the family displays a structure characteristic of GPI-anchored cell wall proteins, consisting of signal sequence, conserved domain, variable length Ser/Thr-rich region, and potential GPI-anchor (Table 2). The homolog ...
... 2; assembly 20 was released after the present study was completed). The majority of the family displays a structure characteristic of GPI-anchored cell wall proteins, consisting of signal sequence, conserved domain, variable length Ser/Thr-rich region, and potential GPI-anchor (Table 2). The homolog ...
Interphase
... There are three stages of interphase, with each phase ending when a cellular checkpoint checks the accuracy of the stage's completion before proceeding to the next. The stages of interphase are: • G1 (Growth 1), in which the cell grows and functions normally. During this time, much protein synthesis ...
... There are three stages of interphase, with each phase ending when a cellular checkpoint checks the accuracy of the stage's completion before proceeding to the next. The stages of interphase are: • G1 (Growth 1), in which the cell grows and functions normally. During this time, much protein synthesis ...
Should reflectance confocal microscopy be the gold standard for
... the tumor cell themselves: nuclear polarization and nuclear axial coalignment; regarding the vasculature, observation of leukocyte infiltrates in the lesion and enlarged and/or more numerous blood vessels with horizontal (en face) orientation; and corresponding to the epidermis, known as pleomorphis ...
... the tumor cell themselves: nuclear polarization and nuclear axial coalignment; regarding the vasculature, observation of leukocyte infiltrates in the lesion and enlarged and/or more numerous blood vessels with horizontal (en face) orientation; and corresponding to the epidermis, known as pleomorphis ...