Activation of clinically used anthracyclines by the formaldehyde
... neoplastic diseases. The major clinically used anthracyclines consist of doxorubicin, daunorubicin, idarubicin, and epirubicin. Doxorubicin is a broad-spectrum antitumor antibiotic, and the tumors most commonly responsive to this drug include breast and esophageal carcinomas, osteosarcoma, soft tiss ...
... neoplastic diseases. The major clinically used anthracyclines consist of doxorubicin, daunorubicin, idarubicin, and epirubicin. Doxorubicin is a broad-spectrum antitumor antibiotic, and the tumors most commonly responsive to this drug include breast and esophageal carcinomas, osteosarcoma, soft tiss ...
MUC1 is a novel costimulatory molecule of human T cells and
... through phosphorylation of transcription factors [18]. In the original studies [8], it was demonstrated that MUC1 was only expressed on a fraction of activated T cells at a given time. Once matured with mitogens, MUC1 was determined to have coinhibitory capabilities in highly purified T-cell cultures ...
... through phosphorylation of transcription factors [18]. In the original studies [8], it was demonstrated that MUC1 was only expressed on a fraction of activated T cells at a given time. Once matured with mitogens, MUC1 was determined to have coinhibitory capabilities in highly purified T-cell cultures ...
A TUrBO SWITCH SpEEdS Up A CRUCIAL CALCIUM PUMP
... such as changes in cell activity or cell division. Calcium signalling derives from the 20.000-fold gradient between the high concentration outside the cells and the low intracellular level. For example, during signalling or under stress the calcium concentration inside the cells increases due to ope ...
... such as changes in cell activity or cell division. Calcium signalling derives from the 20.000-fold gradient between the high concentration outside the cells and the low intracellular level. For example, during signalling or under stress the calcium concentration inside the cells increases due to ope ...
Sorting drops and cells with acoustics: acoustic
... this approach the forces depend on both compressibility contrast and cell size. All of these actuation mechanisms critically depend on the volume of the objects and small objects are inherently more difficult to sort. This also makes it difficult to sort cell populations that have a wide distributio ...
... this approach the forces depend on both compressibility contrast and cell size. All of these actuation mechanisms critically depend on the volume of the objects and small objects are inherently more difficult to sort. This also makes it difficult to sort cell populations that have a wide distributio ...
Report from the Society for Biological Therapy and Vascular Biology
... vessels, it is loosely associated with the endothelial cells and pericytes and may have multiple layers. These abnormalities are particularly conspicuous in rapidly growing tumors. Redundant layers of basement membrane, which are loosely associated with endothelial cells and pericytes, reflect conti ...
... vessels, it is loosely associated with the endothelial cells and pericytes and may have multiple layers. These abnormalities are particularly conspicuous in rapidly growing tumors. Redundant layers of basement membrane, which are loosely associated with endothelial cells and pericytes, reflect conti ...
Review Article Macrophage Plasticity and the - e
... the injured tissues, where they produce proin�ammatory cytokines and phagocytose dying or apoptotic cells. In the blood, circulating monocytes can be classi�ed into at least two populations that are distinguishable by their expression levels of Ly-6C (also known as GR1) and of chemokine receptors CC ...
... the injured tissues, where they produce proin�ammatory cytokines and phagocytose dying or apoptotic cells. In the blood, circulating monocytes can be classi�ed into at least two populations that are distinguishable by their expression levels of Ly-6C (also known as GR1) and of chemokine receptors CC ...
Starfish ApDOCK protein essentially functions in larval
... taken into the blastocoel through the body wall, respectively. With regard to defense cell behaviors, the functions of larval mesenchyme cells have been uncovered through injection experiments with various foreign substances.1 When a relatively large amount of bacteria is injected into the blastocoe ...
... taken into the blastocoel through the body wall, respectively. With regard to defense cell behaviors, the functions of larval mesenchyme cells have been uncovered through injection experiments with various foreign substances.1 When a relatively large amount of bacteria is injected into the blastocoe ...
Assessment of pro-arrhythmic effects using Pluricyte
... Our scientists are ready to help you with any questions you may have regarding this application note or our Pluricyte® Cardiomyocytes. In addition, in-lab training is available upon request. For further information please visit our website www.pluriomics.com, or contact us directly by e-mail (suppor ...
... Our scientists are ready to help you with any questions you may have regarding this application note or our Pluricyte® Cardiomyocytes. In addition, in-lab training is available upon request. For further information please visit our website www.pluriomics.com, or contact us directly by e-mail (suppor ...
Head-tail patterning of the vertebrate embryo: one, two or many
... Textbooks and even some primary papers make the assumption that, as in the fly, vertebrate embryos specify their head-tail axis very early in development, even before gastrulation. Thus, diagrams depicting the organization of the early (blastula- or early gastrula-stage) embryo may include indicatio ...
... Textbooks and even some primary papers make the assumption that, as in the fly, vertebrate embryos specify their head-tail axis very early in development, even before gastrulation. Thus, diagrams depicting the organization of the early (blastula- or early gastrula-stage) embryo may include indicatio ...
insider - The Paleo Diet
... Wiley: So who will this program work for? Dr. Cordain: Well, I think that this will work for most people. We clearly believe that it is genetic susceptibility which predisposes some people to acne. Some people can get by with eating these foods but most can’t, given the notion that 90% of all teenag ...
... Wiley: So who will this program work for? Dr. Cordain: Well, I think that this will work for most people. We clearly believe that it is genetic susceptibility which predisposes some people to acne. Some people can get by with eating these foods but most can’t, given the notion that 90% of all teenag ...
How plant cells explore geometry - The polarity induction and
... are investigated. A standardized system was developed to generate and integrate quantitative data on the temporal patterns of regeneration stages. Hereinafter this system was integrated into a microfluidic platform to study the impacts of chemical and geometrical stimuli during the establishment of ...
... are investigated. A standardized system was developed to generate and integrate quantitative data on the temporal patterns of regeneration stages. Hereinafter this system was integrated into a microfluidic platform to study the impacts of chemical and geometrical stimuli during the establishment of ...
Permeability Fundamentals
... Efflux, the active transport of compounds from inside the cell or membrane back into the lumenal space. Pgp(p-glycoprotein) BCRP (breast cancer resistance protein) ...
... Efflux, the active transport of compounds from inside the cell or membrane back into the lumenal space. Pgp(p-glycoprotein) BCRP (breast cancer resistance protein) ...
Strategies of actin reorganisation in plant cells
... date. The actin-binding domain of mouse talin (Tn) (Kost et al., 1998) allowed the observation of fine actin organisation in all plant tissues and led to a better understanding of F-actin organisation during plant development and morphogenesis (Mathur et al., 1999; Fu et al., 2001; Ilgenfritz et al. ...
... date. The actin-binding domain of mouse talin (Tn) (Kost et al., 1998) allowed the observation of fine actin organisation in all plant tissues and led to a better understanding of F-actin organisation during plant development and morphogenesis (Mathur et al., 1999; Fu et al., 2001; Ilgenfritz et al. ...
Mitochondrial GFA2 Is Required for Synergid Cell
... Little is known about the molecular processes that govern female gametophyte (FG) development and function, and few FG-expressed genes have been identified. We report the identification and phenotypic analysis of 31 new FG mutants in Arabidopsis. These mutants have defects throughout development, in ...
... Little is known about the molecular processes that govern female gametophyte (FG) development and function, and few FG-expressed genes have been identified. We report the identification and phenotypic analysis of 31 new FG mutants in Arabidopsis. These mutants have defects throughout development, in ...
Evidence that Shh cooperates with a retinoic acid inducible co
... are induced in a mirror image fashion (Saunders and Gasseling, 1968). The molecular mechanisms underlying this process, although elusive for long time, are now starting to emerge. RA (Tickle et al., 1982), and Sonic hedgehog (Shh; Riddle, 1993; Chang et al., 1994; Lopez Martinez et al., 1995) have b ...
... are induced in a mirror image fashion (Saunders and Gasseling, 1968). The molecular mechanisms underlying this process, although elusive for long time, are now starting to emerge. RA (Tickle et al., 1982), and Sonic hedgehog (Shh; Riddle, 1993; Chang et al., 1994; Lopez Martinez et al., 1995) have b ...
Interleukin 1 Receptor Antagonist (IL-1Ra) Is an Acute-Phase
... role in tissue repair. APP are produced mainly by hepatocytes in response to several cytokines. Although IL-6 is considered to be the major inducer, other cytokines such IL-1 and tumor necrosis factor (TNF)-a can also stimulate the production of APP (6). IL-1 plays a key role in inflammation, exerti ...
... role in tissue repair. APP are produced mainly by hepatocytes in response to several cytokines. Although IL-6 is considered to be the major inducer, other cytokines such IL-1 and tumor necrosis factor (TNF)-a can also stimulate the production of APP (6). IL-1 plays a key role in inflammation, exerti ...
Cardiac muscle
... multinucleate muscle fibers, which develop by fusion of many individual embryonic cells called myoblasts. Muscle fibers can grow by continued nuclear division within the fibers. Although skeletal muscle fibers are thus not proper, individual cells, the term "muscle cell" is commonly used to refer to ...
... multinucleate muscle fibers, which develop by fusion of many individual embryonic cells called myoblasts. Muscle fibers can grow by continued nuclear division within the fibers. Although skeletal muscle fibers are thus not proper, individual cells, the term "muscle cell" is commonly used to refer to ...
Intrahepatic expression of the hepatic stellate cell marker ®broblast
... Abstract: Background: Activated hepatic stellate cells (HSCs), recognised by their a smooth muscle actin immunoreactivity, are primarily responsible for liver ®brosis. However, the presence of a smooth muscle actin positive HSCs is not always associated with the development of liver ®brosis. Recentl ...
... Abstract: Background: Activated hepatic stellate cells (HSCs), recognised by their a smooth muscle actin immunoreactivity, are primarily responsible for liver ®brosis. However, the presence of a smooth muscle actin positive HSCs is not always associated with the development of liver ®brosis. Recentl ...
Vps41 Phosphorylation and the Rab Ypt7 Control the Targeting of
... for casein kinase I sites within the Vps41-sequence (Netphos, http://www.cbs.dtu.dk/services/NetPhos/; Scansite, http://scansite.mit.edu/) and identified four possible consensus sequences (Figure 2C). The relevant serine and threonine residues were changed into alanines in different combination and ...
... for casein kinase I sites within the Vps41-sequence (Netphos, http://www.cbs.dtu.dk/services/NetPhos/; Scansite, http://scansite.mit.edu/) and identified four possible consensus sequences (Figure 2C). The relevant serine and threonine residues were changed into alanines in different combination and ...
Document
... Materials and Methods: Positively and negatively charged ISCOMATRIX were prepared. BALB/C mice were immunized subcutaneously, three times with 2-week intervals, with different ISCOMATRIX formulations. Soluble Leishmania antigens (SLA) were mixed with ISCOMATRIX right before injection. The extent of ...
... Materials and Methods: Positively and negatively charged ISCOMATRIX were prepared. BALB/C mice were immunized subcutaneously, three times with 2-week intervals, with different ISCOMATRIX formulations. Soluble Leishmania antigens (SLA) were mixed with ISCOMATRIX right before injection. The extent of ...
Selection and the Origin of Cells
... together by internal hydrophobic interactions or had a spontaneously formed, semipermeable bounding layer generated by chemical cross-linking or by self-assembly of lipidlike molecules (the latter would arguably constitute protocells). The implicit or overt argument is that these precellular entitie ...
... together by internal hydrophobic interactions or had a spontaneously formed, semipermeable bounding layer generated by chemical cross-linking or by self-assembly of lipidlike molecules (the latter would arguably constitute protocells). The implicit or overt argument is that these precellular entitie ...
The Cryptic Peptides, Prepro-Thyrotropin Releasing Hormone 186
... in inhibition of the stress axis. Synthesis of TRH precursor peptides and the cellular processing that yields discrete TRH segments has been described in great detail (Nillni 1999). While ppTRH 178-199 is produced by serine protease cleavage in hypothalamus, producing the above described effects, th ...
... in inhibition of the stress axis. Synthesis of TRH precursor peptides and the cellular processing that yields discrete TRH segments has been described in great detail (Nillni 1999). While ppTRH 178-199 is produced by serine protease cleavage in hypothalamus, producing the above described effects, th ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.