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Hypersensitivity (allergy).
Hypersensitivity (allergy).

... These reactions can be fatal, such as reactions to insect venoms, to drugs (antibiotics and sulphonamides) or even to foods which can readily gain access to the general circulation. Note: anaphylactic shock to local anaesthetics such as lidocaine or novocaine although rare, have been reported and sh ...
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... Immature lymphocytes cannot react with antigens. Lymphocyte differentiation & immunocompetence are completed by late fetal or early neonatal period. Mature B cells are found in the lymph nodes, spleen, gut associated lymphoid tissue. Have immunoglobin receptors & numerous ...
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... Pupil discover in pairs of two the lymphatic system in some kind of submerge 3D-journey [Tauchfahrt] up to the lymph nodes, using their own devices (especially suitable with tablets) Pupils “zoom” interactively through the lymphatic system and its major compontents. Thus they understand the lymphati ...
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Investigating the role of CD14 in apoptotic cell clearance in the lungs

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... This is a lecture guide summarizing the events that occur to activate both B cells and T cells and generate an immune response. Let’s get started! When talking about the immune system it is important to identify the key players in the process. First there are the specialized immune cells known as th ...
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PowerPoint Presentation - I. Introduction to class

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... a. Stem cells undergo a series of changes in the bone marrow to form B cell. b. Naive B cells enter peripheral lymphoid organs or lymphoid tissues, under stimulation of specific antigens, proliferate and transform into plasma cells ( effector B cell) and memory B cells. c. Responsible for humoral im ...
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PowerPoint Presentation - I. Introduction to class

...  Antibodies are produced by a subset of lymphocytes called B cells.  B cells that are stimulated will actively secrete antibodies and are called plasma cells.  Antibodies are found in extracellular fluids (blood plasma, lymph, mucus, etc.) and the surface of B cells.  Defense against bacteria, b ...
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... the immune response,” says Korman, adding that there are also technology that defines unique mutations in tumor cells—called molecules on T cells that, when bound, shore up the immune “neoantigens”—to create tailored vaccines. response. These molecules are called “costimulatory receptors,” and compa ...
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... forty years, scientists have been able to harness this knowledge to develop an array of biological assays that have since become essential in the modern molecular biology laboratory. Polyclonal antibodies bind to multiple epitopes of a given antigen and are produced by (1) immunizing a mammal – ofte ...
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Cytoplasm - Austin Community College

... Cellular immune response (they do not produce antibodies) Regulate antibody reactions by helping or suppressing activation of B lymphs. T cells act as “helper cells” (HIV or AIDS virus causes a destruction of these helper cells), which are instrumental in aiding B cells in antibody production, and “ ...
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... Increase the production of free radicals  DNA damage and impaired immune function Increase inflammation through the production of pro-inflammatory cytokines  impair immune function and promote cancer growth Reduce the ability of abnormal cells to undergo apoptosis and DNA repair, important self-re ...
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... “There is accumulating evidence that vaccines can be used therapeutically to treat conditions like cancer, allergy and autoimmune disease. For all of these applications, it is critical that vaccines are designed to stimulate immune responses of the correct ‘character’,” Dr Hermans says. “For example ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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