Molecular signatures of T-cell inhibition in HIV-1 infection
... TIM-1 through TIM-8 exist in mice, whereas humans express only TIM-1, TIM-3, and TIM-4 [41,42]. The TIM family members all have certain structural morphologies in common, i.e. an N-terminal immunoglobulin V domain, a mucin domain, and a transmembrane domain followed by a cytoplasmic tail [41-43]. TI ...
... TIM-1 through TIM-8 exist in mice, whereas humans express only TIM-1, TIM-3, and TIM-4 [41,42]. The TIM family members all have certain structural morphologies in common, i.e. an N-terminal immunoglobulin V domain, a mucin domain, and a transmembrane domain followed by a cytoplasmic tail [41-43]. TI ...
Yersinia pestis targets neutrophils via complement receptor 3
... inflamed, painful bubo. Subsequently, bacteria disseminate to more distant lymph nodes as well as spleen and liver (Sebbane et al., 2005). Although disease progression is different for enteric Yersinia compared with Y. pestis, all three species share a tropism for lymphoid tissue. Investigating the ...
... inflamed, painful bubo. Subsequently, bacteria disseminate to more distant lymph nodes as well as spleen and liver (Sebbane et al., 2005). Although disease progression is different for enteric Yersinia compared with Y. pestis, all three species share a tropism for lymphoid tissue. Investigating the ...
Viscoelastic dissipation stabilizes cell shape changes
... components that exert mechanical forces at the cellular scale (1, 2). Classic examples include cell intercalation, in which polarized activity of Myosin II (MyoII) motors drives tissue elongation (3, 4), or apical constriction in which MyoII recruitment drives tissue folding and invagination (5). Th ...
... components that exert mechanical forces at the cellular scale (1, 2). Classic examples include cell intercalation, in which polarized activity of Myosin II (MyoII) motors drives tissue elongation (3, 4), or apical constriction in which MyoII recruitment drives tissue folding and invagination (5). Th ...
a Gene Encoding a Putative Signal Transduction Receptor in
... (Udani and Karrer, 2002). Asi1p and Asi2p have 22% identity and 40% similarity over a region of 684 amino acids (Fig. 3A). A BLASTp search of the NCBI data base detects a Cache domain in Asi1p and suggests that Asi1p has some similarity to bacterial methyl-accepting chemotaxis proteins (MCPs), at an ...
... (Udani and Karrer, 2002). Asi1p and Asi2p have 22% identity and 40% similarity over a region of 684 amino acids (Fig. 3A). A BLASTp search of the NCBI data base detects a Cache domain in Asi1p and suggests that Asi1p has some similarity to bacterial methyl-accepting chemotaxis proteins (MCPs), at an ...
Bioelectricity Excitatory Postsynaptic Potential The postsynaptic cell
... increases the influx of chloride (Cl−) ions into the postsynaptic cell raising its membrane potential and thus inhibiting it.This is a fast response — taking only about 1 millisecond. In both cases, the resulting facilitated diffusion of ions (chloride IN; potassium OUT) increases the membrane poten ...
... increases the influx of chloride (Cl−) ions into the postsynaptic cell raising its membrane potential and thus inhibiting it.This is a fast response — taking only about 1 millisecond. In both cases, the resulting facilitated diffusion of ions (chloride IN; potassium OUT) increases the membrane poten ...
The Bovine CD1 Family Contains Group 1 CD1 Proteins, but No
... been elucidated. Because SBU-T6 was shown to immunoprecipitate sheep CD1e, and at least one other protein (18, 22), it is regarded as a pan-CD1-specific Ab. CC20 and BCD1b3 are known to recognize human CD1b. Our data, summarized in Table II, show that SBU-T6 recognizes thymocytes, peripheral B cells ...
... been elucidated. Because SBU-T6 was shown to immunoprecipitate sheep CD1e, and at least one other protein (18, 22), it is regarded as a pan-CD1-specific Ab. CC20 and BCD1b3 are known to recognize human CD1b. Our data, summarized in Table II, show that SBU-T6 recognizes thymocytes, peripheral B cells ...
Mice lacking the homeodomain transcription factor
... Nkx2.5 and Nkx2.6 represent more divergent members of the family (Lints et al., 1993). NK2 family members have now been shown to be key regulators of development and differentiation in several tissues: Nkx2.1 is necessary for lung, thyroid and ventral forebrain development and Nkx2.5 is required for ...
... Nkx2.5 and Nkx2.6 represent more divergent members of the family (Lints et al., 1993). NK2 family members have now been shown to be key regulators of development and differentiation in several tissues: Nkx2.1 is necessary for lung, thyroid and ventral forebrain development and Nkx2.5 is required for ...
Botanical Gazette
... prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Please contact the publisher regarding any further use of this work. Publisher contact information may be obtai ...
... prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Please contact the publisher regarding any further use of this work. Publisher contact information may be obtai ...
Centrosome aberrations and G1 phase arrest after in vitro and in
... imatinib-resistant cells, and simultaneous inhibition of ABL are the important features of dasatinib, which also inhibits all other SRC-family members11 and has shown activity against c-KIT and PDGFRB.9,12,13 The efficacy and safety of dasatinib have been demonstrated in patients with Ph-positive le ...
... imatinib-resistant cells, and simultaneous inhibition of ABL are the important features of dasatinib, which also inhibits all other SRC-family members11 and has shown activity against c-KIT and PDGFRB.9,12,13 The efficacy and safety of dasatinib have been demonstrated in patients with Ph-positive le ...
Nuclear centering in Spirogyra
... Plant material. Spirogyra crassa was cultured in MXS (NeuschelerWirth 1970) as described by Grolig (1990). Non-dividing cells with a length/width ratio >2 were obtained after three to four weeks without change of culture medium. Cells with a ratio <1.5 were plasmolyzed by 0.4±0.6 mol á l)1 mannitol ...
... Plant material. Spirogyra crassa was cultured in MXS (NeuschelerWirth 1970) as described by Grolig (1990). Non-dividing cells with a length/width ratio >2 were obtained after three to four weeks without change of culture medium. Cells with a ratio <1.5 were plasmolyzed by 0.4±0.6 mol á l)1 mannitol ...
Hypersensitivity reactions
... Ag /hapten intradermally or with Freund’s adjuvant or by skin contact Circulating Ab may be absent and not responsible for reaction. “Cell mediated reaction” ...
... Ag /hapten intradermally or with Freund’s adjuvant or by skin contact Circulating Ab may be absent and not responsible for reaction. “Cell mediated reaction” ...
The synthesis and migration of nuclear proteins during mitosis and
... Both types of protein leave the nucleus when its interphase form is demolished at the beginning of mitosis and they both return to the nucleus at the end of mitosis. Experiments with nuclear proteins of Viciafaba labelled with 3H-arginine by Prensky and Smith (1964) show that some nuclear proteins o ...
... Both types of protein leave the nucleus when its interphase form is demolished at the beginning of mitosis and they both return to the nucleus at the end of mitosis. Experiments with nuclear proteins of Viciafaba labelled with 3H-arginine by Prensky and Smith (1964) show that some nuclear proteins o ...
Low dose effects of ionizing radiation on normal tissue stem cells
... factor-α (TGF-α), transforming growth factor-ß (TGF β), HGF and to activate WNT and NOTCH signaling pathways, thus ‘switching on’ stem cell signaling [58;59;60]. Hypoxia has also been shown in culture to play a role in increasing the CSC population by dedifferentiation [61]. During the last two deca ...
... factor-α (TGF-α), transforming growth factor-ß (TGF β), HGF and to activate WNT and NOTCH signaling pathways, thus ‘switching on’ stem cell signaling [58;59;60]. Hypoxia has also been shown in culture to play a role in increasing the CSC population by dedifferentiation [61]. During the last two deca ...
THE CELL CYCLE OF PHYTOPLANKTON : COUPLING CELL
... prevents DNA synthesis and blocks S phase cells, allowing to distinguish between G1 and G2 restriction points (e.g. Vaulot et al. 1986). Alternatively, one may limit cells by decreasing the level of the factor under study without removing it totally (e.g. put cells under low light conditions) and de ...
... prevents DNA synthesis and blocks S phase cells, allowing to distinguish between G1 and G2 restriction points (e.g. Vaulot et al. 1986). Alternatively, one may limit cells by decreasing the level of the factor under study without removing it totally (e.g. put cells under low light conditions) and de ...
Dictyostelium lysosomal proteins with different sugar modifications
... and CPs cofractionate with lysosomes and endosomes. GlcNAc-1-P-modified proteins reside in functional vesicles of the endo-lysosomal pathway Magnetic fractionation of vesicles containing iron-coated dextran has been used to purify and characterize functional Dictyostelium lysosomes and endosomes (Ro ...
... and CPs cofractionate with lysosomes and endosomes. GlcNAc-1-P-modified proteins reside in functional vesicles of the endo-lysosomal pathway Magnetic fractionation of vesicles containing iron-coated dextran has been used to purify and characterize functional Dictyostelium lysosomes and endosomes (Ro ...
Reduced Immunoregulatory CD31 T Cells in Patients With
... generated from peripheral blood monocytes of a single healthy donor, as previously described.18 CD8⫹ and CD4⫹ lymphocytes were prepared from 6 healthy individuals on the same day and were isolated by negative selection (DynalBiotech) rather than by positive sorting to avoid the potentially biasing e ...
... generated from peripheral blood monocytes of a single healthy donor, as previously described.18 CD8⫹ and CD4⫹ lymphocytes were prepared from 6 healthy individuals on the same day and were isolated by negative selection (DynalBiotech) rather than by positive sorting to avoid the potentially biasing e ...
Homeostatic proliferation generates long- lived natural killer
... 2009a). We addressed whether the more quiescent state of homeostasis-driven NK cells influenced their ability to turn over at steady state (i.e., in the absence of infection or inflammation). We performed a BrdU pulse for various durations at different time points after transfer and compared long-li ...
... 2009a). We addressed whether the more quiescent state of homeostasis-driven NK cells influenced their ability to turn over at steady state (i.e., in the absence of infection or inflammation). We performed a BrdU pulse for various durations at different time points after transfer and compared long-li ...
Molecular characterization of carnitinedependent transport of
... chain shortening of fatty acids to produce acetyl-CoA and/ or propionyl-CoA plus medium-chain acyl-CoAs. These are then transported to the mitochondria as carnitine esters, where they are further oxidized to CO2 and H2O (Bieber, 1988; Osmundsen et al., 1991; Reddy and Mannnaerts, 1994) as shown conv ...
... chain shortening of fatty acids to produce acetyl-CoA and/ or propionyl-CoA plus medium-chain acyl-CoAs. These are then transported to the mitochondria as carnitine esters, where they are further oxidized to CO2 and H2O (Bieber, 1988; Osmundsen et al., 1991; Reddy and Mannnaerts, 1994) as shown conv ...
Clinical Implications of Intestinal Stem Cell Markers in Colorectal
... be the result of acquired epigenetic and genetic changes in the stem cells. The adult stem cells already possess critical characteristics such as self-renewal capacity and long-term replicative potential, but during normal homeostasis, these capacities are tightly regulated. Because of the propertie ...
... be the result of acquired epigenetic and genetic changes in the stem cells. The adult stem cells already possess critical characteristics such as self-renewal capacity and long-term replicative potential, but during normal homeostasis, these capacities are tightly regulated. Because of the propertie ...
2017 Lecture PDF
... Below are some example historical research finding related to cell membranes from the JCB Archive and other sources. 1957 The invention of freeze fracture EM and the determination of membrane structure (http://jcb.rupress.org/cgi/content/full/168/2/174-a) Russell Steere introduces his home-made cont ...
... Below are some example historical research finding related to cell membranes from the JCB Archive and other sources. 1957 The invention of freeze fracture EM and the determination of membrane structure (http://jcb.rupress.org/cgi/content/full/168/2/174-a) Russell Steere introduces his home-made cont ...
Protection of Retinal Ganglion Cells from Natural and Axotomy
... Several genes have been identified that play a key role in the positive and negative regulation of apoptosis (Oppenheim et al., 1990; Ellis et al., 1991; Osborne and Schwartz, 1994; Davies, 1995; Korsmeyer, 1995). The product of the proto-oncogene bcl-2, an intracellular membrane-associated protein, ...
... Several genes have been identified that play a key role in the positive and negative regulation of apoptosis (Oppenheim et al., 1990; Ellis et al., 1991; Osborne and Schwartz, 1994; Davies, 1995; Korsmeyer, 1995). The product of the proto-oncogene bcl-2, an intracellular membrane-associated protein, ...
Relative Abundance of Nickel in the Leaf
... hairs. In some species the metal was present in subsidiary cells, yet at low levels, while the sites of higher accumulation were epidermal cells away from stomata. Results indicate that nickel is not compatible with the functions and # 2000 Annals of Botany Company development of certain epidermal c ...
... hairs. In some species the metal was present in subsidiary cells, yet at low levels, while the sites of higher accumulation were epidermal cells away from stomata. Results indicate that nickel is not compatible with the functions and # 2000 Annals of Botany Company development of certain epidermal c ...
kim and ronesha presentation
... functions include regulation of immune and inflammatory responses, cell growth, apoptosis, and tumor formation. ...
... functions include regulation of immune and inflammatory responses, cell growth, apoptosis, and tumor formation. ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.