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Setting up a transformation--how will the competent cells be treated?
Setting up a transformation--how will the competent cells be treated?

... What is RNAi? – RNA interference (RNAi) is an evolutionally highly conserved process of post-transcriptional gene silencing (PTGS) by which double stranded RNA (dsRNA) causes sequencespecific degradation of mRNA sequences. – It was first discovered in 1998 by Andrew Fire and Craig Mello in the nema ...
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... Ø Splicing: introns are cut out, and exons are linked. •  There can be many forms of splicing, generating different mRNAs —alternative splicing, so a gene can code for many proteins. •  Splicing can be mediated by spliceosome or the RNA itself. •  Prediction of alternative splicing sites is a challe ...
CHAPTER 17 FROM GENE TO PROTEIN Learning Objectives The
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... 12. Describe all of the ways in which RNA is modified after transcription in eukaryotic cells. 13. Define and explain the role of ribozymes. What three properties allow some RNA molecules to function as ribozymes? 14. Explain why, due to alternative RNA splicing, the number of different protein prod ...
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Nucleic Acids - Biology Innovation
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... be once of five different bases. The pyrimidine bases are thymine, cytosine and uracil. The Purine bases are adenine and guanine. There are also two different types of pentose sugar which differ between DNA and RNA, the pentose sugar in DNA is deoxyribose and in RNA it is ribose. Shown below is a si ...
Chapter 11
Chapter 11

... DNA, that bind tightly to proteins, amino acids, drugs, or other molecules.  They are usually 15-40 nucleotides long, have highly organized secondary and tertiary structures, and bind with high affinity.  The advantages are their high specificity, relative ease of production, low or no immunogenic ...
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No Slide Title

... 2. Bring them to the ribosome and place them on the right spot in the mRNA ...
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... translation level) a.A microRNA (abbr. miRNA) is a small non-coding RNA molecule (~22 nucleotides) found in plants and animals, which functions in transcriptional and post-transcriptional regulation of gene expression. Encoded by eukaryotic nuclear DNA, miRNAs function via base-pairing with compleme ...
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... translation level) a.A microRNA (abbr. miRNA) is a small non-coding RNA molecule (~22 nucleotides) found in plants and animals, which functions in transcriptional and post-transcriptional regulation of gene expression. Encoded by eukaryotic nuclear DNA, miRNAs function via base-pairing with compleme ...
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8.4 Lecture - Issaquah Connect

... – Nucleotides (5) pair with one strand of the DNA (4). – RNA polymerase (7) reads one side of the DNA template and strings together a complementary strand of RNA nucleotides. (6) – The DNA helix winds again as the gene is transcribed. ...
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... Also, notice start & stop codons. Can tell on DNA where protein starts/stops. ...
Slides - nanoHUB
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A comprehensive catalogue of human RNA-binding
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... New tool to map genetic modifiers of transcription factor–gene target connections Fazlollahi et al. have developed a computational approach to determine genetic variants that affect the functional interactions of gene regulatory networks. Using this algorithm, the team were able to map so-called con ...
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bio_ch08

... – Nucleotides pair with one strand of the DNA. – RNA polymerase bonds the nucleotides together. – The DNA helix winds again as the gene is transcribed. DNA ...
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Polyadenylation



Polyadenylation is the addition of a poly(A) tail to a messenger RNA The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for translation. It, therefore, forms part of the larger process of gene expression.The process of polyadenylation begins as the transcription of a gene finishes, or terminates. The 3'-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3' end. In some genes, these proteins may add a poly(A) tail at any one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing.The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.mRNA molecules in both prokaryotes and eukaryotes have polyadenylated 3'-ends, with the prokaryotic poly(A) tails generally shorter and less mRNA molecules polyadenylated.
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