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Lecture notes
Lecture notes

Course of Immunology
Course of Immunology

Ch 31 vocabulary list
Ch 31 vocabulary list

... 3. nonspecific defense- physical or chemical barrier that prevents pathogens from entering the body (Concept 31.2) 4. inflammatory response- nonspecific defense against infection, characterized by redness, heat, swelling, and pain (Concept 31.2) 5. histamine- chemical alarm signal released by mast c ...
Resolution
Resolution

... Activation of Adaptive Immunity • Macrophages are professional antigen presenting cells (APC). • APC capture, process, transport, present and retain antigen • Phagocytosed antigen is digested within the endocytic processing pathway into peptides that associate with class II MHC molecules and the co ...
IMMUNE SYSTEM
IMMUNE SYSTEM

... – antibodies pass from mother to baby across placenta or in mother’s milk – critical role of breastfeeding in infant health ...
Chapter 7: Circulation and Blood
Chapter 7: Circulation and Blood

...  All white blood cells have district nuclei.  There are 5 different types of white blood cells: 1. Neutrophil: when pneumonia is present their count increases by 25% 2. Eosinophil: play major role in allergic reactions 3. Basophil: their numbers increase when Leukemia is present 4. Monocyte: when ...
Glomerular diseases
Glomerular diseases

... - a self-molecule in autoimmune diseases (errant or uncontrolled plasma cells produce antibodies against self-antigens) - a drug or microbial product passively adsorbed onto a cell surface AB binds to the epitope and can stimulate cell damage by a number of effector mechanisms: - AB + complement  o ...
IMMUNE SYSTEM
IMMUNE SYSTEM

... IgA – local immunity antibody ~ in glandular secretions IgM – early protecting antibody ~ first antibodies IgD – B-cell activation IgE – antibodies of allergic reactions ~ histamin ...
Natural Defenses for Healthy Animals
Natural Defenses for Healthy Animals

... foreign matter, they render it harmless. They also absorb the liposome. The DNA is released inside the cell, where it stimulates specific receptors. ...
Immunology Ch 1 1-22 [4-20
Immunology Ch 1 1-22 [4-20

... -All lymphocytes arise in bone marrow; B cells mature in marrow, T cells mature in thymus -sites where mature lymphocytes are produced are called generative lymphoid organs, mature lymphocytes enter circulation and enter peripheral lymphoid organs, where they meet antigen -Naïve lymphocytes recogniz ...
Unit 4 Mind Maps
Unit 4 Mind Maps

... Describe the role of cytokines Damage to connective tissue causes, __________ cells to release a chemical called ___________ ...
Immunity
Immunity

... The baby has her/his immunity from the mother but it only lasts a few months because the baby hasn't developed his/her own immunity. ...
Lymphatic System Notes (2 of 3)
Lymphatic System Notes (2 of 3)

... Medicine given to kill bacterial infection, cannot be used for viral infections Must take it for full 7-10 days otherwise, bacterial infection can come back and/or can cause antibiotic resistance in bacteria Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
Exam 2 2016 Answers
Exam 2 2016 Answers

... 33. Why is a live virus thought to elicit both cell mediated immunity and humoral immunity while killed virus only provokes a humoral response? a. viral antigens stimulate all immune cells b. proliferating viruses do not kill macrophages c. proliferating virus can activate the cytotoxic T cells to k ...
The Immune System
The Immune System

... • A white blood cell engulfs a microbe, then fuses with a lysosome to destroy the microbe • There are different types of phagocytic cells – Neutrophils engulf and destroy pathogens – Macrophages are found throughout the body – Dendritic cells stimulate development of adaptive immunity – Eosinophils ...
AUTOIMMUNE DISEASES
AUTOIMMUNE DISEASES

... deck, random combinations can produce an enormous number of different hands ...
imunity-skin-and-soft-tissue-infection-copy
imunity-skin-and-soft-tissue-infection-copy

... Tinospora cordifolia extract, a plant derived immunostimulant, significantly affected the symptoms of HIV. This was validated by clinical evaluation. However not all of the objective parameters studied by us, Tinospora cordifolia could be used as an adjunct to HIV/AIDS management. ...
Lymphatic & Immune Systems
Lymphatic & Immune Systems

... Describe some specific clinical applications of cytokine therapies. Explain the major steps in the production of monoclonal antibodies, and some of their practical uses. 13.5 Adverse Effects of Immune Responses Discuss the most common immunological mechanisms responsible for allergies. Compare the a ...
Lymphoid System I: Peripheral System, Lymph Node
Lymphoid System I: Peripheral System, Lymph Node

... To put this in context: Your acquired immune system is made of B and T cells, each specific for a single antigen. B and T cells are born in the bone marrow and then matured in the primary lymph organs (bone marrow and thymus respectively). They then circulate in the blood as naïve lymphocytes. Havin ...
Activated Helper T cells
Activated Helper T cells

... CAST YOUR NET: ADVENTURES WITH BLOOD ...
Generation of ligands for the T cell receptor
Generation of ligands for the T cell receptor

CyAn™ ADP Dendritic Cells: Rare Event Analysis E T
CyAn™ ADP Dendritic Cells: Rare Event Analysis E T

... In two other tubes, 400 μL of whole blood collected from a normal, healthy adult was added. To one of the tubes, the following mouse antihuman antibodies were added: 20 μL of the FITC cocktail, 40 μL of HLA-DR APC and 20 μL of CD123 RPE. In the other tube, the following mouse anti-human antibodies w ...
video slide
video slide

... • Helper T cells aid both responses Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Immune System
Immune System

... • Helper T cells aid both responses Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Dead cell-associated antigens
Dead cell-associated antigens

... ► Dead tumor cells in periphery accumulate in the draining lymph node sinus; ► CD169+ macrophages phagocytose and crosspresent dead cell-associated antigens; ► CD169+ macrophage-depleted mice fail to crossprime tumor-specific CD8 T cells; ► CD169+ macrophages link tumor cell death and induction of a ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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