Full-Text PDF
... proteins frequently involves discrete targeting motifs, short sequences present in cytoplasmic domains of such membrane proteins that mediate their inclusion into transport vesicles via direct or indirect interactions with the vesicle forming coat machinery. The best-understood class of cellular tar ...
... proteins frequently involves discrete targeting motifs, short sequences present in cytoplasmic domains of such membrane proteins that mediate their inclusion into transport vesicles via direct or indirect interactions with the vesicle forming coat machinery. The best-understood class of cellular tar ...
Amino Acid Transport Systems in Animal Cells
... levels relative to the extracellular fluid. The comparison is complicated somewhat, however, b y effects of amino acid structure on the intensity of accumulation by System L. My comments may be running contrary t o an assumption about System L that has gained unfortunate currency, namely that it pro ...
... levels relative to the extracellular fluid. The comparison is complicated somewhat, however, b y effects of amino acid structure on the intensity of accumulation by System L. My comments may be running contrary t o an assumption about System L that has gained unfortunate currency, namely that it pro ...
Slide 1
... Search for transcription factors regulating the expression of AQY1 revealed Fkh2 as a potential candidate. • X-gal overlay assay is not suitable for spores, instead βgalactosidase activity assay using ONPG. • Transcription factors regulating late sporulation induced genes are not yet identified. Fin ...
... Search for transcription factors regulating the expression of AQY1 revealed Fkh2 as a potential candidate. • X-gal overlay assay is not suitable for spores, instead βgalactosidase activity assay using ONPG. • Transcription factors regulating late sporulation induced genes are not yet identified. Fin ...
Spatial and temporal changes in the expression of fibroglycan
... glypican, and their extracellular moieties differ also substantially from each other. Yet, the transmembrane and cytoplasmic domains of these proteins are nearly 65% identical, suggesting that together they may constitute a family of integral membrane proteoglycans, the syndecans, with similar domai ...
... glypican, and their extracellular moieties differ also substantially from each other. Yet, the transmembrane and cytoplasmic domains of these proteins are nearly 65% identical, suggesting that together they may constitute a family of integral membrane proteoglycans, the syndecans, with similar domai ...
Coordination between Cell Growth and Cell Cycle Transit in Animal
... therefore of particular interest in tumor biology research. Studies of the molecular basis of these growth control events in G 1 would be facilitated if such studies could focus on a defined and very limited stage within G 1 that is of particular importance for the specific G O arrest. To search for ...
... therefore of particular interest in tumor biology research. Studies of the molecular basis of these growth control events in G 1 would be facilitated if such studies could focus on a defined and very limited stage within G 1 that is of particular importance for the specific G O arrest. To search for ...
Staphylococcal phenomics: metabolomic and proteomic responses
... proline exist in the S.aureus system; a low affinity system encoded by proP homology gene and a high affinity system expressed by putP gene [50]. These processes prevent the pleiotropic effects in the cell during the exposure to osmotic shock [19, 51]. The genomes of staphylococci have revealed that ...
... proline exist in the S.aureus system; a low affinity system encoded by proP homology gene and a high affinity system expressed by putP gene [50]. These processes prevent the pleiotropic effects in the cell during the exposure to osmotic shock [19, 51]. The genomes of staphylococci have revealed that ...
Thyroid Hormones
... anions like percholate and thiocynate, which compete with iodine. Large amounts of iodide with also inhibit the pump and thyroid hormone synthesis (Wolff-Chaikoff effect). i. Iodine ions are oxidized to iodine by peroxidase located on the apical membrane. Iodine is capable of combining with the amin ...
... anions like percholate and thiocynate, which compete with iodine. Large amounts of iodide with also inhibit the pump and thyroid hormone synthesis (Wolff-Chaikoff effect). i. Iodine ions are oxidized to iodine by peroxidase located on the apical membrane. Iodine is capable of combining with the amin ...
toxins
... by vesicle budding from the trans-Golgi system, followed by homotypic fusion to form larger vesicles. Usually they mediate release of peptide transmitter or certain catecholamines whose synthesis depends on the presence in the granule lumen of enzymes (as the dopamine-beta-hydroxylase). Small synapt ...
... by vesicle budding from the trans-Golgi system, followed by homotypic fusion to form larger vesicles. Usually they mediate release of peptide transmitter or certain catecholamines whose synthesis depends on the presence in the granule lumen of enzymes (as the dopamine-beta-hydroxylase). Small synapt ...
IL-13 - York College of Pennsylvania
... tested to confirm their presence beyond just their amino acid sequence ...
... tested to confirm their presence beyond just their amino acid sequence ...
I study the neural circuits that move bodies
... brain came during a surgery that I thought I had messed up during an early step but went through the motions anyway with significantly more speed and less care than normal. It felt like a life lesson. Learning electrophysiology for me became more of a mind game (how do I have to think in order to ma ...
... brain came during a surgery that I thought I had messed up during an early step but went through the motions anyway with significantly more speed and less care than normal. It felt like a life lesson. Learning electrophysiology for me became more of a mind game (how do I have to think in order to ma ...
- Wiley Online Library
... To further test the hypothesis of alternative translation initiation as the FH distribution mechanism, we constructed the above plasmids with the FH gene harboring specific point mutations and examined the distribution of the corresponding plasmid-expressed-FHs. Mutagenesis of the initiation codons ...
... To further test the hypothesis of alternative translation initiation as the FH distribution mechanism, we constructed the above plasmids with the FH gene harboring specific point mutations and examined the distribution of the corresponding plasmid-expressed-FHs. Mutagenesis of the initiation codons ...
Herceptin Resistance Database for Understanding
... per patient’s constraint. Unfortunately, reliability of available Herceptin biomarkers (diagnostic tests) is very poor5,8,9. With the advent of technology particularly high throughput sequencing technologies, it is possible to design genome-based biomarkers for personalized therapy (the right drug f ...
... per patient’s constraint. Unfortunately, reliability of available Herceptin biomarkers (diagnostic tests) is very poor5,8,9. With the advent of technology particularly high throughput sequencing technologies, it is possible to design genome-based biomarkers for personalized therapy (the right drug f ...
Hitting the Target: Emerging Technologies in the Search for Kinase
... conductor. Aside from containing sequences necessary for three-dimensional folding into domains, many proteins have evolved motifs that allow posttranslational modifications that modulate function. By far the largest group of enzymes that catalyze regulatory posttranslational modifications is the fa ...
... conductor. Aside from containing sequences necessary for three-dimensional folding into domains, many proteins have evolved motifs that allow posttranslational modifications that modulate function. By far the largest group of enzymes that catalyze regulatory posttranslational modifications is the fa ...
End4/Sla2 is involved in establishment of a new growth zone in
... the same domain structure and organization as the other Sla2related proteins, namely an N-terminal ENTH (epsin Nterminal homology) domain, a central coiled coil region, and a C-terminal talin-like domain. The talin-like domain contains the I/LWEQ-module predicted to bind to F-actin (McCann and Craig ...
... the same domain structure and organization as the other Sla2related proteins, namely an N-terminal ENTH (epsin Nterminal homology) domain, a central coiled coil region, and a C-terminal talin-like domain. The talin-like domain contains the I/LWEQ-module predicted to bind to F-actin (McCann and Craig ...
Immunocytochemistry of Rhamnogalacturonan II in Cell Walls of
... by Moore et al. (1986) and Williams et al. (1996). Even though the signals were enhanced with alkaline treatment, the signal disappeared when the antisera had been immunoprecipitated with the B-RG-II complex (Fig. 3d, e), indicating that the antisera only recognizes the RG-II region and that other e ...
... by Moore et al. (1986) and Williams et al. (1996). Even though the signals were enhanced with alkaline treatment, the signal disappeared when the antisera had been immunoprecipitated with the B-RG-II complex (Fig. 3d, e), indicating that the antisera only recognizes the RG-II region and that other e ...
Untitled
... signals running along a complex, interconnected neural perception system genetically encoded to detect and respond to painful stimuli. The body detects and converts pain stimuli into electrical signals at the fine nerve endings of “nociceptors,” sensory neurons specialized to respond to pain. Their ...
... signals running along a complex, interconnected neural perception system genetically encoded to detect and respond to painful stimuli. The body detects and converts pain stimuli into electrical signals at the fine nerve endings of “nociceptors,” sensory neurons specialized to respond to pain. Their ...
Characterizing the Secreted Proteome of Mycobacterium
... substrates, quantification of the ESX-1 paralogs sometimes relied on single peptide quantification. In Figure 3, quantification and annotation of two such substrates is shown. Some of the specific y and b-series ions are highlighted on the spectra as they are responsible for distinguishing between t ...
... substrates, quantification of the ESX-1 paralogs sometimes relied on single peptide quantification. In Figure 3, quantification and annotation of two such substrates is shown. Some of the specific y and b-series ions are highlighted on the spectra as they are responsible for distinguishing between t ...
RNA-dependent disassembly of nuclear bodies
... We next verified whether iPNBs fused with nucleoli. The fusion of iPNBs with each other (Fig. 2B, Movie 2) and with nucleoli (Fig. 2C, Movie 3) was easily observed during the first hour after the return to isotonic medium. The frequency of fusion events between iPNBs rapidly declined during the firs ...
... We next verified whether iPNBs fused with nucleoli. The fusion of iPNBs with each other (Fig. 2B, Movie 2) and with nucleoli (Fig. 2C, Movie 3) was easily observed during the first hour after the return to isotonic medium. The frequency of fusion events between iPNBs rapidly declined during the firs ...
The TACC proteins: TACC-ling microtubule dynamics and
... [12,42]. Recently, it was demonstrated that two residues (L229 and M581) in the TACC domain of C. elegans TAC-1 are important for targeting TAC-1 to the centrosome [44]. It is unclear at the moment whether these residues are important for structural reasons or for protein–protein interactions. Howev ...
... [12,42]. Recently, it was demonstrated that two residues (L229 and M581) in the TACC domain of C. elegans TAC-1 are important for targeting TAC-1 to the centrosome [44]. It is unclear at the moment whether these residues are important for structural reasons or for protein–protein interactions. Howev ...
RESPIRATION AND PROTEIN SYNTHESIS IN ESCHERICHIA COLI
... mild techniques. The use of DNAase, RNAase, detergents, sonication, lysozyme, and ethylenediaminetetraacetate were avoided in the belief that rather delicate, but metabolically important, associations may exist between the plasma membrane and various cytoplasmic components . The membrane-envelope fr ...
... mild techniques. The use of DNAase, RNAase, detergents, sonication, lysozyme, and ethylenediaminetetraacetate were avoided in the belief that rather delicate, but metabolically important, associations may exist between the plasma membrane and various cytoplasmic components . The membrane-envelope fr ...
The Arabidopsis TRM1-TON1 interaction reveals a recruitment
... to interact in yeast and confirmed that the last 79 residues of TRM1 are necessary and sufficient for interaction with TON1. Further deletion of TRM1 showed the last 33 C-terminal residues are sufficient for interaction with TON1 in yeast (Figure 1). TRM Proteins Share Six Conserved Sequence Motifs ...
... to interact in yeast and confirmed that the last 79 residues of TRM1 are necessary and sufficient for interaction with TON1. Further deletion of TRM1 showed the last 33 C-terminal residues are sufficient for interaction with TON1 in yeast (Figure 1). TRM Proteins Share Six Conserved Sequence Motifs ...
Cold Shock Proteins
... Abstract: From prokaryotes to eukaryotes or from invertebrates to vertebrates, all organisms have developed various adaptive mechanisms to survive within a wide range of growth temperatures. An important part of the cold adaptation mechanism occurs at the level of the cytoplasmic membrane. Cold shoc ...
... Abstract: From prokaryotes to eukaryotes or from invertebrates to vertebrates, all organisms have developed various adaptive mechanisms to survive within a wide range of growth temperatures. An important part of the cold adaptation mechanism occurs at the level of the cytoplasmic membrane. Cold shoc ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.