Contribution of microtubule growth polarity and flux to spindle
... endosomes entered the nuclear area (Fig. 1L). In addition, the remains of the PPB persisted until spindle initiation (Fig. 1G). Apparently, the NE is first permeable to microtubules and only after NE-breakdown, the nuclear area becomes accessible to larger structures such as endocytic vesicles. Thes ...
... endosomes entered the nuclear area (Fig. 1L). In addition, the remains of the PPB persisted until spindle initiation (Fig. 1G). Apparently, the NE is first permeable to microtubules and only after NE-breakdown, the nuclear area becomes accessible to larger structures such as endocytic vesicles. Thes ...
title of the thesis - UWSpace
... controlling these behaviors remain unknown. However, experimental evidence indicates that the signals regulating cell adhesion originate from within the cell. -parvin is an integrin associated scaffolding protein consisting of two calponin homology (CH) domains. I have examined the role that -parv ...
... controlling these behaviors remain unknown. However, experimental evidence indicates that the signals regulating cell adhesion originate from within the cell. -parvin is an integrin associated scaffolding protein consisting of two calponin homology (CH) domains. I have examined the role that -parv ...
Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects
... in Ad-shScr-transduced CMs (Figure 1A). On the other hand, CMs with foreshortened mitochondria, as defined by an average mitochondrion length smaller than one sarcomere unit (Online Figure IB), were markedly reduced in Ad-shDrp1-transduced CMs. These results suggest that Drp1 is required for mitocho ...
... in Ad-shScr-transduced CMs (Figure 1A). On the other hand, CMs with foreshortened mitochondria, as defined by an average mitochondrion length smaller than one sarcomere unit (Online Figure IB), were markedly reduced in Ad-shDrp1-transduced CMs. These results suggest that Drp1 is required for mitocho ...
Differential Auxin-Transporting Activities of PIN
... PIN polarity, as exemplified for PIN3, whose subcellular localization changes in response to the gravity vector (Friml et al., 2002b). An intriguing question is how different PIN proteins have different subcellular polarities, which might be attributable to PIN-specific molecular properties, celltyp ...
... PIN polarity, as exemplified for PIN3, whose subcellular localization changes in response to the gravity vector (Friml et al., 2002b). An intriguing question is how different PIN proteins have different subcellular polarities, which might be attributable to PIN-specific molecular properties, celltyp ...
A three-stage model of Golgi structure and function
... The properties of Golgi cisternae are linked to the pathways of Golgi membrane traffic, a topic that is vigorously debated (Glick and Luini 2011; Rabouille and Klumperman 2005). Currently, the predominant model is cisternal maturation, which postulates that Golgi cisternae form de novo and then prog ...
... The properties of Golgi cisternae are linked to the pathways of Golgi membrane traffic, a topic that is vigorously debated (Glick and Luini 2011; Rabouille and Klumperman 2005). Currently, the predominant model is cisternal maturation, which postulates that Golgi cisternae form de novo and then prog ...
12 October 2000
... cysteine proteases that are activated specifically in apoptotic cells. These death proteases are homologous to each other, and are part of a large protein family known as the caspases4. Caspases are highly conserved through evolution, and can be found from humans all the way down to insects, nematod ...
... cysteine proteases that are activated specifically in apoptotic cells. These death proteases are homologous to each other, and are part of a large protein family known as the caspases4. Caspases are highly conserved through evolution, and can be found from humans all the way down to insects, nematod ...
SERCA pump level is a critical determinant of Ca2+ homeostasis
... v ventricle), developmental and thyroxine-induced changes may be equally responsible for the observed changes in relaxation time and contractility.27–29 In the past three decades a decrease in SERCA gene expression and activity was observed in a wide variety of pathological conditions. Varying degre ...
... v ventricle), developmental and thyroxine-induced changes may be equally responsible for the observed changes in relaxation time and contractility.27–29 In the past three decades a decrease in SERCA gene expression and activity was observed in a wide variety of pathological conditions. Varying degre ...
The N-Terminal Domain of ERK1 Accounts for the Functional
... Figure 2. Comparison of the nucleo-cytoplasmic shuttling of ERK1 and ERK2. A) After photobleaching of the nucleus of starved NIH 3T3 cells, the ERK1 fluorescence recovered more slowly than ERK2, indicating a slower turnover of ERK1 across the nuclear membrane. Calibration bar 10 mm. B) Time course o ...
... Figure 2. Comparison of the nucleo-cytoplasmic shuttling of ERK1 and ERK2. A) After photobleaching of the nucleus of starved NIH 3T3 cells, the ERK1 fluorescence recovered more slowly than ERK2, indicating a slower turnover of ERK1 across the nuclear membrane. Calibration bar 10 mm. B) Time course o ...
Peer-Review Draft: Report on Carcinogens Monograph on
... The RoC draft monograph for each virus consists of the following components: (Part 1) the cancer evaluation component that reviews the relevant scientific information and assesses its quality, applies the RoC listing criteria to the scientific information, and recommends an RoC listing status, and ( ...
... The RoC draft monograph for each virus consists of the following components: (Part 1) the cancer evaluation component that reviews the relevant scientific information and assesses its quality, applies the RoC listing criteria to the scientific information, and recommends an RoC listing status, and ( ...
The Role of Pollen Tube Reception in Reproductive Isolation
... proteins conferring species-specific interactions of gametes, such as the abalone sperm protein lysin and its egg coat receptor VERL, have been found to co-evolve rapidly under positive selection (9). In Arabidopsis, male gametophyte-specific genes (expressed in the sperm cells, pollen and pollen tu ...
... proteins conferring species-specific interactions of gametes, such as the abalone sperm protein lysin and its egg coat receptor VERL, have been found to co-evolve rapidly under positive selection (9). In Arabidopsis, male gametophyte-specific genes (expressed in the sperm cells, pollen and pollen tu ...
Bostrom Slides
... between are “Crystal diseases” Vascular Calcification and Bone where synovial fibroblasts have an inflammatory response to the crystals. ...
... between are “Crystal diseases” Vascular Calcification and Bone where synovial fibroblasts have an inflammatory response to the crystals. ...
The TSC1–TSC2 complex: a molecular switchboard controlling cell
... TSC2 complex is as a critical negative regulator of mTORC1 activation. The Drosophila genetic experiments described above demonstrated that the TSC1–TSC2 complex inhibits S6K activation, suggesting that the complex might specifically inhibit TORC1 signalling. Indeed, subsequent experiments in mammal ...
... TSC2 complex is as a critical negative regulator of mTORC1 activation. The Drosophila genetic experiments described above demonstrated that the TSC1–TSC2 complex inhibits S6K activation, suggesting that the complex might specifically inhibit TORC1 signalling. Indeed, subsequent experiments in mammal ...
Signals from the lysosome: a control centre for cellular clearance
... have an acidic lumen, which is limited by a single-lipid bilayer membrane and contains several types of hydrolases that are devoted to the degradation of specific substrates. The lysosomal membrane contains proteins that are involved in the transport of substances into and out of the lumen, acidific ...
... have an acidic lumen, which is limited by a single-lipid bilayer membrane and contains several types of hydrolases that are devoted to the degradation of specific substrates. The lysosomal membrane contains proteins that are involved in the transport of substances into and out of the lumen, acidific ...
Nab controls the activity of the zinc-finger
... found that nab is required for proximodistal patterning of the wing imaginal disc and also for determining specific neuronal fates in the embryonic CNS. We identified two partners of Nab: the zinc-finger transcription factors Rotund and Squeeze. Nab is coexpressed with squeeze in a subset of neurons ...
... found that nab is required for proximodistal patterning of the wing imaginal disc and also for determining specific neuronal fates in the embryonic CNS. We identified two partners of Nab: the zinc-finger transcription factors Rotund and Squeeze. Nab is coexpressed with squeeze in a subset of neurons ...
measuring force in the developing zebrafish embryo using
... In addition to large-scale movement of tissue in sheets, changes in force are also capable of driving migration of cells acting as independent entities. This is particularly evident in a phenomenon called differential adhesion. According to the differential adhesion hypothesis, cells segregate base ...
... In addition to large-scale movement of tissue in sheets, changes in force are also capable of driving migration of cells acting as independent entities. This is particularly evident in a phenomenon called differential adhesion. According to the differential adhesion hypothesis, cells segregate base ...
Suppression of Hepatic XBP1s Decreases the Bile Salt Pool
... amyloid-β 1-42 peptide (Aβ) neurotoxicity, which is responsible for Alzheimer’s disease ...
... amyloid-β 1-42 peptide (Aβ) neurotoxicity, which is responsible for Alzheimer’s disease ...
The Hype on the Endothelin Signaling System Muscarinic Receptor
... leads to the accumulation of ET-B as shown using Anti-ET-B antibody (#AER-002) and anti-GFAP in Muller cells, characterized in the central retina by their radial fibers. ET-B also accumulates in presumptive astrocytes in the GCL and at the outer tips of the Muller cells, which lie alongside the phot ...
... leads to the accumulation of ET-B as shown using Anti-ET-B antibody (#AER-002) and anti-GFAP in Muller cells, characterized in the central retina by their radial fibers. ET-B also accumulates in presumptive astrocytes in the GCL and at the outer tips of the Muller cells, which lie alongside the phot ...
The PDZ-GEF Dizzy regulates cell shape of migrating macrophages
... after germ band retraction (Fig. 2I,K). This indicates that these macrophages did not properly adhere to the posterior end of the germ band and failed to enter the posterior germ band before and during its retraction. Later, during the phase of ‘central spreading’ at stage 14, macrophages in wild-ty ...
... after germ band retraction (Fig. 2I,K). This indicates that these macrophages did not properly adhere to the posterior end of the germ band and failed to enter the posterior germ band before and during its retraction. Later, during the phase of ‘central spreading’ at stage 14, macrophages in wild-ty ...
Functional Regulation of MyD88-Activated Interferon Regulatory
... Interferon regulatory factor 5 (IRF-5) plays an important role in the innate antiviral and inflammatory response. Specific IRF-5 haplotypes are associated with dysregulated expression of type I interferons and predisposition to autoimmune disorders. IRF-5 is activated by Toll-like receptor 7 (TLR7) ...
... Interferon regulatory factor 5 (IRF-5) plays an important role in the innate antiviral and inflammatory response. Specific IRF-5 haplotypes are associated with dysregulated expression of type I interferons and predisposition to autoimmune disorders. IRF-5 is activated by Toll-like receptor 7 (TLR7) ...