Screening of Mutations and Polymorphisms in the Glucokinase
... regions in 722 subjects (in 12 patients with an unrecognised type of MODY and their 10 family members, 313 patients with diabetes mellitus type 2 (DM2), 141 gestational diabetics (GDM), 130 healthy offspring of diabetic parents, and 116 healthy controls without family history of DM2). In two MODY fa ...
... regions in 722 subjects (in 12 patients with an unrecognised type of MODY and their 10 family members, 313 patients with diabetes mellitus type 2 (DM2), 141 gestational diabetics (GDM), 130 healthy offspring of diabetic parents, and 116 healthy controls without family history of DM2). In two MODY fa ...
Supplemental File 1 - Poly(A) Tag (PAT) analysis pipeline The
... Note the use of upper case “S” here. This gives a list that may be used for gene-level expression analysis or other purposes. 3. Gene expression analysis using CLC Genomic Workbench The output from Part E.2 was converted to one usable for CLC Genomics Workbench; briefly, this involved removing all b ...
... Note the use of upper case “S” here. This gives a list that may be used for gene-level expression analysis or other purposes. 3. Gene expression analysis using CLC Genomic Workbench The output from Part E.2 was converted to one usable for CLC Genomics Workbench; briefly, this involved removing all b ...
Identification, cloning and sequence determination of genes specifying hexokinase A and B from yeast.
... terminal Ala overlapped the amino terminal Ala from the first subclone. Since this tryptic peptide had been tentatively assigned as spanning residues 385-396 in the approximated structure derived from x-ray crystallography (5), the 5' and 3' ends of the HKB structural gene were calculated to be roug ...
... terminal Ala overlapped the amino terminal Ala from the first subclone. Since this tryptic peptide had been tentatively assigned as spanning residues 385-396 in the approximated structure derived from x-ray crystallography (5), the 5' and 3' ends of the HKB structural gene were calculated to be roug ...
Chapter 15 The Chromosomal Basis of Inheritance
... If a sex-linked trait is due to a recessive allele, a female will express this phenotype only if she is homozygous. ° Heterozygous females are carriers for the recessive trait. ° Because males have only one X chromosome (hemizygous), any male receiving the recessive allele from his mother will expre ...
... If a sex-linked trait is due to a recessive allele, a female will express this phenotype only if she is homozygous. ° Heterozygous females are carriers for the recessive trait. ° Because males have only one X chromosome (hemizygous), any male receiving the recessive allele from his mother will expre ...
DNA mutation bracelets
... 1) What changes in the RNA sequence were caused by the changes in the DNA? When the DNA sequence was changed, the RNA reading frame was shifted. 2) What changes in amino acids were caused by the changes in the DNA? Different amino acid were coded after the deletion shifted the sequence. 3) What happ ...
... 1) What changes in the RNA sequence were caused by the changes in the DNA? When the DNA sequence was changed, the RNA reading frame was shifted. 2) What changes in amino acids were caused by the changes in the DNA? Different amino acid were coded after the deletion shifted the sequence. 3) What happ ...
Differential Regulation of Antagonistic Pleiotropy in Synthetic and
... al. 2013). This is primarily due to limited evidence for the abundance of trade-offs in natural ...
... al. 2013). This is primarily due to limited evidence for the abundance of trade-offs in natural ...
Phenotypic overlap in the contribution of individual genes to CNV
... Many such rearrangements result in the loss or gain of specific genomic segments and thus are referred to as copy number variants (CNV). These regions can contain multiple genes. The phenotypic abnormalities seen in diseases associated with CNVs are thought to be related to altered gene dosage effec ...
... Many such rearrangements result in the loss or gain of specific genomic segments and thus are referred to as copy number variants (CNV). These regions can contain multiple genes. The phenotypic abnormalities seen in diseases associated with CNVs are thought to be related to altered gene dosage effec ...
source file - MIMG — UCLA
... first gene in the operon has a S-D upstream of the start codon and has a stop codon within 5-15 nt of the start codon for the next gene in the operon. In this case, the genes may be close enough that the ribosome does not need to completely dissociate from the RNA transcript, instead it “skids” alon ...
... first gene in the operon has a S-D upstream of the start codon and has a stop codon within 5-15 nt of the start codon for the next gene in the operon. In this case, the genes may be close enough that the ribosome does not need to completely dissociate from the RNA transcript, instead it “skids” alon ...
Cell-Free Protein Synthesis Course
... Protein biosynthesis is a fundamental process for maintaining life. The genetic information defining any living organism is commonly stored in genomic DNA and has to be translated into proteins for “use” for conducting most processes in a cell and multicellular organisms. Hence a wide range of prote ...
... Protein biosynthesis is a fundamental process for maintaining life. The genetic information defining any living organism is commonly stored in genomic DNA and has to be translated into proteins for “use” for conducting most processes in a cell and multicellular organisms. Hence a wide range of prote ...
The Incompatible Desiderata of Gene Cluster Properties
... different genomes have been used extensively to reconstruct the history of chromosomal rearrangements and infer an ancestral genetic map for a diverse group of species [3, 4], as well as to provide novel features for new phylogenetic approaches. Genome self-comparisons reveal ancient large-scale or ...
... different genomes have been used extensively to reconstruct the history of chromosomal rearrangements and infer an ancestral genetic map for a diverse group of species [3, 4], as well as to provide novel features for new phylogenetic approaches. Genome self-comparisons reveal ancient large-scale or ...
Gene expression profiles in rice gametes and zygotes: identification
... 1928 | Abiko et al. exocytosis upon sperm cell attachment to the egg cell, and that the secreted EC1 proteins function in redistribution of GCS1/HAP2 proteins to the sperm cell surface, resulting in successful gamete fusion. ANK6 is a mitochondrial ankyrinrepeat protein with high expression in bot ...
... 1928 | Abiko et al. exocytosis upon sperm cell attachment to the egg cell, and that the secreted EC1 proteins function in redistribution of GCS1/HAP2 proteins to the sperm cell surface, resulting in successful gamete fusion. ANK6 is a mitochondrial ankyrinrepeat protein with high expression in bot ...
"Dual-coding Regions in Alternatively Spliced Human Genes". In
... are annotated as more than one type of codon position. Not surprisingly, two key factors strongly influence the identification of dual-coding regions: the completeness of transcriptome data and the accuracy of reading frame annotation. Based on a set of high-quality and wellannotated transcripts, we o ...
... are annotated as more than one type of codon position. Not surprisingly, two key factors strongly influence the identification of dual-coding regions: the completeness of transcriptome data and the accuracy of reading frame annotation. Based on a set of high-quality and wellannotated transcripts, we o ...
A nested deletion approach to generate Cre deleter mice with
... due either to particular mutations, or, even more of a concern for the future, to the combination of various mutations. Murine Hox genes provide an interesting example of the interest of this system. Mammals have 39 Hox genes encoding transcription factors, whose function is to organize the body pla ...
... due either to particular mutations, or, even more of a concern for the future, to the combination of various mutations. Murine Hox genes provide an interesting example of the interest of this system. Mammals have 39 Hox genes encoding transcription factors, whose function is to organize the body pla ...
quantitative features
... values over 0,5 as high heritability the higher heritability, the higher similarity between parents and the posterity is to be expected and on the contrary!!!!!! ...
... values over 0,5 as high heritability the higher heritability, the higher similarity between parents and the posterity is to be expected and on the contrary!!!!!! ...
Chapter 15 – The Chromosomal Basis of Inheritance
... One of Morgan’s students, Alfred Sturtevant, used crossing over of linked genes to develop a method for constructing a genetic map, an ordered list of the genetic loci along a particular chromosome. ...
... One of Morgan’s students, Alfred Sturtevant, used crossing over of linked genes to develop a method for constructing a genetic map, an ordered list of the genetic loci along a particular chromosome. ...
Mendelian genetics (Word)
... unknown to Darwin). *1900 Mendel's results are rediscovered, ABO blood group system in humans are discovered and shown to be an example of Mendelian inheritance. 1944 DNA is the genetic material. *1953 Watson and Crick discover the molecular structure of DNA. 1970 Gene mapping in humans essentially ...
... unknown to Darwin). *1900 Mendel's results are rediscovered, ABO blood group system in humans are discovered and shown to be an example of Mendelian inheritance. 1944 DNA is the genetic material. *1953 Watson and Crick discover the molecular structure of DNA. 1970 Gene mapping in humans essentially ...
Genespring FAQ - UNC Center for Bioinformatics
... tabs will allow you to set which data each axis represents. Once these are set to the two samples or conditions you are interested in comparing, click on the “Lines to Graph” tab. Here you can set the fold change lines to any value you wish. Click OK. Right-Click on the region you are interested in: ...
... tabs will allow you to set which data each axis represents. Once these are set to the two samples or conditions you are interested in comparing, click on the “Lines to Graph” tab. Here you can set the fold change lines to any value you wish. Click OK. Right-Click on the region you are interested in: ...
Loss And Gain Of Function Experiments Implicate TMEM18
... gap between the identification of a variant as being associated with an adiposity phenotype and the understanding of how that variant actually influences energy balance. Murine models have proven to be essential in moving from statistical association to a fuller understanding of the biology of the g ...
... gap between the identification of a variant as being associated with an adiposity phenotype and the understanding of how that variant actually influences energy balance. Murine models have proven to be essential in moving from statistical association to a fuller understanding of the biology of the g ...
Morphology of nuclear transcription | SpringerLink
... 2009; Shiao et al. 2011). The exact number and degree of variation in composition of individual repeats is largely unknown, mostly because molecular methods to analyze single repetitive elements in a genomic context have been missing. For HeLa cells, it was calculated that about 120 TUs are actively ...
... 2009; Shiao et al. 2011). The exact number and degree of variation in composition of individual repeats is largely unknown, mostly because molecular methods to analyze single repetitive elements in a genomic context have been missing. For HeLa cells, it was calculated that about 120 TUs are actively ...
Mutator Transposon in Maize and MULEs in the Plant Genome
... Mutator line carried active transposons and were consistent with a very high duplication rate. Those progenies that did lose activity appeared to do so due to epigenetic silencing, rather than the segregation of an autonomous, or controlling element. This was confirmed in many later experiments [5,6 ...
... Mutator line carried active transposons and were consistent with a very high duplication rate. Those progenies that did lose activity appeared to do so due to epigenetic silencing, rather than the segregation of an autonomous, or controlling element. This was confirmed in many later experiments [5,6 ...
PowerPoint-presentatie - the biopsychology research group
... Recent data suggest that copy number variants (CNVs) can contribute to complex disease susceptibility. The relative impact of CNVs compared to single nucleotide polymorphisms (SNPs) on one of the processes underlying disease vulnerability, variable gene expression, has been estimated at 18% (1). The ...
... Recent data suggest that copy number variants (CNVs) can contribute to complex disease susceptibility. The relative impact of CNVs compared to single nucleotide polymorphisms (SNPs) on one of the processes underlying disease vulnerability, variable gene expression, has been estimated at 18% (1). The ...
Novel NCC mutants and functional analysis in a new
... Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis in conjunction with significant hypomagnesemia and hypocalciuria. The GS phenotype is caused by mutations in the solute carrier family 12, member 3 (SLC12A3) gene that encodes the thiazide-sens ...
... Gitelman syndrome (GS) is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis in conjunction with significant hypomagnesemia and hypocalciuria. The GS phenotype is caused by mutations in the solute carrier family 12, member 3 (SLC12A3) gene that encodes the thiazide-sens ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.