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Inhibition of Nitric Oxide Production Is Associated
Inhibition of Nitric Oxide Production Is Associated

... RAFT-VERSUS-HOST disease (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation (BMT). GVHD is a complex pathophysiologic process that results from the cooperative interaction of multiple effector cell populations resident in the donor graft ...
WOUND HEALING
WOUND HEALING

... intracellular helical procollagen cleaved into tropocollagen which is secreted, tropocollagen helices (15 Angstrom) form collagen filaments (200 Angstrom) and through further intra and inter-molecular bonds form collagen fibrils (2,000 Angstrom) and fibers (20,000 Angstrom), which in turn form colla ...
Quantification of gap junction selectivity
Quantification of gap junction selectivity

... dynamically regulated parameter of channel function remains unexplored, and the extent of connexin-specific selectivity differences are poorly defined. To understand why the mammalian genome includes 20 or more connexin genes, the functional differences between the gap junctions that they form must ...
Fgf8 induces pillar cell fate and regulates cellular
Fgf8 induces pillar cell fate and regulates cellular

... methods for specific genetic cross) die at birth as a result of defects in the development of the forebrain (Storm et al., 2003); however, overall development of the inner ear and cochlea appeared normal. To examine the effects of inactivation of Fgf8 on PC development, cochleae were obtained from m ...
University of Groningen Bacillus subtilis at near
University of Groningen Bacillus subtilis at near

... heterogeneous (Cozy and Kearns, 2010). The benefits of the chain formation under (near-)zero growth conditions are not clear. In respect to the encountered caloric restriction it seems sensible to reduce energy expenditures, as is reflected in general in the expression levels of genes involved with ...
Complex networks orchestrate epithelial–mesenchymal transitions
Complex networks orchestrate epithelial–mesenchymal transitions

... form layers of cells that are closely adjoined by specialized membrane structures, such as tight junctions, adherens junctions, desmosomes and gap junctions. In addition, epithelial cells have apical–basolateral polarization, which manifests itself through the localized distribution of adhesion mole ...
Group-specific effects on coastal bacterioplankton of
Group-specific effects on coastal bacterioplankton of

... general response patterns could be found for the dominant marine bacterioplankton groups (Alpha- and Gammaproteobacteria or Bacteroidetes), since different species within the same broad phylogenetic groups reacted differently to the PUAs. The enzymatic cascade leading to PUA production has been show ...
Sample Chapter 5 from the Textbook
Sample Chapter 5 from the Textbook

... The epidermis is stratified squamous epithelium. It is separated from the underlying dermis by a basement membrane. The epidermis is not as thick as the dermis and contains no blood vessels. The living cells of the epidermis receive nutrients and excrete waste products by the diffusion of substances ...
lysosomes in skeletal muscle tissue
lysosomes in skeletal muscle tissue

... equilibrium density can be shifted by dextran-500 and Triton WR-1339 . It is suggested that this group of lysosomes is derived from macrophages and other connective tissue cells, whereas the former group represents lysosome-like particles from muscle cells . INTRODUCTION Tissue fractionation studies ...
Downloadable Full Text - DSpace@MIT
Downloadable Full Text - DSpace@MIT

... uring differentiation and embryogenesis, developmental genes are temporally and spatially regulated by multiple cellular mechanisms. Specific histone modifications such as methylation of lysine residues are associated with either the active or silent state of gene transcription. For example, histone 3 ...
Topical aldose reductase inhibitor for correcting
Topical aldose reductase inhibitor for correcting

... routine eye examination was performed, and the subjects were excluded if any abnormal pathology that might affect the morphology of the corneal endothelium was noted. All of the 13 diabetic patients were found to have no diabetic retinopathy or simple (background) retinopathy at the pretreatment exa ...
Full-Text PDF
Full-Text PDF

... models are being developed using these co-cultured cells with the goal of making engineered tissues similar to their natural counterparts. An exclusive full-thickness 3D skin equivalent was developed to model early melanoma invasion by incorporating an inert scaffold with suitable pore sizes to supp ...
Evaluation of the penetration ofciprofloxacin and
Evaluation of the penetration ofciprofloxacin and

... bron chial mucosa samples from patients and related bronchial tissue to sputum. This would occur if the then i to serum concentrations. The absolute drug only process were passive diffusion. The rate of conc,entrations in bronchial mucosa and their relation penetration of antibiotics from blood to b ...
Specification of germ layer identity in the chick gastrula.
Specification of germ layer identity in the chick gastrula.

... © 2007 Chapman et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
A tour of the cell - The Open University
A tour of the cell - The Open University

... Studies into the function and appearance of cells reveal the presence of great diversity, which is particularly striking among eukaryotic cells. Even very different types of eukaryotic cells, however, exhibit many common structures and functions. This mix of uniformity and diversity is also reflecte ...
Macrophage- and dendritic cell–dependent
Macrophage- and dendritic cell–dependent

... the MZ express phenotypic markers typically associated with macrophages and have been referred to as myeloid DCs.9 In vitro–derived myeloid DCs initiate humoral immune responses in mice to TI antigens, expressed by the intact gram-positive extracellular bacteria Streptococcus pneumoniae.10 Recently, ...
Retinoid signaling regulates primitive (yolk sac
Retinoid signaling regulates primitive (yolk sac

... and the hematopoietic stem cells that ultimately seed the bone marrow for adult or “definitive” hematopoiesis are not completely defined. Meanwhile, the signaling molecules that control blood island development and primitive hematopoiesis are unknown and may be distinct from definitive hematopoietic ...
November 2012 - An error occurred.
November 2012 - An error occurred.

... Wood you believe: “Using the legendary properties of heartwood from the black locust tree as their inspiration, scientists have discovered a way to improve the performance of softwoods widely used in construction.” Thus begins an article on PhysOrg titled, “Inspiration from Mother Nature leads to im ...
The pollen wall and tapetum are altered in the
The pollen wall and tapetum are altered in the

... Programmed cell death (PCD), a physiological cell death process involved in the selective elimination of unwanted cells (Pennell and Lamb, 1997), is defined as death resulting from the activation of a specific biochemical pathway that is under the control of the cell and, therefore, amounts to cellu ...
Cellular damage induced by cadmium and
Cellular damage induced by cadmium and

... functions in plant metabolism. Several plants accumulate homologous non-protein thiols with changes in their constituent amino acids; for example, in legumes the glycine of GSH is substituted by alanine, producing homoglutathione (hGSH; Matamoros et al., 1999). The balance between the reduced and th ...
Pass the bicarb: the importance of HCO3 – for mucin release
Pass the bicarb: the importance of HCO3 – for mucin release

... Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is ...
Stage-Specific Histone Modification Profiles Reveal Global
Stage-Specific Histone Modification Profiles Reveal Global

... Our knowledge about the epigenetic changes, which accompany the determination of definitive somatic cell lineages in the mammalian embryo, are derived largely from in vitro differenti- ...
08-Inflammation and repair,hala
08-Inflammation and repair,hala

... by increased blood flow to the injured area, resulting mainly from arteriolar dilation and opening of capillary beds induced by mediators such as histamine. Increased vascular permeability results in the accumulation of protein-rich extravascular fluid, which forms the exudate. Plasma proteins leave ...
The origins, function, and regulation of T follicular helper cells
The origins, function, and regulation of T follicular helper cells

... by B cells drives the full development of Tfh cells. (iii) Within GC, Tfh cells continue to provide help to the B cells, supporting the GC reaction and facilitating the generation of long-lived plasma cells and memory B cells. Reciprocal signals provided by the B cells are also crucial for sustainin ...
Double-Stranded RNA Induces Sickle Erythrocyte
Double-Stranded RNA Induces Sickle Erythrocyte

... endothelium is posited as a major determinant of intracapillary transit time and a modulator of vaso-occlusive complications!-6 In recent years, specific adhesion pathways between both microvascular and large vein endothelium and sickle erythrocytes have been elucidated in a number of independent st ...
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Tissue engineering



Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.
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